Review
Nutrition & Dietetics
Fatema Alkhulaifi, Charles Darkoh
Summary: Dietary patterns and habits play a crucial role in controlling metabolic syndrome risk factors; meal timing and frequency can impact metabolic outcomes.
Article
Nutrition & Dietetics
Ryohei Yamamoto, Ryohei Tomi, Maki Shinzawa, Ryuichi Yoshimura, Shingo Ozaki, Kaori Nakanishi, Seiko Ide, Izumi Nagatomo, Makoto Nishida, Keiko Yamauchi-Takihara, Takashi Kudo, Toshiki Moriyama
Summary: Skipping dinner was identified as a significant predictor of weight gain and overweight/obesity in university students, while skipping breakfast and lunch did not show the same association in this retrospective cohort study.
Article
Food Science & Technology
Farnaz Roshanmehr, Katsuki Hayashi, Yu Tahara, Takahiko Suiko, Yuki Nagamori, Takao Iwai, Shigenobu Shibata
Summary: This study finds that eating a Japanese breakfast is associated with an earlier chronotype (morningness) and higher levels of physical activity.
Article
Nutrition & Dietetics
Daeun Kim, Fumiaki Hanzawa, Shumin Sun, Thomas Laurent, Saiko Ikeda, Miki Umeki, Satoshi Mochizuki, Hiroaki Oda
Summary: Through experiments of delaying meal timing, it is found that skipping breakfast can cause changes in circadian clock regulation, leading to abnormal lipid metabolism. Changes in eating timing can affect body temperature, serum non-esterified fatty acids, and insulin peaks, while skipping breakfast can result in fatty liver and body fat accumulation.
FRONTIERS IN NUTRITION
(2021)
Article
Nutrition & Dietetics
Yuichiro Matsumura, Ryohei Yamamoto, Maki Shinzawa, Taisuke Matsushita, Ryuichi Yoshimura, Naoko Otsuki, Masayuki Mizui, Isao Matsui, Junya Kaimori, Yusuke Sakaguchi, Chisaki Ishibashi, Seiko Ide, Kaori Nakanishi, Makoto Nishida, Takashi Kudo, Keiko Yamauchi-Takihara, Izumi Nagatomo, Toshiki Moriyama
Summary: Skipping breakfast is significantly associated with frequent alcohol drinking among university students.
Article
Gastroenterology & Hepatology
Jiarong Xie, Hangkai Huang, Yishu Chen, Lei Xu, Chengfu Xu
Summary: In individuals with metabolic dysfunction-associated fatty liver disease (MAFLD), skipping breakfast is associated with a higher risk of cardiovascular mortality, while there is no such association in MAFLD-free individuals.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Health Care Sciences & Services
Tong Liu, Yiming Wang, Xiaomeng Wang, Chenan Liu, Qi Zhang, Mengmeng Song, Chunhua Song, Qingsong Zhang, Hanping Shi
Summary: This study found that habitually skipping breakfast may increase the risk of gastrointestinal cancers. Participants who consumed breakfast 1-2 times per week had a higher risk of stomach and liver cancer, while those who did not eat breakfast had a higher risk of esophageal, colorectal, liver, gallbladder, and extrahepatic bile duct cancer. However, factors such as BMI, CRP, and TyG index did not mediate the association between breakfast frequency and the risk of GI cancer incidence.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Giovana Longo-Silva, Priscilla Marcia Bezerra de Oliveira, Anny Kariny Pereira Pedrosa, Jessica Ribeiro da Silva, Renan Serenini Bernardes, Risia Cristina Egito de Menezes, Patricia de Menezes Marinho
Summary: The study found that skipping breakfast and eating lunch late are associated with higher BMI and increased odds of obesity. Understanding the obesogenic behaviors and characteristics related to breakfast skipping and late eating may be useful for future nutritional recommendations and interventions for obesity prevention and treatment.
OBESITY RESEARCH & CLINICAL PRACTICE
(2022)
Article
Endocrinology & Metabolism
Jarl Hellman, Niels Vaever Hartvig, Anne Kaas, Jonas Bech Moller, Mads Reinholdt Sorensen, Johan Jendle
Summary: This study evaluates the association between bolus insulin injection frequency, smart pen engagement, and changes in glycaemic control for individuals with type 1 diabetes. The results indicate that the number of daily bolus injections is significantly correlated with time in the target glucose range. Additionally, effective use of a smart pen is associated with improved glycaemic control.
