Article
Biochemistry & Molecular Biology
Teppei Okabe, Yosuke Kamiya, Takeshi Kikuchi, Hisashi Goto, Masayuki Umemura, Yuki Suzuki, Yoshihiko Sugita, Yoshikazu Naiki, Yoshiaki Hasegawa, Jun-ichiro Hayashi, Shotaro Kawamura, Noritaka Sawada, Yuhei Takayanagi, Takeki Fujimura, Naoya Higuchi, Akio Mitani
Summary: This study found that the culture supernatant of Porphyromonas gingivalis accelerated inflammation in the lungs of Streptococcus pneumoniae-infected mice, and increased inflammatory cell infiltration. Compared to S. pneumoniae infection alone, PgSup synergistically increased TNF-alpha and IL-17 expression/production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Chuan Wang, Xuan Li, Tianfan Cheng, Hongzhe Sun, Lijian Jin
Summary: Periodontitis is a major cause of severe tooth loss and edentulism in adults globally, and is linked to systemic comorbidities like diabetes. The study showed that the combination of bismuth drugs with traditional antibiotics effectively eliminated P. gingivalis persisters without significant cytotoxicity to human cells.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Tan Wan Jiun, Haslina Taib, Wan Majdiah Wan Mohamad, Suharni Mohamad, Wan Syamimee Wan Ghazali
Summary: This study found no significant association between the bacterial load of Porphyromonas gingivalis (P. gingivalis), a primary periodontal pathogen, and the levels of anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with rheumatoid arthritis (RA) and periodontitis. Despite the prevalence of periodontitis among RA patients, the bacterial load does not have an impact on the production of anti-CCP antibodies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Yilin Li, Rui Guo, Patrick Kwabena Oduro, Tongke Sun, Hao Chen, Yating Yi, Weiqian Zeng, Qilong Wang, Ling Leng, Long Yang, Jun Zhang
Summary: This study conducted a meta-analysis to investigate the relationship between Porphyromonas gingivalis (P. gingivalis) exposure and the prevalence of rheumatoid arthritis (RA). The results showed a significant association between P. gingivalis exposure and an increased risk of developing RA, especially in European and North American populations.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jacqueline Rodriguez, Gloria Ines Lafaurie, Wilson Bautista-Molano, Lorena Chila-Moreno, Juan Manuel Bello-Gualtero, Consuelo Romero-Sanchez
Summary: The study demonstrated an association between overweight or obesity and the diagnosis of eRA, with individuals with eRA exhibiting higher levels of leptin and vaspin. The presence of periodontitis and related markers only affected leptin levels in individuals with eRA.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Xin Huang, Xiaoxuan Wang, Li Ma, Huiyi Wang, Yan Peng, Heyu Liu, Junhong Xiao, Zhengguo Cao
Summary: This study investigated the interaction between M2 macrophages and Pg-stimulated cementoblasts for the first time. The results demonstrated that M2 macrophages can promote cementum regeneration through their anti-inflammatory effects, which is of great importance for periodontal regeneration.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Rheumatology
Fulvia Ceccarelli, Matteo Saccucci, Francesco Natalucci, Giulio Olivieri, Erika Bruni, Roberta Iacono, Tania Colasanti, Gabriele Di Carlo, Cristiano Alessandri, Daniela Uccelletti, Paola Russo, Andrea Pilloni, Fabrizio Conti, Antonella Polimeni
Summary: This study evaluated the possible involvement of oral microbiota in SLE erosive arthritis for the first time, finding a significant association between erosive damage and higher expression of Pg on the tongue. High levels of Pg were associated with more frequent erosive damage and other systemic manifestations in SLE patients.
