Article
Urology & Nephrology
Zhi Yu, Morgan E. Grams, Chiadi E. Ndumele, Lynne Wagenknecht, Eric Boerwinkle, Kari E. North, Casey M. Rebholz, Edward L. Giovannucci, Josef Coresh
Summary: This study found that midlife obesity measures were associated with decline in kidney function among White and Black women over 30 years of follow-up, but the association was less consistent in men. Obesity indicators were independently associated with risk for kidney failure with replacement therapy for all sex-race groups except White men. Loss to follow-up during the study period was a limitation.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Endocrinology & Metabolism
Brian T. Steffen, Weihong Tang, Pamela L. Lutsey, Ryan T. Demmer, Elizabeth Selvin, Kunihiro Matsushita, Alanna C. Morrison, Weihua Guan, Mary R. Rooney, Faye L. Norby, Nathan Pankratz, David Couper, James S. Pankow
Summary: Proteomics analysis identified plasma proteins associated with the risk of type 2 diabetes. These proteins may serve as potential targets for intervention or pharmacological approaches to prevent, reverse, or slow down the progression of type 2 diabetes.
Article
Multidisciplinary Sciences
Huijie Wang, Huanwei Zheng, Xu Cao, Ping Meng, Jinli Liu, Caihua Zheng, Haiying Zuo, Zhichao Wang, Teng Zhang
Summary: This study explored the association between β2-microglobulin and colorectal cancer (CRC) among inpatients who underwent colonoscopy. After adjusting for baseline characteristics and laboratory parameters, a positive association was found between β2-M and CRC. Monitoring β2-M levels may be important for predicting CRC.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Jacqueline D. Wright, Aaron R. Folsom, Josef Coresh, A. Richey Sharrett, David Couper, Lynne E. Wagenknecht, Thomas H. Mosley, Christie M. Ballantyne, Eric A. Boerwinkle, Wayne D. Rosamond, Gerardo Heiss
Summary: The ARIC project, initiated in 1987, focuses on community-based surveillance for myocardial infarction and coronary heart disease, aiming to understand the decline in CHD mortality and identify determinants of subclinical atherosclerosis and CHD in middle-aged Black and White adults. Through research in areas such as health disparities, genomics, heart failure, and prevention, ARIC has published over 2,300 papers with significant clinical impact, highlighting the importance of population-based research in improving health.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Justin B. Echouffo-Tcheugui, Chiadi E. Ndumele, Sui Zhang, Roberta Florido, Kunihiro Matsushita, Josef Coresh, Hicham Skali, Amil M. Shah, Elizabeth Selvin
Summary: The study aimed to investigate the influence of diabetes on the progression from preclinical heart failure (HF) stages to overt HF. The results showed that uncontrolled diabetes was significantly associated with the risk of HF progression. Therefore, early intervention and treatment of diabetes are critical in the process of HF.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Clinical Neurology
Faye L. Norby, Alvaro Alonso, Mary R. Rooney, Ankit Maheshwari, Ryan J. Koene, Michael Zhang, Elsayed Z. Soliman, Laura R. Loehr, Thomas Mosley, Rebecca F. Gottesman, Josef Coresh, Lin Y. Chen
Summary: In this study, it was found that the presence of nonsustained ventricular tachycardia (NSVT) and premature ventricular contractions (PVCs) were associated with dementia in elderly black individuals, while there was no significant association between NSVT and dementia in white individuals. Further research and elucidation of underlying mechanisms are warranted.
Article
Multidisciplinary Sciences
Danni Li, Aniqa B. Alam, Fang Yu, Anna Kucharska-Newton, B. Gwen Windham, Alvaro Alonso
Summary: Plasma concentrations of long-chain SM 41:1 were found to be positively associated with physical function in older adults in a cross-sectional analysis, but no significant association was observed with longitudinal changes in physical function or mobility impairment.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Jiaqi Hu, Michael Fang, James R. Pike, Pamela L. Lutsey, A. Richey Sharrett, Lynne E. Wagenknecht, Timothy M. Hughes, Jesse C. Seegmiller, Rebecca F. Gottesman, Thomas H. Mosley, Josef Coresh, Elizabeth Selvin
Summary: This study evaluates whether the association between prediabetes and dementia can be explained by the development of diabetes. It is found that there is an association between prediabetes and dementia risk, but this association can be explained by the subsequent development of diabetes. The age of onset of diabetes is significantly associated with dementia risk.
Article
Endocrinology & Metabolism
Michael Fang, Junichi Ishigami, Justin B. Echouffo-Tcheugui, Pamela L. Lutsey, James S. Pankow, Elizabeth Selvin
Summary: The study found a significant association between diabetes and risk for infection-related hospitalisation, especially in foot infections. The association was more pronounced in younger individuals and the Black population.
Article
Medical Laboratory Technology
Carine E. Hamo, Justin B. Echouffo-Tcheugui, Sui Zhang, Roberta Florido, James S. Pankow, Erin D. Michos, Ronald Goldberg, Vijay Nambi, Gary Gerstenblith, Wendy S. Post, Roger S. Blumenthal, Christie Ballantyne, Elizabeth Selvin, Josef Coresh, Chiadi E. Ndumele
Summary: There is a strong association between the duration of diabetes and subclinical myocardial injury, with longer duration associated with greater risk of myocardial damage.
