Article
Neurosciences
Nathan C. Winn, Elysa M. Wolf, Jamie N. Garcia, Alyssa H. Hasty
Summary: This study shows that loss of Trem2 does not worsen metabolic dysfunction in obese mice, indicating a dissociation between adipose tissue remodeling caused by Trem2 loss and whole-body metabolic homeostasis.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Nutrition & Dietetics
Kari Luotola
Summary: Low-grade inflammation plays a major role in obesity, metabolic syndrome, and the development of type 2 diabetes. The interleukin-1 receptor antagonist (IL-1Ra) is an important natural anti-inflammatory factor involved in glucose homeostasis disturbances. IL-1Ra levels can be used as a potential biomarker for metabolic dysregulation, particularly in prediabetes. Further research is needed to understand the role of IL-1Ra in metabolic abnormalities and its relationship with other lifestyle and metabolic parameters.
Article
Food Science & Technology
Alexis Alonso-Bastida, Manuel Adam-Medina, Dolores-Azucena Salazar-Pina, Ricardo-Fabricio Escobar-Jimenez, Maria-Socorro Parra-Cabrera, Marisol Cervantes-Bobadilla
Summary: This study analyzes the effect of modifying the sequence of macronutrient intake on glycemic variation in individuals without diabetes. The results show that consuming vegetables, fiber, or proteins before carbohydrates can decrease postprandial glucose peaks and average blood glucose levels. This research has the preliminary potential to prevent and solve chronic degenerative diseases, improve glucose management, and enhance individual health through altering the sequence of macronutrient intake.
Article
Nutrition & Dietetics
Chao-Yue Kong, Zhan-Ming Li, Hui-Ling Chen, Yu-Qin Mao, Bing Han, Jian-Jun Guo, Li-Shun Wang
Summary: This study investigated the benefits of a novel dietary treatment in mice with MetS. The results showed that the CR-YD diet had a better therapeutic effect in mice with HFD-induced MetS compared to calorie restriction alone.
JOURNAL OF NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Priscila L. Zimath, Milena S. Almeida, Maciel A. Bruxel, Alex Rafacho
Summary: In this study, the potential therapeutic application of mometasone furoate (MF) with fewer adverse effects was investigated. It was found that MF maintained anti-inflammatory activity, but intraperitoneal administration led to glucose intolerance, while oral administration did not. Regardless of the route of administration, MF reduced insulin sensitivity and increased pancreatic beta-cell mass. Overall, oral administration of MF minimized the adverse effects on metabolism.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Byungtae Hwang, Min-Gi Kwon, Min Ji Cho, Nam-Kyung Lee, Jangwook Lee, Jeong Woong Lee, Kyoung-Jin Oh, Kwang-Hee Bae, Jung Hwan Hwang, Jeong-Ki Min, Jong-Gil Park
Summary: This study highlights the critical role of PTP4A1 in regulating hepatosteatosis and glucose homeostasis. It demonstrates that PTP4A1 prevents the accumulation of hepatic lipids and regulates glucose uptake by activating the CREBH/FGF21 axis. Modulating PTP4A1 may offer a potential therapeutic strategy against hepatosteatosis-related diseases.
Article
Microbiology
Julien Tap, Stine Storsrud, Boris Le Neve, Aurelie Cotillard, Nicolas Pons, Joel Dore, Lena Ohman, Hans Tornblom, Muriel Derrien, Magnus Simren
Summary: Individuals with severe IBS were found to have a higher intake of poorer-quality food items, and the covariations between gut microbiota at subspecies level and diet were associated with factors such as symptom severity. The study provides insight into diet-microbiota-symptom interactions and may guide future interventional studies on gut microbiome-based nutritional recommendations for managing gastrointestinal symptoms.
Article
Behavioral Sciences
Catherine C. Steele, Trevor J. Steele, MacKenzie Gwinner, Sara K. Rosenkranz, Kimberly Kirkpatrick
Summary: Research indicates that high consumption of processed sugar is predictive of impulsive choices, while body fat percentage is associated with impulsive choices only in the high-fat diet group, and fasting glucose is related to impulsive choices in the control group.