Article
Immunology
Parisa Ahmadi, Mahmoud Mahmoudi, Ramiar Kamal Kheder, Tola Abdulsattar Faraj, Samaneh Mollazadeh, Hadi Sajid Abdulabbas, Seyed-Alireza Esmaeili
Summary: In patients with rheumatoid arthritis (RA), certain citrullinated proteins can be targeted by ACCPAs in the synovial sites. Extra-articular sites may be the origin of primary auto-immunization against these proteins. There is a significant association between P. gingivalis periodontitis, anti-P. gingivalis antibodies, and RA. P. gingivalis can degrade proteins such as fibrin and alpha-enolase into citrullinated peptides, and induce inflammation and immune cell attraction.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Franck Zekre, Rolando Cimaz, Mireille Paul, Teresa Giani, Louis Waeckel, Anne-Emmanuelle Berger, Jean-Louis Stephan, Myriam Normand, Stephane Paul, Hubert Marotte
Summary: This study found that children with oligoarticular and ERA subsets in juvenile idiopathic arthritis (JIA) had higher IgG titers against P. gingivalis and P. intermedia, indicating the involvement of oral dysbiosis in the occurrence of JIA in these subgroups.
Article
Immunology
Anna Svard, Alf Kastbom, Karin Roos Ljungberg, Barbara Potempa, Jan Potempa, G. Rutger Persson, Stefan Renvert, Johan Sanmartin Berglund, Maria K. Soderlin
Summary: A Swedish study found that patients with rheumatoid arthritis (RA) had higher levels of saliva antibodies to Porphyromonas gingivalis (P. gingivalis) and these antibodies were associated with RA disease activity, but not with periodontitis or serum antibodies to citrullinated proteins (ACPA).
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Elisa Gremese, Barbara Tolusso, Dario Bruno, Stefano Alivernini, Gianfranco Ferraccioli
Summary: Multiple Sclerosis (MS) is associated with Epstein Barr Virus (EBV) infection, and there may be a link between other autoimmune inflammatory diseases and infection. In the study of Rheumatoid Arthritis (RA), various infectious agents have been considered, but only a few meet the criteria for possible pathogenic causes of autoimmune diseases. This article discusses the breakdown of immune tolerance and the role of infectious agents in triggering arthritis in animal models. Additionally, preventive measures are described.
AUTOIMMUNITY REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Thanyaporn Sang-Ngoen, Laszlo Mark Czumbel, Wuttapon Sadaeng, Alexandra Miko, David Istvan Nemeth, Peter Matrai, Peter Hegyi, Barbara Toth, Dezso Csupor, Istvan Kiss, Andrea Szabo, Gabor Gerber, Gabor Varga, Beata Keremi
Summary: The study found that probiotics have a beneficial effect in reducing the count of A. actinomycetemcomitans, but do not have a significant impact on other key periodontal pathogenic bacteria. Further well-designed randomized clinical trials are needed to assess the efficacy of probiotics in managing periodontal disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Niu Zhou, Fagui Zou, Xiao Cheng, Yilian Huang, Hang Zou, Qingru Niu, Yi Qiu, Fen Shan, Aoxiang Luo, Wei Teng, Jianbo Sun
Summary: Periodontitis induced by P. gingivalis may exacerbate collagen-induced arthritis in mice and affect the differentiation of immune cells, leading to a decrease in B10 cells, which could be a key mechanism in promoting rheumatoid arthritis.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Rheumatology
Joyce A. Lee, Ted R. Mikuls, Kevin D. Deane, Harlan R. Sayles, Geoffrey M. Thiele, Jess D. Edison, Brandie D. Wagner, Marie L. Feser, Laura K. Moss, Lindsay B. Kelmenson, William H. Robinson, Jeffrey B. Payne
Summary: The objective of this study was to quantify the association between anti-P. gingivalis serum antibody concentrations and the risk of developing rheumatoid arthritis (RA), and to quantify the associations among RA cases between anti-P. gingivalis serum antibody concentrations and RA-specific autoantibodies. The results showed no longitudinal elevations of anti-bacterial serum antibody concentrations in RA patients prior to RA diagnosis compared to controls, but anti-P. intermedia displayed significant associations with RA autoantibody concentrations prior to RA diagnosis.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Biochemistry & Molecular Biology
Marina Bekic, Marina Radanovic, Jelena Dokic, Sergej Tomic, Mile Erakovic, Dusan Radojevic, Milos Duka, Dejan Markovic, Milan Markovic, Bashkim Ismaili, Dejan Bokonjic, Miodrag Colic
Summary: Gingiva-derived mesenchymal stromal cells play a significant role in periodontitis. This study investigated how the key etiological agent, P. gingivalis, affects the function and expression of healthy and periodontitis gingiva-derived mesenchymal stromal cells. The results revealed differences in proliferation, immunosuppressive potential, and gene expression between the two cell types, highlighting the impact of P. gingivalis on periodontitis-related inflammation and immune regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Dentistry, Oral Surgery & Medicine
Masaki Honda, Hayato Ohshima
Summary: This article comprehensively describes the biological characteristics and origins of dental pulp stem cells (DPSCs), their identification and harvesting, key aspects related to their characterization, their multilineage differentiation potential, current clinical applications, and their potential use in regenerative medicine for future dental and medical applications.
