Journal
BIOSENSORS & BIOELECTRONICS
Volume 74, Issue -, Pages 799-807Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2015.07.022
Keywords
Localized surface plasmon resonance (LSPR); Double resonance; Au nanodisks; Cell concentration detection; Resonance peak shift; MCF-7 breast cancer cell
Categories
Funding
- Center for Biosystems, Neuroscience, and Nanotechnology (CBNN) of City University of Hong Kong [9360148]
- University Grants Council of Hong Kong (GRF Projects) [120413, 11210814]
- City University of Hong Kong [9380062]
Ask authors/readers for more resources
The double resonance plasmonic biosensors based on Au nanodisks (NDs) with a thin SiO2 spacer between the top and bottom Au layers were employed to detect MCF-7 breast cancer cells. The hybridized modes between the localized surface plasmon resonance of Au NDs and the gap coupling resonance of NDs with the Au film underneath have been observed. These multiple metallic layer NDs exhibit higher sensitivity than the common single metallic layer NDs. The extinction spectra showed double resonance bands that could be tailored by varying the ND size. Three sizes of multiple layer NDs ranging from 60 to 200 nm diameter (dia.) were generated and their refractive sensitivity to the surrounding media were analyzed for cell detection. Nanodisks with 120 dia. showed the highest refractive sensitivity up to 230 nm/refractive index unit. These sensors could be used to detect a broad range of MCF-7 cells from a low cell concentration down of 1.0 x 10(3) cells/ml up to a high cell concentration of 1.7 x 10(7) cells/ml. (C) 2015 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available