Journal
BIOMEDICAL OPTICS EXPRESS
Volume 11, Issue 2, Pages 1122-1138Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.382755
Keywords
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Funding
- Australian Research Council [DP160104969]
- National Institutes of Health [P41EB-015903, R03EB-024803]
- Western Australian Department of Health Merit Award
- Medical and Health Research Infrastructure Fund
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The organization of fibrillar tissue on the micrometer scale carries direct implications for health and disease but remains difficult to assess in vivo. Polarization-sensitive optical coherence tomography measures birefringence, which relates to the microscopic arrangement of fibrillar tissue components. Here, we demonstrate a critical improvement in leveraging this contrast mechanism by employing the improved spatial resolution of focus-extended optical coherence microscopy (1.4 mu m axially in air and 1.6 mu m laterally, over more than 70 mu m depth of field). Vectorial birefringence imaging of sheep cornea ex vivo reveals its lamellar organization into thin sections with distinct local optic axis orientations, paving the way to resolving similar features in vivo. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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