Article
Environmental Sciences
Rachel Lowe, Sophie A. Lee, Kathleen M. O'Reilly, Oliver J. Brady, Leonardo Bastos, Gabriel Carrasco-Escobar, Rafael de Castro Catao, Felipe J. Colon-Gonzalez, Christovam Barcellos, Marilia Sa Carvalho, Marta Blangiardo, Havard Rue, Antonio Gasparrini
Summary: This study aimed to quantify the effects of extreme hydrometeorological hazards on dengue risk in urban areas in Brazil. The risk of dengue increased following extremely wet conditions and drought conditions, with different delays. The study found that the risk associated with extremely wet conditions was higher in rural areas, while the risk associated with extreme drought was exacerbated in highly urbanised areas with water shortages.
LANCET PLANETARY HEALTH
(2021)
Article
Meteorology & Atmospheric Sciences
Vinicius Oliveira Silva, Carlos Rogerio de Mello, Sin Chan Chou
Summary: Southern Minas Gerais state in Brazil is an important region for coffee production and hydroelectricity generation. This study analyzed the severity of droughts in the region from 1970 to 2020 and projected future droughts using global circulation models. The results show that extreme droughts will continue to occur in the future, posing risks to the region's economy.
THEORETICAL AND APPLIED CLIMATOLOGY
(2022)
Article
Geography, Physical
Derek J. Cheung, John R. Giardino
Summary: Wildfire incidents are increasing in frequency and magnitude in southern California. However, there is a lack of research on how ecosystems respond to changing fire regimes. This study found that post-fire debris flows will increase if fires continue to increase in size and occur on specific slopes and watersheds with certain soil burn severities.
Article
Parasitology
Vamilton Alvares Santarem, Giovanni Kalempa Panazzolo, Louise Bach Kmetiuk, Orlei Jose Domingues, Isabella Braghin Ferreira, Roberto Teixeira de Souza Filho, Joao Henrique Farinhas, Fernando Rodrigo Doline, Susana Angelica Zevallos Lescano, Leandro Meneguelli Biondo, Rogerio Giuffrida, Alexander Welker Biondo, Giovani Marino Favero
Summary: The high vulnerability and seroprevalence observed in quilombola communities in Brazil highlight the need for a One Health approach to detect, monitor, and prevent infection by Toxocara spp. in both human and dog populations.
PARASITES & VECTORS
(2023)
Article
Infectious Diseases
Gal Koplewitz, Fred Lu, Leonardo Clemente, Caroline Buckee, Mauricio Santillana
Summary: The study focuses on developing a methodological framework to assess and compare dengue incidence estimates at the city level, evaluating the performance of different models in 20 cities in Brazil. The results show that both random forest-based models and LASSO regression-based models effectively utilize multiple data sources to make accurate predictions at the city level.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Construction & Building Technology
Rocio Escandon, Rafael Suarez, Alicia Alonso, Gerardo Maria Mauro
Summary: This study evaluates the risk of overheating in existing social housing stock in southern Spain, showing that this risk will increase in the future and that global warming will lead to an increase in the percentage of Hours of Exceedance.
BUILDING AND ENVIRONMENT
(2022)
Article
Infectious Diseases
Leticia Santos Balbino, Juliana Correa Bernardes, Winni Alves Ladeia, Felippe Danyel Cardoso Martins, Beatriz de Souza Lima Nino, Regina Mitsuka-Bregano, Italmar Teodorico Navarro, Fernanda Pinto-Ferreira
Summary: The study investigated risk factors for toxoplasmosis during outbreaks in Brazil, finding that fruits and vegetables were the most common transmission routes and municipalities with a high human development index had more infections. Outbreak notifications have increased in recent years, highlighting the need for improved preventive strategies.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Multidisciplinary Sciences
Joao H. N. Palma, Rodrigo Hakamada, Gabriela Goncalves Moreira, Silvana Nobre, Luiz Carlos Estraviz Rodriguez
Summary: This paper presents a method to evaluate the impact of climate change on Eucalyptus plantations using a physiological model. The study shows that while overall rainfall is predicted to increase with climate change, the distribution throughout the year may not support tree growth. The approach provides insights into forest responses to different future climate conditions.
SCIENTIFIC REPORTS
(2021)
Article
Geography
Girliany Santos da Silva, Patricia Araujo Amarante, Jose Carlos Araujo Amarante
Summary: This article evaluates the spatial distribution of agricultural activity in the Northeast Region of Brazil and discusses its implications for poverty conditions. The study finds that despite the large scale of the agricultural sector in the region, there is significant internal differentiation. Family farming dominates, but with limited land and production value. Poor and extremely poor producers are prevalent in this sector and face challenges in accessing technology and financing. The study also highlights the importance of self-consumption for family farming and the reliance on other sources of income.
