Article
Chemistry, Medicinal
Sowmya Shree Gopal, Shinde Vijay Sukhdeo, Baskaran Vallikannan, Ganesan Ponesakki
Summary: Lutein has antiobesity effects in a high-fat diet-induced obese mouse model, reducing adipose tissue weight, serum cholesterol, triglycerides, and blood glucose levels, as well as downregulating genes and proteins associated with obesity.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Rownock Afruza, Nikhil V. Dhurandhar, Vijay Hegde
Summary: This study investigated the effects of E4orf1 expression induced by doxycycline in adipose tissue and dietary fat restriction on hepatic steatosis and its progression in mice. The results showed that E4 expression prevented the development of fatty liver, while diet reversal maintained liver health but did not improve molecular changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rongrong Tan, Jiayang Li, Lu Liu, Qian Wu, Lei Fan, Ningning Ma, Chuwei Yu, Henglei Lu, Xuemei Zhang, Jing Chen, Likun Gong, Jin Ren
Summary: This study discovered that cysteine sulfinic acid decarboxylase (CSAD) expression significantly decreased in non-alcoholic fatty liver disease (NAFLD) patients, which was confirmed in multiple NAFLD mouse models. The overexpression of CSAD in the liver of high-fat diet-fed mice alleviated NAFLD-associated pathologies and increased the expression of fatty acid beta-oxidation genes. CSAD was also found to improve mitochondrial injury. These findings suggest that CSAD has the potential to become a new therapeutic target for NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Xiaoli Qian, Ting Wang, Jiahong Gong, Li Wang, Xuyan Chen, Haiyan Lin, Wenzhan Tu, Songhe Jiang, Shengcun Li
Summary: Exercise can prevent liver injury, steatosis, and fibrosis associated with NAFLD by blocking the upregulation of HMGCS2 and attenuating the Wnt3a/beta-catenin pathway.
Article
Biochemistry & Molecular Biology
Yan-Min Chen, Chun-Fang Lian, Qian-Wen Sun, Ting-Ting Wang, Yuan-Yuan Liu, Jun Ye, Li-Li Gao, Yan-Fang Yang, Shuai-Nan Liu, Zhu-Fang Shen, Yu-Ling Liu
Summary: The study found that Ramulus Mori (Sangzhi) alkaloids (SZ-A) have therapeutic effects on obesity and nonalcoholic fatty liver disease (NAFLD). SZ-A can reduce weight gain caused by a high-fat diet and increase the expression of adiponectin. Additionally, SZ-A can reduce hepatic steatosis and inflammation, regulate lipid metabolism and oxidative stress in the liver.
Article
Food Science & Technology
Qian-Qian Mao, Bang-Yan Li, Jin-Ming Meng, Ren-You Gan, Xiao-Yu Xu, Ying-Ying Gu, Xiao-Hui Wang, Hua-Bin Li
Summary: The study found that several tea extracts have significant effects in preventing NAFLD, reducing body weight, hepatic steatosis, and could be developed into functional foods against NAFLD.
FOOD SCIENCE & NUTRITION
(2021)
Article
Multidisciplinary Sciences
Tingting Zhou, Ligang Cao, Yimei Du, Lin Qin, Yanliu Lu, Qianru Zhang, Yuqi He, Daopeng Tan
Summary: Gypenosides (GP) extracted from Gynostemma pentaphyllum have a beneficial effect on nonalcoholic fatty liver disease, as they can reduce lipid accumulation and improve lipid metabolism in mice through regulating key genes and proteins involved in hepatic lipid metabolism.
Article
Food Science & Technology
Ruiqian Duan, Kai Huang, Xiao Guan, Sen Li, Jian Xia, Meng Shen, Zhu Sun, Zhiquan Yu
Summary: The study found that Tectorigenin (Tg) can alleviate NAFLD by mediating the liver-gut axis, mainly manifested in improving lipid metabolism abnormalities, restoring intestinal barrier, inhibiting pro-inflammatory cytokines release, and affecting intestinal microbiota.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Gastroenterology & Hepatology
Bertha A. Marin-Alejandre, Irene Cantero, Nuria Perez-Diaz-del-Campo, Jose I. Monreal, Mariana Elorz, Jose I. Herrero, Alberto Benito-Boillos, Jorge Quiroga, Ana Martinez-Echeverria, Juan I. Uriz-Otano, Maria P. Huarte-Muniesa, Josep A. Tur, Jose A. Martinez, Itziar Abete, Maria A. Zulet
Summary: The study found that both AHA and FLiO diets were effective in improving weight, body composition, metabolism, and liver status in NAFLD patients over a 2-year period. The FLiO diet showed greater improvements in liver enzymes, liver stiffness, and Fatty Liver Index, as well as a significant increase in adiponectin compared to the AHA diet.
