Article
Chemistry, Physical
Maria Martinez-Negro, Guillermo Gonzalez-Rubio, Emilio Aicart, Katharina Landfester, Andres Guerrero-Martinez, Elena Junquera
Summary: This article discusses the formation of protein corona (PC) on colloidal nanoparticles (NPs) and its impact on the biological behavior of NPs. The focus is on the mechanisms of PC formation and strategies to control PC formation to ensure the successful application of NPs in medicine.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Olesja Bondarenko, Monika Mortimer, Anne Kahru, Neus Feliu, Ibrahim Javed, Aleksandr Kakinen, Sijie Lin, Tian Xia, Yang Song, Thomas P. Davis, Iseult Lynch, Wolfgang J. Parak, David Tai Leong, Pu Chun Ke, Chunying Chen, Yuliang Zhao
Summary: Nanotoxicology and nanomedicine are two sub-disciplines of nanotechnology that focus on nano-bio interface, with shared goals and challenges. In recent years, the relationship between the two fields has become closer, and their joint development can bring greater benefits to human health and environmental safety.
Review
Pharmacology & Pharmacy
Maciej Serda, Julia Korzuch, Dominik Dreszer, Martyna Krzykawska-Serda, Robert Musio
Summary: Fullerenes possess unique properties between small molecules and nanomaterials. Chemical modifications can make them soluble in water and lead to improved stability and bioavailability. Additionally, fullerene nanomaterials can interact with biological targets and inhibit essential proteins involved in tumorigenesis.
DRUG DISCOVERY TODAY
(2023)
Review
Pharmacology & Pharmacy
Hwankyu Lee
Summary: Molecular dynamics simulations have revealed the impact of protein corona on nanoparticles, showing the competitive adsorption and desorption mechanism of proteins on nanoparticle surfaces, as well as the interactions between protein-coated nanoparticles and cell membranes. These simulations provide insights into the Vroman effect and offer predictions consistent with experimental observations on a molecular scale.
Review
Chemistry, Multidisciplinary
Erica Quagliarini, Luca Digiacomo, Serena Renzi, Daniela Pozzi, Giulio Caracciolo
Summary: The study of liposome-protein corona has evolved over the past decade with multidisciplinary efforts, aiming to understand its synthetic-biological duality and applications in nanomedicine, such as targeted drug delivery, vaccination, imaging, and diagnostics. Future research directions need more attention, and it is hoped to attract the attention of researchers, entrepreneurs, and policymakers.
Article
Chemistry, Multidisciplinary
Marilena Hadjidemetriou, Jack Rivers-Auty, Lana Papafilippou, James Eales, Katherine A. B. Kellett, Nigel M. Hooper, Catherine B. Lawrence, Kostas Kostarelos
Summary: Blood-circulating biomarkers have the potential to detect AD pathology early and improve clinical trial outcomes, but currently there are no validated blood-based biomarkers for AD. A nanoparticle-based proteomics enrichment approach was used to discover and track changes in the blood proteome in an AD mouse model, revealing multiple proteomic signals indicative of asymptomatic stages of AD. The potential of this nano-omics approach to enrich the identification of blood-circulating signals associated with neurodegeneration was demonstrated, emphasizing the importance of integrating nanotechnology with proteomic tools for predicting the progression of AD.
Article
Chemistry, Multidisciplinary
Gha Young Lee, Andrew A. Li, Intae Moon, Demos Katritsis, Yoannis Pantos, Francesco Stingo, Davide Fabbrico, Roberto Molinaro, Francesca Taraballi, Wei Tao, Claudia Corbo
Summary: Coronary artery disease (CAD) is a common and serious heart disease. Early detection is crucial and this study introduces a non-invasive diagnostic technology using nanotechnology to detect CAD. By forming disease-specific protein coronas on nanoparticles, a sensor array is developed for CAD detection. The results show high accuracy and sensitivity in detecting CAD using this method.
Article
Chemistry, Multidisciplinary
Stuart T. Johnston, Matthew Faria
Summary: Designing nano-engineered particles for targeted delivery of therapeutic and diagnostic agents is a challenging task. This study presents a machine learning framework that can interpret particle-cell interactions from experimental data, providing insights into the design choices. The framework reveals consistent models of particle-cell interactions for different particle-cell pairs, highlighting the importance of nonlinear saturation effects. Additionally, the framework facilitates quantitative evaluation of particle design choices by providing robust estimates of particle performance.
