Journal
TRENDS IN IMMUNOLOGY
Volume 41, Issue 1, Pages 3-6Publisher
CELL PRESS
DOI: 10.1016/j.it.2019.11.010
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A recent article by Sung et al. identified the CLEC2 platelet receptor as an important factor of lethal dengue virus infection. Formation of neutrophil extracellular traps via crosstalk with CLEC5A and TLR2 neutrophils were ascribed a causative role in DENV infection. This provides new insights for the development of candidate broad-spectrum therapies against hemorrhagic virus infections.
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