Journal
ACS CATALYSIS
Volume 10, Issue 1, Pages 73-80Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.9b04353
Keywords
cross-coupling; Suzuki-Miyaura reaction; homogeneous catalysis; synthetic methods; palladium
Categories
Funding
- National Institutes of Health [GM R35 127010]
Ask authors/readers for more resources
Herein, a mild and operationally simple method for the Suzuki-Miyaura cross-coupling of boronic esters is described. Central to this advance is the use of the organic-soluble base, potassium trimethylsilanolate, which allows for a homogeneous, anhydrous cross coupling. The coupling proceeds at a rapid rate, often furnishing products in quantitative yield in less than 5 min. By applying this method, a >10-fold decrease in reaction time was observed for three published reactions which required >48 h to reach satisfactory conversion.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available