Review
Biotechnology & Applied Microbiology
Linqi Zhu, Yue Huang, Hong Li, Shihe Shao
Summary: Infection with Helicobacter pylori may promote the occurrence and progression of gastric cancer by influencing the tumor microenvironment (TME).
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Oncology
Hui Guo, Jianping Zou, Ling Zhou, Min Zhong, Yan He, Shanshan Huang, Jun Chen, Junhe Li, Jianping Xiong, Ziling Fang, Xiaojun Xiang
Summary: The study identifies NUSAP1 as a novel binding partner of YAP1, with upregulation of NUSAP1 associated with unfavorable clinical outcomes in gastric cancer patients. NUSAP1 functions as a positive regulator of YAP1 protein stability, promoting oncogenic effects on gastric cancer cell growth, migration, and invasion mainly through YAP1 mediation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Dianyun Ren, Yan Sun, Dan Zhang, Dan Li, Zhiqiang Liu, Xin Jin, Heshui Wu
Summary: The research demonstrates that SGLT2 promotes pancreatic cancer progression by activating the Hippo signaling pathway through the hnRNPK-YAP1 axis. Inhibition of SGLT2 alone or in combination with YAP1 inhibition may represent a promising therapeutic approach for pancreatic cancer.
Article
Pathology
Xueyan Guo, Yulong Li, Bingbing Wan, Yifei Lv, Xue Wang, Guisheng Liu, Ping Wang
Summary: This study found that KAT7 is upregulated in gastric cancer and is associated with poor prognosis and metastasis. Overexpression of KAT7 promotes the growth, migration, and invasion of gastric cancer cells, and is involved in cell cycle distribution and epithelial-mesenchymal transition. Additionally, KAT7 promotes the transcription and nuclear translocation of YAP1, and silencing YAP1 partially reverses the promoting effect of KAT7 on gastric cancer cell progression.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Han Yan, Chih-Chieh Yu, Stuart A. Fine, Ayman Lee Youssof, Ye-Ran Yang, Jun Yan, Dillon C. Karg, Edwin C. Cheung, Richard A. Friedman, Haoqiang Ying, Emily Chen, Ji Luo, Yi Miao, Wanglong Qiu, Gloria H. Su
Summary: The restoration of wild-type KRAS expression in human PDAC cell lines significantly attenuates malignancy, positively regulating the HIPPO signaling pathway. In contrast, loss of wild-type KRAS leads to functional activation of YAP1 and enhanced tumor malignancy in PDAC cells, providing insights into therapeutic strategies targeting KRAS.
Article
Cell Biology
Haifeng Jin, Zheng Wu, Bibo Tan, Zhen Liu, Binqian Zhang
Summary: The research suggests that circITGA7 may play a tumor-suppressive role in gastric cancer by regulating the miR-1471/MTDH signaling pathway. This provides a new potential mechanism involved in the progression of gastric cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Yangwei Xu, Yanyan Li, Yue Qiu, Fei Sun, Guifang Zhu, Jingbo Sun, Guixing Cai, Wanmei Lin, Yun Fu, Hongmei Wu, Shanshan Jiang, Zhihui Wen, Feiyan Feng, Junjie Luo, Yuqin Yang, Qingling Zhang
Summary: NEAT1 is upregulated in most GC samples and is associated with poor prognosis. It promotes GC angiogenesis by competitively sponging miR-17-5p to activate the TGF beta/Smad pathway and upregulate proangiogenic factors like VEGF.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Wenchao Chen, Yang Zhou, Gang Wu, Peichun Sun
Summary: CCNI2 is abundantly expressed in gastric cancer and plays a crucial role in the malignant progression of the disease by affecting proliferation, apoptosis, and migration. There is an interaction between CCNI2 and HDGF, and knockdown of CCNI2 can attenuate the promoting effects of HDGF overexpression in gastric cancer cells. These findings suggest that CCNI2 may be a potential therapeutic target for human gastric cancer.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Jia Wang, Chunjie Han, Jinsheng Wang, Qiu Peng
Summary: As a member of the well-studied protein family, DDX5 plays a specific role in binding to RNA helicase and regulating various cellular processes. Its effects on carcinogenesis and cancer progression are becoming more evident. Furthermore, DDX5 induces the production of circRNAs, which are associated with pathological processes such as tumors. The circRNA circPHF14, regulated by DDX5, is essential for the growth and tumorigenesis of DDX5-positive gastric cancer cells, highlighting a potential therapeutic target.