JOURNAL OF ORAL BIOSCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Akira Inaba, Hidemitsu Harada, Shojiro Ikezaki, Mika Kumakami-Sakano, Haruno Arai, Marii Azumane, Hayato Ohshima, Kazumasa Morikawa, Kuniyuki Kano, Junken Aoki, Keishi Otsu
Summary: This study investigated the impact of the LPA-LPA(6)-RhoA signaling axis on maturation stage ameloblasts. The results showed that LPA and LPA-producing enzymes were highly expressed in ameloblasts. In vitro experiments demonstrated the essential role of LPA-LPA(6)-RhoA signaling in establishing proper cell morphology and polarity, as well as regulating cell-cell junctions and actin cytoskeleton expression and stability.
JOURNAL OF ORAL BIOSCIENCES
(2022)
Article
Multidisciplinary Sciences
Naoto Ohkura, Kunihiko Yoshiba, Nagako Yoshiba, Naoki Edanami, Hayato Ohshima, Shoji Takenaka, Yuichiro Noiri
Summary: Ascorbic acid (vitamin C) plays a crucial role in promoting dental pulp wound healing by regulating cell differentiation and anti-inflammatory response. This study provides new insights into the mechanism of action of ascorbic acid and may contribute to the development of novel therapeutic targets for dental pulpal disease treatment.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Dentistry, Oral Surgery & Medicine
Hayato Ohshima, Kenji Mishima
Summary: This article introduces the review articles in the Journal of Oral Biosciences, which cover research topics in Bone Cell Biology, Tooth Development & Regeneration, Tooth Bleaching, Adipokines, Milk Thistle, Epithelial-Mesenchymal Transition, Periodontitis, Diagnosis, Salivary Glands, Tooth Root, Exosome, New Perspectives of Tooth Identification. These review articles have inspired readers to broaden their knowledge about various aspects of oral biosciences.
JOURNAL OF ORAL BIOSCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Hiroto Sano, Kuniko Nakakura-Ohshima, Yasuo Okada, Takuichi Sato, Hayato Ohshima
Summary: This study aimed to validate the effects of pulp chamber floor perforation on pulpal healing after tooth replantation, and results showed that perforation can promote early revascularization and improve pulpal healing.
JOURNAL OF ORAL BIOSCIENCES
(2023)
Article
Anatomy & Morphology
Shusuke Ohshima, Hisako Takami, Yuji Katsumi, Yushi Ueki, Arata Horii, Hayato Ohshima
Summary: This study aimed to reveal the distribution patterns of infraorbital nerve (ION) branches in the upper lip. The results showed that the ION branches include the inferior palpebral, external and internal nasal, and superior labial nerves. It is recommended to use a lateral mucosal incision during oral surgery to avoid damaging the ION branches.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2023)
Article
Dentistry, Oral Surgery & Medicine
Masashi Shin, Aya Matsushima, Hiroshi Kajiya, Fujio Okamoto, Kayoko Ogata, Kyoko Oka, Hayato Ohshima, John D. Bartlett, Koji Okabe
Summary: TRPM7 is an important ion channel in enamel calcification during amelogenesis. The study found that Trpm7 deficient mice and Trpm7 knockdown cell lines exhibited reduced tooth pigmentation, broken incisor tips, lower enamel calcification and microhardness, as well as abnormal enamel matrix protein secretion and impaired intercellular adhesion structures. These findings suggest that TRPM7 plays a critical role in enamel calcification and effective morphogenesis of ameloblasts during amelogenesis.
