Article
Medicine, Research & Experimental
Tong Zhu, Xiaoming Zou, Chunfa Yang, Liangliang Li, Bing Wang, Rong Li, Hongxuan Li, Zhangxuan Xu, Di Huang, Qingyun Wu
Summary: Neutrophil extracellular traps (NETs) in gastric cancer (GC) are associated with tumor progression, metastasis risk, and tumor microenvironment. The study found that NETs formation is affected by the tumor microenvironment and may exacerbate GC progression through promoting epithelial-mesenchymal transition (EMT). Hence, targeting NETs may be therapeutically beneficial in GC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Review
Oncology
Christof Kaltenmeier, Richard L. Simmons, Samer Tohme, Hamza O. Yazdani
Summary: Neutrophil Extracellular Traps (NETs) play a crucial role in cancer progression, particularly in promoting premetastatic niche formation, interacting with circulating cancer cells, and facilitating epithelial to mesenchymal transition during cancer metastasis. Targeting NETs may offer potential treatment options to impede tumor progression.
Review
Oncology
Urszula Demkow
Summary: This review focuses on the pro-tumorigenic action of neutrophil extracellular traps (NETs), which are found in various human and animal tumors. NETs play a crucial role in tumor development by awakening dormant cancer cells, regulating the tumor microenvironment, and enhancing tumor aggressiveness. Understanding the crosstalk between cancer and NETs can lead to novel therapeutic interventions to block cancer evasion mechanisms and prevent metastatic spread.
Article
Oncology
Borja Ruiz-Fernandez de Cordoba, Haritz Moreno, Karmele Valencia, Naiara Perurena, Pablo Ruedas, Thomas Walle, Alberto Pezonaga-Torres, Juan Hinojosa, Elisabet Guruceaga, Antonio Pineda-Lucena, Marta Abengozar-Muela, Denis Cochonneau, Carolina Zandueta, Susana Martinez-Canarias, Alvaro Teijeira, Daniel Ajona, Sergio Ortiz-Espinosa, Xabier Morales, Carlos Ortiz de Solorzano, Marta Santisteban, Luis Ramos-Garcia, Laura Guembe, Vratislav Strnad, Dominique Heymann, Sandra Hervas-Stubbs, Ruben Pio, Maria E. Rodriguez-Ruiz, Carlos E. de Andrea, Silvestre Vicent, Ignacio Melero, Fernando Lecanda, Rafael Martinez-Monge
Summary: Locoregional failure in breast cancer patients after surgery and irradiation is linked to a poor prognosis. The ENPP1/HP axis is exploited by tumor cells to promote local recurrence by suppressing immune cells. Blocking this axis offers new opportunities for therapeutic intervention.
Review
Oncology
Yue Chen, Haoyue Hu, Songtao Tan, Qionglan Dong, Xue Fan, Yi Wang, Huan Zhang, Jun He
Summary: This review discusses the role of neutrophil extracellular traps (NETs) in cancer. Research has found that NETs are closely associated with cancer progression, metastasis, and cancer-associated thrombosis. The article summarizes the current understanding of NET formation and explores the potential applications of NETs in cancer therapy.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Article
Cell Biology
Shifeng Yang, Boshi Sun, Jiacheng Li, Nana Li, Ange Zhang, Xinyu Zhang, Hao Yang, Xiaoming Zou
Summary: Neutrophil extracellular traps (NETs) play a crucial role in promoting angiogenesis in gastric cancer, as confirmed by multiple experiments. These findings provide a theoretical basis for identifying new therapeutic targets for anti-vascular treatment.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
J. Cedervall, M. Herre, A. Dragomir, F. Rabelo-Melo, A. Svensson, C. Thalin, A. Rosell, V Hjalmar, H. Wallen, H. Lindman, G. Pejler, E. Hagstrom, M. Hultstrom, A. Larsson, A. K. Olsson
Summary: This study investigates the role of neutrophil extracellular traps (NETs) in myocardial inflammation and tissue damage in treatment-naive cancer patients. The findings suggest that NETs contribute to inflammation and myocardial stress during malignancy, and removing NETs may prevent cardiac inflammation and dysfunction in cancer patients.