Review
Biochemistry & Molecular Biology
Piero Portincasa, Leonilde Bonfrate, Mirco Vacca, Maria De Angelis, Ilaria Farella, Elisa Lanza, Mohamad Khalil, David Q. -H. Wang, Markus Sperandio, Agostino Di Ciaula
Summary: The gut microbiota consists of trillions of commensal microorganisms including bacteria, fungi, and viruses, which coexist in symbiosis with the host and have profound effects on human health. Short chain fatty acids (SCFAs) are the most abundant bacterial metabolites in the human body and play an important role in metabolic, endocrine, and immune functions. Diet can influence the composition and activity of the gut microbiota, as well as SCFAs production and metabolic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
A. S. Silva, C. S. Cortinhas, T. S. Acedo, M. J. F. Morenz, F. C. F. Lopes, M. B. Arrigoni, M. H. Ferreira, T. L. Jaguaribe, L. D. Ferreira, V. N. Gouvea, L. G. R. Pereira
Summary: The effects of supplementing 25-hydroxyvitamin D-3 on dairy cows were investigated. The study found that supplementing 25-hydroxyvitamin D-3 improved milk yield, energy metabolism, and lactation performance.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Megumi Ueno, Shuang Liu, Takeshi Kiyoi, Masaki Mogi, Takashi Sugiyama
Summary: This study investigated the long-term effects of maternal balanced low-fat interventions on the offspring's metabolic homeostasis. The results showed that changes in maternal dietary composition improved glucose metabolism and insulin levels in the offspring, and compensated for the detrimental effects of a high-fat diet by changing the gene expression profile.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Immunology
Suowen Xu, Qing Rex Lyu, Iqra Ilyas, Xiao-Yu Tian, Jianping Weng
Summary: Atherosclerosis is a chronic disease characterized by lipid deposition, inflammation, and impaired inflammation resolution, leading to narrowing of blood vessels, hardening, and plaque formation. Recent evidence suggests that the vascular system can be viewed as a complex homeostatic system, similar to a mini-ecosystem, consisting of the vascular microenvironment and the interaction among different types of vascular cells. By studying the cellular components in the vascular wall and their impact on vascular homeostasis, structure, function, and atherosclerosis, we can gain insights into the pathogenesis and explore vascular-stabilizing strategies to prevent cardiovascular diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Jia Liu, Kevin W. Aylor, Zhenqi Liu
Summary: Inflammation-induced vascular insulin resistance is an early event in diet-induced obesity and contributes to metabolic insulin resistance. Exercise and glucagon-like peptide 1 (GLP-1) receptor agonism, alone or in combination, improve insulin sensitivity and reduce vascular oxidative stress and inflammation in the early stage of obesity development, enhancing the metabolic actions of insulin. Early combination use of exercise and GLP-1 receptor agonism might be an effective strategy in preventing vascular and metabolic insulin resistance and associated complications during the development of obesity.
Review
Biochemical Research Methods
Richard C. Law, Aliya Lakhani, Samantha O'Keeffe, Sevcan Ersan, Junyoung O. Park
Summary: A complete understanding of a biological system requires quantifying metabolic fluxes, which can be measured using various analytical chemistry tools, enzyme-based probes, and microscopy. However, no single method can provide comprehensive information. Integrating these techniques can result in a systems-level quantitative map of absolute metabolic fluxes that characterize phenotypes.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Review
Endocrinology & Metabolism
Hei Man Fan, Alice L. Mitchell, Catherine Williamson
Summary: This article discusses the metabolic regulation of bile acids and their impact on bile acid homeostasis and metabolism during pregnancy, focusing on the roles of FXR and TGR5 in glucose and lipid metabolism during pregnancy, as well as their potential applications in gestational disorders such as ICP and GDM.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rocio Toro, Alexandra Perez-Serra, Alipio Mangas, Oscar Campuzano, Georgia Sarquella-Brugada, Maribel Quezada-Feijoo, Monica Ramos, Martin Alcala, Esther Carrera, Carlos Garcia-Padilla, Diego Franco, Fernando Bonet