JOURNAL OF RURAL STUDIES
(2022)
Article
Virology
Juliana Schons Gularte, Livia Sacchetto, Meriane Demoliner, Viviane Girardi, Mariana Soares da Silva, Micheli Filippi, Vyctoria Malayhka de Abreu Goes Pereira, Alana Witt Hansen, Luana Leticia da Silva, Juliane Deise Fleck, Paula Rodrigues de Almeida, Mauricio Lacerda Nogueira, Fernando Rosado Spilki
Summary: In this study, the genetic diversity of the dengue virus circulating in southern Brazil during an outbreak in 2022 was monitored and characterized through next-generation sequencing. The results provided important information for managing outbreaks and controlling viral dissemination in the region.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Article
Infectious Diseases
Iasmim Ferreira de Almeida, Raquel Martins Lana, Claudia Torres Codeco
Summary: Dengue transmission profiles in different regions of Brazil vary based on population size and climate, impacting the development of specific surveillance protocols and prevention policies for the disease.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Environmental Sciences
Natalia Bruna Dias Campos, Maria Helena Franco Morais, Ana Paula Romanelli Ceolin, Maria da Consolacao Magalhaes Cunha, Rafael Romero Nicolino, Olivia Lang Schultes, Amelia Augusta Dde Lima Friche, Waleska Teixeira Caiaffa
Summary: This ecological study analyzed the temporal pattern of clinically diagnosed and laboratory confirmed dengue cases in Belo Horizonte, Minas Gerais, Brazil from 1996 to 2017. The study found an increase in the number, severity, and lethality of cases over the last 10 years of the study period. Biological and environmental factors appear to modulate the behavior of dengue in a large urban center.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2021)
Article
Plant Sciences
Maria Aparecida da Cruz, Carmen Silvia Vieira Janeiro Neves, Deived Uilian de Carvalho, Ronan Carlos Colombo, Jinhe Bai, Ines Fumiko Ubukata Yada, Rui Pereira Leite Junior, Zuleide Hissano Tazima
Summary: Rootstocks play a significant role in influencing the characteristics of citrus trees, such as growth, fruit yield, and quality, as well as resistance to pests and diseases. In Brazil, there is a lack of diversity in the combinations of scion and rootstock cultivars, leading to potential pest and disease outbreaks. Evaluations on Emperor mandarin grafted on different rootstocks showed that Cleopatra and Sunki mandarins, Swingle citrumelo, and Fepagro C-13 are more suitable options under Brazilian subtropical conditions than Rangpur lime.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Engineering, Multidisciplinary
Mohsin Khan, Michael Pedersen, Min Zhu, Hong Zhang, Lai Zhang
Summary: This paper extends a compartmental model to analyze the impact of climate and population changes on the spread of dengue fever. The study predicts a significant expansion of the risk area for dengue fever in mainland China and identifies temperature, precipitation, and population density as key factors influencing the spread patterns.
APPLIED MATHEMATICAL MODELLING
(2023)
Article
Development Studies
Jacob Vermeire, Saskia Crucke, Josephine Mutesi, Annelies Vinck
Summary: Climate change exacerbates time-poverty for smallholder farmers, especially women. However, joining agricultural cooperatives can help them overcome these challenges and facilitate the pacing of climate change actions.
SUSTAINABLE DEVELOPMENT
(2023)
Review
Chemistry, Medicinal
Nayra Oliveira Prado, Larissa Araujo Lalli, Lucas Blanes, Dalila Luciola Zanette, Mateus Nobrega Aoki
Summary: Molecular biology is a widely used technique for research and diagnostics, involving the analysis of genetic material. Lyophilization, a dehydration process, can be applied to preserve enzymes, buffers, and reagents with specific storage conditions. This review presents a synthesis of the lyophilization process, describing each step and providing general information. Lyophilization protocols from the literature are also presented in tables for easy access by researchers seeking material for new protocols.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Article
Public, Environmental & Occupational Health
Ana Paula Muraro, Roseany Rocha, Alexandra Crispim Boing, Ligia Regina de Oliveira, Francine Nesello Melanda, Amanda Cristina de Souza Andrade
Summary: This study aims to examine the scale and characteristics of deaths caused by post-COVID conditions in Brazil. It is a descriptive study based on preliminary data from the 2021 Mortality Information System. The analysis considered records with ICD code B94.8 as the Basic Cause and code U09 in some lines of part I or II of the declaration. The study evaluated the distribution of deaths by geographic region, semester of occurrence, sex, age group, ethnicity/skin color, schooling, and place of occurrence. The findings revealed that there were 2,948 recorded deaths from post-COVID conditions, with varying rates across different regions in Brazil. More than half of the deaths occurred among males, individuals aged 60 years or older, and white individuals. The study concludes that deaths from post-COVID conditions have distinct sociodemographic characteristics across different regions.
