Article
Cardiac & Cardiovascular Systems
Jean Selim, Mouad Hamzaoui, Ines Boukhalfa, Zoubir Djerada, Laurence Chevalier, Nicolas Piton, Damien Genty, Emmanuel Besnier, Thomas Clavier, Anais Dumesnil, Sylvanie Renet, Paul Mulder, Fabien Doguet, Fabienne Tamion, Benoit Veber, Vincent Richard, Jean-Marc Baste
Summary: This study revealed that cardiopulmonary bypass significantly increased the impact of ischemia-reperfusion on pulmonary endothelial dysfunction in a lung transplantation rat model, indicating a detrimental effect of CPB on endothelial function.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Zhuqing Li, Qi Li, Li Wang, Chao Li, Mengping Xu, Yajun Duan, Likun Ma, Tingting Li, Qiao Chen, Yilin Wang, Yanxin Wang, Jiaxin Feng, Xuemei Yin, Xiaolin Wang, Jihong Han, Chengzhi Lu
Summary: Chronic sympathetic hyperactivity can lead to oxidative stress and inflammation in endothelial cells, contributing to atherosclerosis development. Renal denervation (RDN) may protect endothelial cells by reducing oxidative stress-induced inflammation, thus reducing atherosclerosis.
Article
Cardiac & Cardiovascular Systems
Tima Dehghani, Phung N. Thai, Harkanwalpreet Sodhi, Lu Ren, Padmini Sirish, Carol E. Nader, Valeriy Timofeyev, James L. Overton, Xiaocen Li, Kit S. Lam, Nipavan Chiamvimonvat, Alyssa Panitch
Summary: This study investigates the potential of DS-IkL, a selectin-targeting glycocalyx mimetic, in limiting inflammation and reperfusion injury after myocardial infarction. The results show that DS-IkL can reduce neutrophil binding and platelet activation on inflamed endothelial cells, as well as provide cardioprotective effects after ischemia/reperfusion.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Lance Hsieh, Lan N. Tu, Alison Paquette, Quanhu Sheng, Shilin Zhao, Douglas Bittel, James O'Brien, Kasey Vickers, Peter Pastuszko, Vishal Nigam
Summary: A study on neonatal patients undergoing cardiopulmonary bypass (CPB) revealed differential expression of multiple miRNAs in circulating leukocytes during and after bypass. These miRNAs are predicted to modulate pathways related to inflammation and signal transduction, contributing to the systemic inflammatory response post-CPB.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medical Laboratory Technology
Maike Schaefer, Andreas Stein, Bettina Ruf, Gunter Balling, Jonas Palm, Andreas Simmelbauer, Julie Cleuziou, Michaela Sander, Josef Auer, Kristina Borgmann, Joachim Struck, Oliver Hartmann, Janin Schulte, Juergen Hoerer, Peter Tassani-Prell, Peter Ewert, Stefan Holdenrieder, Cordula M. Wolf
Summary: This study evaluated the dynamic changes of plasma bioactive adrenomedullin (ADM) levels in pediatric patients with congenital heart disease (CHD) after cardiac surgery and found that higher levels were associated with clinical signs of capillary leakage.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Panagiotis Doukas, Gabriel Hellfritsch, Daniel Wendt, Mirko Magliani, Mohammad E. Barbati, Houman Jalaie, Michael J. Jacobs, Alexander Gombert
Summary: This pilot study investigated the efficacy of cytokine adsorption in controlling early inflammation cascade in patients undergoing open thoracoabdominal aortic repair. The results suggest that intraoperative hemoadsorption may be feasible and safe, but larger trials are needed to evaluate its clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Cristina M. Sena, Ana Pereira, Raquel M. Seica
Summary: The study evaluated the effects of cinnamaldehyde on vascular dysfunction in metabolic syndrome rats. The results showed that cinnamaldehyde significantly reversed endothelial dysfunction caused by a high-fat diet and sucrose diet, reduced vascular oxidative damage and inflammation, and increased Nrf2 activity in the arteries. Cinnamaldehyde can improve metabolic abnormalities and reverse endothelial dysfunction caused by obesity and metabolic syndrome.