Summary: Oxidative stress plays a significant role in cardiovascular diseases, and endoplasmic reticulum stress is an important source of reactive oxygen species. miR-16-5p could promote oxidative stress through ER stress induction and regulation of ATF6. Analysis of oxidative markers in the plasma of ischemic dilated cardiomyopathy patients showed a correlation with oxidative stress. Overexpression of miR-16-5p increased oxidative stress in cardiomyoblasts, while its suppression decreased apoptosis, inflammation, and cardiac damage through activation of the ATF6-mediated cytoprotective pathway. ATF6 was identified as a direct target gene of miR-16-5p.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Jesus Fernandez-Felipe, Maria Valencia-Avezuela, Beatriz Merino, Beatriz Somoza, Victoria Cano, Ana B. Sanz-Martos, Laura M. Frago, Maria S. Fernandez-Alfonso, Mariano Ruiz-Gayo, Julie A. Chowen
Summary: This study found that diets rich in fatty acids can increase body weight and adiposity, even without increased energy intake. Different intake of saturated and unsaturated fatty acids can differentially modify metabolic parameters. Further research is needed to understand how specific nutrients affect metabolism and obesity-associated complications.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Francisco Javier Manzano-Lista, Marta Sanz-Gomez, Daniel Gonzalez-Moreno, Elena Vega-Martin, Marta Gil-Ortega, Angela Schulz, Miguel Angel Rubio, Gema Ruiz-Hurtado, Luis Miguel Ruilope, Isabel Aranguez, Reinhold Kreutz, Maria S. Fernandez-Alfonso
Summary: Arterial stiffness is a common complication in patients with chronic kidney disease (CKD). Imbalance between BMP-2 and BMP-7 may contribute to the development of kidney damage, hypertension, and increased pulse wave velocity (PWV) in CKD patients. This study found that BMP-2 levels were higher, while BMP-7 levels were lower in CKD patients compared to controls, and this imbalance was associated with higher blood pressure and PWV. The expression of related proteins in kidney and perivascular adipose tissues (PVAT) was also abnormal, indicating a potential role in vascular damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Quentin Sastourne-Arrey, Maxime Mathieu, Xavier Contreras, Sylvie Monferran, Virginie Bourlier, Marta Gil-Ortega, Enda Murphy, Claire Laurens, Audrey Varin, Christophe Guissard, Corinne Barreau, Mireille Andre, Noemie Juin, Marie Marques, Benoit Chaput, Cedric Moro, Donal O'Gorman, Louis Casteilla, Amandine Girousse, Coralie Sengenes
Summary: Fibro-adipogenic progenitors (FAPs) are crucial for skeletal muscle regeneration, and recent research has shown that a subset of FAP-like cells released from subcutaneous adipose tissue (ScAT) plays a role in this process. These cells, known as adipose stromal cells (ASCs), infiltrate the injured muscle through a platelet-dependent mechanism and contribute to the heterogeneity of FAPs. Blocking ASCs infiltration or removing ASCs tissue source impairs muscle regeneration, highlighting the importance of ScAT as a physiological reservoir of regenerative cells.
NATURE COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Jose-Luis Rodriguez, Paola Berrios, Zoyla-Mirella Clavo, Manuel Marin-Bravo, Luis Inostroza-Ruiz, Mariella Ramos-Gonzalez, Miguel Quispe-Solano, Maria S. Fernandez-Alfonso, Olga Palomino, Luis Goya
Summary: It is proposed that oxidative stress is a pathogenic mechanism for cytotoxicity and cardiovascular and neuronal diseases. This study evaluated the antioxidant and cytoprotective capacity of Desmodium tortuosum (D. tortuosum) extract in cell lines subjected to oxidative stress induced by t-BOOH. The results showed that D. tortuosum extract was able to reduce the oxidative and cytotoxic effects induced by t-BOOH, possibly due to its high content of phenolic compounds.
Article
Environmental Sciences
Juan Corral-Perez, Martin Alcala, Daniel Velazquez-Diaz, Alejandro Perez-Bey, Maria A. Vazquez-Sanchez, Maria Calderon-Dominguez, Cristina Casals, Jesus G. Ponce-Gonzalez
Summary: This study aims to analyze the associations between physical activity and sedentary behavior with oxidative stress and inflammatory markers in a young adult population, with sex-specific differences observed. The findings suggest that women have better redox and inflammatory status compared to men, while oxidative stress markers are only associated with physical activity and sedentary behaviors in men.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Fabiola Alvarez-Gallego, Raquel Gonzalez-Blazquez, Marta Gil-Ortega, Beatriz Somoza, Maria Calderon-Dominguez, Javier Moratinos, Virginia Garcia-Garcia, Paloma Fernandez, Daniel Gonzalez-Moreno, Marta Viana, Martin Alcala
Summary: AT2R activation increases BAT mass and activity, reduces tissue inflammation and oxidative stress in obesity. It enhances insulin sensitivity and improves vascular responsiveness, showing potential therapeutic value in the treatment of obesity.
