Article
Cardiac & Cardiovascular Systems
Rafael Escate, Teresa Padro, Rosa Suades, Sandra Camino, Ovidio Muniz, Jose Luis Diaz-Diaz, Alessandro Sionis, Pedro Mata, Lina Badimon
Summary: The study investigated the predictive role of miRNAs in atherosclerotic plaque progression and clinical event presentation in FH patients, identifying miR-133a as the best predictor for CVE.
CARDIOVASCULAR RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Lara Ottaviani, Rio P. Juni, Ricardo C. de Abreu, Marida Sansonetti, Vasco Sampaio-Pinto, Julie Halkein, Jana C. Hegenbarth, Nadja Ring, Kevin Knoops, Jordy M. M. Kocken, Carlos de Jesus, Auriane C. Ernault, Hamid El Azzouzi, Frank Ruhle, Serve Olieslagers, Hugo Fernandes, Lino Ferreira, Luca Braga, Monika Stoll, Diana S. Nascimento, Leon J. de Windt, Paula A. da Costa Martins
Summary: miR-200c-3p in extracellular vesicles secreted by cardiac myocytes plays a crucial role in the communication between cardiac cells and endothelial cells, affecting cardiac function and disease development.
Article
Nutrition & Dietetics
Merwan Barkallah, Judith Nzoughet-Kouassi, Gilles Simard, Loric Thoulouze, Sebastien Marze, Marie-Helene Ropers, Ramaroson Andriantsitohaina
Summary: This study demonstrated that encapsulating delphinidin in sEVs significantly enhances its inhibitory effects on angiogenesis, increasing potency for endothelial proliferation, NO production, and capillary-like formation. Therefore, sEV-loaded delphinidin may be a promising approach for treating angiogenesis-related diseases.
Article
Cell Biology
Nils Ludwig, Saigopalakrishna S. Yerneni, Juliana H. Azambuja, Monika Pietrowska, Piotr Widlak, Cynthia S. Hinck, Alicja Gluszko, Miroslaw J. Szczepanski, Teresa Karmer, Isabella Kallinger, Daniela Schulz, Richard J. Bauer, Gerrit Spanier, Steffen Spoerl, Johannes K. Meier, Tobias Ettl, Beatrice M. Razzo, Torsten E. Reichert, Andrew P. Hinck, Theresa L. Whiteside
Summary: Transforming growth factor beta (TGF beta) is a major component of tumor-derived small extracellular vesicles (TEX) that can promote tumor growth and pro-tumor activities in the tumor microenvironment (TME). TGF beta(+) TEX can stimulate macrophage chemotaxis and reprogram primary human macrophages to promote angiogenesis and tumor progression. Inhibition of TGF beta signaling in TEX can suppress these pro-tumor activities in head and neck squamous cell carcinoma (HNSCC).
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Review
Biochemistry & Molecular Biology
Natalia Gebara, Yolanda Correia, Keqing Wang, Benedetta Bussolati
Summary: Angiogenesis, regulated by extracellular vesicles (EVs) from gestational tissues, plays a crucial role in healthy pregnancy and is dysregulated in pregnancy-related diseases like preeclampsia. The use of EVs from placental stem cells shows promise in clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Lizhuang Shu, Xingyong Li, Zengli Liu, Kangshuai Li, Anda Shi, Yongchang Tang, Liming Zhao, Lingling Huang, Zhiyue Zhang, Dong Zhang, Shaohui Huang, Shuo Lian, Guoli Sheng, Zhangdi Yan, Zongli Zhang, Yunfei Xu
Summary: The study reveals the importance of bile exosomal miR-182/183-5p and the interaction between biliary epithelium and CCA cells in the progression of cholangiocarcinoma.
