A Diterpenoid, 14-Deoxy-11, 12-Didehydroandrographolide, in Andrographis paniculata Reduces Steatohepatitis and Liver Injury in Mice Fed a High-Fat and High-Cholesterol Diet

Andrographolide impairs alpha-naphthylisothiocyanate-induced cholestatic liver injury in vivo

(2019) Lei Wang et al.   Journal of Natural Medicines

Bioavailability of the diterpenoid 14-deoxy-11,12-didehydroandrographolide in rats and up-regulation of hepatic drug-metabolizing enzyme and drug transporter expression

(2019) Chih-Ching Yen et al.   PHYTOMEDICINE

Phytosterols and Triterpenoids for Prevention and Treatment of Metabolic- related Liver Diseases and Hepatocellular Carcinoma

(2019) Sanchez-Crisostomo Isabel et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Oxidative Stress and Non-Alcoholic Fatty Liver Disease: Effects of Omega-3 Fatty Acid Supplementation

(2019) Jinchunzi Yang et al.   Nutrients

Fermented black radish ( Raphanus sativus L. var. niger ) attenuates methionine and choline deficient diet‐induced nonalcoholic fatty liver disease in mice

(2019) Meejung Ahn et al.   Food Science & Nutrition

Overview of pharmacological activities of Andrographis paniculata and its major compound andrographolide

(2018) Yan Dai et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Freshwater clam extract reduces liver injury by lowering cholesterol accumulation, improving dysregulated cholesterol synthesis and alleviating inflammation in high-fat, high-cholesterol and cholic acid diet-induced steatohepatitis in mice

(2018) Hsien-Tsung Yao et al.   Food & Function

Understanding the Impact of Dietary Cholesterol on Chronic Metabolic Diseases through Studies in Rodent Models

(2018) Ángela Vinué et al.   Nutrients

Sortilin 1 Loss-of-Function Protects Against Cholestatic Liver Injury by Attenuating Hepatic Bile Acid Accumulation in Bile Duct Ligated Mice

(2017) Jibiao Li et al.   TOXICOLOGICAL SCIENCES

Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis

(2017) Daniel Cabrera et al.   Scientific Reports

Metabolomic characteristics of cholesterol-induced non-obese nonalcoholic fatty liver disease in mice

(2017) Lan N. Tu et al.   Scientific Reports

Prolonged feeding with green tea polyphenols exacerbates cholesterol-induced fatty liver disease in mice

(2016) Nina Hirsch et al.   MOLECULAR NUTRITION & FOOD RESEARCH

14-Deoxy-11,12-didehydroandrographolide induces DDIT3-dependent endoplasmic reticulum stress-mediated autophagy in T-47D breast carcinoma cells

(2016) Heng Kean Tan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Role of Cholesterol in the Pathogenesis of NASH

(2016) George N. Ioannou   TRENDS IN ENDOCRINOLOGY AND METABOLISM

14-Deoxy-11,12-dehydroandrographolide exerts anti-influenza A virus activity and inhibits replication of H5N1 virus by restraining nuclear export of viral ribonucleoprotein complexes

(2015) Wentao Cai et al.   ANTIVIRAL RESEARCH

Supplementation of Chitosan Alleviates High-Fat Diet-Enhanced Lipogenesis in Rats via Adenosine Monophosphate (AMP)-Activated Protein Kinase Activation and Inhibition of Lipogenesis-Associated Genes

(2015) Chen-Yuan Chiu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease

(2015) Mariana Verdelho Machado et al.   PLoS One

Effect of commercially available green and black tea beverages on drug-metabolizing enzymes and oxidative stress in Wistar rats

(2014) Hsien-Tsung Yao et al.   FOOD AND CHEMICAL TOXICOLOGY

Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent

(2014) Lay T. Gan et al.   JOURNAL OF HEPATOLOGY

Review on Liver Inflammation and Antiinflammatory Activity ofAndrographis paniculatafor Hepatoprotection

(2014) Lee Suan Chua   PHYTOTHERAPY RESEARCH

Nuclear erythroid 2-related factor 2: A novel potential therapeutic target for liver fibrosis

(2013) Jing-Jing Yang et al.   FOOD AND CHEMICAL TOXICOLOGY

Hepatic cholesterol crystals and crown-like structures distinguish NASH from simple steatosis

(2013) George N. Ioannou et al.   JOURNAL OF LIPID RESEARCH

A new flavonoid from the aerial parts ofAndrographis paniculata

(2013) Li-Xia Chen et al.   NATURAL PRODUCT RESEARCH

Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease

(2012) Hae-Ki Min et al.   Cell Metabolism

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Cardiovascular Activity of Labdane Diterpenes fromAndrographis paniculatain Isolated Rat Hearts

(2012) Khalijah Awang et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Protective Role of 14-Deoxy-11,12-didehydroandrographolide, a Noncytotoxic Analogue of Andrographolide, in Allergic Airway Inflammation

(2011) Shou-Ping Guan et al.   JOURNAL OF NATURAL PRODUCTS

Effect of Chitosan on Hepatic Drug-Metabolizing Enzymes and Oxidative Stress in Rats Fed Low- and High-Fat Diets

(2010) Hsien-Tsung Yao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Nrf2 the rescue: Effects of the antioxidative/electrophilic response on the liver

(2010) Curtis D. Klaassen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian)

(2010) Wen-Wan Chao et al.   Chinese Medicine

A Review of Glutamate Receptors I: Current Understanding of Their Biology

(2008) Colin G. Rousseaux   Journal of Toxicologic Pathology