Article
Cell Biology
Xiang Ma, Gang Wang, Hao Fan, Zengliang Li, Wangwang Chen, Jian Xiao, Peidong Ni, Kanghui Liu, Kuan Shen, Yuanhang Wang, Zekuan Xu, Li Yang
Summary: This study found that FAM225A is associated with gastric cancer, and high expression is correlated with poor prognosis. FAM225A promotes gastric cell proliferation, invasion, and migration. Mechanistic investigation revealed that FAM225A acts as a competitive endogenous RNA network of FAM225A/miR-326/PADI2 to promote the development and progression of gastric cancer.
CELL DEATH DISCOVERY
(2022)
Article
Biotechnology & Applied Microbiology
Mingliang Wang, Jing Li, Xiaodong Yang, Qiang Yan, Huizhen Wang, Xin Xu, Yida Lu, Deguan Li, Yigao Wang, Ruochuan Sun, Shangxin Zhang, Yonghong Zhang, Zhen Zhang, Futao Meng, Yongxiang Li
Summary: TLK2 is upregulated in gastric cancer and plays a role in tumor progression. It regulates the mTORC1/ASNS axis to promote the invasive abilities of gastric cancer cells. TLK2 may serve as a potential therapeutic target for gastric cancer.
CANCER GENE THERAPY
(2023)
Article
Oncology
Janson Tse, Thomas Pierce, Annalisa L. E. Carli, Mariah G. Alorro, Stefan Thiem, Eric G. Marcusson, Matthias Ernst, Michael Buchert
Summary: MicroRNA-21 (miR-21) is a small, non-coding RNA that is overexpressed in gastric cancer and other solid malignancies, with both pro- and anti-tumorigenic properties. However, the regulation of miR-21 and the effects of its inhibition in gastric cancer are not fully understood. In this study, the researchers investigated the molecular pathways that control miR-21 expression in gastric cancer and evaluated the therapeutic potential of targeting miR-21 with a synthetic miR-21 antagomir. They found that miR-21 expression in early gastric cancer is dependent on Stat3, which is activated by IL-6 family cytokines through the gp130 receptor. Inhibition of miR-21 with the antagomir reduced gastric tumor growth, epithelial-to-mesenchymal transition, and matrix remodeling. The study highlights miR-21 as a promising target for anti-cancer therapy in gastric cancer.
Article
Cell Biology
Hualin Chen, Wenjie Yang, Yingjie Li, Zhigang Ji
Summary: PLAGL2 is overexpressed in bladder cancer tissues and is associated with decreased survival. Mechanistically, overexpressed PLAGL2 activates the RACGAP1/RhoA GTPase/YAP1 signaling pathway, promoting proliferation and metastasis of bladder cancer cells. Targeting the core nodes of this signaling pathway may have therapeutic potential for bladder cancer.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Zhen Liu, Junhe Li, Yun Ding, Mei Ma, Jun Chen, Wan Lei, Li Li, Yangyang Yao, Xin Yu, Min Zhong, Quan Liao, Weidan Fang, Linwei Fan, Chunye Huang, Hongguang Zhong, Qin Wen, Zi Fang, Jingyi Chen, Shanshan Huang, Jianpin Xiong, Xiaojun Xiang, Jun Deng
Summary: The study reveals that the aberrant activation of the USP49/YAP1 positive feedback loop plays a critical role in the malignant progression of gastric cancer, providing potential novel prognostic factors and therapeutic targets.
Article
Oncology
Qiuming He, Zheyu Ding, Tingna Chen, Haitao Wu, Jialing Song, Zhenxian Xiang, Chaogang Yang, Shuyi Wang, Bin Xiong
Summary: Gastric cancer is a global health burden with limited understanding and poor prognosis. In this study, we identified PFDN2 as a key gene in gastric cancer and found that its upregulation is associated with cancer progression. Further investigations revealed that PFDN2 promotes cell cycle progression by facilitating the expression of MYBL2 through the nuclear translocation of hnRNPD. These findings suggest that PFDN2 may serve as a potential biomarker and therapeutic target for gastric cancer.
FRONTIERS IN ONCOLOGY
(2023)