Article
Multidisciplinary Sciences
Kebede Haile Misgina, Lindsay Levine, H. Marike Boezen, Afework Mulugeta Bezabih, Eline M. van der Beek, Henk Groen
Summary: In low-income countries, perinatal distress, including anxiety, depression, and stress during pregnancy, is associated with adverse birth outcomes such as low birth weight and small for gestational age birth. This study found that perinatal distress acts as a mediator between socioeconomic adversity and adverse birth outcomes.
Review
Biochemistry & Molecular Biology
Julie A. Talbert, Jacky Lu, Sabrina K. Spicer, Rebecca E. Moore, Steven D. Townsend, Jennifer A. Gaddy
Summary: Adverse pregnancy outcomes, such as preterm birth and infection, affect millions of people worldwide annually. Current interventions, including universal screening and intrapartum antibiotic prophylaxis, have improved early-onset disease outcomes but have not effectively reduced the incidences of late-onset disease or complications occurring early on during pregnancy. Lactoferrin, a glycoprotein with strong antimicrobial and anti-biofilm activity, shows promise as a potential therapeutic for preventing adverse pregnancy outcomes caused by Group B Streptococcus infection.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Clinical Neurology
Eliza Miller, Anni E. Kauko, Sarah Tom, Hannele Laivuori, Teemu A. Niiranen, Natalie Bello
Summary: The study found that adverse pregnancy outcomes are associated with an earlier onset of maternal cerebrovascular disease, especially in cases where women had more than one affected pregnancy.
Review
Cardiac & Cardiovascular Systems
Sukainah Y. Al Khalaf, Eilis J. O'Reilly, Peter M. Barrett, Debora F. B. Leite, Lauren C. Pawley, Fergus P. McCarthy, Ali S. Khashan
Summary: Chronic hypertension is associated with adverse pregnancy outcomes, and these associations appear to be independent of maternal race/ethnicity. Women with chronic hypertension on antihypertensive treatment have a higher risk of SGA. Further testing with large randomized controlled trials is needed to explore the effect of antihypertensive treatment on SGA.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Peripheral Vascular Disease
Sukainah Al Khalaf, Lucy C. C. Chappell, Ali S. S. Khashan, Fergus P. P. McCarthy, Eilis J. O'Reilly
Summary: There is a strong association between chronic hypertension and the risk of cardiovascular disease (CVD) in mothers, especially those with adverse pregnancy outcomes (APOs). This risk can lead to premature CVD, thus intervention programs targeting these high-risk groups might reduce their risk of subsequent CVD.
Article
Cardiac & Cardiovascular Systems
Sadiya S. Khan, Lucia C. Petito, Xiaoning Huang, Katharine Harrington, Rebecca B. McNeil, Natalie A. Bello, C. Noel Bairey Merz, Eliza C. Miller, Rupa Ravi, Christina Scifres, Janet M. Catov, Victoria L. Pemberton, Jasmina Varagic, Phyllis C. Zee, Lynn M. Yee, Mitali Ray, Jin Kyung Kim, Abbi D. Lane-Cordova, Jennifer Lewey, Lauren H. Theilen, George R. Saade, Philip Greenland, William A. Grobman
Summary: This study found a significant association between early pregnancy obesity and postpartum hypertension, hyperlipidemia, and diabetes risk. Adverse pregnancy outcomes were related to increased incidence of postpartum hypertension and hyperlipidemia. However, these adverse pregnancy outcomes only partially mediated the association between early pregnancy obesity and postpartum hypertension.
