Article
Medicine, Research & Experimental
Huimin Shi, Renyu Kong, Xu Miao, Lingshan Gou, Xin Yin, Yuning Ding, Xiliang Cao, Qingyong Meng, Maosheng Gu, Feng Suo
Summary: Reduced levels of PPP1R3G may contribute to the progression of pre-eclampsia by suppressing trophoblast invasion and migration and targeting the Akt/MMP-9 signaling pathway.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Endocrinology & Metabolism
Peng Zhou, Chao Yang, Shan Zhang, Zun-Xiang Ke, Dian-Xi Chen, Yi-Qing Li, Qin Li
Summary: The importance of early diagnosis and treatment of diabetes and its cutaneous complications is increasingly recognized. High glucose affects collagen gene expression in human dermal fibroblasts, leading to an imbalance of matrix metalloproteinases and tissue inhibitors of metalloproteinases. Inhibiting MMP-2 and MMP-9 can alleviate collagen deposition disorder in the skin of diabetic mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Kai-Min Guo, Wei Li, Zhao-Hua Wang, Lang-Chi He, Yan Feng, Hui-Shu Liu
Summary: LDA can inhibit trophoblast cell apoptosis in pre-eclampsia by activating the CREB/Bcl-2 pathway, providing novel evidence for the protective mechanism of LDA in pre-eclampsia.
Article
Endocrinology & Metabolism
Gongchen Huang, Yukun Wang, Linyuan Qin, Bo Huang, Xiangyuan Yu
Summary: This study investigated the relationship between potential functional single-nucleotide polymorphisms (SNPs) of the ACE2 gene and the pathogenesis of pre-eclampsia (PE) in Guangxi, China. The results showed that the rs2106809 A>G variant of the ACE2 gene is significantly associated with the risk of PE, particularly severe PE. The association was even stronger in subjects with pre-pregnancy BMI >23 kg/m(2) and triglyceride >2.84 mmol/L. Functional analysis suggested that rs2106809 A>G may regulate the expression of functional genes involved in PE. The study highlights the importance of genetic factors in the development of PE.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhiyin Wang, Bin Cai, Chenrui Cao, Haining Lv, Yimin Dai, Mingming Zheng, Guangfeng Zhao, Yanfang Peng, Wenjing Gou, Jingmei Wang, Dan Liu, Yali Hu
Summary: The study demonstrated that CD151 is a key regulator of antioxidants in the placenta, and its expression levels are negatively correlated with the expression of antioxidant genes in PE patients. CD151 may be a new target for PE treatment.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Medicine, Research & Experimental
Wenwen Ning, Bin Wu, Yijie Chen, Jiejing Lian, Yiming Chen
Summary: Pre-eclampsia is a complex pregnancy-specific disease that is the primary cause of maternal and fetal mortality and morbidity. The underlying causes of pre-eclampsia remain unclear but involve an imbalance of molecular pathways regulating trophoblast function. Abnormal expression of certain microRNAs is associated with pre-eclampsia, with these microRNAs playing a role in regulating pregnancy-associated genes. This review discusses the role of microRNAs in trophoblast function, their impact on the pathogenesis of pre-eclampsia, and their potential use in screening, diagnosis, and treatment.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Obstetrics & Gynecology
Laura Governini, Camilla Marrocco, Bianca Semplici, Valentina Pavone, Giuseppe Belmonte, Stefano Luisi, Felice Petraglia, Alice Luddi, Paola Piomboni
Summary: The study compared the expression profiles of MMPs and TIMPs in the endometrium of women with and without type 3 leiomyomas, finding differential expression and localization of these proteins in leiomyoma patients, along with associations with key molecules involved in the inflammatory pathway.
