Article
Dermatology
David H. Truong, Anthony K. Ngoo, Shirling Tsai, Anna K. Yang, Dane K. Wukich, Lawrence A. Lavery
Summary: A retrospective review of patients who underwent transmetatarsal amputation (TMA) and had an angiogram or computed tomography angiography (CTA) perioperatively at the Dallas VA Medical Center from 2010 to 2020 found that the success rate of TMA is crucial as it determines the need for a major amputation in the future.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Multidisciplinary Sciences
Wonryung Lee, Seung-Hwan Jeong, Young-Woo Lim, Hyunhwan Lee, Joohyuk Kang, Hyunjae Lee, Injun Lee, Hyung-Seop Han, Shingo Kobayashi, Masaru Tanaka, Byeong-Soo Bae
Summary: The study developed a microneedle sensor on a hybrid substrate based on high Young's modulus epoxy siloxane and low Young's modulus polydimethylsiloxane, successfully achieving a microneedle sensor array on a flexible substrate. Mechanical durability was assessed through insertion into pig skin 1000 times, and the utility of flexible microneedle pH sensors in monitoring pH distribution in a disease model was demonstrated.
Article
Cardiac & Cardiovascular Systems
Juline N. Deppen, Sydney C. Ginn, Na Hee Kim, Lanfang Wang, Ronald J. Voll, Steven H. Liang, Mark M. Goodman, John N. Oshinski, Rebecca D. Levit
Summary: A large animal model suitable for assessing the efficacy of therapies for peripheral artery disease (PAD) was established by creating sustained gait dysfunction and other quantifiable ischemic limb symptoms through ligating different arteries. The visualization of genetically engineered porcine mesenchymal stromal cells post-administration was achieved. These findings provide a new platform for improving the clinical translational success of PAD therapies.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Jonathan Golledge
Summary: This article summarizes recent research on treatment targets for peripheral artery disease (PAD)-related limb ischemia. The current treatments for PAD have limitations and complications, and new therapies including exercise programs, drugs, stem cell treatments, and RNA therapeutics are being developed and tested. Multiple clinical trials are expected to provide results within the next 5 years.
CLINICAL THERAPEUTICS
(2023)
Review
Nutrition & Dietetics
Ahmed Ismaeel, K. Leigh Greathouse, Nathan Newton, Dimitrios Miserlis, Evlampia Papoutsi, Robert S. Smith, Jack L. Eidson, David L. Dawson, Craig W. Milner, Robert J. Widmer, William T. Bohannon, Panagiotis Koutakis
Summary: PAD affects over 200 million people worldwide, resulting in significant functional decline, with limited treatment options. Phytochemicals may have therapeutic effects on functional outcomes in PAD patients.
Review
Cardiac & Cardiovascular Systems
Tanner I. Kim, Raul J. Guzman
Summary: Medial artery calcification (MAC) is a regulated process associated with age, diabetes, and chronic kidney disease. It often occurs with atherosclerotic occlusive disease in lower extremity arteries, leading to negative limb outcomes. In patients with peripheral artery disease (PAD), MAC independently correlates with major amputation and mortality rates, affecting outcomes after endovascular interventions. Understanding the role of medial calcification in PAD and developing strategies for patient outcomes improvement are areas for further investigation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Hematology
Jonathan D. Newman, MacIntosh G. Cornwell, Hua Zhou, Caron Rockman, Adriana Heguy, Yajaira Suarez, Henry S. Cheng, Mark W. Feinberg, Judith S. Hochman, Kelly Ruggles, Jeffrey S. Berger
Summary: A transcriptomic signature identified patients with symptomatic PAD and those at increased risk of major adverse cardiac or limb events (MACLE). A specific microRNA, microRNA-4477b, was found to be overexpressed in prevalent PAD, incident MACLE, and in a mouse hindlimb ischemia model. This novel signature provides insights into potential mechanisms of severe symptomatic PAD.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Medicine, General & Internal
Tamar S. Polonsky, Mary M. McDermott
Summary: Peripheral artery disease affects approximately 230 million people worldwide and can be diagnosed noninvasively with ABI, although some patients may not exhibit typical symptoms. PAD patients not only have an increased risk of cardiovascular events, but also a greater risk of functional decline compared to those without PAD.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Review
Medicine, Research & Experimental
Jingxuan Han, Lailiu Luo, Olivia Marcelina, Vivi Kasim, Shourong Wu
Summary: Peripheral artery disease (PAD) poses a significant challenge to society and its prevalence is expected to increase in the coming years. Patients in severe stages of PAD are at high risk of amputation and death, leading to decreased quality of life and socio-economic burden. Therapeutic angiogenesis has emerged as a potential strategy for treating PAD, but further efforts are needed to address certain issues.
