Assessment of the Mode of Action Underlying the Effects of GenX in Mouse Liver and Implications for Assessing Human Health Risks

Adverse Maternal, Fetal, and Postnatal Effects of Hexafluoropropylene Oxide Dimer Acid (GenX) from Oral Gestational Exposure in Sprague-Dawley Rats

(2019) Justin M. Conley et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The NCATS BioPlanet – An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics

(2019) Ruili Huang et al.   Frontiers in Pharmacology

Establishing Transcriptional Signatures to Differentiate PXR-, CAR-, and AhR-Mediated Regulation of Drug Metabolism and Transport Genes in Cryopreserved Human Hepatocytes

(2018) Jamie E. Moscovitz et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Human relevance of rodent liver tumors: Key insights from a Toxicology Forum workshop on nongenotoxic modes of action

(2018) Susan P. Felter et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

BMDExpress 2: enhanced transcriptomic dose-response analysis workflow

(2018) Jason R Phillips et al.   BIOINFORMATICS

Network and Pathway Analysis of Toxicogenomics Data

(2018) Gal Barel et al.   Frontiers in Genetics

Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice

(2017) Grace A. Chappell et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Transcriptomics in toxicology

(2017) Pius Joseph   FOOD AND CHEMICAL TOXICOLOGY

From the Cover: Genomic Effects of Androstenedione and Sex-Specific Liver Cancer Susceptibility in Mice

(2017) John P. Rooney et al.   TOXICOLOGICAL SCIENCES

PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling

(2017) Mitchell B. Rosen et al.   TOXICOLOGY

A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling

(2017) Joanne M. Yeakley et al.   PLoS One

RNA-sequencing analysis reveals the hepatotoxic mechanism of perfluoroalkyl alternatives, HFPO2 and HFPO4, following exposure in mice

(2016) Jianshe Wang et al.   JOURNAL OF APPLIED TOXICOLOGY

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Recommendations from the INHAND Apoptosis/Necrosis Working Group

(2016) Susan A. Elmore et al.   TOXICOLOGIC PATHOLOGY

Absorption, distribution, metabolism, excretion, and kinetics of 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid ammonium salt following a single dose in rat, mouse, and cynomolgus monkey

(2016) Shawn A. Gannon et al.   TOXICOLOGY

Toxicity Mechanisms Identification via Gene Set Enrichment Analysis of Time-Series Toxicogenomics Data: Impact of Time and Concentration

(2015) Ce Gao et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

WikiPathways: capturing the full diversity of pathway knowledge

(2015) Martina Kutmon et al.   NUCLEIC ACIDS RESEARCH

Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study

(2013) J. Christopher Corton et al.   CRITICAL REVIEWS IN TOXICOLOGY

Enriching the gene set analysis of genome-wide data by incorporating directionality of gene expression and combining statistical hypotheses and methods

(2013) Leif Väremo et al.   NUCLEIC ACIDS RESEARCH

Liver Hypertrophy

(2012) A. P. Hall et al.   TOXICOLOGIC PATHOLOGY

A Species Difference in the Peroxisome Proliferator-Activated Receptor α-Dependent Response to the Developmental Effects of Perfluorooctanoic Acid

(2012) Prajakta P. Albrecht et al.   TOXICOLOGICAL SCIENCES

Mode of Action analysis of perfluorooctanoic acid (PFOA) tumorigenicity and Human Relevance

(2011) James E. Klaunig et al.   REPRODUCTIVE TOXICOLOGY

Perfluoroalkyl and polyfluoroalkyl substances in the environment: Terminology, classification, and origins

(2011) Robert C Buck et al.   Integrated Environmental Assessment and Management

Phosphoenolpyruvate carboxykinase (Pck1) helps regulate the triglyceride/fatty acid cycle and development of insulin resistance in mice

(2010) Carrie A. Millward et al.   JOURNAL OF LIPID RESEARCH

Reactome: a database of reactions, pathways and biological processes

(2010) D. Croft et al.   NUCLEIC ACIDS RESEARCH

Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System

(2010) Bob Thoolen et al.   TOXICOLOGIC PATHOLOGY

Effects on coagulation factor production following primaryhepatomitogen-induced direct hyperplasia

(2009) Kohei Tatsumi et al.   WORLD JOURNAL OF GASTROENTEROLOGY

PID: the Pathway Interaction Database

(2008) Carl F. Schaefer et al.   NUCLEIC ACIDS RESEARCH

Peroxisome Proliferator Activated Receptors and Lipoprotein Metabolism

(2007) Sander Kersten   PPAR Research