FERTILITY AND STERILITY
(2021)
Review
Medicine, General & Internal
Zhenzhen Liu, Chengjie Wang, Jiangnan Pei, Mingqing Li, Weirong Gu
Summary: Pre-eclampsia is a severe complication of pregnancy characterized by insufficient trophoblast invasion, impaired uterine spiral artery remodeling, placental hypoxia and ischemia, and endothelial dysfunction. The role of SIRT1, a NAD+-dependent deacetylase, in pre-eclampsia and its mechanisms have been explored in recent studies. SIRT1 seems to affect placental development and trophoblast invasion, while protecting vascular endothelial cells from oxidative stress, inflammatory response, autophagy, and senescence. Activation of SIRT1 using compounds such as resveratrol has shown potential in attenuating symptoms of pre-eclampsia.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Cell Biology
Hanhong Zhu, Changxiu Wang
Summary: This study elucidated the important role of the HDAC2/miR-183/FOXA1/IL-8 pathway in the pathogenesis of preeclampsia, providing a novel molecular target for the treatment of PE.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Deanna Maybee, Nicole L. Ink, Mohammad A. M. Ali
Summary: This review article discusses the subcellular localization and intracellular roles of matrix metalloproteinases (MMPs), focusing on membrane-type-1 matrix metalloproteinase (MT1-MMP) and matrix metalloproteinase-2 (MMP-2). The article highlights the diverse subcellular localizations of these enzymes and their involvement in cell migration, gene expression, and tumor migration and invasion. The authors suggest that targeting nuclear MT1-MMP or MMP-2 may lead to the development of new therapies for cancer and other diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Stephanie E. Reitsma, Lori A. Holle, Emma G. Bouck, Dougald M. Monroe, Alan E. Mast, John Burthem, Paula H. B. Bolton-Maggs, Gillian N. Gidley, Alisa S. Wolberg
Summary: This study suggests that tissue factor pathway inhibitor (TFPI) may play a role in modifying the bleeding risk in individuals with factor XI (FXI) deficiency. In vitro experiments showed that inhibition of TFPI enhanced clot formation and reduced fibrinolysis in FXI-deficient plasma, while increased TFPI had the opposite effects. Higher TFPI concentrations were observed in FXI-deficient individuals with bleeding compared to controls, and total plasma TFPI correlated with clotting and fibrinolysis parameters associated with bleeding risk. These findings indicate that TFPI may be a potential modifier of bleeding risk in FXI-deficient individuals.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Physiology
Karla R. Castro, Karen M. Prado, Aline R. Lorenzon, Mara S. Hoshida, Eliane A. Alves, Rossana P. V. Francisco, Marcelo Zugaib, Aldilane L. X. Marques, Elaine C. O. Silva, Eduardo J. S. Fonseca, Alexandre U. Borbely, Mariana M. Veras, Estela Bevilacqua
Summary: This study found that serum factors in pregnant women with preeclampsia may impact placental morphology, viability, and secreted functional factors, while triggering endoplasmic reticulum stress and unfolded protein responses. The study also revealed molecular differences between preeclampsia and control groups.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eleni Dede, Dimitrios Liapis, Constantinos Davos, Michalis Katsimpoulas, Aimilia Varela, Ioannis Mpotis, Nikolaos Kostomitsopoulos, Nikolaos P. E. Kadoglou
Summary: The study revealed that systemic exercise training can beneficially alter ECM proteins and cardiac function in mice with diabetic cardiomyopathy. ET reduced cardiac collagen and MMP-9 levels, increased TIMP-1 levels, and improved left ventricle function, indicating a therapeutic effect on diabetic cardiomyopathy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Biotechnology & Applied Microbiology
Katrina Z. Freimane, Lauren Kerrigan, Kelly-Ann Eastwood, Chris J. Watson
Summary: This study aimed to identify the most promising biomarker candidates for clinical implementation in existing pre-eclampsia (PE) models among women with type 1 diabetes mellitus (T1DM). The study found that higher levels of HbA1c and urinary albumin in the first trimester were associated with an increased risk of PE development in women with T1DM. Additionally, urinary neutrophil gelatinase-associated lipocalin and adipokines were identified as novel biomarkers with moderate predictive ability before 15 weeks of gestation. Furthermore, two T1DM-specific PE prediction models were proposed, which measured adipokines or urinary neutrophil gelatinase-associated lipocalin along with maternal clinical characteristics. Contradicting previous literature, the study found correlations between PE risk in women with T1DM and vitamin D levels and atherogenic lipid profile in the context of haptoglobin phenotype 2-2.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Obstetrics & Gynecology
Hongbiao Yu, Ling Chen, Ping Du, Xianping Liu, Ying Xia
Summary: This study found that SIRT1 deficiency may contribute to the pathogenesis of pre-eclampsia by reducing trophoblastic migration, invasion, and PlGF secretion and increasing sFlt-1 secretion.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)