Article
Hematology
B. Cucuruz, R. Kopp, H. Hampe-Hecht, O. Andercou, W. Schierling, K. Pfister, M. Koller, T. Noppeney
Summary: Neuromodulation with spinal cord stimulation (SCS) can enable limb salvage and reduce pain significantly in end-stage peripheral arterial disease (PAD) patients, as well as improve walking distance.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2022)
Review
Pharmacology & Pharmacy
Damianos G. Kokkinidis, Adarsh Katamreddy, Stefanos Giannopoulos, Dimitrios Schizas, Sotirios Georgopoulos, Theodore Liakakos, Ehrin J. Armstrong, Christos Bakoyiannis
Summary: Peripheral artery disease (PAD) and chronic limb-threatening ischemia (CLTI) patients require personalized assessment and treatment based on specific risk factors, disease characteristics, and expected outcomes. Risk models and scores with external validation or promising initial findings have higher reliability. Although limitations exist in available scoring systems, further optimization and development of new scores can transition the field of PAD and CLI towards personalized medicine approach.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Medicine, General & Internal
Alessia Scatena, Pasquale Petruzzi, Filippo Maioli, Francesca Lucaroni, Cristina Ambrosone, Giorgio Ventoruzzo, Francesco Liistro, Danilo Tacconi, Marianna Di Filippi, Nico Attempati, Leonardo Palombi, Leonardo Ercolini, Leonardo Bolognese
Summary: The study showed that treatment with autologous PBMNC implants in NO-CLI patients with DFUs significantly reduced amputation rate, improved survival, and promoted wound healing. Autologous PBMNC injection may effectively prevent amputations in patients with DFUs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Jennifer A. Rymer, Dennis Narcisse, Michael Cosiano, John Tanaka, Mary M. McDermott, Diane J. Treat-Jacobson, Michael S. Conte, Brandi Tuttle, Manesh R. Patel, Kim G. Smolderen
Summary: This review summarizes the validation of patient-reported outcome measures (PROMs) in people with symptomatic peripheral artery disease. The findings suggest that disease-specific PROMs have good reliability and sensitivity, while generic PROMs have more extensive validation evidence. These findings can guide the selection of PROMs aligned with scientific and clinical goals.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Surgery
Keyuree Satam, Edouard Aboian, Jonathan Cardella, Martin Slade, Naiem Nassiri, Alan Dardik, Raul J. Guzman, Cassius Iyad Ochoa Chaar
Summary: Comparing outcomes of urgent endovascular and open repair of popliteal artery aneurysm (PAA) causing acute limb ischemia (ALI), it was found that endovascular repair is associated with decreased complications and hospital length of stay. However, patients receiving endovascular repair had higher perioperative mortality, possibly due to selection bias.
JOURNAL OF VASCULAR SURGERY
(2023)
Review
Cardiac & Cardiovascular Systems
Justin T. Morrison, Nicholas Govsyeyev, Connie N. Hess, Marc P. Bonaca
Summary: PAD is a severe manifestation of atherosclerosis that increases the risk of both cardiovascular and limb events. Recent trials have shown that vorapaxar, a thrombin inhibitor, can reduce the risk of complications in PAD patients.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
(2022)
Article
Surgery
Jonathan Golledge, Ramesh Velu, Frank Quigley, Jason Jenkins, Tejas P. Singh
Summary: This study aimed to identify the biomarkers that can independently predict major adverse cardiovascular events (MACE) in patients with small abdominal aortic aneurysm (AAA), and found that C-reactive protein (CRP) can assist in classifying the risk of MACE.
