Journal
TRENDS IN PARASITOLOGY
Volume 36, Issue 2, Pages 158-169Publisher
CELL PRESS
DOI: 10.1016/j.pt.2019.12.003
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Funding
- National Health and Medical Research Council of Australia (NHMRC)
- Wellcome Trust
- Victorian State Government Operational Infrastructure Support NHMRC Independent Research Institute Infrastructure Support Scheme (IRIISS), Australia
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Plasmodium parasites cause malaria and are maintained between Anopheles mosquitoes and mammalian hosts in a complex life cycle. Malaria parasites occupy tissue niches that can be difficult to access, and models to study them can be challenging to recapitulate experimentally, particularly for Plasmodium species that infect humans. 2D culture models provide extremely beneficial tools to investigate Plasmodium biology but they have limitations. More complex 3D structural networks, such as organoids, have unveiled new avenues for developing more physiological tissue models, and their application to malaria research offers great promise.Here, we review current models for studying Plasmodium infection with a key focus on the obligatepre-erythrocytic stage that culminates in blood infection, causing malaria, and discuss how organoids should fulfil an important and unmet need.
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