Journal
CANCER LETTERS
Volume 379, Issue 1, Pages 24-31Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2016.05.023
Keywords
Nanotechnology; Drug delivery system; Chemotherapy; Cancer therapy
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Funding
- National Natural Science Foundation of China [81372916, 81572976]
- Six Talent Peaks' Project of Jiangsu Province [2013-WSN-014]
- Science and Technology Department of Jiangsu Province [BK20141142]
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Despite significant improvements in diagnostic methods and innovations in therapies for specific cancers, effective treatments for neoplastic diseases still represent major challenges. Nanotechnology as an emerging technology has been widely used in many fields and also provides a new opportunity for the targeted delivery of cancer drugs. Nanoscale delivery of chemotherapy drugs to the tumor site is highly desirable. Recent studies have shown that nanoscale drug delivery systems not only have the ability to destroy cancer cells but may also be carriers for chemotherapy drugs. Some studies have demonstrated that delivery of chemotherapy via nanoscale carriers has greater therapeutic benefit than either treatment modality alone. In this review, novel approaches to nanoscale delivery of chemotherapy are described and recent progress in this field is discussed. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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