Journal
STEROIDS
Volume 152, Issue -, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2019.108492
Keywords
FGF/FGFR axis; Steroid receptor pathway; Nuclear FGF/FGFR; Endocrine-related tissues and cancer; Breast cancer; Endocrine resistance
Funding
- Institute Nacional del Cancer [20182019]
- Agencia Nacional de Promocion de Ciencia y Tecnologia (ANAPCYT) [PICT 2015/1022]
- Fundacion para el Progreso de la Medicina [C03]
- Fundacion Gador
- Fundacion Rene Baron
- Fundacion Williams
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Dysregulation of the fibroblast growth factors/fibroblast growth factor receptor (FGF/FGFR) pathway has been implicated in a wide range of human disorders and several members have been localized in the nuclear compartment. Hormone-activated steroid receptors or ligand independent activated receptors form nuclear complexes that activate gene transcription. This review aims to highlight the interplay between the steroid receptor and the FGF/FGFR pathways and focuses on the current knowledge on nuclear action of FGF members in endocrine-related tissues and cancer. The nuclear trafficking and targets of FGF/FGFR members and the available evidence on the interplay with steroid hormones and receptors is described. Finally, the data on aberrant FGF/FGFR signaling is summarized and the nuclear action of FGF members on endocrine resistant breast cancer is highlighted. Identifying the mechanisms underlying FGF-induced endocrine resistance will be important to understand how to efficiently target endocrine-related diseases and even enhance or restore endocrine sensitivity in hormone receptor positive tumors.
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