Review
Pharmacology & Pharmacy
Xue-Kai Wang, Zong-Gen Peng
Summary: NAFLD and its advanced stage NASH pose a global public health threat, with no specific drugs approved for NASH treatment yet promising candidates in development. LSECs have been shown to play a crucial role in liver inflammation of NAFLD, offering potential as a therapeutic target for controlling liver inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jean Selim, Mouad Hamzaoui, Antoine Ghemired, Zoubir Djerada, Laurence Chevalier, Nicolas Piton, Emmanuel Besnier, Thomas Clavier, Anais Dumesnil, Sylvanie Renet, Paul Mulder, Fabien Doguet, Fabienne Tamion, Benoit Veber, Jeremy Bellien, Vincent Richard, Jean-Marc Baste
Summary: The use of human albumin and hypertonic sodium lactate as priming agents during mechanical circulatory support in lung transplantation can reduce pulmonary endothelial dysfunction. However, hypertonic sodium lactate may lead to the development of pulmonary edema.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Critical Care Medicine
Alexis L. Benscoter, Jeffrey A. Alten, Mihir R. Atreya, David S. Cooper, Jonathan W. Byrnes, David P. Nelson, Nicholas J. Ollberding, Hector R. R. Wong
Summary: This study aims to determine whether a new model can be derived by combining PERSEVERE biomarkers and clinical data to assess the risk of persistent MODS in the early post-operative period for children undergoing cardiac surgery requiring CPB. The study found that the model containing IL-8, CCL3, and age as predictor variables can effectively differentiate those with or without persistent MODS and provide a risk assessment model.
Article
Hematology
Lian Li, Jiaxing Miao, Nargis Shaheen, Sarah J. Taleb, Jian Hu, Qinmao Ye, Jinshan He, Jiasheng Yan, Rama K. Mallampalli, Jing Zhao, Yutong Zhao
Summary: NF-kappa Bp65 is ISGylated and this posttranslational modification is reversible. TNF alpha and endotoxin stimulation decrease p65 ISGylation and promote its serine phosphorylation, affecting endothelial cell functions.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Medicine, General & Internal
Martine E. Bol, J. B. Huckriede, K. G. H. van de Pas, T. Delhaas, R. Lorusso, G. A. F. Nicolaes, J. E. M. Sels, M. C. G. van de Poll
Summary: This study aimed to compare different indices of glycocalyx shedding and dysfunction in patients undergoing coronary artery bypass grafting (CABG) surgery. The results showed that glycocalyx thinning was accompanied by impaired glycocalyx function and increased endothelial activation during CABG surgery with cardiopulmonary bypass (CPB).
FRONTIERS IN MEDICINE
(2022)
Review
Cell Biology
Jing Qu, Yue Cheng, Wenchao Wu, Lixing Yuan, Xiaojing Liu
Summary: The glycocalyx plays a crucial role in inflammation and the development of vascular diseases, with endothelial dysfunction potentially leading to tissue swelling, chronic inflammation, and thrombosis. Eliminating endothelial inflammation may be a key target for treating vascular diseases. Research indicates that by disrupting the cycle of endothelial dysfunction and inflammation, the glycocalyx can help alleviate the progression of inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Health Care Sciences & Services
Luan Oliveira Ferreira, Victoria Winkler Vasconcelos, Janielle de Sousa Lima, Jaime Rodrigues Vieira Neto, Giovana Escribano da Costa, Jordana de Castro Esteves, Sallatiel Cabral de Sousa, Jonathan Almeida Moura, Felipe Ruda Silva Santos, Joao Monteiro Leitao Filho, Matheus Ramos Protasio, Pollyana Sousa Araujo, Claudio Jose da Silva Lemos, Karina Dias Resende, Dielly Catrina Favacho Lopes
Summary: Patients undergoing coronary revascularization with extracorporeal circulation or cardiopulmonary bypass may develop systemic inflammatory response due to biochemical changes in the microcirculation. Inflammatory signaling pathways can be activated by surgical incision, reperfusion injury, and blood contact with non-endothelial membranes, leading to the production and activation of inflammatory cells, cytokine production, and oxidative stress. Addressing new perspectives for intraoperative treatment and management may reduce this inflammatory storm, improve prognosis, and potentially lower mortality rates in these patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Giuseppe Filiberto Serraino, Federica Jiritano, Davide Costa, Nicola Ielapi, Domenica Battaglia, Umberto Marcello Bracale, Pasquale Mastroroberto, Michele Andreucci, Raffaele Serra
Summary: This systematic review aims to explore the role of matrix metalloproteinases (MMPs) in routine cardiac operations, especially cardiopulmonary bypass (CPB). The results show that MMP levels are significantly correlated with CPB and the gelatinases MMP-2 and MMP-9 are highly released during cardiac surgery with CPB. Increased MMP levels are associated with adverse post-operative outcomes. Future large-scale prospective multicenter randomized clinical trials are needed to investigate the impact of mechanical and pharmacological strategies on the inflammatory response and postoperative outcomes in cardiac surgery and CPB.
