Journal
CANCER LETTERS
Volume 380, Issue 1, Pages 356-358Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2015.12.028
Keywords
Tumor microenvironment; Tumor macroenvironment; Commensal; Microbes; Carcinogenesis
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Funding
- NCI NIH HHS [U01 CA164337, R01 CA108854] Funding Source: Medline
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It has been recently shown that gut microbes modulate whole host immune and hormonal factors impacting the fate of distant preneoplastic lesions toward malignancy or regression. This raises the possibility that the tumor microenvironment interacts with broader systemic microbial-immune networks. These accumulated findings suggest novel therapeutic opportunities for holobiont engineering in emerging tumor microenvironments. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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