Article
Medicine, General & Internal
Myungsik Nam, Sun Woong Kim
Summary: Corneal epithelial thickness (CET) was found to be smaller in patients with glaucoma receiving topical medications compared to controls. Among various factors influencing CET, the use of beta-blockers, prostaglandin, and frequency of BAK-containing instillations were significant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Mengliang Wu, Laura E. Downie, Lisa J. Hill, Holly R. Chinnery
Summary: In this study, the neuroprotective and immunomodulatory effects of topical decorin in a murine model of BAK-induced corneal neuropathy were evaluated. The results showed that decorin reduced the infiltration of inflammatory cells and the decrease in corneal nerve density. This suggests that decorin can be a potential treatment for BAK-induced corneal neuropathy.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Yaru Li, Lei Zhou, Mengmeng Zhang, Runzhi Li, Guohu Di, Hongyun Liu, Xianggen Wu
Summary: The study demonstrates the potential feasibility of APO-VA64 nano-ophthalmic solution as a new treatment for ocular inflammatory diseases. The solution, fabricated via a simple process, exhibits valuable characteristics such as good ocular tolerance and improved drug permeation ability. It shows significant efficacy in treating ocular damage induced by benzalkonium chloride.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Multidisciplinary Sciences
Yuan-Chieh Lee, Li-Yi Sun, Jia-Rong Zhang
Summary: This study demonstrated the protective effects of low-molecular-weight adipose-derived stem cell-conditioned medium (LADSC-CM) in a mouse model of dry eye syndrome. LADSC-CM stimulated tear secretion, preserved tight junction and microvilli of the corneal epithelium, and increased the density of goblet cells in the conjunctiva. The active ingredients in LADSC-CM were lipophobic and stable after heating and lyophilization, providing potential for further exploration.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Tsutomu Imaizumi, Ryuhei Hayashi, Yuji Kudo, Xiaoqin Li, Kaito Yamaguchi, Shun Shibata, Toru Okubo, Tsuyoshi Ishii, Yoichi Honma, Kohji Nishida
Summary: The conditioned medium of human adipose-derived mesenchymal stem cells (hAdMSC-CM) has been found to suppress cytotoxicity and inflammation in human corneal epithelial cells (hCECs), improve barrier dysfunction, and serve as a potential therapeutic agent for dry eye syndrome (DES).
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Sujuan Duan, Yanyan Zhang, Fangxiu Yuan, Alan Jiang, Yi Sang, Guofu Huang
Summary: This study demonstrated that conditioned medium derived from human umbilical cord mesenchymal stem cells (HUMSCs-CM) significantly enhanced the proliferation ability of rabbit corneal endothelial cells (RCECs), maintained necessary characteristic phenotypes, and promoted RCECs from G0/G1 phase entrance to S phase. This suggests a promising cell source for experimental research and clinical therapy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Elizabeth C. Y. Kao, Junghee Seo, David J. McCanna, Lakshman N. Subbaraman, Lyndon W. Jones
Summary: Cytotoxicity testing is a regulatory requirement for safety testing of new ocular implants, and this study developed a method using fluorescent viability dyes to assess the cytotoxicity of ocular implants. The study found that using confocal microscopy, significant toxicity was detected on treated surfaces compared to the untreated control. The release of cytokines from cells varied depending on the toxin evaluated and the toxin concentration, and did not directly correlate with the reduction in cell metabolic activity.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
David Wirta, Ranjan Malhotra, James Peace, Bridgitte Shen Lee, Brittany Mitchell, Kenneth Sall, Matthew McMenemy
Summary: This study evaluated the noninferiority of latanoprost without benzalkonium chloride (BAK) compared to latanoprost with BAK in lowering intraocular pressure (IOP). The results showed that latanoprost without BAK did not meet two out of three criteria for noninferiority, but had a similar safety profile to latanoprost with BAK.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2022)
Article
Neurosciences
Qasim A. El-Dwairi, Saleh M. Al-Hussain, Ayat S. Banihani, Ziad M. Bataineh, Laiche Djouhri, Ayman G. Mustafa, Sami Zaqout
Summary: The morphological study of neurons in the spinal trigeminal nucleus of camels using the Golgi impregnation method revealed at least 12 morphological types of neurons with various sizes, shapes, and appendages. These neurons exhibited unique adaptations, such as large dilatations especially at their dendritic branching points, suggesting evolutionary modifications in pain and temperature processing pathways. This study provides insights into the neural adaptations of camels living in harsh environments with frequent exposure to painful stimuli.
