Article
Biochemistry & Molecular Biology
Ling-Ling Qian, Xiaojing Sun, Jingchun Yang, Xiao-Li Wang, Michael J. Ackerman, Ru-Xing Wang, Xiaolei Xu, Hon-Chi Lee, Tong Lu
Summary: Loss of SORBS2 protein can lead to abnormal cardiac ion channels, causing cardiac structural and electrical remodeling, leading to cardiac conduction delays and arrhythmias.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Cardiac & Cardiovascular Systems
Mary R. Sy, Joshua A. Keefe, Jeffrey P. Sutton, Xander H. T. Wehrens
Summary: Space medicine is crucial for human exploration of outer space and contributes to advancements in science, technology, and medicine. Astronauts and spaceflight participants face unique health challenges due to the harsh conditions in outer space, including microgravity and other hazards, particularly in relation to the heart. This review summarizes the existing literature on the effects of spaceflight on cardiac structure and function, as well as the impact of microgravity on cardiac calcium handling. The findings can inform future studies and therapies, and are also relevant to other physiological states resembling microgravity, such as prolonged horizontal bed rest and immobilization.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Qing Zhang, Deqiang Yao, Bing Rao, Liyan Jian, Yang Chen, Kexin Hu, Ying Xia, Shaobai Li, Yafeng Shen, An Qin, Jie Zhao, Lu Zhou, Ming Lei, Xian-Cheng Jiang, Yu Cao
Summary: Phosphatidylcholine (PC) undergoes re-acylation catalyzed by lysophosphatidylcholine acyltransferases (LPCAT), with LPCAT3 introducing polyunsaturated acyl to modulate membrane fluidity and membrane protein functions. The structures of LPCAT3 reveal a reaction chamber and tunnels for substrate positioning, providing insights into the re-acylation mechanism.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Oscar Casis, Leire Echeazarra, Beatriz Saenz-Diez, Monica Gallego
Summary: Hypothyroidism is a common endocrine disorder, especially in women. Apart from overt hypothyroidism, subclinical hypothyroidism is also prevalent. This condition affects cardiac electrical activity, particularly during the repolarization phase, increasing the susceptibility to cardiac arrhythmias. The traditional view attributing these effects to thyroid hormone deficiency is being challenged by recent studies, which demonstrate the crucial role of TSH in cardiac electrical remodeling. Therefore, different types of hypothyroidism can result in varying forms of cardiac electrical remodeling, raising the question of redefining TSH reference ranges.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Ting-Chun Huang, Li-Wei Lo, Yu-Hui Chou, Wei-Lun Lin, Shih-Lin Chang, Yenn-Jiang Lin, Shin-Huei Liu, Wen-Han Cheng, Ping-Yen Liu, Shih-Ann Chen
Summary: Renal denervation (RDN) has been found to suppress the renin-angiotensin-aldosterone system and reduce inflammatory cytokines, leading to the prevention of cardiac remodeling. However, limited studies have investigated the effect of RDN on ventricular electrophysiology. This study used optical mapping to evaluate the impact of RDN on ventricular structural and electrical remodeling in a tachycardia-induced cardiomyopathy rabbit model. The results showed that RDN reversed the reduction of conduction velocity and prolongation of action potential duration, which are significant hallmarks of heart failure.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Zhan-Yue Shi, Chao Yang, Liu-Yi Lu, Can-Xiang Lin, Shi Liang, Gen Li, Hong-Min Zhou, Jun-Meng Zheng
Summary: The adoptive transfer of ex vivo generated myeloid-derived suppressor cells (MDSCs) may be a promising therapeutic strategy for preventing allograft rejection after solid organ transplantation. Addition of HK2 inhibitor 3-BrPA into traditional MDSCs induction system in vitro significantly promoted MDSCs production and enhanced their immunosuppressive function. Moreover, the adoptive transfer of 3-BrPA-treated MDSCs significantly prolonged the survival time of mouse heart allografts.
CELLULAR IMMUNOLOGY
(2023)
Article
Biology
Alexandra Polyak, Leila Topal, Noemi Zombori-Toth, Noemi Toth, Janos Prorok, Zsofia Kohajda, Szilvia Deri, Vivien Demeter-Haludka, Peter Hegyi, Viktoria Venglovecz, Gergely Agoston, Zoltan Husti, Peter Gazdag, Jozefina Szlovak, Tamas Arpadffy-Lovas, Muhammad Naveed, Annamaria Sarusi, Norbert Jost, Laszlo Virag, Norbert Nagy, Istvan Baczko, Attila S. Farkas, Andras Varro
Summary: Exercise in elite athletes can cause cardiac arrhythmias and sudden cardiac death. A study on a dog model showed that chronic training induces electrophysiological remodeling and increases susceptibility to ventricular arrhythmias. These changes were associated with increased fibrosis and enhanced expression of HCN4 protein.