Editorial Material
Cardiac & Cardiovascular Systems
Friederike I. Schoettler, Payam Akhyari, Paul W. M. Fedak
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Surgery
Maximilian Luehr, Carolyn Weber, Martin Misfeld, Artur Lichtenberg, Sems-Malte Tugtekin, Mahmoud Diab, Shekhar Saha, Yupeng Li, Klaus Matsche, Torsten Doenst, Michael A. Borger, Thorsten Wahlers, Payam Akhyari, Christian Hagl
Summary: This study aimed to explore the virulence of Staphylococcus species in infectious endocarditis (IE) compared to other commonly causative bacteria in terms of short-term and long-term mortality. The results showed that patients with Staphylococcus IE had significantly higher mortality rates than those with IE caused by other bacteria. It is recommended to make an early diagnosis and refer patients with Staphylococcus infection to specialized centers for surgical treatment to reduce the risk of septic embolism and stroke.
Article
Engineering, Biomedical
Moritz Benjamin Immohr, Fabio Dos Santos Adrego, Helena Lauren Teichert, Vera Schmidt, Yukiharu Sugimura, Sebastian Bauer, Mareike Barth, Artur Lichtenberg, Payam Akhyari
Summary: Calcific aortic valve disease (CAVD) is a common cardiac pathology in the aging society, and the mechanisms behind it are not fully understood. 3D-bioprinting can be used to develop tissue-engineered cellular models to investigate the underlying mechanisms of CAVD.
BIOMEDICAL MATERIALS
(2023)
Article
Cardiac & Cardiovascular Systems
Hendrik Wienemann, Victor Mauri, Laurin Ochs, Maria Isabel Koerber, Kaveh Eghbalzadeh, Christos Iliadis, Marcel Halbach, Thorsten Wahlers, Stephan Baldus, Matti Adam, Elmar Kuhn
Summary: This study examined the clinical, procedural, and outcome parameters of patients undergoing transcatheter mitral valve implantation with self-expanding (SAV) or balloon-expandable (BAV) valves for mitral valve disease. The results showed similar baseline characteristics between the two groups, and comparable mortality rates at 320 days. The study suggests that TMVI with SAV or BAV could be a promising treatment option for high-risk patients with mitral valve disease.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Surgery
Moritz Benjamin Immohr, Christina Ballazs, Vincent Hettlich, Daniel Scheiber, Florian Boenner, Ralf Westenfeld, Hug Aubin, Igor Tudorache, Payam Akhyari, Artur Lichtenberg, Udo Boeken
Summary: The COVID-19 pandemic has had a significant impact on heart transplantation, affecting both donors and recipients. The pandemic has led to changes in the etiology of heart failure in recipients, a decrease in high urgency status and the use of left ventricular assist devices, and a shorter waiting time. Donors are more likely to have heart disease and marginal donors are being accepted. Surprisingly, the postoperative outcome has not been affected.
CLINICAL TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Ihor Krasivskyi, Ilija Djordjevic, Mahmoud Tayeh, Kaveh Eghbalzadeh, Borko Ivanov, Soi Avgeridou, Stephen Gerfer, Christopher Gaisendrees, Laura Suhr, Anton Sabashnikov, Christian Joerg Rustenbach, Navid Mader, Fabian Doerr, Thorsten Wahlers
Summary: Acute mesenteric ischemia (AMI) is associated with poor clinical outcomes after cardiac surgery. This study aimed to analyze the impact of AMI on short-term outcomes and relevant risk factors for in-hospital mortality after cardiac surgery. It also investigated the role of opioids and lactic acid in the detection and prevention of AMI. The study found that higher levels of lactic acid and treatment with opioids were independent predictors of mesenteric ischemia, while peripheral vascular disease, dialysis, and septic shock were relevant predictors of in-hospital mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Ihor Krasivskyi, Clara Grossmann, Marit Dechow, Ilija Djordjevic, Borko Ivanov, Stephen Gerfer, Walid Bennour, Elmar Kuhn, Anton Sabashnikov, Navid Mader, Kaveh Eghbalzadeh, Thorsten Wahlers
Summary: Through the analysis of our mobile ECMO program patients from the past seven years, we found that despite extensive experience, the ECMO team learning curve does not significantly benefit patients' outcomes. There were significant differences in complications after ECMO implantation between the survival and non-survival groups, with a higher incidence of thromboembolic events, hepatic failure, renal failure, dialysis, and systemic inflammatory response syndrome in the non-survival group. This highlights the need for greater focus on patient selection and ECMO indication.
Article
Surgery
Moritz Benjamin Immohr, Arash Mehdiani, Daniel Oehler, Vincent Hendrik Hettlich, Freya Sophie Jenkins, Ralf Westenfeld, Hug Aubin, Igor Tudorache, Udo Boeken, Artur Lichtenberg, Payam Akhyari
Summary: This study investigated the impact of circadian rhythm and daytime variation on heart transplantation outcomes. The results showed that the timing of the surgery in the morning, afternoon, or night did not significantly affect postoperative adverse events and survival rates. Therefore, the current practice of scheduling surgery can continue.
