Article
Oncology
Juan Li, Aiqin Gao, Fang Zhang, Shuyun Wang, Jingnan Wang, Jing Wang, Shuyi Han, Zijiang Yang, Xiaozheng Chen, Yuying Fang, Guosheng Jiang, Yuping Sun
Summary: ILT3, an immunosuppressive molecule, is enriched in NSCLC cells and promotes tumor cell migration, invasion, and angiogenesis, potentially serving as a poor prognostic factor for NSCLC patients.
Article
Biochemistry & Molecular Biology
Huan Ma, Siyu Jiang, Yinan Yuan, Ji Li, Yizhuo Li, Yanping Lv, Tengjiao Du, Jingqian Guan, Xizi Jiang, Lei Tian, Qianqian Zheng, Lianhe Yang, Qingchang Li
Summary: RUNX1, a member of the RUNX family, is involved in the regulation of non-small cell lung cancer. It promotes cell proliferation and migration via the mTOR pathway and may serve as a potential therapeutic target for NSCLC.
Article
Medicine, Research & Experimental
Zhihua Teng, Jie Yao, Ling Zhu, Lufeng Zhao, Gang Chen
Summary: This study revealed that ZNF655 is abundantly expressed in NSCLC, and its knockdown can inhibit the malignant behaviors of tumor cells, leading to decreased tumorigenesis. ZNF655 may regulate apoptosis of NSCLC cells through the PI3K/Akt and p53 signaling pathways.
Article
Plant Sciences
Kaili Lin, Lijuan Huang, Yu Zhang, Minshan Chen, Zhan Li, Ken Kin Lam Yung, Sha Lv, Qianrong Pan, Weisong Zhang, Jijun Fu, Wanshan Li, Qiudi Deng
Summary: Angiogenesis and vasculogenic mimicry play crucial roles in the growth and metastasis of NSCLC. Current angiogenesis inhibitors mainly target endothelial cell-mediated angiogenesis, leaving tumor cell-mediated VM unaddressed. Scoparasin B, a compound derived from a marine fungus, showed strong inhibition effects on both angiogenesis and VM in vitro and in vivo. It effectively suppressed tumor growth, angiogenesis, and VM in a xenograft model, likely by reducing VEGF-A levels and inhibiting the VEGF-A/VEGFR2 signaling pathway. These findings highlight the potential of scoparasin B as a novel angiogenesis inhibitor and suggest the exploration of more natural product-based angiogenesis inhibitors.
JOURNAL OF NATURAL PRODUCTS
(2023)
Review
Biochemistry & Molecular Biology
Aaron C. Tan, Nick Pavlakis
Summary: The management of advanced lung cancer has been transformed by the identification of targetable oncogenic driver alterations, including ALK gene rearrangements. ALK tyrosine kinase inhibitors have become the first-line treatment options for advanced ALK rearranged NSCLC. However, drug resistance remains a challenge, and the role of anti-angiogenic therapy in ALK rearranged NSCLC needs further exploration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Rui Xue, Yuqiao Sheng, Xixi Duan, Yang Yang, Shengli Ma, Jingjing Xu, Na Wei, Xiaoping Shang, Feng Li, Jiajia Wan, Zhihai Qin
Summary: The study found that the frequency of TEMs in the peripheral blood of lung cancer patients was significantly higher than in patients with benign pulmonary disease and healthy controls, and was positively correlated with NSCLC recurrence and microvascular density. A high TEM frequency was associated with poor overall survival. Circulating TEM frequency may serve as a diagnostic marker for NSCLC.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Letter
Medicine, General & Internal
Hollis Viray, Deepa Rangachari, Daniel B. Costa
Summary: The study reported initial data of trastuzumab deruxtecan in the treatment of lung cancers with ERBB2 mutations, including patients who had previously received ineffective ERBB2 tyrosine kinase inhibitors.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Cell Biology
Changhui Li, Jiaqi Zhang, Xiaohua Yang, Cheng Hu, Tianqing Chu, Runbo Zhong, Yinchen Shen, Fang Hu, Feng Pan, Jianlin Xu, Jun Lu, Xiaoxuan Zheng, Hai Zhang, Wei Nie, Baohui Han, Xueyan Zhang
Summary: The study has demonstrated the significant role of hsa_circ_0003222 in NSCLC progression and resistance, with its high expression associated with disease stage, metastasis, and patient survival rate. Silencing hsa_circ_0003222 led to reduced stemness-like properties and chemoresistance in tumor cells.
CELL DEATH & DISEASE
(2021)
Article
Food Science & Technology
Ming Jiang, Shiying Zheng
Summary: Geniposide, derived from Gardenia jasminoides Ellis, shows anti-tumor effect against multiple cancers. This study investigates the role of geniposide in migration and angiogenesis of NSCLC cells. Geniposide reduces NSCLC cell proliferation, migration, and angiogenesis, possibly through regulation of PPARγ/VEGF-A pathway.