Article
Multidisciplinary Sciences
Dai Woo Kim, Jonghoon Shin, Chang Kyu Lee, Myungjin Kim, Sohyeon Lee, Seungsoo Rho
Summary: This study conducted a phase 4 multicenter research to compare the efficacy and safety of preserved and preservative-free latanoprost in treating patients with open-angle glaucoma or ocular hypertension. The results showed that the preservative-free group had better adherence and lower hyperemia scores compared to the preserved group.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Masamichi Fukuda, Nobuo Takeda, Hidetoshi Ishida, Yusuke Seki, Naoko Shibata, Nobuo Takahashi, Kazuhisa Sugiyama, Eri Kubo, Hiroshi Sasaki
Summary: The study showed that rebamipide ophthalmic solution effectively reduces corneal epithelial injury caused by BAK, as demonstrated by corneal resistance and fluorescein staining experiments.
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
(2022)
Article
Ophthalmology
Karin R. Pillunat, Johanna Orphal, Maike Haase, Lutz E. Pillunat, Robert Herber
Summary: The study found that corneal densitometry returned close to normal 6 months after trabeculectomy, with no significant difference compared to a healthy control group. The significant reduction in diurnal IOP and the decrease in pressure-lowering substances may be the main reasons for this finding.
Article
Chemistry, Medicinal
Joseph Blondeau, Heleen DeCory
Summary: The combination of besifloxacin with benzalkonium chloride can enhance the killing activity against common bacteria implicated in ophthalmic infections, potentially helping prevent resistance development and treat resistant organisms.
Review
Biology
Tom Paterson, Serap Azizoglu, Moneisha Gokhale, Madeline Chambers, Cenk Suphioglu
Summary: Anti-allergy eyedrops are widely used for treating ocular allergies, but the common preservative benzalkonium chloride may damage corneal cells and increase the risk of corneal damage, especially when there is inflammation and eye rubbing action.
Article
Biochemistry & Molecular Biology
Mauricio Tavares Jacques, Luciano Saso, Marcelo Farina
Summary: Neuron-glia interactions are crucial for maintaining the central nervous system's stability. Microglial cells, as important support cells in the brain, play a role in responding to disruptions in this stability. In this study, the researchers investigated the potential protective effects of activated microglia on neuronal cells against ferroptosis, an iron-dependent form of cell death. The findings suggest that activated microglial cell-derived molecules may contribute to the protection of neuronal cells against ferroptosis, highlighting the potential for controlling this cell death mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Toxicology
Noemie Bonneau, Christophe Baudouin, Annabelle Reaux-Le Goazigo, Francoise Brignole-Baudouin
Summary: The increasing social awareness of animal suffering in the 21st century has led to a goal by OECD to reduce animal testing through developing new integrated testing strategies. Currently, there is a lack of alternative models to test for ocular surface toxicity, but five alternative methods have been validated to replace the current reference test.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Dermatology
Laurent Misery, Annabelle Reaux-Le Goazigo, Stephane Morisset, Sophie Seite, Veronique Delvigne, Beatrice Cochener, Charles Taieb
Summary: This study conducted a comprehensive survey on self-reported sensitive eyes and found that they are very common and commonly associated with sensitive skin. The triggering factors of sensitive eyes are more specific.
