Article
Surgery
El Mahdy Hossam, Ayman H. K. Alserr, Constantine N. Antonopoulos, Ahmed Zaki, Waleed Eldaly
Summary: This study aimed to evaluate the role of autologous platelet rich plasma (PRP) in promoting non-ischemic diabetic foot ulcer (DFU) healing. The results showed that PRP treatment can accelerate wound healing, reduce infection rate, and is cost-effective.
ANNALS OF VASCULAR SURGERY
(2022)
Article
Medicine, General & Internal
Wei Li, Qiao-Yun Wang, Xiao-Gang Bai, Jie Xu
Summary: This study retrospectively investigated the effectiveness and safety of APRG for the treatment of DFU. The results showed that APRG may benefit patients with DFU, with significant differences in DFU healing time, length of hospital stay, DFU healing rate, and DFU surface area reduction between the treatment and control groups.
Article
Pharmacology & Pharmacy
Yanling Wang, Bang Liu, Yinzhen Pi, Li Hu, Yeling Yuan, Jiao Luo, Yixiao Tao, Ping Li, Shan Lu, Wei Song
Summary: The purpose of this study was to assess the risk factors for morbidity and mortality of diabetic foot ulcers (DFUs). The study also investigated the effectiveness of negative pressure wound therapy (NPWT) combined with platelet-rich plasma-fibrin glue (PRP) in the treatment of diabetic foot ulcers. They found new risk factors for DFUs and concluded that the combination therapy could accelerate wound healing and reduce mortality rate.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Dermatology
Yasser A. Orban, Mahmoud A. E. Soliman, Yasmine Hany Hegab, Mohamed M. Alkilany
Summary: This research aimed to study the efficacy of autologous platelet-rich plasma (PRP) in managing diabetic foot ulcers (DFUs). Results showed that PRP treatment significantly increased the healing rate and reduced the healing duration compared to conventional dressing. Therefore, PRP is an effective and promising treatment for chronic DFUs.
WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
(2022)
Review
Orthopedics
Juan Deng, Mei Yang, Xingyu Zhang, Hongmin Zhang
Summary: Autologous platelet-rich plasma (Au-PRP) is a promising method for promoting ulcer healing due to its similarities to the physiological wound healing process. The results of the meta-analysis show that Au-PRP has significant positive effects on healing rate, healing time, reduction of ulcer area, and amputation rate, without increasing the incidence of adverse events compared to conventional therapy.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Danielle Dixon, Michael Edmonds
Summary: Recent evidence-based treatments for diabetic foot ulcers have emerged from multicentre, randomised, controlled trials, highlighting new advances in wound therapy. The overview of current and future pharmacotherapies includes proposed mechanisms of action and supporting evidence for various treatments. Looking forward, novel therapies utilizing nanotechnology and bioactive agents may provide possibilities for pharmacotherapy in the future.
Article
Immunology
Rokhsareh Meamar, Laleh Ghasemi-Mobarakeh, Mohammad-Reza Norouzi, Mansour Siavash, Michael R. Hamblin, Mehrafarin Fesharaki
Summary: The study investigated the effectiveness of nanofibers containing hPDMSCs and PRP for healing of DFUs. Implantation of hPDMSCs in GNS accelerated wound healing and improved clinical parameters in DFU patients, with significant improvements observed in wound closure and pain-free walking distance in group B.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Veterinary Sciences
Anamika Changrani-Rastogi, Krutika Swadi, Mitali Barve, Niyati Bajekal
Summary: This study evaluated the effect of autologous platelet-rich fibrin (PRF) in the management of feline cutaneous wounds. The results showed that PRF could serve as a low-risk and convenient adjunctive therapy to promote wound healing in cats.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Medicine, General & Internal
Giuseppe Della Pepa, Gianluca Lombardi, Salvatore Gianfrancesco, Roberto Piccolo, Giovanni Chirico, Micaela Pellegrino, Luigi Santella, Nicola Tecce, Anastasia Volpicelli, Elena Sollo, Lutgarda Bozzetto, Maria Masulli, Gabriele Riccardi, Angela Albarosa Rivellese, Gennaro Saldalamacchia
Summary: This study compared the efficacy and safety of Triticum vulgare extract and polyhexanide (Fitostimoline(R) hydrogel/Fitostimoline(R) Plus gauze) with saline gauze dressings for the treatment of diabetic foot ulcers. The results showed that compared to saline gauze, Fitostimoline(R) hydrogel/Fitostimoline(R) Plus gauze significantly improved the symptoms of the wound and perilesional skin. There were no significant differences in healing rate and reduction in ulcer size between the two groups.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biophysics
Ting Chang, Huiyi Yin, Xi Yu, Lihuan Wang, Longfei Fan, John H. Xin, Hui Yu
Summary: Nanofibrous dressings have significant technological implications for treating diabetic foot ulcers (DFUs) due to their high specific surface areas, good histocompatibility, enhanced wound healing, and reduced inflammation. In this study, a 3D polycaprolactone/collagen nanofibrous dressing loaded with matrix metalloproteinases inhibitor and antibacterial agent showed high water absorption capacity, antibacterial activity, and biocompatibility, providing a potential candidate for promoting DFU wound healing.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Dermatology
Grant Switzer Nolan, Oliver John Smith, Susan Heavey, Gavin Jell, Afshin Mosahebi
Summary: The study found that using fat grafts with PRP in treating diabetic foot ulcers increased neovascularization and graft survival. However, histological results were not correlated with wound healing time. Future studies should explore the mechanisms behind enhanced fat graft survival further.
INTERNATIONAL WOUND JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Ching-Wen Lin, Chien-Min Hung, Wan-Jiun Chen, Jui-Ching Chen, Wen-Yen Huang, Chia-Sing Lu, Ming-Liang Kuo, Shyi-Gen Chen
Summary: Diabetic foot ulcers are costly and problematic complications of diabetes. The chronicity of these ulcers presents a challenge in treatment. Modulating the activity of M1 and M2 macrophages seems to be an effective approach in improving the healing process of DFUs.
Article
Gastroenterology & Hepatology
Ting Xu, Yin Tian, Yi Wang, Zhongmei Yi, Chenchen Li, Shichun Wang, Yahan Fan, Chunyan Yao, Guiyong Peng, Hua Lu
Summary: This study investigated the use of autologous platelet-rich plasma (aPRP) for the treatment of peptic ulcer and observed its effectiveness. The results showed that the healing time was shorter in the aPRP group compared to the control group, and the repaired ulcer in the aPRP group resembled normal gastric mucosa tissue. This study has implications for improving the clinical treatment of peptic ulcer.
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2022)
Review
Medicine, General & Internal
David G. Armstrong, Tze-Woei Tan, Andrew J. M. Boulton, Sicco A. Bus
Summary: Approximately 18.6 million people worldwide are affected by diabetic foot ulcers each year, with 1.6 million people in the United States. These ulcers precede 80% of lower extremity amputations among people with diabetes and are associated with an increased risk of death.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Rebecca Voelker
Summary: This article describes diabetic foot ulcers and their evaluation and treatment.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)