QUALITY ASSURANCE AND SAFETY OF CROPS & FOODS
(2022)
Article
Cell Biology
Yitong Xu, Chenglong Wang, Xizi Jiang, Yao Zhang, Hongbo Su, Jun Jiang, Hongjiu Ren, Xueshan Qiu
Summary: KLHL38 plays a promoting role in non-small cell lung cancer, enhancing cell proliferation, migration, and invasion through activating the Akt signaling pathway, and is closely associated with the malignancy of tumors.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Jerome Levallet, Tiphaine Biojout, Celine Bazille, Manon Douyere, Fatemeh Dubois, Dimitri Leite Ferreira, Jasmine Taylor, Sylvain Teulier, Jerome Toutain, Nicolas Elie, Myriam Bernaudin, Samuel Valable, Emmanuel Bergot, Guenaelle Levallet
Summary: The over-activation of NDR2 kinase under hypoxia conditions promotes brain metastasis formation in NSCLC. NDR2 expression serves as a reliable indicator for predicting the risk of metastasis in NSCLC patients.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Giuseppe Giaccone, Yongfeng He
Summary: Lung cancer is the leading cause of cancer related death, with two major histological subtypes, NSCLC and SCLC. Transformation from NSCLC to SCLC can cause treatment resistance, potentially due to therapy-induced changes or clonal selection. This article discusses the potential mechanisms, cell of origin, and genomic alterations in both de novo and transformed SCLC, as well as treatment options including chemotherapy, radiotherapy, TKIs, immunotherapy, and antiangiogenic agents.
SEMINARS IN CANCER BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Wenjuan Liu, Bingli Zuo, Wenting Liu, Yanfei Huo, Nasha Zhang, Ming Yang
Summary: Lung cancer has the highest mortality and morbidity rates worldwide. The current treatment options are not very effective, and there is a need for the discovery of new biomarkers and therapeutic targets for early diagnosis and improved treatment outcomes. Recent studies have found that long noncoding RNAs have diagnostic and prognostic value in non-small cell lung cancer treatment.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Review
Oncology
Agnese Montanino, Anna Manzo, Guido Carillio, Giuliano Palumbo, Giovanna Esposito, Vincenzo Sforza, Raffaele Costanzo, Claudia Sandomenico, Gerardo Botti, Maria C. Piccirillo, Priscilla Cascetta, Giacomo Pascarella, Carmine La Manna, Nicola Normanno, Alessandro Morabito
Summary: Inhibition of angiogenesis has shown efficacy in treating SCLC, with anlotinib being the only drug that has demonstrated improvement in both overall survival (OS) and progression-free survival (PFS) in Chinese patients. Future challenges include evaluating angiogenesis inhibitors in combination with immune-checkpoint inhibitors and chemotherapy in SCLC patients, as well as identifying predictive biomarkers of response to these agents.
FRONTIERS IN ONCOLOGY
(2021)
Review
Chemistry, Medicinal
Sun Ha Choi, Seung Soo Yoo, Shin Yup Lee, Jae Yong Park
Summary: Anti-angiogenic therapy plays an important role in the treatment of NSCLC by maximizing clinical efficacy, overcoming resistance, and transforming the tumor microenvironment, leading to improved immunotherapy outcomes.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Immunology
Williams Walana, Jing-Jing Wang, Iddrisu Baba Yabasin, Michael Ntim, Sylvanus Kampo, Mahmoud Al-Azab, Abdalkhalig Elkhider, Eugene Dogkotenge Kuugbee, Jya-wei Cheng, John R. Gordon, Fang Li
Article
Food Science & Technology
Yaser Gamallat, Xiaomeng Ren, Williams Walana, Abdo Meyiah, Ren Xinxiu, Yanyan Zhu, Meiqi Li, Siyuan Song, Luhan Xie, Yazeed Jamalat, Mohammad Zubair Saleem, Yufang Ma, Yi Xin, Dong Shang
JOURNAL OF FUNCTIONAL FOODS
(2019)
Article
Biochemistry & Molecular Biology
Mahmoud Al-Azab, Eskandar Qaed, Xunli Ouyang, Abdalkhalig Elkhider, Williams Walana, Han Li, Weiping Li, Yawei Tang, Salah Adlat, Jing Wei, Bing Wang, Xia Li
Article
Cell Biology
Mahmoud Al-Azab, Bing Wang, Abdalkhalig Elkhider, Williams Walana, Weiping Li, Bo Yuan, Yunshan Ye, Yawei Tang, Marwan Almoiliqy, Salah Adlat, Jing Wei, Yan Zhang, Xia Li
Article
Neurosciences
Michael Ntim, Qi-Fa Li, Yue Zhang, Xiao-Da Liu, Na Li, Hai-Lun Sun, Xuan Zhang, Bakhtawar Khan, Bin Wang, Qiong Wu, Xue-Fei Wu, Williams Walana, Khizar Khan, Quan-Hong Ma, Jie Zhao, Shao Li
Article
Oncology
Xiaodong Li, Yuanyue Zhang, Williams Walana, Feng Zhao, Fang Li, Fuwen Luo
