Review
Chemistry, Multidisciplinary
Sanjay S. Timilsina, Pawan Jolly, Nolan Durr, Mohamed Yafia, Donald E. Ingber
Summary: The team developed an efficient antifouling coating for multiplexed EC sensors, addressing the sensitivity and selectivity loss caused by biological samples, and made significant progress.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Food Science & Technology
Simone Balbinot, Anand Mohan Srivastav, Jasmina Vidic, Ibrahim Abdulhalim, Marisa Manzano
Summary: This article highlights the importance and advantages of optical biosensors in food safety, comparing them with traditional methods and showcasing the applications of different technologies and future trends.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Syazana Ameera Syed Amri, Nor Azah Yusof, Jaafar Abdullah, Siti Fatimah Abd Rahman, Umi Zulaikha Mohd Azmi
Summary: A new electrochemical immunosensor based on Fe3O4-Au NC was developed for sensitive detection of M. tuberculosis. The sensor showed sensitive detection in the range of 0-9.0 μg/mL with a detection limit of 1.32 ng/mL, offering a promising platform for future diagnostic studies on various mycobacterium pathogens.
IEEE SENSORS JOURNAL
(2021)
Article
Chemistry, Analytical
Yanping Xia, Haibing Zhu, Ruixin Liu, Xin Li, Xiaoli Xie, Jie Zhao, Juan Li, Xin 'an Jiao, Zhanjun Yang, Xiang Chen
Summary: The His-CFP10-ESAT-6 recombinant protein was used to develop stable and specific ESAT-6 monoclonal antibodies. These antibodies were then used to construct an ultrasensitive electrochemical impedance immunosensor for label-free detection of M. tb infection. The immunosensor showed high sensitivity, wide linear range, and simple operation, making it suitable for quantitative detection of ESAT-6.
Article
Electrochemistry
Manjoosha R. Yerrapragada, Beharuza Farha Kunnambra, Vijayamohanan K. Pillai, Dileep Mampallil
Summary: This study presents an electrochemical immunosensor for detecting Interferon-γ (IFN-γ). The sensor utilizes an indium-tin oxide electrode modified with a nanocomposite of gold nanorods and reduced graphene oxide (AuNR-rGO). The detection is based on the drop of peak current in differential pulse voltammetry (DPV) due to hindered electron transfer caused by analyte proteins. The sensor shows high specificity to IFN-γ and has a detection limit of 2.5 pg/mL.
JOURNAL OF APPLIED ELECTROCHEMISTRY
(2023)
Article
Chemistry, Analytical
Qianying Qiu, Xiao Ni, Tianchen Liu, Zening Li, Xinyi An, Xiaojun Chen
Summary: A novel electrochemical aptasensor was developed for quantitative detection of beta-Lg in hypoallergenic formula milk. By utilizing a tri-functional hairpin, the sensor exhibited a wide linear range and low detection limit for beta-Lg, demonstrating high selectivity, reproducibility, and stability, making it a promising platform for beta-Lg detection in real food samples.
Article
Chemistry, Analytical
Anabel Laza, Ana Godoy, Sirley Pereira, Pedro R. Aranda, Carlos D. Garcia, Julio Raba, Franco A. Bertolino
Summary: A simple sensor for the determination of progesterone has been developed using a molecularly imprinted polymer. The sensor showed good linear response, selectivity, and stability, making it a promising alternative for analysis of progesterone.