CLINICAL CHEMISTRY
(2022)
Article
Oncology
Baijun Zhou, Jiayun Lu, James D. Beck, Kevin L. Moss, Anna E. Prizment, Ryan T. Demmer, Kori A. Porosnicu Rodriguez, Corinne E. Joshu, Dominique S. Michaud, Elizabeth A. Platz
Summary: This study explores the associations between periodontal bacteria and lung cancer risk. The results indicate positive associations between certain oral bacteria, particularly the orange complex, and lung cancer, suggesting a potential role of periodontal bacteria in lung cancer etiology. Further research is needed to validate these associations and develop novel lung cancer prevention strategies.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Endocrinology & Metabolism
Mary R. Rooney, Jingsha Chen, Justin B. Echouffo-Tcheugui, Keenan A. Walker, Pascal Schlosser, Aditya Surapaneni, Olive Tang, Jinyu Chen, Christie M. Ballantyne, Eric Boerwinkle, Chiadi E. Ndumele, Ryan T. Demmer, James S. Pankow, Pamela L. Lutsey, Lynne E. Wagenknecht, Yujian Liang, Xueling Sim, Rob van Dam, E. Shyong Tai, Morgan E. Grams, Elizabeth Selvin, Josef Coresh
Summary: This study identified 47 plasma proteins predictive of incident diabetes, established causal effects for 3 proteins, and identified diabetes-associated inflammation and lipid pathways with potential implications for diagnosis and therapy.
Article
Endocrinology & Metabolism
Shaoping Zhang, Kamaira H. Philips, Kevin Moss, Di Wu, Hamdi S. Adam, Elizabeth Selvin, Ryan T. Demmer, Faye L. Norby, Indra Z. Mustapha, James D. Beck
Summary: This study found that periodontal disease is associated with incident diabetes, especially in nonobese individuals. The risk of diabetes related to periodontal disease may be modified by body mass index levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Shaoping Zhang, Kamaira H. Philips, Kevin Moss, Di Wu, Hamdi S. Adam, Elizabeth Selvin, Ryan T. Demmer, Faye L. Norby, Indra Z. Mustapha, James D. Beck
Summary: This study found a positive association between periodontal disease and incident diabetes, especially in nonobese participants. Furthermore, the risk of periodontal disease for incident diabetes was higher in individuals with lower BMI.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Neurosciences
Yifei Lu, James R. Pike, Elizabeth Selvin, Thomas Mosley, Priya Palta, A. Richey Sharrett, Alvin Thomas, Laura Loehr, A. Sidney Barritt, Ron C. Hoogeveen, Gerardo Heiss
Summary: Low levels of ALT and AST, particularly ALT, below the 10th percentile of the physiologic range at mid-life, were associated with a greater long-term risk of dementia, highlighting the potential role of hepatic function in the pathogenesis of dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Faye L. Norby, Pamela L. Lutsey, Nathan D. Shippee, Lin Y. Chen, Carrie Henning-Smith, Alvaro Alonso, Rob F. Walker, Aaron R. Folsom
Summary: Using Medicare data, the study found that patients in rural areas were more likely to initiate anticoagulation therapy after being diagnosed with AF, but were less likely to initiate DOACs compared to urban patients.
AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS
(2022)
Article
Oncology
Sithara Vivek, Heather Hammond Nelson, Anna E. Prizment, Jessica Faul, Eileen M. Crimmins, Bharat Thyagarajan
Summary: The prevalence of cognitive impairment/dementia is higher among cancer survivors and is likely due to a combination of factors, including exposure to cytomegalovirus (CMV) and inflammation. This study found that CMV seropositivity and high inflammation were associated with a higher risk of cognitive impairment among cancer survivors, particularly those diagnosed with cancer within three years.
CANCER CAUSES & CONTROL
(2022)
Article
Geriatrics & Gerontology
Kelsie M. Full, Snigdha Pusalavidyasagar, Priya Palta, Kevin J. Sullivan, Jung-Im Shin, Rebecca F. Gottesman, Adam P. Spira, Matthew P. Pase, Pamela L. Lutsey
Summary: This study aimed to examine the association between the use of sleep medications and incident dementia in a community-based cohort of older adults. The results showed that sleep medication use was associated with a 48% greater risk of dementia compared to nonuse.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Clinical Neurology
Sanaz Sedaghat, Pamela L. Lutsey, Yuekai Ji, Jean-Philippe Empana, Farzaneh Sorond, Timothy M. Hughes, Thomas H. Mosley, Rebecca F. Gottesman, David S. Knopman, Keenan A. Walker, Vilmundur Gudnason, Lenore J. Launer, Thomas T. van Sloten
Summary: Better cardiovascular health at midlife and improvement of cardiovascular health within midlife are associated with lower dementia risk.