CIRCULATION RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Maitry Mehta, Rupa Basu, Rakesh Ghosh
Summary: Evidence is emerging on the link between temperature and adverse perinatal and pregnancy outcomes. However, there are important gaps in knowledge and methodological challenges that need to be addressed, including the lack of understanding of how body temperature is modulated during extreme ambient temperature exposure in pregnancy.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Medicine, General & Internal
Courtney Bisson, Sydney Dautel, Easha Patel, Sunitha Suresh, Patricia Dauer, Sarosh Rana
Summary: Preeclampsia is a disease that has wide-ranging effects on the body's organ systems, with consequences lasting beyond the immediate postpartum period. Current research aims to understand the pathophysiology of preeclampsia for accurate screening and treatment. Preeclampsia impacts maternal morbidity and mortality in the cardiovascular system and other organs, with effects persisting after pregnancy. This review discusses the current understanding of preeclampsia's pathophysiology and ways to improve overall outcomes.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Mefkure Eraslan Sahin, Erdem Sahin, Mehmet Mete Kirlangic
Summary: The current study aimed to investigate the relationship between third-trimester persistent maternal hypotension and small for gestational age (SGA) neonates as well as other adverse perinatal outcomes. A large retrospective cohort study was conducted, enrolling 6560 pregnant women who were divided into two groups based on maternal blood pressure: a normotensive group (n: 6290) and a persistent maternal hypotension group (n: 270). The study found no significant association between persistent maternal hypotension and SGA neonates or other adverse perinatal outcomes.
Article
Environmental Sciences
Kokeb Tesfamariam, Alemayehu Argaw, Giles T. Hanley-Cook, Seifu H. Gebreyesus, Patrick Kolsteren, Tefera Belachew, Mario Van de Velde, Sarah De Saeger, Marthe De Boevre, Carl Lachat
Summary: This study aimed to assess biomarkers of multiple mycotoxin exposure during pregnancy in rural Ethiopia and their associations with adverse birth outcomes. The findings indicated an extensive presence of multiple mycotoxin exposure among pregnant women, but no statistically significant associations were found with adverse birth outcomes.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Infectious Diseases
Kidu Gidey, Abadi Mache, Berhane Yohannes Hailu, Solomon Weldegebreal Asgedom, Segen Gebremeskel Tassew, Yirga Legesse Nirayo
Summary: Ethiopia has a high burden of HIV, but studies on the effectiveness of second-line antiretroviral therapy (ART) are scarce. This study evaluated treatment outcomes and predictors of unfavorable outcomes in HIV patients receiving second-line ART in two hospitals. The incidence rate of unfavorable outcomes was high and low body mass index (BMI) and low CD4 count were significant predictors.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Immunology
Salome Maswime, Caroline Pule, Zama Mtshali, Richard Chawana, Mushi Matjila
Summary: Africa has the highest number of pregnant women with HIV, which is associated with adverse perinatal outcomes. The use of antiretroviral therapy has helped reduce transmission and adverse fetal outcomes, but further research is needed to understand the placental mechanisms and fetal immune responses to maternal HIV infection.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Qian Yang, Maria C. Magnus, Fanny Kilpi, Gillian Santorelli, Ana Goncalves Soares, Jane West, Per Magnus, John Wright, Siri Eldevik Haberg, Eleanor Sanderson, Deborah A. Lawlor, Kate Tilling, Maria Carolina Borges
Summary: Observational studies have shown that maternal sleep duration is associated with adverse pregnancy and perinatal outcomes. However, it is unclear whether there are nonlinear causal effects. This study used Mendelian randomization and multivariable regression to examine the nonlinear effects of sleep duration on various outcomes. The results suggest that shorter and longer sleep duration may increase the risks of stillbirth, perinatal depression, and low offspring birthweight.
Article
Multidisciplinary Sciences
Temesgen Getaneh, Azezu Asres, Toyiba Hiyaru, Selamawit Lake
Summary: The study highlights that advanced maternal age poses a higher risk for adverse perinatal outcomes compared to adult aged women, with significantly higher rates of preterm birth, low birth weight infants, and low Apgar scores. Maternal illiteracy, short birth intervals, and pregnancy complications were also found to be factors significantly associated with adverse perinatal outcomes. Recommendations include equal access to education, family planning services, and improved perinatal care for early detection and management of complications.
SCIENTIFIC REPORTS
(2021)
Review
Health Care Sciences & Services
Stepan Feduniw, Dawid Golik, Anna Kajdy, Michal Pruc, Jan Modzelewski, Dorota Sys, Sebastian Kwiatkowski, Elzbieta Makomaska-Szaroszyk, Michal Rabijewski
Summary: This study investigates the evidence for using artificial intelligence methods in obstetric pregnancy risk assessment and prediction of adverse pregnancy outcomes. It finds that ANN methods have the best application for assessing medical conditions, with an average accuracy of 80-90%.