MICROCHEMICAL JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Gozde Atik, Nur Melis Kilic, Nesrin Horzum, Dilek Odaci, Suna Timur
Summary: Multifunctional electrospun nanofibers (ENs) with improved properties are receiving increased attention. These ENs are insoluble in water and have reduced hydrophobicity, making them suitable for immobilizing biological molecules. By adding functional groups to the backbone, biomolecules can be conjugated to the surface of ENs via covalent bonding, enhancing their stability. In this study, poly(vinylidene fluoride) (PVDF) was used as a platform to prepare insoluble ENs, and polyethylenimine (PEI) was added to introduce amine groups on the surface for binding biomolecules. The results showed that PVDF-PEI ENs can serve as an immobilization matrix for biorecognition elements in bio-based detection systems, and the addition of METH derivative (METH-DNC) increased the sensitivity of PVDF-PEI/Anti-METH.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
Guan-Cheng Chen, Chi-Hsien Liu, Wei-Chi Wu
Summary: An electrochemical platform based on a screen-printed carbon electrode (SPCE) was developed to detect parathyroid hormone (PTH). The nanocomposite of multi-walled carbon nanotube (MWCNT) and gold nanoparticles (AuNP) deposited on the SPCE improved the stability and conductivity of the immunosensor, while enhancing the electrochemical signal for enzyme-linked immunosensing.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Kai-Xin Xie, Qian Liu, Shu-Shu Jia, Xiu-Xian Xiao
Summary: The introduction of a hollow plasmonic structure led to enhanced surface plasmon-coupled emission (SPCE), resulting in significant fluorescence signal enhancements. This was primarily attributed to the unique hot-spot plasmonic structure between GNS and gold substrate, the intense electromagnetic field of GNSs, and the strong coupling interactions between fluorescence and surface plasmons.
ANALYTICA CHIMICA ACTA
(2021)
Review
Biochemistry & Molecular Biology
Michal Stros, Eva Volfova Polanska, Tereza Hlavacova, Petr Skladal
Summary: Extracellular HMGB1 protein induces inflammatory responses and is associated with the severity of inflammation-mediated diseases. Accurate detection methods for plasma/serum HMGB1 levels are crucial for monitoring and predicting treatment outcomes in patients with inflammation-mediated diseases.
Article
Chemistry, Applied
Ricarda Torre, Maria Freitas, Estefania Costa-Rama, Henri P. A. Nouws, Cristina Delerue-Matos
Summary: This study reports the development of an electrochemical immunosensor for detecting tropomyosin (TPM) in the muscles of crustacean species, a major shellfish allergen. The sensor showed good selectivity and accuracy in detecting TPM, enabling effective control of food labelling according to EU regulations.
Article
Immunology
Nathella Pavan Kumar, Syed Hissar, Kannan Thiruvengadam, Velayuthum V. Banurekha, N. Suresh, Janani Shankar, S. Elilarasi, N. S. Gomathi, S. Kalpana, J. Ganesh, M. A. Aravind, Dhanaraj Baskaran, Srikanth Tripathy, Soumya Swaminathan, Subash Babu
Summary: The study identified IFN-γ, TNF-α, IL-2, and IL-17A as potential biomarkers for pediatric tuberculosis. Following anti-tuberculosis treatment, cytokine levels decreased significantly, and combiROC models showed high sensitivity and specificity, providing an accurate diagnostic method.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Analytical
Rafael Aparecido Ciola Amoresi, Noemi Angelica Vieira Roza, Talita Mazon
Summary: In this study, a flexible electrochemical immunosensor based on CeO2 nanorods immobilized with CRP antibody was developed for the detection of cardiovascular disease biomarker. The CeO2 nanorods were obtained by microwave-assisted hydrothermal method and characterized by XRD, TEM, and XPS. The immunosensor's working electrode was prepared by dispersing the nanorods in organic solvent, functionalizing them with cystamine and glutaraldehyde, and then modifying them with CRP antibody. The developed immunosensor exhibited good reproducibility, a wide detection range, and a low detection limit, making it suitable for point-of-care applications.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Jantima Upan, Napaporn Youngvises, Adisorn Tuantranont, Chanpen Karuwan, Philippe Banet, Pierre-Henri Aubert, Jaroon Jakmunee
Summary: A label-free electrochemical aptamer-based sensor was developed for AFP detection, utilizing a PtNPs/GO-COOH modified platform with an AFP aptamer as the recognition element. The sensor demonstrated good sensitivity, selectivity, and stability for sensitive detection of AFP in serum samples.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Eissa Mohamed Almbrok, Nor Azah Yusof, Jaafar Abdullah, Ruzniza Mohd Zawawi
Summary: The study focused on the electrochemical characterization and detection of protonated dibucaine (DIC+) using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) across a microinterface array. The results showed that DPV was more efficient in detecting lower concentrations of DIC+ in artificial serum matrices compared to CV, with a detection limit of 0.9 +/- 0.06 μM. Additionally, the presence of bovine serum albumin (BSA) was found to impact the dibucaine detection, affecting the current responses in CV assays.