Article
Medicine, Research & Experimental
Elina Idiiatullina, Mahmoud Al-Azab, Williams Walana, Valentin Pavlov, Bingrong Liu
Summary: The study demonstrates that EnDuo inhibits the migration of colon cancer cells in a dose-dependent manner by reducing the phosphorylation of AKT and ERK proteins and inhibiting the expression of MMP-2 and MMP-9 proteins. This provides novel insights into the potential clinical applications of EnDuo against colon cancers in the future.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Public, Environmental & Occupational Health
Maroun Soribang Ziem, Fidelis Adam Saaka, Ezekiel Kofi Vicar, Eugene Dogkotenge Kuugbee, Akosua Bonsu Karikari, Sebastian Yidana Ninimiya, Juventus Benogle Ziem, Williams Walana
Summary: The study found a relatively high NICU admission rate in the Nandom Municipality, Ghana, with multiple factors contributing to it. Mothers who attended fewer antenatal visits, nulliparous mothers, mothers with multiple pregnancies, preterm and post-term deliveries, instrumental and cesarean deliveries, low birth weight babies, and male infants had a higher risk of NICU admission. Additionally, severe and moderate birth asphyxia at one minute and severely asphyxiated babies at five minutes were significantly associated with NICU admission. Tailored intervention programs are needed to reduce NICU admissions in the study area.
HEALTH SCIENCE REPORTS
(2023)
Article
Microbiology
Ezekiel K. K. Vicar, Samuel E. K. Acquah, Williams Wallana, Eugene D. D. Kuugbee, Emmanuel K. K. Osbutey, Abigail Aidoo, Emmanuel Acheampong, Gloria Ivy Mensah
Summary: The prevalence of urinary tract infection (UTI) is high among pregnant women in the northern part of Ghana, and there is a significant association between sociodemographic, obstetric, and personal hygiene variables and UTI. Escherichia coli is the most common bacteria causing UTI, and there is variation in the resistance pattern of isolates to different antibiotics, emphasizing the importance of urine culture and susceptibility testing before treatment.
INTERNATIONAL JOURNAL OF MICROBIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Ezekiel K. Vicar, Williams Walana, Augustina Mbabila, George K. Darko, Kwame Opare-Asamoah, Saeed F. Majeed, Mauvina Obeng-Bempong
Summary: This study examines the relationship between knowledge, attitude, and practices of antibiotic use among households in urban informal settlements in Ghana. The results show that a significant number of households in these settlements misuse antibiotics, with a considerable percentage using them without a prescription. Knowledge of appropriate antibiotic use and resistance is influenced by factors such as gender, household size, and income.
HEALTH SCIENCE REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Williams Walana, Ezekiel K. Vicar, Eugene D. Kuugbee, Isaac Dari, Grace Bichenlib, Christian N. Aneba, Kwasi N. Hinneh, Iddrisu B. Yabasin, Koray N. Issaka, Michael O. Danso, Theophilus N. Amoatey, Juventus B. Ziem
Summary: Ghana has a high prevalence and significant disparities in transfusion transmissible infections (TTIs), with HBV, HCV, HIV, and T. pallidum being the major infectious agents. First-time blood donors and rural dwellers are more susceptible to infection.
HEALTH SCIENCE REPORTS
(2023)
Article
Multidisciplinary Sciences
Williams Walana, Bernard Posotoso Bobzah, Eugene Dogkotenge Kuugbee, Samuel Acquah, Vicar Kofi Ezekiel, Iddrisu Baba Yabasin, Alhassan Abdul-Mumin, Juventus Benogle Ziem
SCIENTIFIC AFRICAN
(2020)
Article
Rheumatology
A. Elkhider, J. Wei, M. Al-Azab, Y. Tang, W. Walana, W. Li, B. Yuan, Y. Ye, G. Wang, Y. Zhang, X. Li
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2020)
Article
Cell & Tissue Engineering
Mahmoud Al-Azab, Williams Walana, Jing Wei, Weiping Li, Yawei Tang, Xiaoqing Wei, Marwan Almoiliqy, Abdullah Shopit, Elrayah Eltahir Abbas, Salah Adlat, Mohammed Awsh, Xia Li, Bing Wang
Summary: The TL1A/TNFR2 pathway affects the biological behaviors and therapeutic potency of BMSCs through IHH. Stimulation by TL1A increases the expression of stemness-related genes in BMSCs, corrects biased differentiation, and enhances proliferation and migration while reducing inflammation. Additionally, intervention with IHH enhances the anti-inflammatory effects of BMSCs.
INTERNATIONAL JOURNAL OF STEM CELLS
(2021)