JOURNAL OF VASCULAR SURGERY
(2023)
Letter
Surgery
Shivshankar Thanigaimani, Jonathan Golledge
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Multidisciplinary Sciences
Yutang Wang, Yan Fang, Paul K. Witting, Fadi J. Charchar, Christopher G. Sobey, Grant R. Drummond, Jonathan Golledge
Summary: The study investigated the relationship between dietary intake of major types of fatty acids and heart disease mortality in a general adult cohort. The findings showed that saturated and monounsaturated fatty acids were associated with heart disease mortality, while a higher intake of polyunsaturated fatty acids was associated with a lower risk of heart disease mortality. The study suggests the importance of increasing dietary intake of polyunsaturated fatty acids in the general population.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Xiaoying Liu, Kaye E. Brock, Tara C. Brennan-Speranza, Leon Flicker, Jonathan Golledge, Graeme J. Hankey, Christian M. Girgis, Bu B. Yeap
Summary: Older people are more prone to vitamin D deficiency, and individual lifestyle factors have an impact on vitamin D levels. This study focused on older men and found that engaging in multiple healthy lifestyle behaviors, including physical activity, was associated with better vitamin D status. Further research is needed to determine the effects of promoting healthy lifestyle behaviors on vitamin D sufficiency.
CLINICAL ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Shivshankar Thanigaimani, Harry Jin, Usama Ahmad, Raghuveeran Anbalagan, Jonathan Golledge
Summary: This study compared the effectiveness of different growth factor therapies in healing diabetes-related foot ulcers. The results showed that epidermal growth factor, plasma-rich protein, and platelet-derived growth factor significantly improved the likelihood of complete ulcer healing. However, the evidence quality was found to be low, highlighting the need for larger, well-designed trials.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Surgery
Chanika Alahakoon, Tejas P. Singh, Dylan Morris, James Charles, Malindu Fernando, Peter Lazzarini, Joseph Moxon, Jonathan Golledge
Summary: This study investigated the distribution, severity, and outcome of peripheral artery disease (PAD) in Aboriginal and Torres Strait Islanders compared with non-indigenous Australians. The results showed that Aboriginal and Torres Strait Islander patients had a higher likelihood of presenting with chronic limb threatening ischaemia symptoms, more severe angiographic scores, particularly in the tibial arteries, and a higher risk of major amputation and major adverse cardiovascular events compared with non-indigenous Australians.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Surgery
Dylan R. Morris, Tejas P. Singh, Tahmid Zaman, Ramesh Velu, Francis Quigley, Jason Jenkins, Jonathan Golledge
Summary: This cohort study showed no significant differences in stroke rates among patients with different presentations of carotid artery stenosis.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Jonathan Golledge, Lisan Yip, Alkira Venn, Anthony S. Leicht, Jason S. Jenkins, Maria A. Singh, Christopher M. Reid, Zanfina Ademi, Belinda J. Parmenter, Joseph V. Moxon, Nicola W. Burton, BIP Investigators
Summary: This randomized clinical trial found no significant effect of brief counseling on step count in people with peripheral artery disease (PAD). Alternate interventions are needed to enable walking.
Review
Biochemistry & Molecular Biology
Chinmay Sharma, Tejas P. Singh, Shivshankar Thanigaimani, Domenico Nastasi, Jonathan Golledge
Summary: This study assessed the incidence rate of major adverse cardiovascular events (MACE) in patients with unrepaired abdominal aortic aneurysm (AAA) and their association with modifiable risk factors (diabetes, hypertension) and medication use (aspirin, statins). The study found a high incidence of cardiovascular death, myocardial infarction (MI), and stroke in patients with unrepaired AAA, but the prescription rate of preventive medication was suboptimal. Therefore, greater emphasis should be placed on secondary prevention measures in this population.
