Development of T cells carrying two complementary chimeric antigen receptors against glypican-3 and asialoglycoprotein receptor 1 for the treatment of hepatocellular carcinoma

1. A Direct Comparison of Foamy and Lentiviral Vector Genotoxicity in SCID-Repopulating Cells Shows Foamy Vectors Are Less Prone to Clonal Dominance

(2016) Elizabeth M. Everson et al.   MOLECULAR THERAPY

Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity

(2015) H. G. Caruso et al.   CANCER RESEARCH

Variable asialoglycoprotein receptor 1 expression in liver disease: Implications for therapeutic intervention

(2015) Dominik Witzigmann et al.   HEPATOLOGY RESEARCH

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

(2015) Adrienne H Long et al.   NATURE MEDICINE

Adoptive immunotherapy using T lymphocytes redirected to glypican-3 for the treatment of lung squamous cell carcinoma

(2015) Kesang Li et al.   Oncotarget

Identification of an Exon 4-Deletion Variant of Epidermal Growth Factor Receptor with Increased Metastasis-Promoting Capacity

(2015) Hai Wang et al.   NEOPLASIA

Development of T Cells Redirected to Glypican-3 for the Treatment of Hepatocellular Carcinoma

(2014) H. Gao et al.   CLINICAL CANCER RESEARCH

Identification of biomarkers for hepatocellular carcinoma by semiquantitative immunocytochemistry

(2014) Hong Mu   WORLD JOURNAL OF GASTROENTEROLOGY

Prognostic and clinicopathological significance of glypican-3 overexpression in hepatocellular carcinoma: A meta-analysis

(2014) Jia Li   WORLD JOURNAL OF GASTROENTEROLOGY

Immunotherapy with gene-modified T cells: limiting side effects provides new challenges

(2013) H J Stauss et al.   GENE THERAPY

Expression of Asialoglycoprotein Receptor 1 in Human Hepatocellular Carcinoma

(2013) Bin Shi et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Liver-Targeting of Interferon-Alpha with Tissue-Specific Domain Antibodies

(2013) Edward Coulstock et al.   PLoS One

Chimeric Antigen Receptor T Cells with Dissociated Signaling Domains Exhibit Focused Antitumor Activity with Reduced Potential for Toxicity In Vivo

(2013) E. Lanitis et al.   Cancer Immunology Research

Dual Targeting of ErbB2 and MUC1 in Breast Cancer Using Chimeric Antigen Receptors Engineered to Provide Complementary Signaling

(2012) Scott Wilkie et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells

(2012) Christopher C Kloss et al.   NATURE BIOTECHNOLOGY

In vitro generated anti-tumor T lymphocytes exhibit distinct subsets mimicking in vivo antigen-experienced cells

(2011) Shicheng Yang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

CARs on Track in the Clinic

(2011) Donald B Kohn et al.   MOLECULAR THERAPY

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

(2011) David L. Porter et al.   NEW ENGLAND JOURNAL OF MEDICINE

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

(2011) M. Kalos et al.   Science Translational Medicine

Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

(2010) Richard A Morgan et al.   MOLECULAR THERAPY

Simplified lentivirus vector production in protein-free media using polyethylenimine-mediated transfection

(2009) Hitoshi Kuroda et al.   JOURNAL OF VIROLOGICAL METHODS

Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains

(2009) C. Carpenito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glypican 3 Expression in Human Nonneoplastic, Preneoplastic, and Neoplastic Tissues

(2008) Daniel Baumhoer et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

The application of markers (HSP70 GPC3 and GS) in liver biopsies is useful for detection of hepatocellular carcinoma

(2008) Luca Di Tommaso et al.   JOURNAL OF HEPATOLOGY

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE