Article
Medicine, General & Internal
Nicolas Poupore, Renee Chosed, Sergio Arce, Robert Rainer, Richard L. Goodwin, Thomas I. Nathaniel
Summary: Using metabolomics analysis, this study identified multiple metabolic pathways and metabolites associated with male and female AIS patients. Female AIS patients had 14 distinct altered metabolic pathways and 49 corresponding metabolites, while male patients had 39 metabolites and 5 metabolic pathways. Further research is needed to understand how these metabolites are linked to the pathophysiology in male and female AIS patients.
Article
Nutrition & Dietetics
Ninglin Wang, Yuan Ru, Zhiying Yang, Changxuan Sun, Shanshan Li, Yan Min, Xueyin Zhao, Ying Lu, Ann W. Hsing, Shankuan Zhu
Summary: The study revealed a positive association between plasma retinol levels and dyslipidemia, with higher levels in men than in women. Retinol may be associated with hormone metabolism and inflammation status.
FRONTIERS IN NUTRITION
(2021)
Article
Oncology
Seungyoun Jung, Sarah Silva, Cher M. Dallal, Erin Leblanc, Kenneth Paris, John Shepherd, Linda G. Snetselaar, Linda Van Horn, Yuji Zhang, Joanne F. Dorgan
Summary: This study aimed to investigate the metabolic influences on breast density phenotypes. Serum metabolomics analyses identified metabolic signatures associated with breast density phenotypes among young women. The results showed an inverse association of branched chain amino acids with breast density.
CANCER CAUSES & CONTROL
(2023)
Article
Food Science & Technology
Yu-Xi Liu, Yu-Ying Zhang, Jie Zheng, Jia-Nan Chen, Xu-Hui Huang, Xiu-Ping Dong, Bei-Wei Zhu, Lei Qin
Summary: This study found that the content of free amino acids and 5'-nucleotides in scallops collected in summer was significantly higher than in other seasons, with adenosine 5'-monophosphate, glycine, and alanine being dominant during this period. The lipid composition of scallops varied significantly, with the unsaturation degree of triacylglycerols increasing from July to November and the highest proportion of polyunsaturated phospholipids appearing in August and September.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Serena Correnti, Mariaimmacolata Preiano, Annalisa Fregola, Fabia Gamboni, Daniel Stephenson, Rocco Savino, Angelo D'Alessandro, Rosa Terracciano
Summary: Male infertility is a significant global concern, and traditional semen analysis is inadequate for diagnosis. Metabolomics profiling has become a valuable diagnostic tool in various diseases. This study identified a new pattern of biomarkers for male infertility through metabolomics and lipidomics analysis of seminal plasma samples.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Geriatrics & Gerontology
Hyung Eun Shin, Chang Won Won, Miji Kim
Summary: This study explored potential noninvasive biomarkers of severe sarcopenia through metabolomic analysis and identified several potential biomarkers.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Chemistry, Medicinal
Mateus Manfrin Artencio, Alvaro Luis Lamas Cassago, Renata Kelly da Silva, Janaina de Moura Engracia Giraldi, Fernando Batista da Costa
Summary: Coffee has transformed from an agricultural commodity to a specialty beverage, with a focus on sensory complexity and high quality. Metabolomics, a valuable tool for evaluating the chemical profiles of natural products, was employed to obtain the metabolic fingerprints of 21 coffee samples. Using metabolomic data, coffee samples were successfully discriminated based on their chemical profiles. Chemical markers for C. canephora samples were identified as caffeine, 2,4-dihydroxy-7-methoxy-(2H)-1,4-benzoxazin-3(4H)-one glucoside, roemerine, and cajanin, while toralactone, cnidilide, 2,3-dehydrosilybin, and lysophosphatidylcholines LysoPC (18:2(9Z,12Z)) and LysoPC (16:0/0:0) were markers for C. arabica samples. Our results also suggested the possible influence of terroir in the production of secondary metabolites, particularly in C. canephora.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2023)
Article
Public, Environmental & Occupational Health
Melissa Lopez-Pentecost, David O. Garcia, Xiaoxiao Sun, Cynthia A. Thomson, H. -H. Sherry Chow, Jessica A. Martinez
Summary: This study aimed to investigate the differences in metabolomic profiles between foreign and U.S-born Mexican-origin Hispanic men and shed light on the mechanisms through which birthplace influences cancer risk and risk factors. The results showed that the plasma metabolomic profiles of MO Hispanic men differed based on their birthplace. These findings improve our understanding of the relevant exposures that may impact cancer risk among MO Hispanic men.