DIABETES OBESITY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Rodrigo Chamorro, Karen Basfi-fer, Bernardita Sepulveda, Rut Farias, Pamela Rojas, Fernando Carrasco, Juana Codoceo, Jorge Inostroza, Manuel Ruz
Summary: This study assessed the association between meal timing and diet composition and metabolic parameters in patients with type-2 diabetes. The results showed that increased energy intake late during the day was related to increased total food and daily energy intake. Conversely, a greater proportion of total carbohydrates eaten early in the day was related to lower total energy intake. These findings suggest that earlier food intake may play an important role in dietary and metabolic control in patients with type-2 diabetes.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Fatema Alkhulaifi, Suad Al-Hooti, Sameer Al-Zenki, Husam AlOmirah, Charles Darkoh
Summary: This study describes the dietary habits of Kuwaiti adults, revealing that a significant portion of adults eat after 10 p.m., skip breakfast and dinner, with women more likely to skip breakfast, and married adults less likely to skip meals. The study emphasizes the importance of further investigating the relationship between meal timing, meal frequency, and the prevalence of NCDs in Kuwait.
Article
Nutrition & Dietetics
Allie S. Carew, Rania A. Mekary, Susan Kirkland, Olga Theou, Ferhan Siddiqi, Robin Urquhart, Michelle George, Chris Blanchard, Mary L. Biggs, Luc Djousse, Kenneth J. Mukamal, Leah E. Cahill
Summary: This study aimed to assess the relationship between breakfast frequency and timing and T2DM risk in older adults and found that a later daily first eating occasion time was associated with a lower risk of T2DM, particularly in participants with impaired fasting glucose at baseline.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
J-J Liu, R. L. Gurung, S. Liu, M. Yiamunaa, J. Lee, K. Ang, S. Tavintharan, W. E. Tang, C. F. Sum, S-C Lim
Summary: This study showed that young onset age and low genetic risk are independently associated with the risk of glycaemic progression in individuals with type 2 diabetes. However, genetic risk does not seem to significantly modulate the risk of glycaemic progression for individuals with young-onset type 2 diabetes.
DIABETES & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Dongze Chen, Hanyu Wu, Xinpei Wang, Tao Huang, Jinzhu Jia
Summary: This study found genetic correlation and causation between TV watching and type 2 diabetes, and identified shared genetic architectures. Mediation analysis also suggested that factors such as body mass index, glucose, and lipids may play a role in this relationship.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Jie Wu, Xin Hong, Chenchen Wang, Shengxiang Qi, Qing Ye, Zhenzhen Qin, Hairong Zhou, Chao Li, Weiwei Wang, Nan Zhou
Summary: The study found that adult patients with diabetes mellitus who consumed over 100 grams of fresh fruit per day and engaged in sufficient physical activity had the highest likelihood of glycemic control.
Letter
Endocrinology & Metabolism
Erika B. Parente, Stefan Mutter, Lena M. Thorn, Valma Harjutsalo, Per-Henrik Groop
Article
Endocrinology & Metabolism
Patrik Smidtslund, Fanny Jansson Sigfrids, Anni Ylinen, Nina Elonen, Valma Harjutsalo, Per-Henrik Groop, Lena M. Thorn
Summary: This study aims to investigate the prognosis after a first-ever myocardial infarction (MI) in individuals with type 1 diabetes and how different MI- and diabetes-related factors affect the prognosis and risk of secondary cardiovascular events. The study found that individuals with type 1 diabetes have a high cardiovascular and diabetes-related mortality after their first-ever MI, and poor kidney function is associated with high mortality and excessive risk of secondary cardiovascular events.
Correction
Cardiac & Cardiovascular Systems
Anniina Tynjala, Valma Harjutsalo, Fanny Jansson Sigfrids, Per-Henrik Groop, Daniel Gordin
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Multidisciplinary Sciences
Anmol Kumar, Stefan Mutter, Erika B. Parente, Valma Harjutsalo, Raija Lithovius, Sinnakaruppan Mathavan, Markku Lehto, Timo P. Hiltunen, Kimmo K. Kontula, Per-Henrik Groop
Summary: This study investigated the effect of L-type calcium channel blockers (LTCCBs) on VEGF concentrations in retinal cells and human serum, and evaluated the association between LTCCB usage and risk of severe diabetic eye disease (SDED). The results showed that LTCCBs increase VEGF concentrations in retinal cells and human serum, but they are not associated with the risk of SDED in adults with type 1 diabetes.
