Article
Biochemistry & Molecular Biology
Xiaoxiao Chen, Yang Liu, Pu Li, Yichen Xing, Chaobiao Huang
Summary: A method for the trace detection of chloramphenicol (CAP) was established using a dual recognition system with a fluorescence quenching of quantum dots (QDs) and specific recognition of molecularly imprinted polymer (MIP). The MIP@SiO2@QDs showed good detection selectivity for CAP and was successfully applied to quantify CAP in lake water with promising potential for on-site detection in environmental waters.
Article
Spectroscopy
Rongkun Zhu, Mushen Lai, Mingfang Zhu, Huanru Liang, Qing Zhou, Rui Li, Wenhao Zhang, Hongqing Ye
Summary: A functional ratio fluorescence sensor based on molecularly imprinted polymer coated double quantum dots has been developed for the sensitive, selective, and visual detection of sinapic acid. The sensor shows a linear response range, low detection limit, ability to distinguish molecules with similar structure, as well as fast response time and long-lasting fluorescence intensity.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Spectroscopy
Manal A. Alossaimi, Abdulmalik S. A. Altamimi, Heba Elmansi, Galal Magdy
Summary: A new spectrofluorimetric method based on nitrogen-doped carbon quantum dots (N-CQDs) fluorescent probes was proposed for the determination of larotrectinib. The method is simple, involves no pre-treatment steps or complicated techniques, and showed sufficient sensitivity for the analysis of the drug. The synthesized N-CQDs exhibited high fluorescence intensity, allowing for the selective quenching and sensitive determination of larotrectinib.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Analytical
Yulu Liu, Lei Cao, Minghui Zan, Jiahui Peng, Panyong Wang, Xinpei Pang, Yan Zhang, Li Li, Wen-Fei Dong, Qian Mei
Summary: In this study, cyan fluorescent silicon quantum dots were synthesized for the rapid detection of chlorogenic acid (CGA), an important bioactive component in plants. The SiQDs showed high sensitivity and selectivity in detecting CGA, providing a valuable platform for biological and pharmaceutical analysis with broad application prospects.
Review
Chemistry, Multidisciplinary
Xinzhe Xiao, Yumin Zhang, Lei Zhou, Bin Li, Lin Gu
Summary: Graphene oxide (GO) is an excellent photoluminescence (PL) material with unique optical properties. It has been widely used in various fields such as material science and biomedicine. The luminescence mechanism of GO and GOQDs is still not fully understood, but they show potential in medical imaging and biosensors.
Article
Spectroscopy
Furkan Burak Sen, Nilay Begic, Mustafa Bener, Resat Apak
Summary: In this study, a fluorescent polyethylenimine capped carbon quantum dots (PEI-C-dots) probe was synthesized and used to detect TNT residues. The synthesized PEI-C-dots exhibited high fluorescence quantum yield and low detection limit for TNT. The detection of TNT was not interfered by similar structured explosives, common soil ions, and camouflage agents.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Spectroscopy
Mohamed Ahmed Abdel Hamid, Samar H. Elagamy, Aya Gamal, Fotouh R. Mansour
Summary: A simple and eco-friendly microwave method was used to prepare highly fluorescent nitrogen and sulfur co-doped carbon quantum dots (NS-CQDs) for the determination of ascorbic acid (ASC) in pharmaceutical dosage forms. The NS-CQDs were prepared within one minute using citric acid and L-cysteine. The fluorescence of NS-CQDs was quenched by ferric ions but could be restored by the addition of ASC due to its reducing properties.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Food Science & Technology
Wenshuo Zhang, Hongda Zhong, Pingping Zhao, Aiguo Shen, Houbin Li, Xinghai Liu
Summary: Carbon quantum dots (CDs) show great potential in detecting food ingredients and contaminants due to their easy preparation, good biocompatibility, and adjustable modification. The design of probes for CDs can be categorized into three types, with the introduction of functional groups on the surface being a key factor. The intermolecular interactions of different target substances play a role in determining the choice of carbon source and synthesis method.
Article
Chemistry, Analytical
Xue Sun, Minwen Jiang, Ligang Chen, Na Niu
Summary: A new ratiometric molecularly imprinted fluorescence probe based on biomass carbon quantum dots and europium ions has been developed for sensitive detection of tetracycline, with a linear fluorescence quenching range in milk of 25-2000 nM and a detection limit of 7.9 nM. The probe demonstrates high recoveries and low relative standard deviations, showing improved selectivity in practical applications.
Article
Spectroscopy
Yuting Wang, Fengming Zhang, Jia Liu, Bin Yang, Yue Yuan, Yanyan Zhou, Shuyun Bi
Summary: A method for detecting the content of nitrofurazone (NFZ) using fluorescence quenching of N-Acetyl-L-Cysteine (NAC) coated cadmium telluride quantum dots (CdTe QDs) was established. The synthesized CdTe QDs were characterized using transmission electron microscopy (TEM), fluorescence, and ultraviolet visible spectra (UV-vis). The interaction between NFZ and CdTe QDs was investigated by Stern-Volmer analysis and time-resolved fluorescence, and the binding forces were found to be hydrogen bonds or van der Waals forces. The method showed high correlation, with a detection limit of 0.04 μg mL-1 and good recovery rate and precision.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Review
Chemistry, Analytical
Myriam Diaz-Alvarez, Antonio Martin-Esteban
Summary: This paper reviews the development of optical sensors using a combination of quantum dots and molecularly imprinted polymers. These sensors overcome the limitations of traditional analytical methods and improve sensor selectivity and sensitivity.
Article
Nanoscience & Nanotechnology
Jesna K. George, Shwetharani Ramu, Vishaka V. Halali, R. Geetha Balakrishna
Summary: Perovskite quantum dots (PQDs) exhibit exceptional fluorescence property and are potential candidates for fluorescent metalion sensors. The study reveals the significance of inner filter effect (IFE) in perovskite sensing systems, which enhances detection limits. Two different sensing systems for Co2+ were developed with elucidation of the fluorescence quenching mechanism, a combination of FRET and IFE, and successful modification of PQDs to reduce IFE.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Multidisciplinary
Tong Xue, Yiyi Shi, Jie Guo, Meixian Guo, Ya Yan
Summary: Water-soluble AgInS2 quantum dots (AIS QDs) were successfully prepared and characterized for their properties. Factors affecting the fluorescence intensity of AIS QDs, as well as their stability and selectivity in detecting Pb2+, were investigated. Under optimized conditions, linear relationships between Pb2+ concentration and relative fluorescence quenching amount of AIS QDs were achieved, providing a method for the determination of Pb2+ content in water.
Article
Chemistry, Multidisciplinary
Xin Zhang, Bo Tang, Yansong Li, Chengbin Liu, Pengfei Jiao, Yuping Wei
Summary: A new strategy for designing molecularly imprinted magnetic fluorescent nanocomposites for selective fluorescence detection of target proteins has been proposed. The multifunctional nanocomposite with optics, magnetism, and biocompatibility has shown promising results in the detection of lysozyme in biological samples.
Article
Physics, Multidisciplinary
Mian Muhammad, Behisht Ara, Faiz Ali, Ikram Ullah
Summary: A simple and fast spectrofluorimetric method based on fluorescence quenching principle was established for determination of sparfloxacin, showing good linearity and accuracy.
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)