ALZHEIMERS & DEMENTIA
(2023)
Article
Endocrinology & Metabolism
Brian T. Steffen, Weihong Tang, Pamela L. Lutsey, Ryan T. Demmer, Elizabeth Selvin, Kunihiro Matsushita, Alanna C. Morrison, Weihua Guan, Mary R. Rooney, Faye L. Norby, Nathan Pankratz, David Couper, James S. Pankow
Summary: Proteomics analysis identified plasma proteins associated with the risk of type 2 diabetes. These proteins may serve as potential targets for intervention or pharmacological approaches to prevent, reverse, or slow down the progression of type 2 diabetes.
Review
Cardiac & Cardiovascular Systems
Pamela L. Lutsey, Neil A. Zakai
Summary: Venous thromboembolism is an under-appreciated vascular disease with significant health disparities in incidence and outcomes. In addition to understanding the epidemiological characteristics and risk factors of this disease, attention should also be given to prevention measures and reducing disparities.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Hematology
Brian T. Steffen, James S. Pankow, Faye L. Norby, Pamela L. Lutsey, Ryan T. Demmer, Weihua Guan, Nathan Pankratz, Aixin Li, Guning Liu, Kunihiro Matsushita, Adrienne Tin, Weihong Tang
Summary: This study identified proteomic signatures and pathways related to 23 gene loci associated with abdominal aortic aneurysm (AAA). The results suggest that low levels of neogenin and kit ligand may be novel risk factors for AAA development.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Arun Kumar, Pamela L. Lutsey, Wendy L. St. Peter, Jon C. Schommer, Jeremy R. Van't Hof, Abhijeet Rajpurohit, Joel F. Farley
Summary: In acute coronary syndrome following percutaneous coronary intervention, newer P2Y12 inhibitors (ticagrelor and prasugrel) reduce cardiovascular outcomes compared to clopidogrel, but have a higher bleeding risk. This study examines the safety of each inhibitor in a real-world population.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Arun Kumar, Pamela L. Lutsey, Wendy L. St Peter, Jon C. Schommer, Jeremy R. Van't Hof, Abhijeet Rajpurohit, Joel F. Farley
Summary: This study compared the effectiveness of newer P2Y12 inhibitors (prasugrel and ticagrelor) with clopidogrel in real-world US populations. The results showed that ticagrelor reduced the risk of cardiovascular events by 10% at 90 days compared to clopidogrel. There were no significant differences for other comparisons. This study provides valuable information for clinicians in selecting P2Y12 inhibitors after ACS.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Biochemical Research Methods
Bruno Bohn, Pamela L. Lutsey, Weihong Tang, James S. Pankow, Faye L. Norby, Bing Yu, Christie M. Ballantyne, Eric A. Whitsel, Kunihiro Matsushita, Ryan T. Demmer
Summary: This study compared the proteome of statin users and nonusers and found differences in proteins unrelated to lipid metabolism. Further investigation into these differences may help elucidate the pleiotropic effects of statins.
JOURNAL OF PROTEOMICS
(2023)
Article
Medicine, General & Internal
Jennifer M. Geris, Mark R. Schleiss, Anthony J. Hooten, Erica Langer, Nelmary Hernandez-Alvarado, Michelle A. Roesler, Jeannette Sample, Lindsay A. Williams, David S. Dickens, Rajen J. Mody, Yaddanapudi Ravindranath, Kate L. Gowans, Matthew G. Pridgeon, Logan G. Spector, Heather H. Nelson
Summary: Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer and a leading cause of death in children. Congenital cytomegalovirus (cCMV) has been identified as a potential risk factor for ALL. This study compared the prevalence of cCMV infection between ALL cases and matched controls, and found that cCMV was associated with increased risk of hyperdiploid ALL.
Article
Medicine, General & Internal
Bruno Bohn, Pamela L. Lutsey, Jeffrey R. Misialek, Keenan A. Walker, Charles H. Brown, Timothy M. Hughes, Junichi Ishigami, Kunihiro Matsushita, Ryan T. Demmer
Summary: This study found an association between hospitalization with infection and incident dementia, suggesting that infections are risk factors for dementia.
Article
Nutrition & Dietetics
Linzi Li, Pamela L. Lutsey, Lin Yee Chen, Elsayed Z. Soliman, Mary R. Rooney, Alvaro Alonso
Summary: Higher serum magnesium is associated with a lower risk of cardiovascular events, especially myocardial infarction, in patients with atrial fibrillation.
Article
Hematology
Pamela L. Lutsey
Summary: The case-control design is an observational study design that compares the exposure prevalence between individuals with and without disease. Proper control selection is crucial for case-control study design, and optimizing control selection can maximize causal inference and enhance the scientific rigor of hematologic case-control studies.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Respiratory System
David M. MacDonald, Yuekai Ji, Selcuk Adabag, Alvaro Alonso, Lin Yee Chen, Benjamin E. Henkle, Stephen P. Juraschek, Faye L. Norby, Pamela L. Lutsey, Ken M. Kunisaki
Summary: This study found that better cardiovascular autonomic function was associated with a lower risk of COPD hospitalization, while worse autonomic function was associated with a higher risk of COPD hospitalization. This relationship was more significant in participants without airflow obstruction.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)