Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 124, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2019.115780
Keywords
Chemiluminescence immunoassay; Enhanced chemiluminescence; Nanomaterials; Multifunctional antibody; Aptamer; Immunochromatography; Microfluidic chip
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Funding
- Hebei Education Department, China [ZD2015119]
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Chemiluminescence immunoassay (CLIA) has been greatly developed in the past several decades due to its good sensitivity and specificity. Nowadays, CLIA has been highly improved with novel nanomaterials and newly-developed technologies. The advancement of CLIA combined with relevant technologies are reviewed in the paper, including enhanced chemiluminescent, antibody preparation, aptamer selection, nanomaterials assisted CLIA, and CLIA coupling with newly-developed technologies. Finally, some critical challenges are discussed in the field and the future development direction of CLIA is prospected. The review will be of great significance for CLIA basic research and practical applications in the fields of biomedical diagnostics, food and drug testing, environmental monitoring, and other fields. (C) 2019 Elsevier B.V. All rights reserved.
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