Article
Chemistry, Multidisciplinary
Nan Zhang, Chaoren Yan, Changji Yin, Xiaoling Hu, Ping Guan, Yuan Cheng
Summary: Epigallocatechin-3gallate (EGCG) extracted from green tea is a promising small-molecule drug candidate for Alzheimer's disease. This study used molecular dynamics simulations and experiments to investigate the mechanism of EGCG-induced remodeling of Aβ fibrils.
Article
Materials Science, Ceramics
Priyanka Singh, Brajendra Singh, Mukul Gupta
Summary: This study investigated the positive magneto capacitance in La0.66Pb0.3Mn0.4Ti0.56O3 and negative magneto capacitance in La0.7Pb0.3Mn0.4Fe0.6O3 due to interactions of different valence states, with Fe-doped composition showing a significantly higher magnetic moment than Ti-doped composition.
CERAMICS INTERNATIONAL
(2022)
Review
Cell Biology
Christine Mages, Heike Gampp, Pascal Syren, Ann-Kathrin Rahm, Florian Andre, Norbert Frey, Patrick Lugenbiel, Dierk Thomas
Summary: This review highlights the pathomechanisms underlying arrhythmogenicity in patients with heart failure, such as myocardial fibrosis and ion channel remodeling. It emphasizes the association of dysregulated ion channel expression with cardiomyopathy and arrhythmia development, and discusses potential therapeutic options.
Article
Cardiac & Cardiovascular Systems
Shin-Huei Liu, Li-Wei Lo, Yu-Hui Chou, Wei-Lun Lin, Tseng-Ying Tsai, Wen-Han Cheng, Shinya Yamada, Shih-Ann Chen
Summary: The study investigated the effects of renal artery denervation (RDN) on arrhythmogenicity in a rabbit model of chronic kidney disease (CKD). The results showed that RDN reduced the inducibility of ventricular arrhythmias (VAs), decreased ventricular fibrosis, and lowered sympathetic innervation in CKD rabbits. Ultimately, neuromodulation by RDN demonstrated protective effects with less structural and electrical remodeling, leading to attenuated VAs.
Article
Clinical Neurology
Guilherme L. Fialho, Trudy D. Pang, Wan Yee Kong, Anthony P. Tran, Calvin G. Yu, Ivo D. Rodriguez, Bruce D. Nearing, Jonathan W. Waks, Timothy R. Maher, John-Ross Clarke, Alyssa Shepherd, Andre D'Avila, Steven C. Schachter, Richard L. Verrier
Summary: Identification of epilepsy patients with increased risk for atrial fibrillation is crucial. The study found that epilepsy patients have P-wave heterogeneity levels comparable to atrial fibrillation patients, indicating possible structural changes and cardiac electrical instability in epilepsy.
Article
Immunology
Zhao Fang, Shuang Li, Feierkaiti Yushanjiang, Gaoke Feng, Shengyu Cui, Shan Hu, Xuejun Jiang, Chengyin Liu
Summary: Cardiac remodeling is a complex process that contributes to heart failure and arrhythmias in cardiovascular diseases. This study explored the protective effect of curcumol on cardiac remodeling and revealed its underlying mechanism. Curcumol attenuated cardiac dysfunction, fibrosis, and hypertrophy in an animal model of cardiac remodeling. It also alleviated cardiac electrical remodeling and inhibited inflammation and apoptosis through the AKT/NF-KB pathway. These findings suggest that curcumol holds potential as a therapeutic agent for cardiac remodeling.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Qi Liu, Jun Zhu, Bin Kong, Wei Shuai, He Huang
Summary: The study revealed that tirzepatide, a dual GLP-1 and GIP receptor agonist, has a protective effect on sepsis-induced cardiac dysfunction, and its mechanism of action is through the inhibition of the TLR4/NF-kB/NLRP3 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Yan Zhang, Xiaoyun Pang, Jian Li, Jiashu Xu, Victor W. Hsu, Fei Sun
Summary: By using cryoelectron microscopy, researchers have revealed the protein lattice formed by SNX1, which helps to understand how it functions in generating transport carriers. Comparing the structure of SNX1 with that of an endosomal coat complex formed by retromer coupled to a SNX provides insights into the molecular organization of SNX and the intermediary stages of assembly leading to the formation of the complex on the membrane.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)