Article
Chemistry, Multidisciplinary
Warda Mohamed Altogbia, Nor Azah Yusof, Zulkarnain Zainal, Azni Idris, Siti Khadijah Ab Rahman, Siti Fatimah Abd Rahman, Azizul Isha
Summary: Palm oil mill effluent (POME) is a significant pollutant in water, which can negatively impact aquatic life. This study aims to develop a molecularly imprinted polymer (MIP) for removing beta-carotene from POME. The results showed that the sorption of beta-carotene by MIP increased with the dosage of MIP used.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Polymer Science
Nur Alia Sheh Omar, Yap Wing Fen, Irmawati Ramli, Amir Reza Sadrolhosseini, Jaafar Abdullah, Nor Azah Yusof, Yasmin Mustapha Kamil, Mohd Adzir Mahdi
Summary: This study demonstrates the enhancement of sensitivity and selectivity of an SPR sensor for detecting DENV-2 E-proteins through the use of PAMAM dendrimer-based nanocomposite thin film. The sensor showed significant improvements in sensitivity and binding affinity towards lower range DENV-2 E-protein concentrations, with good selectivity and an average recovery rate of 80-120%. The combination of PAMAM dendrimer-based nanocomposite thin film with SPR sensor proves to be a promising diagnostic tool for sensitive and selective detection of DENV-2 E-proteins.
Article
Chemistry, Multidisciplinary
Yakubu Newman Monday, Jaafar Abdullah, Nor Azah Yusof, Suraya Abdul Rashid, Rafidah Hanim Shueb
Summary: This research demonstrates that carbon dots with excellent properties can be produced from palm kernel shell biomass that is often discarded as waste, showing potential for various applications such as sensing and biosensing.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Multidisciplinary
Nur Alia Sheh Omar, Yap Wing Fen, Irmawati Ramli, Umi Zulaikha Mohd Azmi, Hazwani Suhaila Hashim, Jaafar Abdullah, Mohd Adzir Mahdi
Summary: A novel vanadium-cellulose composite thin film-based surface plasmon resonance sensor was developed for ppb-level detection of Ni(II) ions, showing a linear response and high sensitivity. The sensor exhibits better sensing performance than previous film-based sensors and has promising applications in environmental monitoring.
APPLIED SCIENCES-BASEL
(2021)
Article
Pharmacology & Pharmacy
Fariza Aina Abd Manan, Nor Azah Yusof, Jaafar Abdullah, Faruq Mohammad, Armania Nurdin, Latifah Saiful Yazan, Sachin K. Khiste, Hamad A. Al-Lohedan
Summary: Nanotechnology-based drug delivery systems are used for targeted delivery of chemotherapeutic agents in cancer therapy with low/no toxicity to non-cancer cells. A synthesized nanocarrier system showed the highest drug release at pH 6.8, fitting the Higuchi model well for a diffusion-controlled mechanism.
Article
Materials Science, Multidisciplinary
Norzila Kusnin, Nor Azah Yusof, Nurul Asyikeen Ab Mutalib, Faruq Mohammad, Jaafar Abdullah, Suriana Sabri, Shuhaimi Mustafa, Ahmad Farabi Mohamad Saman, Fatin Nabilah Mohd Faudzi, Ahmed A. Soleiman
Summary: Electrochemical application has been widely used in biosensor research. In this study, a sensor electrode was improved to enhance the electrochemical conductivity for detecting small DNA molecule interactions. The electrode was modified with copper nanowires/gold nanoparticles, which were randomly distributed and compacted on the electrode surface, enhancing its electrochemical conductivity. The modified electrode exhibited efficient electrochemical conductivity of 20.3 mu A, with an increased effective surface area of 2.3-fold compared to the unmodified electrode, making it promising for biosensor applications.
Article
Optics
Nurul Illya Muhamad Fauzi, Yap Wing Fen, Jaafar Abdullah, Mazliana Ahmad Kamarudin, Nur Alia Sheh Omar, Faten Bashar Kamal Eddin, Nur Syahira Md Ramdzan, Wan Mohd Ebtisyam Mustaqim Mohd Daniyal
Summary: In this study, a GO-PVA composite thin film was successfully synthesized using spin coating techniques, and its properties and morphology were characterized. The GO-PVA thin film exhibited high absorbance and increased thickness, and showed potential for the detection of carbaryl pesticide at low concentrations of 0.02 ppb using an optical method based on surface plasmon resonance.