Article
Biotechnology & Applied Microbiology
Lei Cao, Tian Tian, Yuanbo Huang, Shiqin Tao, Xiaohong Zhu, Mifang Yang, Jing Gu, Guangdong Feng, Yinni Ma, Rushan Xia, Wenrong Xu, Lei Wang
Summary: The study found that ReN-NV promotes DPC proliferation and accelerates HF cycling transition in a mouse model. This acceleration is achieved through the activation of the Wnt/beta-catenin signaling pathway.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Oncology
Francesca Pontis, Luca Roz, Mavis Mensah, Miriam Segale, Massimo Moro, Giulia Bertolini, Ilaria Petraroia, Giovanni Centonze, Anna Maria Ferretti, Paola Suatoni, Ugo Pastorino, Orazio Fortunato, Gabriella Sozzi
Summary: This study investigated the role of extracellular vesicles (EVs) in lung cancer, finding that high-risk MSCpos-EVs had different membrane composition, biological cargo, and pro-tumorigenic activity compared to low-risk MSCneg-EVs. The study also showed that specific miRNAs inside EVs, such as miR-126 and miR-320, could promote angiogenesis and M2 polarization in endothelial cells and macrophages, respectively. Additionally, EVs containing miR-320 were identified as a new prognostic biomarker in lung cancer patients, with higher levels correlating with shorter overall survival.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Xingru Yang, Xianjing Song, Zhibo Li, Ning Liu, Youyou Yan, Bin Liu
Summary: Extracellular vesicles are crucial carriers of biological information between cells in the diagnosis and treatment of cardiovascular diseases, with their biogenesis closely linked to autophagy. There is significant crosstalk between extracellular vesicles and autophagy, playing important roles in cardiovascular pathophysiology.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cell Biology
Tom G. Keulers, Sten F. Libregts, Joel E. J. Beaumont, Kim G. Savelkouls, Johan Bussink, Hans Duimel, Ludwig Dubois, Marijke Zonneveld, Carmen Lopez-Iglesias, Karel Bezstarosti, Jeroen A. Demmers, Marc Vooijs, Marca Wauben, Kasper M. A. Rouschop
Summary: GABARAPL1 is essential for cargo loading and secretion of extracellular vesicles, with GABARAPL1(+)EVs being detectable and targetable for blocking pro-angiogenic effects. Silencing GABARAPL1 results in impaired early endosomal pathway and secretion of EVs with pro-angiogenic properties, affecting tumor growth and therapy efficacy.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Biochemistry & Molecular Biology
Mohit Parekh, Tiago Ramos, Stefano Ferrari, Sajjad Ahmad
Summary: The transparency of the human cornea relies on non-proliferative human corneal endothelial cells (HCEnCs). Dysfunction of these cells can lead to irreversible corneal blindness. This study aimed to investigate the inhibitory effect of miR-195-5p on the proliferation of HCEnCs, as miR-195-5p has been shown to inhibit proliferation in non small cell lung cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Andrew Chin, Javier Mariscal, Minhyung Kim, Giorgia Guerra, Blandine Victor, Chen Qian, Elisabetta Broseghini, Edwin Posadas, Michael R. Freeman, Shivani Sharma, Paolo Gandellini, Nadia Zaffaroni, Sungyong You, Keith Syson Chan, Jlenia Guarnerio, Muller Fabbri, Dolores Di Vizio
Summary: This study reveals a novel mechanism of extracellular vesicles (EVs) shedding, in which the inhibition of SEC23A by miR-1227 induces a shift in EV shedding, favoring the shedding of large EV over small EV.
Article
Oncology
Jolene Chisholm, Sandor Haas-Neill, Peter Margetts, Khalid Al-Nedawi
Summary: Prostate cancer (PC) is a major cause of death in men, and current biomarker tests have limitations in accurately diagnosing the disease. This study examined the protein, mRNA, and miRNA content of extracellular vesicles (EVs) collected from PC patients and healthy subjects. The analysis revealed distinct groups of proteins, mRNAs, and miRNAs that differed between healthy subjects and PC patients, as well as between different tumor types. These findings suggest potential molecular markers for diagnosing PC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Isra Marei, Omar Chidiac, Binitha Thomas, Jennifer Pasquier, Soha Dargham, Amal Robay, Muneera Vakayil, Mohammad Jameesh, Christopher Triggle, Arash Rafii, Amin Jayyousi, Jassim Al Suwaidi, Charbel Abi Khalil
Summary: This study found that levels of apoptotic endothelial microparticles (EMPs) are increased in patients with type 2 diabetes, especially in those with acute coronary syndrome (ACS). The protein contents of these microparticles interact in networks that indicate vascular dysfunction.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaohui Xu, Kritisha Bhandari, Chao Xu, Katherine Morris, Wei-Qun Ding