CIENCIA & SAUDE COLETIVA
(2023)
Review
Oncology
Daniele Campa, Manuel Gentiluomo, Angelika Stein, Mateus Nobrega Aoki, Martin Oliverius, Ludmila Vodickova, Krzysztof Jamroziak, George Theodoropoulos, Claudio Pasquali, William Greenhalf, Paolo Giorgio Arcidiacono, Faik Uzunoglu, Raffaele Pezzilli, Claudio Luchini, Marta Puzzono, Martin Loos, Matteo Giaccherini, Verena Katzke, Andrea Mambrini, Edita Kiudeliene, Kauffmann Emanuele Federico, Julia Johansen, Tamas Hussein, Beatrice Mohelnikova-Duchonova, Casper H. J. van Eijck, Hermann Brenner, Riccardo Farinella, Juan Sainz Perez, Martin Lovecek, Markus W. Buechler, Viktor Hlavac, Jakob R. Izbicki, Thilo Hackert, Roger Chammas, Alessandro Zerbi, Rita Lawlor, Alessio Felici, Mara Goetz, Gabriele Capurso, Laura Ginocchi, Maria Gazouli, Juozas Kupcinskas, Giulia Martina Cavestro, Pavel Vodicka, Stefania Moz, John P. Neoptolemos, Lumir Kunovsky, Stig E. Bojesen, Silvia Carrara, Domenica Gioffreda, Egidijus Morkunas, Olga Abian, Stefania Bunduc, Daniela Basso, Ugo Boggi, Barbara Wlodarczyk, Andrea Szentesi, Giuseppe Vanella, Inna Chen, Maarten F. Bijlsma, Vytautas Kiudelis, Stefano Landi, Ben Schoettker, Chiara Corradi, Nathalia Giese, Rudolf Kaaks, Giulia Peduzzi, Peter Hegyi, Luca Morelli, Niccolo Furbetta, Pavel Soucek, Anna Latiano, Renata Talar-Wojnarowska, Sidsel C. Lindgaard, Frederik Dijk, Anna Caterina Milanettoj, Francesca Tavano, Klara Cervena, Balint Eross, Sabrina G. Testoni, Judith H. E. Verhagen-Oldenampsen, E. Malecka-Wojciesko, Eithne Costello, Roberto Salvia, Evaristo Maiello, Stefano Ermini, Cosimo Sperti, Bernd Holleczek, Francesco Perri, Jurgita Skieceviciene, Livia Archibugi, Maurizio Lucchesi, Cosmeri Rizzato, Federico Canzian
Summary: Pancreatic cancer is a deadly disease with few known risk factors and susceptibility loci. The rarity of the disease and lack of adequate research power have hindered progress in understanding its genetic mechanisms. However, the PANDoRA consortium, the largest in Europe, has made significant contributions in discovering susceptibility loci, which will be crucial in developing preventive strategies.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Genetics & Heredity
Chiara Corradi, Giulia Lencioni, Manuel Gentiluomo, Alessio Felici, Anna Latiano, Gediminas Kiudelis, Casper H. J. van Eijck, Katalin Marta, Rita T. Lawlor, Francesca Tavano, Ugo Boggi, Frederike Dijk, Giulia Martina Cavestro, Roel C. H. Vermeulen, Thilo Hackert, Maria Chiara Petrone, Faik Guentac Uzunoglu, Livia Archibugi, Jakob R. Izbicki, Luca Morelli, Alessandro Zerbi, Stefano Landi, Hannah Stocker, Renata Talar-Wojnarowska, Gregorio Di Franco, Peter Hegyi, Cosimo Sperti, Silvia Carrara, Gabriele Capurso, Maria Gazouli, Hermann Brenner, Stefania Bunduc, Olivier Busch, Francesco Perri, Martin Oliverius, Peter Jeno Hegyi, Mara Goetz, Pasquale Scognamiglio, Andrea Mambrini, Paolo Giorgio Arcidiacono, Edita Kreivenaite, Juozas Kupcinskas, Tamas Hussein, Stefano Ermini, Anna Caterina Milanetto, Pavel Vodicka, Vytautas Kiudelis, Viktor Hlavac, Pavel Soucek, George E. Theodoropoulos, Daniela Basso, John P. Neoptolemos, Mateus Nobrega Aoki, Raffaele Pezzilli, Claudio Pasquali, Roger Chammas, Sabrina Gloria Giulia Testoni, Beatrice Mohelnikova-Duchonova, Maurizio Lucchesi, Cosmeri Rizzato, Federico Canzian, Daniele Campa
Summary: This study identified a novel risk locus for PDAC which modulates cancer risk by controlling gene expression through DNA methylation.