Article
Peripheral Vascular Disease
Giuseppe Mancia, Reinhold Kreutz, Mattias Brunstrom, Michel Burnier, Guido Grassi, Andrzej Januszewicz, Maria Lorenza Muiesan, Konstantinos Tsioufis, Enrico Agabiti-Rosei, Engi Abd Elhady Algharably, Michel Azizi, Athanase Benetos, Claudio Borghi, Jana Brguljan Hitij, Renata Cifkova, Antonio Coca, Veronique Cornelissen, J. Kennedy Cruickshank, Pedro G. Cunha, A. H. Jan Danser, Rosa Maria de Pinho, Christian Delles, Anna F. Dominiczak, Maria Dorobantu, Michalis Doumas, Maria S. Fernandez-Alfonso, Jean-Michel Halimi, Zoltan Jarai, Bojan Jelakovic, Jens Jordan, Tatiana Kuznetsova, Stephane Laurent, Dragan Lovic, Empar Lurbe, Felix Mahfoud, Athanasios Manolis, Marius Miglinas, Krzystof Narkiewicz, Teemu Niiranen, Paolo Palatini, Gianfranco Parati, Atul Pathak, Alexandre Persu, Jorge Polonia, Josep Redon, Pantelis Sarafidis, Roland Schmieder, Bart Spronck, Stella Stabouli, George Stergiou, Stefano Taddei, Costas Thomopoulos, Maciej Tomaszewski, Philippe Van de Borne, Christoph Wanner, Thomas Weber, Bryan Williams, Zhen-Yu Zhang, Sverre E. Kjeldsen, Int Soc Hypertension ISH, European Renal Assoc ERA
Summary: This is an article introducing a list of document reviewers from various countries such as Mexico, Greece, Turkey, Brazil, Lebanon, and more.
JOURNAL OF HYPERTENSION
(2023)
Article
Biochemistry & Molecular Biology
Diego Valor, Antonio Montes, Maria Calderon-Dominguez, Inass Aghziel, Ismael Sanchez-Gomar, Martin Alcala, Ma Carmen Duran-Ruiz, Clara Pereyra
Summary: Submicron particles were produced from an ethanolic extract of Myrtus communnis leaves using supercritical carbon dioxide technology. The particles had small sizes, quasi-spherical shape, and high antioxidant activity. It was also observed that increasing pressure and temperature resulted in smaller particle sizes.
Article
Physiology
Raquel Gonzalez-Blazquez, Marta Gil-Ortega, Martin Alcala, Daniel Gonzalez-Moreno, Marta Viana, Julie A. Chowen, Marta Sanz-Gomez, Maria S. Fernandez-Alfonso, Beatriz Somoza
Summary: This study aimed to investigate if replacing a high-fat diet with a standard diet for a short period could reverse obesity-induced endothelial dysfunction through AMPK-CREB activation. The results showed that improving dietary intake significantly improved vascular function and the antioxidant system mediated by the AMPK/CREB signaling pathway.
Review
Pharmacology & Pharmacy
Patricia Azocar, Marisela Valdes-Gonzalez, Barbara B. Garrido-Suarez, Maria S. Fernandez-Alfonso, Gabino Garrido
Summary: The study found a high prevalence of self-medication among university students majoring in medical and biological sciences, with women being more likely to self-medicate. The main reasons for self-medication were the knowledge acquired through their curriculum and previous experiences. Pharmacies, friends, relatives, and home medicine cabinets were the most common sources for acquiring medications.
JOURNAL OF PHARMACY & PHARMACOGNOSY RESEARCH
(2023)
Article
Medicine, Research & Experimental
M. Sanz-Gomez, F. J. Manzano-Lista, E. Vega-Martin, D. Gonzalez-Moreno, M. Alcala, M. Gil-Ortega, B. Somoza, C. Pizzamiglio, L. M. Ruilope, I. Aranguez, P. Kolkhof, R. Kreutz, M. S. Fernandez-Alfonso
Summary: The non-steroidal mineralocorticoid receptor antagonist (MRA) finerenone (FIN) improves kidney and cardiovascular outcomes in patients with chronic kidney disease (CKD) in type 2 diabetes (T2D). The study explores the effect of FIN in a new rat model of type 1 diabetic kidney disease (DKD), and finds that it reduces inflammation, fibrosis, and osteogenic factors, leading to improvements in kidney and vascular damage.
BIOMEDICINE & PHARMACOTHERAPY
(2023)