EUROPEAN JOURNAL OF ORAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sanako Makishi, Taisuke Watanabe, Kotaro Saito, Hayato Ohshima
Summary: This study aimed to analyze the effects of HA/beta-TCP on osseointegration at the bone-implant interface after immediately placed implants in the maxillae of 4-week-old mice. The lack of HA/beta-TCP on the implant surface affects the OPN immunoreactivity at the bone-implant interface and the rate of direct osteogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
E. -j. Kim, H. -y. Kim, L. Li, Q. Tang, K. -h. Kim, H. Ohshima, H. -s. Jung
Summary: The enamel knot (EK) is a cluster of nondividing epithelial cells that acts as a signaling center in tooth germs. This study analyzed the cellular mechanisms in the EK related to bone morphogenetic protein (Bmp) and compared two species with different cuspal patterning. The findings suggest that the cellular mechanisms in the EK, such as cell proliferation and apoptosis, are associated with Bmp4 and play a crucial role in tooth morphogenesis.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Naoto Ohkura, Kunihiko Yoshiba, Nagako Yoshiba, Yohei Oda, Naoki Edanami, Hayato Ohshima, Shoji Takenaka, Takashi Okiji, Yuichiro Noiri
Summary: This study investigated the localization of components of the PGE2-transporting pathway in human dental pulp and their relevance to angiogenesis and dentinogenesis. The results showed that EP2/EP4 agonists promoted the generation of endothelial cell filopodia and upregulated the expression of angiogenesis and odontoblast differentiation-related genes.
JOURNAL OF ENDODONTICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Junko Shimomura-Kuroki, Masayuki Tsuneki, Hiroko Ida-Yonemochi, Yuta Seino, Keiko Yamamoto, Yoshitoshi Hirao, Tadashi Yamamoto, Hayato Ohshima
Summary: This study comprehensively analyzed protein expression in epithelial and mesenchymal tissues of tooth germ and identified three highly expressed proteins (ATP synthase subunit beta, receptor of activated protein C kinase 1, and calreticulin). The expression profiles of these proteins were found to be stage-specific during amelogenesis, with RACK1 involved in cell proliferation and differentiation, and ATP5B and CALR involved in mineral transport, removal of organic materials, and matrix deposition.
Article
Dentistry, Oral Surgery & Medicine
Ayako Ikarashi, Hiroto Sano, Mikako Tanaka, Hayato Ohshima
Summary: This study aimed to verify the accuracy of calcification assessed by micro-focus X-ray computed tomography (μCT) by comparing the images obtained via different methods such as μCT and electron probe micro analyzer (EPMA) analyses. The results showed that μCT can accurately evaluate calcification density and detect minute differences. Rating: 8/10.
JOURNAL OF ORAL BIOSCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Anish Ashok Adpaikar, Jong-Min Lee, Dong-Joon Lee, Hye-Yeon Cho, Hayato Ohshima, Seok Jun Moon, Han-Sung Jung
Summary: Taste receptor cells can dedifferentiate and acquire stem/progenitor cell-like states after nerve injury, leading to enhanced taste bud regeneration. This finding suggests that differentiated taste receptor cells have the potential to enter the cell cycle and contribute to taste bud renewal. These dedifferentiated cells, along with resident stem/progenitor cells, play a crucial role in the regeneration of taste buds following nerve injury.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
H. Ida-Yonemochi, K. Otsu, T. Irie, A. Ohazama, H. Harada, H. Ohshima
Summary: Autophagy plays a crucial role in the maintenance of dental epithelial stem cells and enamel formation. Deficiency in autophagy may lead to tumorigenesis in dental epithelial cells.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Cell & Tissue Engineering
Hiroto Sano, Kuniko Nakakura-Ohshima, Angela Quispe-Salcedo, Yasuo Okada, Takuichi Sato, Hayato Ohshima
Summary: Perforation of the pulp chamber floor promotes pulpal healing and enhances the survival and differentiation of dental pulp stem cells. This study provides insights into the crosstalk mechanism between immune cells and DPSCs, and the differentiation process of DPSCs into odontoblast-like cells.
REGENERATIVE THERAPY
(2023)