AMERICAN JOURNAL OF MENS HEALTH
(2023)
Article
Nutrition & Dietetics
P. Kochhar, P. Dwarkanath, G. Ravikumar, A. Thomas, J. Crasta, T. Thomas, A. Kurpad, A. Mukhopadhyay
Summary: The study identified miR-16-5p and RNU44 as suitable reference miRNAs for placental miRNA expression analysis in small and appropriate for gestational age full-term singleton pregnancies. The stability of expression of these miRNAs was evaluated, with miR-16-5p and RNU44 found to be equally stable across all samples tested.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Pediatrics
Krishnamurthy Jayanna, Suman Rao, Arin Kar, Prabhu Dev Gowda, Tinku Thomas, Narayana Swaroop, Maryann Washington, A. Rao Shashidhar, Prathibha Rai, Suresh Chitrapu, Harnalli Lakkappa Mohan, Jose Martines, Prem Mony
Summary: This study explores intervention models to accelerate the coverage of Kangaroo Mother Care (KMC) for low birth weight newborns in a high priority district in Karnataka, India. The interventions included training, mentoring, and constant advocacy at various levels to promote the implementation of KMC in health facilities and the community.
Article
Nutrition & Dietetics
S. Ghosh, T. Thomas, A. Kurpad, H. S. Sachdev
Summary: The study found that high body iron status is associated with non-communicable diseases in adolescents, depending on wealth and co-existing prediabetes. This has important implications for iron intake in anemia prevention programs and the relationship between NCD and body iron stores should be studied.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Nutrition & Dietetics
Santu Ghosh, Tinku Thomas, Raghu Pullakhandam, Krishnapillai Madhavan Nair, Harshpal S. Sachdev, Anura Kurpad
Summary: This article proposes a framework for micronutrient fortification, suggesting that the targeted median nutrient intake should be set at the Estimated Average Requirement to avoid risks of inadequacy and excess intake.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Critical Care Medicine
Amarja Ashok Havaldar, Jay Prakash, Sanjeev Kumar, Kaladhar Sheshala, Abhilash Chennabasappa, Ria Rachel Thomas, E. A. Chinny Sushmitha, Mohd Saif Khan, Raman Kumar, Srishti Kindo, Ritu Singh, Munta Kartik, Akshay Hiruyur Manjunatha Swamy, John Michael Raj, Tinku Thomas, Sumithra Selvam
Summary: This study analyzed the risk factors associated with mortality in critically ill COVID-19-vaccinated patients admitted to the ICU. It was found that receiving a single dose, neutrophil:lymphocyte ratio, and SOFA score were associated with higher mortality. The mortality rate in vaccinated ICU patients was 43.68%, with lower mortality in patients who had received two doses.
INDIAN JOURNAL OF CRITICAL CARE MEDICINE
(2022)
Article
Nutrition & Dietetics
Nirupama Shivakumar, Tinku Thomas, Sarita Devi, Farook Jahoor, Anura V. Kurpad
Summary: This study found that children with stunting and EED have higher total energy expenditure, but metabolic rate is not associated with stunting or EED.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Sulagna Bandyopadhyay, Deepa Puttaswamy, Mamatha Philip Gabriel, J. Jayakumar, Julia L. Finkelstein, Sumithra Selvam, Anura Kurpad, Rebecca Kuriyan
Summary: This study found that previously published constants for measuring body fat mass in South Asian children do not accurately reflect the actual conditions in this population. Using these constants may lead to errors in measuring body fat mass. Therefore, more accurate methods are needed when measuring body fat mass in South Asian children.
JOURNAL OF NUTRITION
(2023)
Article
Computer Science, Interdisciplinary Applications
Harshvardhan Gazula, Kelly Rootes-Murdy, Bharath Holla, Sunitha Basodi, Zuo Zhang, Eric Verner, Ross Kelly, Pratima Murthy, Amit Chakrabarti, Debasish Basu, Subodh Bhagyalakshmi Nanjayya, Rajkumar Lenin Singh, Roshan Lourembam Singh, Kartik Kalyanram, Kamakshi Kartik, Kumaran Kalyanaraman, Krishnaveni Ghattu, Rebecca Kuriyan, Sunita Simon Kurpad, Gareth J. Barker, Rose Dawn Bharath, Sylvane Desrivieres, Meera Purushottam, Dimitri Papadopoulos Orfanos, Eesha Sharma, Matthew Hickman, Mireille Toledano, Nilakshi Vaidya, Tobias Banaschewski, Arun L. W. Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rudiger Bruhl, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Frauke Nees, Tomas Paus, Luise Poustka, Juliane H. Frohner, Lauren Robinson, Michael N. Smolka, Henrik Walter, Jeanne Winterer, Robert Whelan, Jessica A. Turner, Anand D. Sarwate, Sergey M. Plis, Vivek Benegal, Gunter Schumann, Vince D. Calhoun
Summary: With the growth of decentralized/federated analysis approaches in neuroimaging, the opportunities to study brain disorders using data from multiple sites has grown multi-fold. One such initiative is the Neuromark, a fully automated spatially constrained independent component analysis (ICA) that is used to link brain network abnormalities among different datasets, studies, and disorders while leveraging subject-specific networks.