Article
Environmental Sciences
Alem Desta Wuneh, Afework Mulugeta Bezabih, Lars Ake Persson, Yemisrach Behailu Okwaraji, Araya Abrha Medhanyie
Summary: This study explores the inequities in maternal, newborn, and child health services in rural Ethiopia and identifies factors that contribute to these disparities. The findings suggest that maternal health services are distributed unfairly, while child immunization services are distributed more equitably. Factors such as poverty, lack of education, limited access, and poor-quality services are associated with these inequities.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Anteneh Omer, Dejene Hailu, Gezahegn Nigusse, Afework Mulugeta
Summary: This study found that the prevalence of anemia among children aged 6-59 months in Ethiopia is 44.7%. Microcytic hypochromic anemia with high red cell distribution width is the most common type, primarily affecting children under the age of two. Normocytic normochromic anemia is significantly more prevalent among children aged 24-59 months, while macrocytic anemia is not related to age.
Article
Multidisciplinary Sciences
Mekonnen Haileselassie, Getachew Redae, Gebretsadik Berhe, Carol J. Henry, Michael T. Nickerson, Afework Mulugeta
Summary: This study assessed the effectiveness of nutrition education intervention in improving the consumption of animal source foods (ASFs) among children in Tigray, Ethiopia. The results showed that age-appropriate educational interventions for mothers and owning small livestock in the household can improve the consumption of ASFs and increase the diet diversity of children.
Article
Obstetrics & Gynecology
Gebretsadkan Gebremedhin Gebretsadik, Zuriash Tadesse, Liya Mamo, Amaha Kahsay Adhanu, Afework Mulugeta
Summary: This study assessed the knowledge, attitude, and determinants of exclusive breastfeeding during COVID-19 among lactating mothers in Mekelle, Tigrai, Ethiopia. The study found that household head, maternal educational, parity, breastfeeding information, knowledge of breastfeeding, and attitude towards exclusive breastfeeding were significant determinants of exclusive breastfeeding. Improving women's education and decision-making and providing adequate and up-to-date breastfeeding information during the COVID-19 pandemic could enhance exclusive breastfeeding practice.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Environmental Sciences
Fisseha Ashebir Gebregizabher, Araya Abrha Medhanyie, Afework Mulugeta Bezabih, Lars Ake Persson, Della Berhanu Abegaz
Summary: This study aims to assess the association between engagement in women's groups and the utilization of maternal and neonatal health services. The results indicate that pregnant women who had contact with women's groups were more likely to utilize maternal and neonatal health services, but there was no significant impact on facility delivery and postnatal care utilization. Therefore, there is a need to improve the organization and management of the women's development group program and strengthen the engagement of group leaders to promote the utilization of maternal and neonatal health services.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Obstetrics & Gynecology
Kidane Tadesse Gebremariam, Afework Mulugeta, Danielle Gallegos
Summary: This study assessed the effectiveness of an SMS-based mHealth intervention targeting fathers and mothers in improving exclusive breastfeeding at three months in a low-income country. The results showed that both the mothers-and-fathers intervention group and the mothers-only intervention group had significantly higher rates of exclusive breastfeeding at three months compared to the control group. This study highlights the potential of SMS-based interventions in improving exclusive breastfeeding in low-income countries.
INTERNATIONAL BREASTFEEDING JOURNAL
(2023)
Letter
Obstetrics & Gynecology
H. E. Abraha, M. M. Ebrahim, H. Teka, A. Yemane, A. Mulugeta
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Medical Informatics
Kidane Tadesse Gebremariam, Afework Mulugeta, Danielle Gallegos
Summary: This study designed an SMS intervention targeting parents in Tigray, Ethiopia, and found that sending SMS messages related to infant feeding can effectively improve exclusive breastfeeding rates.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2023)
Article
Multidisciplinary Sciences
Hale Teka, Awol Yemane, Hiluf Ebuy Abraha, Ephrem Berhe, Habtom Tadesse, Fanos Gebru, Mohammedtahir Yahya, Ytbarek Tadesse, Daniel Gebre, Marta Abrha, Bisrat Tesfay, Ashenafi Tekle, Tsega Gebremariam, Birhane Amare, Mohamedawel Mohamedniguss Ebrahim, Yibrah Berhe Zelelow, Afework Mulugeta
Summary: This study aimed to investigate the clinical presentation and maternal-fetal and neonatal outcomes of early and late onset preeclampsia. The results showed that women with early onset disease had unfavorable maternal outcomes, such as severe preeclampsia with severity features, liver dysfunction, uncontrolled diastolic blood pressure, and prolonged hospitalization. They also had increased unfavorable perinatal outcomes, including low APGAR score at the 5th minute, low birth weight, and neonatal death.