LIVER INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Zhixin Luo, Mengqian Li, Qiong Yang, Yuhong Zhang, Fang Liu, Lan Gong, Lin Han, Min Wang
Summary: Ferulic acid (FA) has a protective effect on high-fat diet-induced non-alcoholic fatty liver disease (NAFLD) by activating PPARα to decrease triacylglycerol accumulation and increase energy expenditure.
Article
Food Science & Technology
Kahori Shimizu, Yuka Egusa, Syogo Nishimuta, Yuri Fukumura, Misato Yoshimura, Tomoya Inomoto, Tomoyuki Terada, Koji Tomita, Toru Nishinaka
Summary: Components in calamondin such as nobiletin, hesperidin, and vitamin C may help ameliorate metabolic disturbances induced by a high-fat diet, including reducing lipid accumulation in the liver, improving hepatocyte ballooning, and decreasing inflammation levels.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2021)
Article
Cell Biology
Jing-Hua Wang, Seung-Ju Hwang, Dong-Woo Lim, Chang-Gue Son
Summary: The ethanol extract of Cynanchum atratum (CAE) was found to have anti-fatty liver effects. A six-week treatment of CAE in mice on a high-fat, high-fructose diet significantly reduced body weight, liver weight, and mesenteric fat. CAE also improved blood parameters and liver damage, and normalized gene and protein expression related to liver lipid metabolism. Additionally, CAE decreased hepatic inflammation and fecal endotoxin levels, suggesting its potential for treating chronic metabolic diseases.
Article
Food Science & Technology
Hui Yu, Xiangzhou Yi, Xia Gao, Jun Ji, Zhongyuan Liu, Guanghua Xia, Chuan Li, Xueying Zhang, Xuanri Shen
Summary: The study found that tilapia-head chondroitin sulfate (TH-CS) can be used as an oral supplement to effectively prevent the development of nonalcoholic fatty liver disease (NAFLD). TH-CS can improve liver damage, blood lipid accumulation, and insulin resistance (IR), reduce inflammatory response and oxidative stress, restore gut microbiota balance, and increase the abundance of bacteria producing short-chain fatty acids (SCFAs).
Article
Plant Sciences
Jing Tian, Mengjie Cai, Shenyi Jin, Qingguang Chen, Jiahui Xu, Qiuyue Guo, Zihui Yan, Xu Han, Hao Lu
Summary: A study on mice with NAFLD induced by a high-fat diet found that JianPi-QingHua formula (JPQH), a Chinese herbal formula, has a significant hepatoprotective effect. It can reduce body weight, adipose mass, blood glucose, and liver weight, as well as decrease the levels of serum triglycerides, cholesterol, and liver injury markers. In addition, JPQH can improve liver histopathological changes, reduce lipid accumulation, and suppress inflammatory responses. The study suggests that JPQH protects against HFD-induced NAFLD by regulating the SIRT1/AMPK/NF-kappa B pathway.
PHARMACEUTICAL BIOLOGY
(2023)
Review
Cell Biology
Qiannan Ren, Qiming Sun, Junfen Fu
Summary: Non-alcoholic fatty liver disease (NAFLD) is closely associated with a high-fat diet. Autophagy plays a protective role in NAFLD, but dysfunction of liver autophagy may contribute to the development of NAFLD.