Article
Chemistry, Multidisciplinary
Muhammad Hafiznur Yunus, Nor Azah Yusof, Suhainie Ismail, Siti Suraiya Md Noor, Faruq Mohammad, Yusran Sulaiman, Nurul Hanun Ahmad Raston, Jaafar Abdullah, Ahmed A. Soleiman
Summary: This study proposes an improved tuberculosis diagnosis method based on an amperometry approach, which can sensitively detect the MPT64 antigen in clinical samples. The developed aptasensor is found to be simple in fabrication, sensitive, and capable of efficiently detecting and diagnosing TB in sputum samples.
Article
Chemistry, Multidisciplinary
Siti Fatimah Abd Rahman, Nor Azah Yusof, Mohd Khairuddin Md Arshad, Uda Hashim, Mohammad Nuzaihan Md Nor, Mohd Nizar Hamidon
Summary: A highly sensitive silicon nanowire-based sensor device was developed using electron beam lithography integrated with CMOS technology. The device showed good alignment and linearity for pH sensing, and could also be used for detecting specific ssDNA molecules.
Article
Chemistry, Analytical
Zixuen Gan, Muhamad Aidilfitri Mohamad Roslan, Mohd Yunus Abd Shukor, Murni Halim, Nur Adeela Yasid, Jaafar Abdullah, Ina Salwany Md Yasin, Helmi Wasoh
Summary: Aptamers are synthetic single-stranded nucleic acids generated through the SELEX technology with high affinity and specificity. While progress has been made in aptamer design and applications, only a few have achieved widespread commercial and clinical acceptance. Finding more effective ways to acquire high-affinity aptamers remains a challenge.
Article
Pharmacology & Pharmacy
Fariza Aina Abd Manan, Nor Azah Yusof, Jaafar Abdullah, Armania Nurdin
Summary: Cancer is a devastating disease with high mortality rates worldwide, leading to extensive research on drug nanocarrier vectors as a potential treatment option. In this study, a drug delivery system was developed using chitosan nanocarriers to optimize the encapsulation efficiency of an anticancer drug. The optimized parameters resulted in an encapsulation efficiency of 55.31%, and the nanocarriers showed efficient drug release in different pH conditions. The study demonstrates the potential of the synthesized MMC nanocarrier for effective drug delivery and treatment of non-muscle invasive bladder cancer.
Article
Chemistry, Analytical
Muhammad Hafiznur Yunus, Nor Azah Yusof, Jaafar Abdullah, Yusran Sulaiman, Nurul Hanun Ahmad Raston, Siti Suraiya Md Noor
Summary: A novel dual aptasensor was developed for the simultaneous detection of Mycobacterium tuberculosis secreted antigens CFP10 and MPT64, improving the diagnosis and control of TB.
Proceedings Paper
Nanoscience & Nanotechnology
Siti Fatimah Abd Rahman, Mohd Khairuddin Md Arshad, Subash C. B. Gopinath, Mohamad Faris Mohamad Fathil, Frederic Sarry, Mohammad Nuzaihan Md Nor
Summary: A highly effective lectin-based biosensor was developed for the sensitive detection of PSA glycosylation, achieving a low detection limit.
2021 IEEE INTERNATIONAL CONFERENCE ON SENSORS AND NANOTECHNOLOGY (SENNANO)
(2021)
Article
Chemistry, Multidisciplinary
Siti Fatimah Abd Rahman, Mohd Khairuddin Md Arshad, Subash C. B. Gopinath, Mohamad Faris Mohamad Fathil, Frederic Sarry, Conlathan Ibau
Summary: The traditional PSA screening lacks precision, leading to unnecessary biopsies and treatment delays; Glycans have emerged as novel biomarkers for early detection of prostate cancer; Biosensing technologies offer versatile detection methods for various analytes, including glycosylated molecules.
CHEMICAL COMMUNICATIONS
(2021)
