Journal
VIRUSES-BASEL
Volume 12, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/v12010097
Keywords
colorectal cancer; hepatitis B virus; population-based; case-control study
Categories
Funding
- Ministry of Science and Technology [MOST105-2314-B-038-038]
- Health and Welfare Surcharge of Tobacco Products [MOHW107-TDU-B-212-114020, MOHW108-TDU-B-212-124020]
- Ministry of Health and Welfare, Taiwan [MOHW108-TDU-B-212-133004]
- China Medical University Hospital [DMR-108-024, DMR-108-111]
- Academia Sinica Taiwan Biobank Stroke Biosignature Project [BM10701010021]
- Taiwan Clinical Trial Consortium for Stroke [MOST 107-2321-B-039-004]
- Tseng-Lien Lin Foundation, Taichung, Taiwan
- Katsuzo and Kiyo Aoshima Memorial Funds, Japan
- Taiwan Brain Disease Foundation, Taipei, Taiwan
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Chronic hepatitis B virus (HBV) infections and colorectal cancer (CRC) are prevalent in Taiwan. We carried out a population-based case-control study to assess the association between HBV infection and CRC risk. Using the National Health Insurance Research Database of Taiwan, we identified 69,478 newly diagnosed patients with CRC from 2005 to 2011. We further randomly selected 69,478 age- and gender-matched controls without CRC from the same database. Odds ratios (ORs) were calculated to evaluate the association between chronic HBV infection and CRC using a logistic regression analysis. HBV infection was found to be associated with the risk of CRC (OR = 1.27, 95% confidence interval (CI) = 1.20-1.33). This relationship was similar in men and women. Age-specific analysis revealed that the CRC risk associated with HBV decreased with age. The adjusted ORs for patients aged <55, 55-64, and 65-74 years were 1.63 (95% CI = 1.48-1.79), 1.24 (95% CI = 1.13-1.37), and 1.02 (95% = 0.92-1.13), respectively. In conclusion, this study suggests that chronic HBV infection is significantly associated with an increased risk of CRC. Monitoring the risk of CRC development in young patients with HBV infection is crucial.
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