4.5 Article

NONLOCAL ADHESION MODELS FOR MICROORGANISMS ON BOUNDED DOMAINS

Journal

SIAM JOURNAL ON APPLIED MATHEMATICS
Volume 80, Issue 1, Pages 382-401

Publisher

SIAM PUBLICATIONS
DOI: 10.1137/19M1250315

Keywords

cell-cell adhesion; nonlocal models; no-flux boundary conditions; global existence; semigroups

Funding

  1. NSERC

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In 2006 Armstrong, Painter, and Sherratt formulated a nonlocal differential equation model for cell-cell adhesion. For the one-dimensional case on a bounded domain we derive various types of biological boundary conditions, describing adhesive, repulsive, and neutral boundaries. We prove local and global existence and uniqueness for the resulting integrodifferential equations. In numerical simulations we consider adhesive, repulsive, and neutral boundary conditions, and we show that the solutions mimic known behavior of fluid adhesion to boundaries. In addition, we observe interior pattern formation due to cell-cell adhesion.

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