Review
Pharmacology & Pharmacy
Yamini Boinapalli, Ravi Shankar Pandey, Abhay Singh Chauhan, M. S. Sudheesh
Summary: Cell uptake study is a routine experiment used to predict in vivo response in cancer nanomedicine research. It is critical to understand the factors responsible for particle internalization and the limitations of the two-dimensional cell culture model. The three-dimensional cell culture technology can better mimic the tumor microenvironment and improve the accuracy of in vitro studies.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Rebeca Burgos-Panadero, Souhaila H. El Moukhtari, Inmaculada Noguera, Carlos Rodriguez-Nogales, Susana Martin-Vano, Pablo Vicente-Munuera, Adela Canete, Samuel Navarro, Maria J. Blanco-Prieto, Rosa Noguera
Summary: Treatment of high-risk neuroblastoma is challenging due to metastases and drug resistance. This study found that the interaction between vitronectin and its ligands is related to the stiffness of the extracellular matrix in high-risk neuroblastoma, providing insights for targeting tumor cells within altered matrices using nanomedicine and combination therapy. Synergistic effects were observed between etoposide and cilengitide in increasing efficacy against neuroblastoma cells within these altered matrices.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Yuxiu Chu, Wenjing Tang, Zui Zhang, Cheng Li, Jun Qian, Xiaoli Wei, Tianlei Ying, Weiyue Lu, Changyou Zhan
Summary: A novel affinity chromatography technique has been developed for precise and efficient separation of protein coronas, demonstrating higher collecting efficiency than traditional methods, and offering a new approach for deciphering protein coronas.
Article
Chemistry, Multidisciplinary
Donghui Song, Qiaobing Xu
Summary: The field of nanomedicine is growing rapidly, but there are still challenges in targeting tissues beyond the liver. The formation of a protein corona on the surface of nanoparticles in biological fluids affects their drug delivery efficiency. Engineering the nano/bio interface can enhance protein-corona-mediated cell and organ-selective drug delivery.
Article
Nanoscience & Nanotechnology
Aparna Nandakumar, Wei Wei, Ghizal Siddiqui, Huayuan Tang, Yuhuan Li, Aleksandr Kakinen, Xulin Wan, Kairi Koppel, Sijie Lin, Thomas P. Davis, David T. Leong, Darren J. Creek, Feng Ding, Yang Song, Pu Chun Ke
Summary: This study investigated the protein coronae associated with gold nanoparticles of different shapes and found distinct differences in protein composition, shedding light on the implications for future nanomedicine research.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Giordano Perini, Francesca Giulimondi, Valentina Palmieri, Alberto Augello, Luca Digiacomo, Erica Quagliarini, Daniela Pozzi, Massimiliano Papi, Giulio Caracciolo
Summary: Nanoparticles have been effective carriers for delivering anticancer drugs to the brain, with liposomal temozolomide being a preferred choice for treating brain tumors. However, the therapeutic benefit of liposomal TMZ is often suboptimal due to inefficient tumor penetration. Recent research has shown that the protein corona surrounding NPs after exposure to human plasma plays a crucial role in determining their anticancer efficacy by facilitating interactions with specific receptors of target cells. By coating liposomal TMZ with a protein corona made of human plasma proteins, researchers were able to increase drug penetration in a 3D brain cancer model and inhibit tumor growth. Fine-tuning the composition of the corona also showed varying effects on tumor growth, clarifying that certain protein corona fingerprints enable favored interactions with specific receptors of brain cancer cells. These findings suggest the potential of developing corona-coated liposomal drugs with enhanced tumor penetration and antitumor efficacy.
Review
Biochemistry & Molecular Biology
Donya Esmaeilpour, Jens Albert Broscheit, Sergey Shityakov
Summary: This article reviews the applications of cyclodextrins (CDs) in personalized medicine. CDs can enhance drug solubility, stability, and bioavailability, as well as enable controlled and targeted delivery of small molecules. The structure of CDs also allows the preparation of CD-based polymers (CDbPs) with optimal pharmacokinetic and pharmacodynamic properties. The addition of protein corona to nanoparticles improves their biodistribution and half-life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Sherleen Xue-Fu Adamson, Ruoxing Wang, Wenzhuo Wu, Bruce Cooper, Jonathan Shannahan
Article
Medicine, Research & Experimental
Saeed Alqahtani, Bruce Cooper, Claire A. Spears, Christa Wright, Jonathan Shannahan
EXPERIMENTAL BIOLOGY AND MEDICINE
(2020)
Review
Medicine, Research & Experimental
Lisa Kobos, Jonathan Shannahan
Summary: Particulate matter poses significant health risks globally, particularly affecting the pulmonary and cardiovascular systems. Individuals with metabolic syndrome may be more susceptible to particulate exposure, though the toxicological mechanisms remain unclear. This review explores the impact of metabolic syndrome on responses to particulate matter and potential therapeutic approaches for treating related illnesses.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