Article
Agriculture, Dairy & Animal Science
Leonardo Recena Aydos, Luane Aparecida do Amaral, Ana Cristina Jacobowski, Roberta Serafim de Souza, Eduardo Benedetti Parisotto, Mariana Biava de Menezes, Felipe Francisco Bittencourt Junior, Emely Schuindt Fernandes, Iandara Schettert Silva, Luciane Candeloro Portugal, Claudio Goncalves Oliveira, Gustavo Tsuyoshi Senra Masuko, Leandro Fontoura Cavalheiro, Carlos Eduardo Domingues Nazario, Elisvania Freitas dos Santos, Maria Ligia Rodrigues Macedo
Summary: The study found that supplementation of BPO may worsen metabolic disorders caused by a high-fat diet, exacerbating risk factors associated with MetS.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2021)
Article
Chemistry, Medicinal
Ana Cristina Jacobowski, Eduardo Benedetti Parisotto, Leonardo Recena Aydos, Roberta Serafim de Souza, Sandra Viveros, Ana Laura Colin-Gonzalez, Iandara Schettert Silva, Eliana Janet Sanjinez-Argandona, Danilo Wilhelm Filho, Abel del Angel Santamaria, Maria Ligia Rodrigues Macedo
Summary: The study demonstrated that A. aculeata pulp oil and microencapsulated pulp oil have protective effects on brain oxidative damage in rats induced by chronic restraint stress, mainly by increasing GSH content and enhancing the ability of neural tissues to deal with oxidative stress, thus protecting against neurodegenerative diseases.
JOURNAL OF MEDICINAL FOOD
(2021)
Article
Multidisciplinary Sciences
Kellen Natalice Vilharva, Daniel Ferreira Leite, Helder Freitas dos Santos, Katia Avila Antunes, Paola dos Santos da Rocha, Jaqueline Ferreira Campos, Claudiane Vilharroel Almeida, Maria Ligia Rodrigues Macedo, Denise Brentan Silva, Caio Fernando Ramalho de Oliveira, Edson Lucas dos Santos, Kely de Picoli Souza
Summary: Zootherapy is a traditional secular practice among the Guarani-Kaiowa indigenous ethnic group in Brazil, who use oil extracted from larvae of the snout beetle Rhynchophorus palmarum for treating skin wounds and respiratory diseases. Research has shown that the oil possesses antioxidant, antimicrobial, and healing properties, promotes cell migration, and is non-toxic in in vitro and in vivo models.
Article
Nutrition & Dietetics
Luane Aparecida do Amaral, Taina da Silva Fleming de Almeida, Gabriel Henrique Oliveira de Souza, Adrivanio Baranoski, Rafael Souza Maris, Felipe Francisco Bittencourt Junior, Bruna Paola Murino Rafacho, Antonio Carlos Duenhas Monreal, Candida Aparecida Leite Kassuya, Andreia Conceicao Milan Brochado Antoniolli-Silva, Elisvania Freitas dos Santos, Rodrigo Juliano Oliveira
Summary: The study aimed to formulate a natural fiber-rich food product (NFRFP) for colorectal cancer prevention and evaluate its safety and effects in a preclinical model. Results showed that NFRFP exhibited a chemopreventive effect and reduced the incidence of aberrant crypts in the colon.
Article
Nutrition & Dietetics
Mayra Lopes de Oliveira, Juliana de Lara Castagnoli, Kerulyn Maria Chanivski Machado, Jaqueline Machado Soares, Flavia Teixeira, Dalton Luiz Schiessel, Elisvania Freitas dos Santos, Daiana Novello
Summary: This study aimed to evaluate the effects of interdisciplinary educational intervention on elementary-school students' knowledge of eating, nutrition, and physical activity. The findings showed that the intervention significantly increased students' knowledge in these areas, regardless of gender or nutritional status.
Article
Food Science & Technology
Jaqueline Machado Soares, Flavia Teixeira, Mayra Lopes de Oliveira, Luane Aparecida do Amaral, Taina da Silva Fleming de Almeida, Gabriel Henrique Oliveira de Souza, Lais Maluf Hokama, Bruna Menegassi, Elisvania Freitas Dos Santos, Daiana Novello
Summary: This research evaluated the effects of adding different levels of eggplant flour on the characteristics of cookies. It was found that adding 5% eggplant flour maintained the sensory acceptability among children and improved the physicochemical and nutritional characteristics of the cookies.
Article
Chemistry, Medicinal
Breno Emanuel Farias Frihling, Ana Paula de Araujo Boleti, Caio Fernando Ramalho de Oliveira, Simone Camargo Sanches, Pedro Henrique de Oliveira Cardoso, Newton Verbisck, Maria Ligia Rodrigues Macedo, Paula Helena Santa Rita, Cristiano Marcelo Espinola Carvalho, Ludovico Migliolo
Summary: In this study, a new acidic phospholipase with antitumor activity was identified from Bothrops moojeni venom. The enzyme showed selectivity towards colorectal adenocarcinoma cells and could be a potential candidate for the development of new biotechnological tools.
