Review
Biochemistry & Molecular Biology
Rola A. Bekdash
Summary: Methyl donors, such as choline, betaine, folic acid, methionine, and vitamins B6 and B12, play critical roles in the one-carbon metabolism and have neuroprotective functions. Imbalances in the levels of these micronutrients during critical periods of brain development have been linked to epigenetic alterations and stress-related disorders. Monitoring appropriate levels of methyl donors at all stages of development is important for a healthier brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Kay Boulton, Peter W. Wilson, Valerie R. Bishop, Jonathan H. Perez, Toby Wilkinson, Kris Hogan, Natalie Z. M. Homer, Christelle Robert, Jacqueline Smith, Simone L. Meddle, Ian C. Dunn, Kellie Watson
Summary: The study found that the diet and egg treatment of Japanese quail parents significantly affect the growth, reproductive capacity, and stress response of the first generation. Additionally, while maternal stress may have an impact on offspring, enhanced methyl diets appear to have positive effects on bird reproduction, growth, and stress function.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Xiao Han, Fang Fang, Weiwei Cui, Ya Liu, Yuxin Liu
Summary: This study investigates the effect of alcohol consumption on cervical cancer by examining the methylation status of cervical cancer cells. The results suggest that ethanol can affect the expression of DNMT by inducing methyl donor consumption, leading to genome-wide hypomethylation in cervical cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Jing Yuan, Xue Liu, Chunyu Liu, Alvin F. A. Ang, Joseph Massaro, Sherral A. Devine, Sanford H. Auerbach, Jan Krzysztof Blusztajn, Rhoda Au, Paul F. Jacques
Summary: This study aimed to investigate the association between dietary choline intake and the risks of incident dementia and Alzheimer's disease. The analysis of the data revealed that low choline intake was associated with increased risks of incident dementia and Alzheimer's disease.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Medicine, Research & Experimental
Alejandra Arguelles-Lopez, Ana Maria Calderon de la Barca
Summary: Rapid growth during infancy is associated with the risk of future overweight and obesity. Both formula-fed and exclusively breastfed infants may experience this problem due to variations in breastmilk composition and/or maternal dietary intake during pregnancy. We hypothesize that breastfed infants continue to grow through adequate consumption of methyl donors by breastfeeding mothers, which induce or maintain DNA methylation through breastmilk or the infant gut microbiota. Several supporting facts include increasing DNA methylation in the early postnatal stage, greater variation in methylation in exclusively breastfed infants compared to formula-fed infants, and the influence of compounds like betaine in breastmilk on infant growth.
MEDICAL HYPOTHESES
(2023)
Review
Nutrition & Dietetics
Joseph Allison, Aleksandra Kaliszewska, Sara Uceda, Manuel Reiriz, Natalia Arias
Summary: Metabolism and nutrition play a significant role in epigenetic modifications, such as DNA methylation, which can influence gene expression. Recently, it has been suggested that bioactive nutrients and gut microbiota can alter DNA methylation in the central nervous system (CNS) through the gut-brain axis, affecting CNS functions and behavior. This study focuses on how metabolic signals shape brain DNA methylation in adulthood and explores interactions among diet, gut microbiota, and epigenetic alterations on brain methylation and behavior.
Review
Chemistry, Medicinal
Julio J. Secades
Summary: Citicoline, a neuroprotective drug, has the potential to accelerate recovery of consciousness and improve the outcomes of patients with TBI. It could play a role in the management of TBI with its excellent safety profile.
Article
Nutrition & Dietetics
Ryszard Pluta, Wanda Furmaga-Jablonska, Slawomir Januszewski, Stanislaw J. Czuczwar
Summary: Curcumin, a natural polyphenolic compound, has pleiotropic biological properties and can regulate changes in the brain after ischemia and neurodegenerative diseases. It can prevent the aggregation and insolubility of aging-related proteins, and reduce neurotoxicity. Animal models of cerebral ischemia have demonstrated that curcumin can reduce various pathological changes and improve neurological and behavioral deficits.
Article
Nutrition & Dietetics
Michael K. K. Georgieff
Summary: Early life nutrition plays a crucial role in shaping health outcomes, particularly in brain development and mental health. Recent scientific breakthroughs have identified two mechanisms through which long-term nutrient effects on the brain occur: critical periods for nutrient requirements during brain development and nutrient-driven epigenetic modifications. The challenge lies in determining whether changes in nutritional status indeed impact the development and performance of the brain in humans.
PROCEEDINGS OF THE NUTRITION SOCIETY
(2022)
Review
Biochemistry & Molecular Biology
Ryszard Pluta, Slawomir Januszewski, Stanislaw J. Czuczwar
Summary: This article highlights the neuroprotective effects of molecular hydrogen following ischemic brain injury, including its potential for improving cognitive and neurological deficits and preventing neurodegenerative changes. The study suggests that molecular hydrogen may be a promising therapeutic agent in the treatment of neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Vittoria Borgonetti, Nicoletta Galeotti
Summary: This study investigated the potential enhancement of choline activity through association with adaptogen plant extracts. The results showed that the combination of choline with adaptogens can attenuate the effects of oxidative stress and improve memory in chronic stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Elizabeth A. Recker, David Hardy, Grace I. Anderson, Arsalan Mirjafari, Durgesh V. Wagle
Summary: This study investigated the impact of a covalent link between hydrogen bond donor species on the behavior of deep eutectic solvents (DES). The presence of a glycosidic bond in trehalose limited the movement of sugar units, resulting in fewer interactions with choline chloride in DES(t). This limitation influenced the physical state of DES(t), making it behave more like a semi-solid material compared to the liquid-like behavior of DES(g).
JOURNAL OF CHEMICAL PHYSICS
(2021)
Review
Biochemistry & Molecular Biology
Sana Javaid, Talha Farooq, Zohabia Rehman, Ammara Afzal, Waseem Ashraf, Muhammad Fawad Rasool, Faleh Alqahtani, Sary Alsanea, Fawaz Alasmari, Mohammed Mufadhe Alanazi, Metab Alharbi, Imran Imran
Summary: The increasing incidences of traumatic brain injuries globally due to population growth and reliance on motorized vehicles and machines have resulted in higher socio-economic burden on healthcare systems. Choline-containing phospholipids play a crucial role in TBIs and can be used to evaluate injury severity and mitigate neuro-degradation, serving as a potential biomarker for predicting prognosis. The therapeutic potential of choline phospholipids provides new insights for the management of TBIs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Rola A. Bekdash
Summary: Research shows that early-life diet quality is closely linked to long-term mental health, with environmental factors such as maternal diet during pregnancy and offspring diet causing changes in one-carbon metabolism associated micronutrients that impact brain function and mental health. Individualized dietary recommendations are needed to better understand the effects of these nutrients at different stages of development for improved mental health outcomes.
Review
Biology
Julio Jose Secades, Helmut Trimmel, Byron Salazar, Jose Antonio Gonzalez
Summary: A systematic review and meta-analysis showed that the use of citicoline can increase the rate of independence in patients with traumatic brain injury (TBI), indicating its positive effects on patient outcomes.
