Journal
CANCER INVESTIGATION
Volume 34, Issue 2, Pages 105-113Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/07357907.2015.1104690
Keywords
DNA methylation; Laryngeal squamous cell carcinoma; Runt-related transcription factor; Expression; Cell migration
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Funding
- Science and Technology Project of Guizhou Province [25-LKZ2013]
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This study identifies promoter methylation status of RUNX3 in 77 LSCC patient tissues and their paired adjacent healthy tissues. Hypermethylation percentage RUNX3 occurred in LSCC samples was significantly higher than that in normal tissues, as well as associated with suppression of RUNX3 expression, TNM classification of malignant tumors stage, lymph node metastasis and poor overall survival rate. Reduced methylation and increased expression of RUNX3 genes in vitro was observed and decreased cell migration was further confirmed following 5-azacytidine treatment. RUNX 3 promoter hypermethylation can lead to down-regulation of RUNX3 in LSCC cancerous tissue.
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