SKIN PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Juliette Buffault, Francoise Brignole-Baudouin, Elodie Reboussin, Karima Kessal, Antoine Labbe, Stephane Melik Parsadaniantz, Christophe Baudouin
Summary: Comparing the effects of latanoprost and a Rho-kinase inhibitor on TGF-beta 2-induced glaucoma-like model revealed that the ROCKi was able to reverse the TGF-beta 2-induced cytoskeletal and ECM rearrangements, while latanoprost only affected the extracellular matrix.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Xin Zhang, Stephane Melik-Parsadaniantz, Christophe Baudouin, Annabelle Reaux-Le Goazigo, Nathan Moreau
Summary: The cornea, a crucial part of the eye, requires constant renewal and efficient healing to maintain ocular homeostasis. The Hedgehog signaling pathway plays a vital role in corneal wound healing, promoting cell proliferation, migration, and maintenance of the corneal epithelial barrier.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Elodie Reboussin, Juliette Buffault, Francoise Brignole-Baudouin, Annabelle Reaux-Le Goazigo, Luisa Riancho, Celine Olmiere, Jose-Alain Sahel, Stephane Melik Parsadaniantz, Christophe Baudouin
Summary: This study demonstrated the neuroprotective and immunomodulatory effects of MSCs on RGCs in an ex vivo neuroretina explant model. However, co-culture with MSCs led to explant edema and the formation of an epiretinal membrane-like phenotype. The use of MSC secretome may offer the beneficial effects of MSCs without their potential adverse effects through paracrine signaling.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Ophthalmology
Marc Labetoulle, Andrea Leonardi, Pierre-Jean Pisella, Christophe Baudouin
Summary: Dry eye disease is a chronic inflammatory disease of the ocular surface that requires long-term therapy. Treatment with ciclosporin A 0.1% cationic emulsion can improve clinical signs and symptoms as early as 4 weeks after treatment initiation.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Review
Pharmacology & Pharmacy
Darine Fakih, Tiffany Migeon, Nathan Moreau, Christophe Baudouin, Annabelle Reaux-Le Goazigo, Stephane Melik Parsadaniantz
Summary: Dry eye disease (DED) is a disorder characterized by abnormal sensations in the eyes, such as dryness and pain. Corneal pain, one of the main symptoms of DED, is recognized as a growing problem with significant social burden. The cornea, being highly innervated, relies on the specific expression of transient receptor potential (TRP) channels to maintain its integrity. These channels play important roles as cellular sensors and can be targeted for therapeutic benefit in treating ocular pain associated with DED.
Review
Ophthalmology
Juliette Buffault, Francoise Brignole-Baudouin, Antoine Labbe, Christophe Baudouin
Summary: The purpose of this article is to provide an overview of the existing alternative models for studying the trabecular meshwork (TM). The TM is a complex tissue that regulates aqueous humor outflow and dysfunction of the TM is a major contributor to open-angle glaucoma. Traditional animal models have limitations, leading to a focus on developing alternative in vitro models. These models have shown promise in reducing reliance on animal experimentation in glaucoma research.
CURRENT EYE RESEARCH
(2023)
Article
Ophthalmology
Jason Bacharach, Iqbal Ike K. Ahmed, Elizabeth Sharpe, Michael S. Korenfeld, Steven Zhang, Christophe Baudouin
Summary: This study evaluated the safety and efficacy of a preservative-free formulation of latanoprost (T2345) compared to benzalkonium chloride-preserved latanoprost in patients with primary open-angle glaucoma or ocular hypertension. The results showed that both formulations effectively controlled intraocular pressure, with T2345 demonstrating better safety profile.
CLINICAL OPHTHALMOLOGY
(2023)
Article
Sport Sciences
Morten Carstens Moe, Emin Ozmert, Christophe Baudouin, Abhinav Binadra, Sven Crafoord, Young Jo, Hayyam Kiratli, Melita Moore, Yannis P. Pitsiladis, Udo Rolle, Ben Tan, Ozge Yanik, Richard Budgett, Ugur Erdener, Kathrin Steffen, Lars Engbretsen
Summary: Vision plays a crucial role in athletes' success, with 80% of perceptual input being visual. Eye health and sports medicine are closely intertwined, as the physical nature of sports makes athletes more prone to eye injuries. In addition to injuries, vision problems such as blurred vision and light sensitivity can also affect athletes' performance. Collaboration between sports medicine professionals and ophthalmologists is necessary to provide athletes with appropriate eye care and guidance on eye protection.
BMJ OPEN SPORT & EXERCISE MEDICINE
(2023)