Summary: Pancreatic cancer is a major cause of cancer-related deaths, and early detection is crucial for improving survival rates. Recent studies suggest that miRNA signatures in plasma small EVs could be potential biomarkers for early detection of pancreatic cancer. However, inconsistent results have been reported due to the heterogeneity of plasma small EVs and isolation methods. In this study, a refined protocol for plasma small EV isolation was used, and miRNA signatures were analyzed in a pilot cohort of early-stage pancreatic cancer patients. The results showed that miR-18a and miR-106a levels were significantly elevated in the plasma small EVs of PDAC patients, indicating their potential as biomarkers for early detection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Victor Navarro-Tableros, Maria Beatriz Herrera Sanchez, Federico Figliolini, Renato Romagnoli, Ciro Tetta, Giovanni Camussi
TISSUE ENGINEERING PART A
(2015)
Article
Medicine, Research & Experimental
Maria Chiara Deregibus, Federico Figliolini, Sergio D'antico, Paola Maria Manzini, Chiara Pasquino, Michela De Lena, Ciro Tetta, Maria Felice Brizzi, Giovanni Camussi
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2016)
Article
Transplantation
Vincenzo Cantaluppi, Davide Medica, Alessandro Domenico Quercia, Sergio Dellepiane, Federico Figliolini, Grazia Maria Virzi, Alessandra Brocca, Marco Quaglia, Marita Marengo, Carlo Olivieri, Mara Senzolo, Francesco Garzotto, Francesco Della Corte, Giuseppe Castellano, Loreto Gesualdo, Giovanni Camussi, Claudio Ronco
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2018)
Article
Multidisciplinary Sciences
Claudia Cavallari, Andrea Ranghino, Marta Tapparo, Massimo Cedrino, Federico Figliolini, Cristina Grange, Valentina Giannachi, Paolo Garneri, Maria Chiara Deregibus, Federica Collino, Pietro Rispoli, Giovanni Camussi, Maria Felice Brizzi
SCIENTIFIC REPORTS
(2017)
Article
Cell & Tissue Engineering
Vincenzo Cantaluppi, Luigi Biancone, Federico Figliolini, Silvia Beltramo, Davide Medica, Maria Chiara Deregibus, Francesco Galimi, Renato Romagnoli, Mauro Salizzoni, Ciro Tetta, Giuseppe Paolo Segoloni, Giovanni Camussi
CELL TRANSPLANTATION
(2012)
Article
Urology & Nephrology
Vincenzo Cantaluppi, Luigi Biancone, Giuseppe Mauriello Romanazzi, Federico Figliolini, Silvia Beltramo, Francesco Galimi, Maria Gavina Camboni, Elisa Deriu, Piergiulio Conaldi, Antonella Bottelli, Viviana Orlandi, Maria Beatriz Herrera, Alfonso Pacitti, Giuseppe Paolo Segoloni, Giovanni Camussi
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2008)
Article
Urology & Nephrology
Vincenzo Cantaluppi, Stefano Gatti, Davide Medica, Federico Figliolini, Stefania Bruno, Maria C. Deregibus, Andrea Sordi, Luigi Biancone, Ciro Tetta, Giovanni Camussi
KIDNEY INTERNATIONAL
(2012)
Article
Transplantation
Vincenzo Cantaluppi, Davide Medica, Claudio Mannari, Giulia Stiaccini, Federico Figliolini, Sergio Dellepiane, Alessandro Domenico Quercia, Massimiliano Migliori, Vincenzo Panichi, Luca Giovannini, Stefania Bruno, Ciro Tetta, Luigi Biancone, Giovanni Camussi
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2015)
Article
Multidisciplinary Sciences
Federico Figliolini, Vincenzo Cantaluppi, Michela De Lena, Silvia Beltramo, Renato Romagnoli, Mauro Salizzoni, Raffaella Melzi, Rita Nano, Lorenzo Piemonti, Ciro Tetta, Luigi Biancone, Giovanni Camussi
Article
Multidisciplinary Sciences
Vincenzo Cantaluppi, Sergio Dellepiane, Michela Tamagnone, Davide Medica, Federico Figliolini, Maria Messina, Ana Maria Manzione, Massimo Gai, Giuliana Tognarelli, Andrea Ranghino, Caterina Dolla, Silvia Ferrario, Ciro Tetta, Giuseppe Paolo Segoloni, Giovanni Camussi, Luigi Biancone
Article
Biotechnology & Applied Microbiology
Stefania Bruno, Chiara Pasquino, Maria Beatriz Herrera Sanchez, Marta Tapparo, Federico Figliolini, Cristina Grange, Giulia Chiabotto, Massimo Cedrino, Maria Chiara Deregibus, Ciro Tetta, Giovanni Camussi
Article
Hematology
Federico Figliolini, Andrea Ranghino, Cristina Grange, Massimo Cedrino, Marta Tapparo, Claudia Cavallari, Andrea Rossi, Gabriele Togliatto, Saveria Femmino, Maria Vittoria Gugliuzza, Giovanni Camussi, Maria Felice Brizzi
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Margherita Pomatto, Chiara Gai, Federica Negro, Massimo Cedrino, Cristina Grange, Elena Ceccotti, Gabriele Togliatto, Federica Collino, Marta Tapparo, Federico Figliolini, Tatiana Lopatina, Maria Felice Brizzi, Giovanni Camussi
Summary: Research demonstrates that EVs derived from adipose tissue have a positive impact on diabetic wound healing, while those from bone marrow primarily promote cell proliferation. Significant differences exist in the molecular cargo of these two types of EVs, with ADSC-EVs showing greater angiogenic effects, and BMSC-EVs being more inclined towards cellular proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Critical Care Medicine
Vincenzo Cantaluppi, Viktoria Weber, Carola Lauritano, Federico Figliolini, Silvia Beltramo, Luigi Biancone, Massimo De Cal, Dinna Cruz, Claudio Ronco, Giuseppe Paolo Segoloni, Ciro Tetta, Giovanni Camussi