Article
Biochemical Research Methods
Minghui Ou, Qian Zhang, Huidong Zhao, Chang Shu
Summary: The study revealed that PUFAs and LXA4 have an impact on PE by regulating LOX and inflammatory responses.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Giovanni Civieri, Laura Iop, Francesco Tona
Summary: This review summarizes the current evidence regarding the effects of AT1R-AAs and ETAR-AAs in cardiovascular pathologies, highlighting their roles in heart transplantation and mechanical circulatory support, preeclampsia, and acute coronary syndromes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Claudio Derada Troletti, Gaby Enzmann, Valerio Chiurchiu, Alwin Kamermans, Silvia Martina Tietz, Paul C. Norris, Neda Haghayegh Jahromi, Alessandro Leuti, Susanne M. A. van der Pol, Marijn Schouten, Charles N. Serhan, Helga E. de Vries, Britta Engelhardt, Gijs Kooij
Summary: The study shows that the SPM lipoxin A(4) can alleviate symptoms of experimental autoimmune encephalomyelitis and inhibit T cell infiltration into the central nervous system. It also reduces encephalitogenic Th1 and Th17 effector functions and affects the spinal cord lipidome composition.
Article
Biochemistry & Molecular Biology
Yasmine F. Ibrahim, Somaia Hassan Hammady, Rehab A. Rifaai, Shaimaa Waz, Mohamed Abdellah Ibrahim, Heba M. Hafez
Summary: Lipoxin A4 (LXA4) can ameliorate GEN-induced nephrotoxicity through its antioxidant, anti-inflammatory, and anti-apoptotic effects, reducing renal dysfunction, histopathological changes, and elevated serum lipid biomarkers.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Medical Laboratory Technology
Luiza Oliveira Perucci, Kelerson Mauro de Castro Pinto, Sirlaine Pio Gomes da Silva, Eura Martins Lage, Patricia Goncalves Teixeira, Alexandre Simoes Barbosa, Patricia Nessralla Alpoim, Lirlandia Pires de Sousa, Andre Talvani, Luci Maria SantAna Dusse
Summary: In pregnant women with risk factors for preeclampsia, levels of LTB4 tended to be upregulated while RvD1 levels were lower, indicating an imbalance of lipid mediators in the pathogenesis of preeclampsia. Future longitudinal studies are needed to confirm the potential use of these lipid mediators as clinical markers for preeclampsia development.
CLINICAL BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Bingbing Zheng, Feifei Cai, Ru Shen, Feng Lin
Summary: The aim of this study was to discuss the effects and mechanism of LXA4's improvement effect in LPS-induced preeclampsia in an in vitro study. LPS induction was used to create a preeclampsia cell model. Various parameters such as ROS, MDA, SOD, and GSH were evaluated in different groups. Cell proliferation, apoptosis, invasion, and migration were measured using assays such as CCK-8, flow cytometry, transwell, and wound healing assay. Protein levels of Nrf2 and HO-1 were measured using Western blot assay. Results showed that LPS stimulation led to up-regulation of ROS and MDA levels, down-regulation of GSH and SOD levels, and significant changes in cell biological activities. However, supplementation with LXA4 led to significant improvement in these activities, but these effects disappeared after Nrf2 knockdown. This study suggests that LXA4 can improve LPS-induced preeclampsia by regulating the Nrf2/HO-1 pathway in an in vitro setting.
LATIN AMERICAN JOURNAL OF PHARMACY
(2022)
Article
Pharmacology & Pharmacy
Ruonan Zhai, Yuan Liu, Jiahao Tong, Ying Yu, Lin Yang, Yong Gu, Jianying Niu
Summary: The research demonstrates that in mice with AT1-AA-induced preeclampsia, EMPA treatment significantly improved high systolic blood pressure, proteinuria, and kidney injury, without affecting fetal outcomes, suggesting EMPA could be a potential pharmacological agent for PE.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Peripheral Vascular Disease
M. Satra, M. Samara, G. Alatsathianos, D. Vamvakopoulou, A. Baka, T-M Tsalazidou-Founta, A. Sidiropoulos, K-O Vamvakopoulos, A. Garas, A. Daponte, N. Vamvakopoulos, S. Sotiriou
Summary: Allelic variations affecting the maternal renin-angiotensin system may be linked to the development of hypertensive disorders of pregnancy. Women with three mutant receptor combination genotypes are more likely to have early-onset preeclampsia.