Review
Cardiac & Cardiovascular Systems
Jonathan Golledge, Shivshankar Thanigaimani, Janet T. Powell, Phil S. Tsao
Summary: Abdominal aortic aneurysm (AAA) causes a high number of deaths worldwide every year, but no drug therapy has been proven to effectively limit AAA growth in randomized controlled trials. Genome-wide association studies have identified potential drug targets, and treatments to reduce low-density lipoprotein cholesterol and smoking cessation are also being considered. However, previous placebo-controlled randomized trials have not shown convincing evidence of drug efficacy, mainly due to limitations such as small sample sizes and poor participant retention. Further large prospective studies on other targets are needed to address this issue.
EUROPEAN HEART JOURNAL
(2023)
Meeting Abstract
Surgery
G. A. Antoniou, N. Kontopodis, S. K. Rogers, J. Golledge, T. L. Forbes, F. Torella, H. J. M. Verhagen, M. L. Schermerhorn
JOURNAL OF VASCULAR SURGERY
(2023)
Review
Surgery
George A. Antoniou, Nikolaos Kontopodis, Steven K. Rogers, Jonathan Golledge, Thomas L. Forbes, Francesco Torella, Hence J. M. Verhagen, Marc L. Schermerhorn
Summary: The objective of this study is to compare the survival of patients who attended surveillance after endovascular aneurysm repair (EVAR) with those who were non-compliant. Thirteen cohort studies with a total of 22,762 patients were included. The results showed no statistically significant difference in the hazard of all cause mortality, aneurysm related mortality, or secondary intervention between patients who had incomplete and complete follow up after EVAR. The certainty of evidence was very low for all outcomes. The conclusion is that patients who were non-compliant with EVAR surveillance had similar survival to those who were compliant, questioning the value of intense surveillance in all patients post-EVAR and highlighting the need for further research on individualized or risk adjusted surveillance.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tejas P. P. Singh, Joseph V. V. Moxon, T. Christian Gasser, Jason Jenkins, Michael Bourke, Benard Bourke, Jonathan Golledge
Summary: The aim of this study was to assess the association between aortic peak wall stress (PWS) and peak wall rupture index (PWRI) and the risk of abdominal aortic aneurysm (AAA) rupture or repair (AAA events). PWS and PWRI were estimated from computed tomography angiography (CTA) scans of 210 participants with small AAAs. After a median follow-up of 2.0 years, it was found that both PWS and PWRI were significantly associated with a higher risk of AAA events. Furthermore, PWRI significantly improved the risk stratification compared to aortic diameter alone.
EUROPEAN RADIOLOGY
(2023)
Article
Endocrinology & Metabolism
Chanika Alahakoon, Malindu Fernando, Charith Galappaththy, Peter Lazzarini, Joseph V. Moxon, Rhondda Jones, Jonathan Golledge
Summary: This study compared the reproducibility, completion times, and ability to predict 30-day amputation of four classification systems (WIfI, UTWCS, SINBAD, and Wagner) for diabetes-related foot ulcers. Through photographs, three trained observers independently scored the ulcers of 45 participants on two separate occasions. The WIfI score showed substantial agreement between observers but was not predictive of 30-day amputation.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Stephanie Y. Tan, S. A. Paul Chubb, Leon Flicker, Osvaldo P. Almeida, Jonathan Golledge, Graeme J. Hankey, Bu B. Yeap
Summary: The study aimed to assess the prevalence and incidence of subclinical thyroid dysfunction in older men. The results showed that one-fifth of initially euthyroid men developed subclinical or overt hypothyroidism, and age and higher baseline thyroid stimulating hormone (TSH) levels predicted this outcome.
CLINICAL ENDOCRINOLOGY
(2023)