Article
Psychiatry
Eesha Sharma, G. S. Ravi, Keshav Kumar, Kandavel Thennarasu, Jon Heron, Matthew Hickman, Nilakshi Vaidya, Bharath Holla, Madhavi Rangaswamy, Urvakhsh Meherwan Mehta, Murali Krishna, Amit Chakrabarti, Debashish Basu, Subodh Bhagyalakshmi Nanjayya, Rajkumar Lenin Singh, Roshan Lourembam, Kalyanaraman Kumaran, Rebecca Kuriyan, Sunita Simon Kurpad, Kamakshi Kartik, Kartik Kalyanram, Sylvane Desrivieres, Gareth Barker, Dimitri Papadopoulos Orfanos, Mireille Toledano, Meera Purushottam, Rose Dawn Bharath, Pratima Murthy, Sanjeev Jain, Gunter Schumann, Vivek Benegal
Summary: This study is based on the cVEDA study, which assessed cognitive abilities in over 8000 individuals aged 6-23 years in India. The findings suggest that both executive and social cognitive abilities continue to develop into adulthood. Developmental trajectories showed maturation and stabilization in increasing order of complexity, from working memory to inhibitory control to cognitive flexibility. Wealth index had the largest influence on developmental change, while sex differences were prominent in certain cognitive abilities and childhood adversity had a negative influence.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Nutrition & Dietetics
Santu Ghosh, Ravindranadh Palika, Teena Dasi, Rajeev K. K. Varshney, Devraj J. J. Parasannanavar, Sourav Sen Gupta, Annapurna Chitikineni, Santosh Kumar Banjara, Raghu Pullakhandam, Tinku Thomas, Harshpal S. S. Sachdev, Anura V. V. Kurpad, Bharati Kulkarni
Summary: Despite long-term iron supplementation, the high prevalence of anaemia among Indian women of reproductive age remains, possibly due to over-diagnosis using an inappropriate haemoglobin cut-off. A study was conducted to determine a suitable diagnostic haemoglobin cut-off for iron-responsive anaemia in this population. The derived cut-off is lower than the current adult values and could contribute to the high prevalence of anaemia.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Sandra M. Travasso, Smitha Joseph, Sumathi Swaminathan, Jawahar R. Manivannan, Patrick Webb, Anura Kurpad, Tinku Thomas
Summary: This study investigated the food security, diet diversity, and employment status of households in Bihar, India before and during the COVID-19 pandemic. The findings showed that the prevalence of food insecurity and low diet diversity significantly increased during the pandemic. Employment status was not associated with food insecurity or low diet diversity during the baseline survey, but households that changed their employment from agriculture to nonagriculture during the pandemic were more likely to experience food insecurity and low diet diversity.
JOURNAL OF NUTRITION
(2023)
Article
Multidisciplinary Sciences
Ekta Chaudhary, Franciosalgeo George, Aswathi Saji, Sagnik Dey, Santu Ghosh, Tinku Thomas, Anura. V. Kurpad, Sumit Sharma, Nimish Singh, Shivang Agarwal, Unnati Mehta
Summary: This study showed that increased exposure to PM2.5 is associated with higher prevalence of anemia, acute respiratory infection, and low birth weight among children in India. Nitrate, elemental carbon, and ammonium were found to be more correlated with these health outcomes compared to other PM2.5 species. The study also suggests that using total PM2.5 mass as an indicator of air pollution exposure may underestimate the composite impact of different components of PM2.5.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Ankita Hazarika, Bajanai Nongkhlaw, Arpita Mukhopadhyay
Summary: Selection of suitable and stable reference genes is crucial for reliable normalization of mRNA transcript levels in Type 2 diabetes mellitus (T2DM) patients' Peripheral Blood Mononuclear Cells (PBMCs). This study evaluated the stability of commonly used reference genes in PBMCs from T2DM patients and identified ACTB and YWHAZ as the most stable genes, while GAPDH and PPIB were found to be unstable. Dysregulation of GAPDH in female T2DM patients may be associated with sex-specific differences in T2DM pathogenesis and outcomes.
SCIENTIFIC REPORTS
(2023)
Article
Critical Care Medicine
Natesh Prabu Ravisankar, Carol Shayne D'Silva, Manu Manjula Krishnappa Gowda Varma, Thomas Isiah Sudarsan, Sriram Sampath, Tinku Thomas, Bhuvana Krishna
Summary: This study evaluated the prevalence of fogging impairing vision and techniques to reduce fogging in protective eyewear. It found that applying tape over the mask can best avoid disturbances in vision; in addition, soap coating and wearing the eyewear at a distance from the eyes are potential alternatives.
INDIAN JOURNAL OF CRITICAL CARE MEDICINE
(2023)
Article
Pediatrics
Deepa Puttaswamy, Santu Ghosh, Rebecca Kuriyan
Summary: This study aims to explore the walkability index in urban Bengaluru and its association with childhood obesity indices. The findings indicate a negative correlation between walkability and obesity indices in younger children, but the effects decrease with age.