JOURNAL OF MEDICAL GENETICS
(2023)
Article
Multidisciplinary Sciences
E. K. G. D. Ferreira, D. S. D. Lara, G. F. Silveira
Summary: The objective of this study is to evaluate the performance of predictive models using CNN in identifying the number of cells in HCS digital contrast microscopy images. The study found that the number and quality of images significantly affect the predictive ability.
SCIENTIFIC REPORTS
(2023)
Article
Genetics & Heredity
Carolina Mathias, Anelis Maria Marin, Ana Flavia Kohler, Heloisa Bruna Soligo Sanchuki, Natalie Sukow, Marcia Holsbach Beltrame, Suelen Cristina Soares Baal, Ana Paula Martins Sebastiao, Enilze Maria de Souza Fonseca Ribeiro, Daniela Fiori Gradia, Mateus Nobrega Aoki, Jaqueline Carvalho de Oliveira
Summary: Long noncoding RNAs (lncRNAs) are a type of RNA molecule that do not code for proteins and have a regulatory role. This study identified lncRNA-SNPs with a potential biological role in the development of breast cancer (BC) in the Brazilian population. Certain SNPs were found to be associated with BC development and patient characteristics.
Article
Multidisciplinary Sciences
Yingpu Yu, William M. Schneider, Maximilian A. Kass, Eleftherios Michailidis, Ashley Acevedo, Ana L. Pamplona Mosimann, Juliano Bordignon, Alexander Koenig, Christine M. Livingston, Hardeep van Gijzel, Yi Ni, Pradeep M. Ambrose, Catherine A. Freije, Mengyin Zhang, Chenhui Zou, Mohammad Kabbani, Corrine Quirk, Cyprien Jahan, Xianfang Wu, Stephan Urban, Shihyun You, Amir Shlomai, Ype P. de Jong, Charles M. Rice
Summary: Hepatitis B virus (HBV) is a chronic infection affecting approximately 300 million people, with current treatments being ineffective. The virus increases the risk of liver cirrhosis and hepatocellular carcinoma, causing nearly 1 million deaths annually. A new method using synthetic RNA to initiate HBV replication is described, eliminating background signals from input virus or plasmid DNA. This approach can be used to study multiple stages of HBV replication and identify sequence variants that confer resistance to antiviral drugs.
Article
Cell Biology
Carina Z. Segato-Vendrameto, Camila Zanluca, Amanda Z. Zucoloto, Tiago H. Zaninelli, Mariana M. Bertozzi, Telma Saraiva-Santos, Camila R. Ferraz, Larissa Staurengo-Ferrari, Stephanie Badaro-Garcia, Marilia F. Manchope, Amanda M. Dionisio, Felipe A. Pinho-Ribeiro, Sergio M. Borghi, Ana Luiza Pamplona Mosimann, Rubia Casagrande, Juliano Bordignon, Victor Fattori, Claudia N. Duarte dos Santos, Waldiceu A. Verri
Summary: This article investigates therapeutic strategies against Chikungunya virus, finding that inhibiting viral proteins and using recombinant antibodies can alleviate virus-induced pain symptoms.
Review
Biochemistry & Molecular Biology
Anelis Maria Marin, Heloisa Bruna Soligo Sanchuki, Guilherme Naccache Namur, Miyuki Uno, Dalila Luciola Zanette, Mateus Nobrega Aoki
Summary: The lack of reliable early diagnostic tools is a major challenge in managing pancreatic cancer, which is often diagnosed at an advanced stage. The emergence of liquid biopsy as a less invasive approach focusing on plasmatic biomarkers such as DNA and RNA has addressed this issue. Circulating tumor cells (CTCs) and cell-free nucleic acids (cfNAs) like DNA, mRNA, and non-coding RNA (miRNA and lncRNA) in the blood of cancer patients have been investigated as potential biomarkers. This article focuses on circulating cfNAs as plasmatic biomarkers for pancreatic cancer and analyzes their advantages compared to traditional biopsy methods.
