The iron chelator Deferasirox causes severe mitochondrial swelling without depolarization due to a specific effect on inner membrane permeability
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Title
The iron chelator Deferasirox causes severe mitochondrial swelling without depolarization due to a specific effect on inner membrane permeability
Authors
Keywords
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Journal
Scientific Reports
Volume 10, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-01-31
DOI
10.1038/s41598-020-58386-9
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Note: Only part of the references are listed.- Identification of an ATP-sensitive potassium channel in mitochondria
- (2019) Angela Paggio et al. NATURE
- Pneumolysin-damaged cells benefit from non-homogeneous toxin binding to cholesterol-rich membrane domains
- (2018) Patrick Drücker et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- The iron chelator deferasirox synergizes with chemotherapy to treat triple negative breast cancers
- (2018) Sandrine Tury et al. JOURNAL OF PATHOLOGY
- Acute Liver Failure During Deferasirox Chelation
- (2017) Nathan Menaker et al. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
- Fulminant Liver Failure in a Child With β-Thalassemia on Deferasirox
- (2017) Archie Ramaswami et al. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
- Deferasirox-induced iron depletion promotes BclxL downregulation and death of proximal tubular cells
- (2017) Diego Martin-Sanchez et al. Scientific Reports
- The mitochondrial permeability transition pore in AD 2016: An update
- (2016) Lucia Biasutto et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Effect of N-Phenylanthranilic Acid Scaffold Nonsteroidal Anti-inflammatory Drugs on the Mitochondrial Permeability Transition
- (2016) Yohei Tatematsu et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Kidney-on-a-chip technology for renal proximal tubule tissue reconstruction
- (2016) Tom T.G. Nieskens et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Long wavelength multiphoton excitation is advantageous for intravital kidney imaging
- (2016) C.D. Schuh et al. KIDNEY INTERNATIONAL
- Imidazolium Salts Mimicking the Structure of Natural Lipids Exploit Remarkable Properties Forming Lamellar Phases and Giant Vesicles
- (2016) Patrick Drücker et al. LANGMUIR
- Drug induced mitochondrial dysfunction: Mechanisms and adverse clinical consequences
- (2016) Madhusudanarao Vuda et al. MITOCHONDRION
- Comprehensive analysis of mitochondrial permeability transition pore activity in living cells using fluorescence-imaging-based techniques
- (2016) Massimo Bonora et al. Nature Protocols
- Static Clathrin Assemblies at the Peripheral Vacuole—Plasma Membrane Interface of the Parasitic Protozoan Giardia lamblia
- (2016) Jon Paulin Zumthor et al. PLoS Pathogens
- Physiological and Pathological Roles of the Mitochondrial Permeability Transition Pore in the Heart
- (2015) Jennifer Q. Kwong et al. Cell Metabolism
- Cyclosporine before PCI in Patients with Acute Myocardial Infarction
- (2015) Thien-Tri Cung et al. NEW ENGLAND JOURNAL OF MEDICINE
- Design and performance of an ultra-flexible two-photon microscope for in vivo research
- (2015) Johannes M. Mayrhofer et al. Biomedical Optics Express
- Deferasirox nephrotoxicity—the knowns and unknowns
- (2014) Juan Daniel Díaz-García et al. Nature Reviews Nephrology
- The C Ring of the F1Fo ATP Synthase Forms the Mitochondrial Permeability Transition Pore: A Critical Appraisal
- (2014) Andrew P. Halestrap Frontiers in Oncology
- Mitochondrial permeability transition pore is a potential drug target for neurodegeneration
- (2013) Valasani Koteswara Rao et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Iron and Copper in Mitochondrial Diseases
- (2013) Wenjing Xu et al. Cell Metabolism
- What is the nature of the mitochondrial permeability transition poreand What is it Not?
- (2013) Detlef Siemen et al. IUBMB LIFE
- Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases
- (2013) Stephen L. Archer NEW ENGLAND JOURNAL OF MEDICINE
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- (2012) Scott J. Dixon et al. CELL
- In vivo multiphoton imaging of mitochondrial structure and function during acute kidney injury
- (2012) Andrew M. Hall et al. KIDNEY INTERNATIONAL
- Deferasirox-induced renal impairment in children: an increasing concern for pediatricians
- (2012) Laurence Dubourg et al. PEDIATRIC NEPHROLOGY
- Mitochondria-Derived Superoxide Links to Tourniquet-Induced Apoptosis in Mouse Skeletal Muscle
- (2012) Thai P. Tran et al. PLoS One
- Mitochondrial Fission, Fusion, and Stress
- (2012) R. J. Youle et al. SCIENCE
- The Development of Structure-Activity Relationships for Mitochondrial Dysfunction: Uncoupling of Oxidative Phosphorylation
- (2012) Russell T. Naven et al. TOXICOLOGICAL SCIENCES
- Mitochondria-Targeted Peptide Accelerates ATP Recovery and Reduces Ischemic Kidney Injury
- (2011) H. H. Szeto et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Mitochondrial Structure and Function Are Disrupted by Standard Isolation Methods
- (2011) Martin Picard et al. PLoS One
- Effects of deferasirox on renal function and renal epithelial cell death
- (2011) Penélope D. Sánchez-González et al. TOXICOLOGY LETTERS
- Roles of mitochondria in human disease: Figure 1
- (2010) Michael R. Duchen et al. Essays in Biochemistry
- Acquired Proximal Renal Tubular Dysfunction in β-Thalassemia Patients Treated With Deferasirox
- (2010) Joanne Yacobovich et al. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
- Mitochondrial protein import: from proteomics to functional mechanisms
- (2010) Oliver Schmidt et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Acute renal failure and Fanconi syndrome due to deferasirox
- (2010) S. Grange et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Reversible Fanconi syndrome in a pediatric patient on deferasirox
- (2010) Michelle N. Rheault et al. PEDIATRIC BLOOD & CANCER
- Fanconi Syndrome Due to Deferasirox
- (2009) Cédric Rafat et al. AMERICAN JOURNAL OF KIDNEY DISEASES
- The role of the mitochondrial permeability transition pore in heart disease
- (2009) Andrew P. Halestrap et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Renal Vulnerability to Drug Toxicity
- (2009) M. A. Perazella Clinical Journal of the American Society of Nephrology
- Multiphoton Imaging Reveals Differences in Mitochondrial Function between Nephron Segments
- (2009) A. M. Hall et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Toxicology for the twenty-first century
- (2009) Thomas Hartung NATURE
- Universal behavior of the osmotically compressed cell and its analogy to the colloidal glass transition
- (2009) E. H. Zhou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Neutral red uptake assay for the estimation of cell viability/cytotoxicity
- (2008) Guillermo Repetto et al. Nature Protocols
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