Article
Food Science & Technology
Pedro Henrique de Oliveira Cardoso, Ana Paula de Araujo Boleti, Patricia Souza E. Silva, Lincoln Takashi Hota Mukoyama, Alexya Sandim Guindo, Luiz Filipe Ramalho Nunes de Moraes, Caio Fernando Ramalho de Oliveira, Maria Ligia Rodrigues Macedo, Cristiano Marcelo Espinola Carvalho, Alinne Pereira de Castro, Ludovico Migliolo
Summary: The importance of neuroinflammation is increasingly recognized in neurological disorders, including both inflammatory diseases like multiple sclerosis and non-inflammatory conditions such as stroke, epilepsy, and cancer. A peptide called Ca-MAP1, inspired by a toxin from C. albicans, has shown promising anti-neuroinflammatory, antibacterial, and cytotoxic activity. In vitro and in silico studies demonstrated its effectiveness at lower concentrations, with low toxicity to normal cells. Ca-MAP1 also exhibited activity against various bacteria and demonstrated anti-neuroinflammatory effects. This peptide holds potential for controlling infections and serving as an alternative therapy for cancer.
Article
Food Science & Technology
Patricia Souza e Silva, Alexya Sandim Guindo, Pedro Henrique Cardoso Oliveira, Luiz Filipe Ramalho Nunes de Moraes, Ana Paula de Araujo Boleti, Marcos Antonio Ferreira, Caio Fernando Ramalho de Oliveira, Maria Ligia Rodrigues Macedo, Luana Rossato, Simone Simionatto, Ludovico Migliolo
Summary: Antimicrobial peptides derived from amphibian toxins have emerged as promising multifunctional drugs with the ability to interact with various molecular targets. In this study, we designed a novel peptide based on temporin-PTa, which exhibited antimicrobial, biofilm eradication, and antitumor activities. The peptide also showed potential as a structural model for the development of new multifunctional molecules.
Article
Biotechnology & Applied Microbiology
Isabela Bezende Ferreira, Valfredo de Almeida Santos Junior, Edina Caroline Ferreira Almeida, Felipe Francisco Bittencourt Junior, Ariany Carvalho dos Santos, Virginia Demarchi Kappel Trichez, Elisvania Freitas dos Santos, Mariana Manfroi Fuzinatto, Priscila Neder Morato
Summary: Adding banana bract flour to a high-calorie diet can prevent pathological damage, reduce total cholesterol and glucose levels, and have a hepatoprotective effect. Using banana bract flour as a supplement can increase the intake of fiber, antioxidants, and bioactive compounds.
FOOD TECHNOLOGY AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Tamaeh Monteiro-Alfredo, Maria Ligia Rodrigues Macedo, Kely de Picoli Souza, Paulo Matafome
Summary: Brazil's Cerrado biome is rich in biodiversity and contains plants with therapeutic potential against obesity and metabolic conditions. These plants have been shown to reduce inflammation and oxidative stress, and could be used in the treatment of conditions such as obesity and type 2 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Juliana de Lara Castagnoli, Elisvania Freitas dos Santos, Daiana Novello
Summary: This research evaluated the impact of interdisciplinary educational interventions on children's attitudes, knowledge, preferences, and perceptions of different nutrition labels. The results indicate that the interventions improved children's attitudes and knowledge, and that children prefer front labels on food packaging. Warning labels were considered the most beneficial for assessing the healthiness of food products.
Article
Agriculture, Multidisciplinary
Welington de Araujo Leite, Ana Cristina Jacobowski, Maria Ligia Rodrigues Macedo
Summary: This study isolated and characterized a new trypsin inhibitor that has inhibitory activity against the digestive enzymes trypsin and chymotrypsin from Anagasta kuehniella larvae. The inhibitor reduces proteolytic activity and affects larval weight and survival.
CIENCIA E AGROTECNOLOGIA
(2022)
Article
Agronomy
Graziela Nunes, Flavia Teixeira, Kelin Schwarz, Cristiano Kopanski Camargo, Juliano Tadeu Vilela de Resende, Elisvania Freitas dos Santos, Bruna Callegari Franco, Daiana Novello
Summary: The research evaluated the sensorial, physical-chemical, and nutritional characteristics of different strawberry cultivars to identify genotypes with the best characteristics for commercialization and human consumption. Among the cultivars studied, Camarosa and Tudla were found to be the most favorable for human consumption based on their sensorial, physical-chemical, and nutritional characteristics.
ACTA SCIENTIARUM-AGRONOMY
(2021)