CLINICAL TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Moritz Benjamin Immohr, Arash Mehdiani, Sebastian Johannes Bauer, Hayato Ise, Yukiharu Sugimura, Artur Lichtenberg, Payam Akhyari
Summary: This study explored the application of AMDS in patients requiring additional aortic root surgery and found that although the surgery time was prolonged, the postoperative complications and mortality rate during hospitalization were comparable to conventional surgical methods.
JOURNAL OF CARDIOTHORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Moritz Benjamin Immohr, Vincent Hendrik Hettlich, Detlef Kindgen-Milles, Timo Brandenburger, Torsten Feldt, Hug Aubin, Igor Tudorache, Payam Akhyari, Artur Lichtenberg, Hannan Dalyanoglu, Udo Boeken
Summary: This study analyzed the effectiveness and changes in vv-ECMO therapy for COVID-19-related acute respiratory distress syndrome patients in Germany. The study found that during the second wave, there were changes in cannulation technique and the implementation of awake ECMO. The duration of ECMO support increased significantly and there were improvements in the weaning rate and in-hospital mortality.
THORACIC AND CARDIOVASCULAR SURGEON
(2023)
Article
Engineering, Biomedical
Alicia Fernandez-Colino, Fabian Kiessling, Ioana Slabu, Laura De Laporte, Payam Akhyari, Saskia K. Nagel, Julia Stingl, Stefanie Reese, Stefan Jockenhoevel
Summary: By studying the construction rules of living organisms, it is possible to develop biomimetic materials and biomedical systems. The article highlights recent advances in transformative biohybrid systems for tissue regeneration and biomedicine, as well as the progress in computational simulations and data-driven predictions. The ongoing development of imaging methods is also essential for validating computational models and enabling longitudinal monitoring. The challenges and future prospects of lifelike biohybrid materials are discussed.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biology
Ihor Krasivskyi, Clara Grossmann, Marit Dechow, Ilija Djordjevic, Borko Ivanov, Stephen Gerfer, Walid Bennour, Elmar Kuhn, Anton Sabashnikov, Parwis Baradaran Rahmanian, Navid Mader, Kaveh Eghbalzadeh, Thorsten Wahlers
Summary: The use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for cardiogenic shock is increasing. Acute limb ischaemia is a common complication after ECMO initiation. This study aimed to investigate the impact of acute limb ischaemia on short-term outcomes in patients receiving ECMO therapy. The results showed that acute limb ischaemia occurred in 18.3% of cases and was associated with a significantly higher bleeding rate.
Article
Cardiac & Cardiovascular Systems
Anna Kathrin Assmann, Artur Lichtenberg, Alexander Assmann, Payam Akhyari
Summary: This study used a microsurgical small animal model to investigate the effects of pioglitazone, a PPAR-γ agonist, on the degeneration of cardiovascular grafts. It was found that pioglitazone administration significantly reduced inflammatory and calcifying degeneration of the grafts, and improved their functional outcome.
ZEITSCHRIFT FUR HERZ THORAX UND GEFASSCHIRURGIE
(2023)
Article
Cardiac & Cardiovascular Systems
Stephen Gerfer, Walid Bennour, Alina Chigri, Ahmed Elderia, Ihor Krasivskyi, Clara Grossmann, Christopher Gaisendrees, Borko Ivanov, Soi Avgeridou, Kaveh Eghbalzadeh, Parwis Rahmanian, Ferdinand Kuhn-Regnier, Navid Mader, Ilija Djordjevic, Anton Sabashnikov, Thorsten Wahlers
Summary: Patients with simultaneous relevant internal carotid artery stenosis and coronary artery heart or valve disease are at high risk for severe cerebral or cardiovascular events during surgery. The timing and modality of carotid revascularization in patients with heart disease are controversial. More data are needed to predict and measure outcomes in order to understand the best treatment option for these patients.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Stephen Gerfer, Elmar W. Kuhn, Hannah Gablac, Borko Ivanov, Ilija Djordjevic, Victor Mauri, Matti Adam, Navid Mader, Stephan Baldus, Kaveh Eghbalzadeh, Thorsten C. W. Wahlers
Summary: This study retrospectively analyzed predictors and outcomes of patients undergoing periprocedural CPR during TAVR. Impaired preoperative LVEF and unstable hemodynamics before valve deployment were identified as independent risk factors for CPR and associated with compromised outcomes. Heart rhythm disturbances, malpositioning of the prosthesis, and pericardial tamponade were found to be the main causes of the high mortality in the CPR group. However, mechanical circulatory support and conversion to open heart surgery were shown to reduce mortality rates in CPR patients.
THORACIC AND CARDIOVASCULAR SURGEON
(2023)