Article
Engineering, Biomedical
Ying Zhang, Cong Wang, Weishuo Li, Wei Tian, Chunming Tang, Lingjing Xue, Ziming Lin, Guilai Liu, Dongfei Liu, Ying Zhou, Qianqian Wang, Xu Wang, Lutz Birnbaumer, Yong Yang, Xianjing Li, Caoyun Ju, Can Zhang
Summary: The study proposes a general CTC intervention strategy based on neutrophil cyto-pharmaceuticals to suppress CTC colonization and metastasis formation, offering a new perspective for understanding the mechanism of CTC colonization and suggesting targeted intervention as a meaningful treatment for tumor metastasis.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Oncology
Ze-Zhou Jiang, Zhi-Peng Peng, Xing-Chen Liu, Hao-Fan Guo, Meng-Meng Zhou, Da Jiang, Wan-Ru Ning, Yu-Fan Huang, Limin Zheng, Yan Wu
Summary: Neutrophil extracellular traps (NETs) formation is increased in human hepatocellular carcinoma (HCC) tumor tissues, promoting cancer cell migration and facilitating tumor metastasis. Inhibiting NETs can suppress tumor metastasis in HCC, with the levels of NETs-releasing neutrophils being negatively correlated with patient survival.
Article
Biochemical Research Methods
Junho Lee, Donggu Lee, Sean Lawler, Yangjin Kim
Summary: This study investigates the mutual interactions between tumor cells and neutrophils in facilitating tumor invasion through a mathematical model. The model shows that tumor-associated neutrophils can enhance tumor cell invasion by secreting neutrophil elastase, reproducing major experimental observations and making important predictions for future experiments.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Review
Oncology
Wentao Zhong, Qianyu Wang, Xiaofei Shen, Junfeng Du
Summary: Neutrophil extracellular traps (NETs) are web-like structures composed of DNA, histones, and granule proteins released by neutrophils. They play an important role in innate immunity against pathogenic bacteria. Recent studies have shown that NETs are also involved in the progression of sterile inflammation and have been implicated in the development of cancer, particularly metastasis. Targeting NETs may be a promising treatment strategy for various types of cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Michio Okamoto, Rei Mizuno, Kenji Kawada, Yoshiro Itatani, Yoshiyuki Kiyasu, Keita Hanada, Wataru Hirata, Yasuyo Nishikawa, Hideyuki Masui, Naoko Sugimoto, Takuya Tamura, Susumu Inamoto, Yoshiharu Sakai, Kazutaka Obama
Summary: This study investigated the expression and clinical relevance of neutrophil extracellular traps (NETs) in colorectal cancers (CRCs). The results showed that high expression of intratumoral or systemic NETs correlated with poor relapse-free survival (RFS) in CRC patients. In vitro and in vivo experiments demonstrated that NETs promoted CRC cell migration mediated by neutrophil elastase (NE), and NE inhibition suppressed liver metastases in CRC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Dakai Yang, Jing Liu
Summary: Neutrophil Extracellular Traps (NETs) are essential for host defense and have implications in diseases such as cancer, particularly in metastasis. Researchers are working on strategies targeting NETs in pre-clinical models and facing challenging questions in the field.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Zeng Hanhai, Qin Bin, Zhou Shengjun, Li Jingbo, Guo Yinghan, Cai Lingxin, Cao Shenglong, Zhou Hang, Chen Huaijun, Zhuang Jianfeng, Peng Yucong, Fu Xiongjie, Yu Xiaobo, Tan Xiaoxiao, Li Jianru, Gu Chi, Yan Feng, Chen Gao
Summary: Neutrophils in peripheral blood were found to be higher in subarachnoid hemorrhage patients compared to healthy subjects. The presence of neutrophil extracellular traps released post-SAH could shift microglia towards a more proinflammatory phenotype, contributing to neuroinflammation and poor outcome.
Article
Chemistry, Multidisciplinary
Lianghan Zhu, Zhaoting Li, Ning Liu, Honghao Sun, Yixin Wang, Minjie Sun
Summary: The study explores a protein delivery strategy using poly amino acid conjugated with polyethylene glycol (PAAP) to prevent liver metastasis by degrading chromatin and disassembling NET-DNA. This approach not only suppresses tumor growth by degrading intracellular chromatin, but also prevents liver metastasis by disassembling NET-NDA, providing potential new inspiration for patients with metastatic colon and breast cancer.
ADVANCED FUNCTIONAL MATERIALS
(2021)