Article
Oncology
Dalila Luciola Zanette, Karoline Brito Caetano Andrade Coelho, Eneas de Carvalho, Mateus Nobrega Aoki, Jeanine Marie Nardin, Larissa Araujo Lalli, Rafael dos Santos Bezerra, Marta Giovanetti, Victoria Simionatto Zucherato, Gabriel Montenegro de Campos, Jardelina de Souza Todao Bernardino, Vincent Louis Viala, Massimo Ciccozzi, Luiz Carlos Junior Alcantara, Sandra Coccuzzo Sampaio, Maria Carolina Elias, Simone Kashima, Dimas Tadeu Covas, Svetoslav Nanev Slavov
Summary: A study examined the composition of plasma virome in patients with prostate cancer, finding that Anelloviruses and Human Pegivirus-1 (HPgV-1) were the most abundant components. Clinically important viruses like hepatitis C virus (HCV), cytomegalovirus, and human adenovirus type C were also identified. In comparison, the virome of blood donors was mainly composed of torque teno virus types (TTV). This study sheds light on the viral abundance and diversity in patients with prostate cancer, suggesting that malignant processes may influence virome composition.
MOLECULAR & CELLULAR ONCOLOGY
(2023)
Review
Genetics & Heredity
Nayra Oliveira Prado, Denise Kusma Wosniaki, Anelis Maria Marin, Carolina Mathias, Heloisa Bruna Soligo Sanchuki, Dalila Luciola Zanette, Mateus Nobrega Aoki
Summary: Leukemia is a cancer that affects white blood cells, involving genetic mutations that promote excessive cell replication and reduced cell death. Conventional cancer treatments may have adverse effects, but gene therapy, particularly using microRNAs, offers a safe alternative. This review focuses on recent advances in cancer gene therapy for leukemia through microRNA-based approaches.
CURRENT GENE THERAPY
(2023)
Article
Neuroimaging
Adrien Guenego, Robert Fahed, Aymeric Rouchaud, Gregory Walker, Tobias D. Faizy, Peter B. Sporns, Mohamed Aggour, Pascal Jabbour, Andrea M. Alexandre, Pascal John Mosimann, Adam A. Dmytriw, Noemie Ligot, Niloufar Sadeghi, Chengbo Dai, Ameer E. Hassan, Vitor M. Pereira, Justin Singer, Jeremy J. Heit, Fabio Silvio Taccone, Michael Chen, Jens Fiehler, Boris Lubicz
Summary: Our study highlights the significant heterogeneity among the neurointerventional community regarding the diagnosis of vasospasm and endovascular management. Randomized trials and guidelines are needed to improve standard of care, determine optimal management approaches, and track outcomes.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Biology
Margherita Piccardi, Manuel Gentiluomo, Stefania Bertoncini, Raffaele Pezzilli, Balint Eross, Stefania Bunduc, Faik G. Uzunoglu, Renata Talar-Wojnarowska, Tomas Vanagas, Cosimo Sperti, Martin Oliverius, Mateus Nobrega Aoki, Stefano Ermini, Tamas Hussein, Ugo Boggi, Krzysztof Jamroziak, Evaristo Maiello, Luca Morelli, Ludmila Vodickova, Gregorio Di Franco, Stefano Landi, Andrea Szentesi, Martin Lovecek, Marta Puzzono, Francesca Tavano, Hanneke W. M. van Laarhoven, Alessandro Zerbi, Beatrice Mohelnikova-Duchonova, Hannah Stocker, Eithne Costello, Gabriele Capurso, Laura Ginocchi, Rita T. Lawlor, Giuseppe Vanella, Francesca Bazzocchi, Jakob R. Izbicki, Anna Latiano, Bas Bueno-de-Mesquita, Ruggero Ponz de Leon Pisani, Ben Schoettker, Pavel Soucek, Peter Hegyi, Maria Gazouli, Thilo Hackert, Juozas Kupcinskas, Lina Poskiene, Matteo Tacelli, Susanne Roth, Silvia Carrara, Francesco Perri, Viktor Hlavac, George E. Theodoropoulos, Olivier R. Busch, Andrea Mambrini, Casper H. J. van Eijck, Paolo Arcidiacono, Aldo Scarpa, Claudio Pasquali, Daniela Basso, Maurizio Lucchesi, Anna Caterina Milanetto, John P. Neoptolemos, Giulia Martina Cavestro, Dainius Janciauskas, Xuechen Chen, Roger Chammas, Mara Goetz, Hermann Brenner, Livia Archibugi, Michael Dannemann, Federico Canzian, Sergio Tofanelli, Daniele Campa
Summary: This study investigated the association between specific genes and the risk of pancreatic ductal adenocarcinoma (PDAC). The results showed no significant association in the European population, but identified a gene associated with increased risk in the East Asian population.
BIOLOGICAL RESEARCH
(2023)
