Journal
ONCOLOGY LETTERS
Volume 19, Issue 3, Pages 1649-1656Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2020.11284
Keywords
inflammasome; NLRP1; NLRP3; skin carcinogenesis; UVR
Categories
Funding
- Medical University of Lodz [503/5-064-01/503-1]
- National Centre of Science [2017/25/N/NZ5/02064, 2017/27/B/NZ5/02011]
Ask authors/readers for more resources
Inflammasomes are key innate immune system receptors that detect pathogenic endo- and exogenous stressors like microorganisms or ultraviolet radiation (UVR) which activate the highly proinflammatory cytokines interleukin-1 beta and interleukin-18. Inflammasomes are not only involved in inflammation, but also in carcinogenesis and tumor progression. Due to the dynamic increase in non-melanoma skin cancers (NMSC), it has become necessary to determine how UVR, which plays a key role in NMSC development, can regulate the structure and function of inflammasomes. In the present study, the regulatory mechanisms of NOD-Like Receptor Family Pyrin Domain Containing 1 and 3 inflammasome activation as well as an effective inflammasome-mediated immune response after UVR exposition are discussed. The differences and similarities between these molecular complexes that monitor cellular health, inflammation, and skin carcinogenesis are also highlighted. Despite numerous scientific data, more studies are still required to better understand the biology of inflammasomes in skin cancer development and to explore their therapeutic potential.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available