Article
Endocrinology & Metabolism
Minna Harsunen, Jani Haukka, Valma Harjutsalo, Nina Mars, Anna Syreeni, Taina Harkonen, Annemari Karajaemaki, Jorma Ilonen, Mikael Knip, Niina Sandholm, Paivi Johanna Miettinen, Per-Henrik Groop, Tiinamaija Tuomi
Summary: Contrary to the presumption that type 1 diabetes leads to an absolute insulin deficiency, this study found that many individuals with type 1 diabetes still have circulating C-peptide years after diagnosis. The study also identified the correlation between age at diagnosis and decline in C-peptide secretion, as well as the association between polygenic risk scores, clinical factors, and random serum C-peptide concentrations.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Health Care Sciences & Services
Valma Harjutsalo, Milla Kallio, Carol Forsblom, Per-Henrik Groop, FinnDiane Study Grp
Summary: This study investigated the impact of diabetic nephropathy and diabetic retinopathy on the risk of chronic limb threatening ischemia (CLTI) in patients with type 1 diabetes. It found that diabetic nephropathy and severe diabetic retinopathy were key risk factors for CLTI in these patients.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Endocrinology & Metabolism
Ina Lampenius, Valma Harjutsalo, Erika Parente, Per-Henrik Groop
Summary: Alcohol consumption is linearly associated with visceral fat mass percentage in adults with type 1 diabetes, regardless of sex, whereas the association with body fat mass percentage is sex-dependent.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Editorial Material
Endocrinology & Metabolism
Roberto Pecoits-Filho, Beatriz Yanez Jimenez, Gloria E. Ashuntantang, Federica de Giorgi, Salvatore De Cosmo, Per-Henrik Groop, Adrien Liew, Anne Hradsky, Roberto Pontremoli, Laura Sola, Antonio Ceriello
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Multidisciplinary Sciences
Raija Lithovius, Stefan Mutter, Erika B. Parente, Ville-Petteri Makinen, Erkka Valo, Valma Harjutsalo, Per-Henrik Groop
Summary: Effective treatment can prevent kidney complications in women with type 1 diabetes, but there may be underprescription in some cases. Data analysis of prescriptions and their relationship with kidney health can provide insights to optimize treatment.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Anniina Pirttiniemi, Krishna Adeshara, Natalie Happonen, Elisabet Einarsdottir, Shintaro Katayama, Hanne Salmenkari, Sohvi Horkko, Juha Kere, Per-Henrik Groop, Markku Lehto
Summary: Inorganic polyphosphates are bioactive phosphate polymers found in all living organisms, and in mammals, they play a vital role in regulating cellular metabolism, coagulation, and inflammation. Long-chain polyphosphates, particularly P700, can modulate the type I interferon signaling and cytokine secretion in human leukocytes. P700 treatment decreases interferon signaling and subsequent gene expression, while augmenting the secretion of various cytokines. This study demonstrates the extensive modulatory effects of P700 on cytokine signaling, specifically targeting type I interferon signaling in human leukocytes.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Ishant Khurana, Harikrishnan Kaipananickal, Scott Maxwell, Sorine Birkelund, Anna Syreeni, Carol Forsblom, Jun Okabe, Mark Ziemann, Antony Kaspi, Haloom Rafehi, Anne Jorgensen, Keith Al-Hasani, Merlin C. Thomas, Guozhi Jiang, Andrea O. Y. Luk, Heung Man Lee, Yu Huang, Yotsapon Thewjitcharoen, Soontaree Nakasatien, Thep Himathongkam, Christopher Fogarty, Rachel Njeim, Assaad Eid, Tine Willum Hansen, Nete Tofte, Evy C. Ottesen, Ronald C. W. Ma, Juliana C. N. Chan, Mark E. Cooper, Peter Rossing, Per-Henrik Groop, Assam El-Osta
Summary: Diabetic nephropathy (DN) is a polygenic disorder with poorly defined genome-wide methylation patterns. Methylation sequencing using leukocytes from a Finnish diabetes study identified differentially methylated genes associated with DN, which were further validated in independent T1D registries from Denmark, Hong Kong, and Thailand. Reduced DNA methylation at certain sites was connected with DN pathways related to insulin signaling, lipid metabolism, and fibrosis. Experimental observations in human renal cells, macrophages, and vascular endothelial cells supported the findings.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
M. I. Eriksson, A. Syreeni, N. Sandholm, E. H. Dahlstrom, D. Gordin, T. Tatlisumak, J. Putaala, Per-Henrik Groop, J. Martola, L. M. Thorn
Summary: This study aimed to evaluate the association between haptoglobin genotype and cerebral small-vessel disease (SVD). The results showed no significant association between haptoglobin genotype and SVD.
ACTA DIABETOLOGICA
(2023)
Article
Food Science & Technology
Reijo Laatikainen, Markku Lehto, Noora Maekelae-Salmi, Markku Hillilae, Per-Henrik Groop, Hanne Salmenkari
Summary: This study suggests that short-term usage of food-grade carrageenan is safe among people with UC, but further rigorous human studies are needed due to the limitations of the current study.
FOOD & NUTRITION RESEARCH
(2023)