Article
Multidisciplinary Sciences
Akeza Awealom Asgedom, Birhanu Tewoldemedhin Abirha, Askual Girmay Tesfay, Kelali Kaleaye Gebreyowhannes, Hayelom Birhanu Abraha, Gessessew Bugssa Hailu, Mesele Bahre Abrha, Mache Tsadik, Tesfay Gebregziabher Gebrehiwet, Aregawi Gebreyesus, Tilahun Desalew, Yibrah Alemayehu, Afework Mulugeta
Summary: Access to water, sanitation, and hygiene (WASH) is a global public health problem that is particularly severe in conflict-affected areas. This study aimed to investigate the sources of WASH during the war in Tigray and the incidence of diarrhoeal diseases among children.
SCIENTIFIC REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Aregawi Weldegebreal Weldegiargis, Haftom Temesgen Abebe, Hiluf Ebuy Abraha, Meron Micheale Abrha, Tsegay Berihu Tesfay, Rieye Esayas Belay, Alemnesh Abraha Araya, Mengish Bahresilassie Gebregziabher, Hagos Godefay, Afework Mulugeta
Summary: The objective of this study was to determine the status of household food insecurity in the armed conflict affected communities of Tigray. The results showed that the levels of household food insecurity and hunger were unacceptably high, indicating a significant negative effect of the armed conflict on food security in Tigray. It is recommended to take measures to protect these communities from the immediate and long-term consequences of conflict-induced household food insecurity.
CONFLICT AND HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Gebretsadkan Gebremedhin Gebretsadik, Mahlet Abraha, Tedros Bereket, Ferehiwot Hailemariam, Freweini Gebrearegay, Tigist Hagos, Mizan Assefa, Kidanemaryam Berhe, Hadush Gebregziabher, Amaha Kahsay Adhanu, Mekonnen Haileselassie, Mulugeta Gebregziabher, Afework Mulugeta
Summary: Armed conflict in Tigray, Ethiopia has led to acute malnutrition among children, with factors such as age, gender, vitamin A supplementation, diarrhea history, and poor water, toilet, and food security conditions significantly associated with the condition. Immediate international intervention is required to alleviate the problem.
CONFLICT AND HEALTH
(2023)
Article
Nutrition & Dietetics
Gebretsadkan Gebremedhin Gebretsadik, Zuriyash Tadesse, Tesfay Yohannes Ambese, Afework Mulugeta
Summary: Despite an increasing trend, the consumption of animal source foods among children in Tigrai is not statistically significant. The study found that the age of the child, religion, maternal education, household assets, and livestock count were predictors of animal source foods consumption.
Article
Medicine, General & Internal
Mussie Alemayehu, Araya Abrha Medhanyie, Elizabeth Reed, Znabu Hadush Kahsay, Mebrhatu Kalayu, Afework Mulugeta
Summary: This study examines the effect of continuum care for maternal health service utilisation on intention to use family planning among the pastoralist community in Ethiopia. The results indicate that intention to use family planning would increase by 12.2% if all married pastoralist women received continuum of care for maternal health service utilisation. Factors such as discussion about family planning with their husband, possession of electronic devices, and unmet need for family planning were associated with higher intention to use family planning, while being in a polygamous marriage was associated with lower intention. Attitude towards family planning, subjective norm, and perceived control over family planning were positively associated with intention to use family planning.
Article
Multidisciplinary Sciences
Kebede Haile Misgina, Lindsay Levine, H. Marike Boezen, Afework Mulugeta Bezabih, Eline M. van der Beek, Henk Groen
Summary: In low-income countries, perinatal distress, including anxiety, depression, and stress during pregnancy, is associated with adverse birth outcomes such as low birth weight and small for gestational age birth. This study found that perinatal distress acts as a mediator between socioeconomic adversity and adverse birth outcomes.
