TGF-β/SMAD signaling regulation of mesenchymal stem cells in adipocyte commitment

TGF-β Signaling Plays an Essential Role in the Lineage Specification of Mesenchymal Stem/Progenitor Cells in Fetal Bone Marrow

(2019) Grazia Abou-Ezzi et al.   Stem Cell Reports

Mechanistic insight into contextual TGF-β signaling

(2018) Ying E Zhang   CURRENT OPINION IN CELL BIOLOGY

Contextual determinants of TGFβ action in development, immunity and cancer

(2018) Charles J. David et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

BMP4 facilitates beige fat biogenesis via regulating adipose tissue macrophages

(2018) Shu-Wen Qian et al.   Journal of Molecular Cell Biology

A Reciprocal Role of the Smad4-Taz Axis in Osteogenesis and Adipogenesis of Mesenchymal Stem Cells

(2018) Jin Seok Park et al.   STEM CELLS

BMP4 Gene Therapy in Mature Mice Reduces BAT Activation but Protects from Obesity by Browning Subcutaneous Adipose Tissue

(2017) Jenny M. Hoffmann et al.   Cell Reports

SERPINB2 is a novel TGFβ-responsive lineage fate determinant of human bone marrow stromal cells

(2017) Mona Elsafadi et al.   Scientific Reports

Emerging Complexities in Adipocyte Origins and Identity

(2016) Joan Sanchez-Gurmaches et al.   TRENDS IN CELL BIOLOGY

BMP4 mediates the interplay between adipogenesis and angiogenesis during expansion of subcutaneous white adipose tissue

(2016) Yan Tang et al.   Journal of Molecular Cell Biology

Regulation of TGF-β Family Signaling by Inhibitory Smads

(2016) Keiji Miyazawa et al.   Cold Spring Harbor Perspectives in Biology

A stringent validation of mouse adipose tissue identity markers

(2015) Jasper M. A. de Jong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Role of developmental transcription factors in white, brown and beige adipose tissues

(2015) Catriona Hilton et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

BMP4 and BMP Antagonists Regulate Human White and Beige Adipogenesis

(2015) Birgit Gustafson et al.   DIABETES

Cellular origins of cold-induced brown adipocytes in adult mice

(2015) Yun-Hee Lee et al.   FASEB JOURNAL

miR-20a regulates adipocyte differentiation by targeting lysine-specific demethylase 6b and transforming growth factor-β signaling

(2015) J Zhou et al.   INTERNATIONAL JOURNAL OF OBESITY

Bone Morphogenetic Protein-2 Induces Donor-Dependent Osteogenic and Adipogenic Differentiation in Human Adipose Stem Cells

(2015) Sari Vanhatupa et al.   Stem Cells Translational Medicine

BMP7 Drives Human Adipogenic Stem Cells into Metabolically Active Beige Adipocytes

(2014) Meshail Okla et al.   LIPIDS

The different shades of fat

(2014) Vivian Peirce et al.   NATURE

Brown Fat Determination and Development from Muscle Precursor Cells by Novel Action of Bone Morphogenetic Protein 6

(2014) Ankur Sharma et al.   PLoS One

Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed

(2014) Joan Sanchez-Gurmaches et al.   Nature Communications

Adipose-derived mesenchymal stromal/stem cells: An update on their phenotype in vivo and in vitro

(2014) Patrick C Baer   World Journal of Stem Cells

BMP4 and BMP7 induce the white-to-brown transition of primary human adipose stem cells

(2013) Manuela Elsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Role of bone morphogenetic protein 4 in the differentiation of brown fat-like adipocytes

(2013) Ruidan Xue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT)

(2013) Philippe Bourin et al.   CYTOTHERAPY

Inhibition of in vitro and in vivo brown fat differentiation program by myostatin

(2013) Melissa Braga et al.   Obesity

TGF-beta1 Does Not Induce Senescence of Multipotent Mesenchymal Stromal Cells and Has Similar Effects in Early and Late Passages

(2013) Gudrun Walenda et al.   PLoS One

WISP2 regulates preadipocyte commitment and PPAR  activation by BMP4

(2013) A. Hammarstedt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

The WNT Inhibitor Dickkopf 1 and Bone Morphogenetic Protein 4 Rescue Adipogenesis in Hypertrophic Obesity in Humans

(2012) Birgit Gustafson et al.   DIABETES

Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice

(2011) C. Zhang et al.   DIABETOLOGIA

The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation

(2010) G. Barbatelli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Involvement of Cytoskeleton-associated Proteins in the Commitment of C3H10T1/2 Pluripotent Stem Cells to Adipocyte Lineage Induced by BMP2/4

(2010) Hai-Yan Huang et al.   MOLECULAR & CELLULAR PROTEOMICS

BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage

(2009) H. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PDGF, TGF- , and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and osteogenic lineages

(2008) F. Ng et al.   BLOOD

Nucleocytoplasmic shuttling of Smad proteins

(2008) Caroline S Hill   CELL RESEARCH

Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146+ perivascular cells and fibroblasts

(2008) Dimas T. Covas et al.   EXPERIMENTAL HEMATOLOGY

The Effects of Myostatin on Adipogenic Differentiation of Human Bone Marrow-derived Mesenchymal Stem Cells Are Mediated through Cross-communication between Smad3 and Wnt/β-Catenin Signaling Pathways

(2008) Wen Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

(2008) Yu-Hua Tseng et al.   NATURE

Tumor Immunotherapy Using Gene-Modified Human Mesenchymal Stem Cells Loaded into Synthetic Extracellular Matrix Scaffolds

(2008) Marta Compte et al.   STEM CELLS