JOURNAL OF HUMAN HYPERTENSION
(2022)
Article
Cardiac & Cardiovascular Systems
Meili Wang, Xiaochen Yin, Shuanglei Li, Xi Zhang, Ming Yi, Chunyu He, Xiaoyue Li, Wei Wang, Suli Zhang, Huirong Liu
Summary: In this study, we provide compelling evidence that dysfunction of the BK channel alpha-subunit mediates AT1-AAs-induced mesenteric artery remodeling. Preservation of BK channel activity may serve as a potential strategy for the treatment of AT1-AAs-induced maladaptive resistance artery remodeling.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Immunology
Sijia Li, Chenguang Zhou, Yinghui Zhu, Zhiwen Chao, Zhiyuan Sheng, Yongxin Zhang, Yuanzheng Zhao
Summary: The study shows that Ferrostatin-1 can effectively protect astrocytes from ferroptosis induced by Angiotensin II, reduce the production of inflammatory factors, and exert protective effects by activating the Nrf2/HO-1 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Davy Aubeux, Solene Tessier, Fabienne Perez, Valerie Geoffroy, Alexis Gaudin
Summary: This study evaluated the effect of LXA4 on macrophage activity and phenotype modulation of polarized M1 and M2 macrophages. The results showed that LXA4 did not affect the viability and phagocytic activity of macrophages, but exhibited anti-inflammatory properties by reducing pro-inflammatory cytokine expression in M1 and increasing anti-inflammatory cytokine expression in M2 macrophages.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Peripheral Vascular Disease
Mari Sotozawa, Sho Kinguchi, Hiromichi Wakui, Kengo Azushima, Kengo Funakoshi, Waki Nakajima, Tomoyuki Miyazaki, Takuya Takahashi, Kouichi Tamura
Summary: The renin-angiotensin system in the brain plays a crucial role in hypertension. ATRAP, a protein that regulates the AT1R signaling pathway, has unknown pathophysiological function in the brain. This study found that enhancing ATRAP expression in the PVN can suppress Ang II-induced hypertension.
HYPERTENSION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Tlili Barhoumi, Fatmah A. Mansour, Maroua Jalouli, Hassan S. Alamri, Rizwan Ali, Abdel Halim Harrath, Maha Aljumaa, Mohamed Boudjelal
Summary: Angiotensin II (Ang II) is a key component of the renin-angiotensin-aldosterone system and is associated with cardiopathology. High levels of Ang II have been linked to inflammatory conditions such as coronary heart disease, obesity, and type 2 diabetes. This study evaluated the cellular effects of Ang II on THP-1-derived macrophages, showing that it stimulates differentiation markers and proinflammatory markers while decreasing an M2 marker. Ang II also induces calcium overload, increases reactive oxygen species, and arrests cells in the G1 phase, primarily through the angiotensin II type 1 receptor (AT1R).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Environmental Sciences
Chih-Chia Chang, Hui-Ching Cheng, Wan-Ching Chou, Yu-Ting Huang, Pei-Ling Hsieh, Pei-Ming Chu, Shin-Da Lee
Summary: Myocardial hypertrophy is a crucial factor in the development of cardiovascular disease. Sesamin, a natural compound found in sesame seeds, has been shown to have anti-inflammatory and anti-apoptotic effects. This study found that Sesamin could attenuate hypertrophic damage and oxidative injuries in H9c2 cells stimulated by Ang-II.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Immunology
Xin Zhang, Siting Wu, Zetian Liu, Hong Chen, Jiaming Liao, Jingguang Wei, Qiwei Qin
Summary: In this study, the researchers cloned and characterized the RIP2 homolog from orange-spotted grouper (EcRIP2) and investigated its role in fish DNA virus infection. They found that EcRIP2 could inhibit the replication of SGIV and suppress the expression of inflammatory factors by competing with EcASC for binding EcCaspase-1. This study provides new insights into the modulatory mechanism of the RIP2-associated pathway and RIP2-mediated fish diseases.
FRONTIERS IN IMMUNOLOGY
(2023)