Article
Oncology
Chengheng Liao, Cherise Ryan Glodowski, Cheng Fan, Juan Liu, Kevin R. Mott, Akash Kaushik, Hieu Vu, Jason W. Locasale, Samuel K. McBrayer, Ralph J. DeBerardinis, Charles M. Perou, Qing Zhang
Summary: Metabolic dysregulation in breast cancer was characterized and divided into two major metabolic groups. Genes strongly correlated with metabolic dysregulation and predicted patient prognosis were identified. Targeting metabolic dysregulation led to effective therapeutic outcomes. This study is of great significance in guiding therapeutic strategies for breast cancer subsets.
Article
Biochemistry & Molecular Biology
Shanna Dewaele, Louis Delhaye, Boel De Paepe, Eric James de Bony, Jilke De Wilde, Katrien Vanderheyden, Jasper Anckaert, Nurten Yigit, Justine Nuytens, Eveline Vanden Eynde, Joel Smet, Maxime Verschoore, Fariba Nemati, Didier Decaudin, Manuel Rodrigues, Peihua Zhao, Aart Jochemsen, Eleonora Leucci, Jo Vandesompele, Jo Van Dorpe, Jean-Christophe Marine, Rudy Van Coster, Sven Eyckerman, Pieter Mestdagh
Summary: The inhibition of SAMMSON in uveal melanoma cells has shown to impair cell growth and viability, induce apoptosis, and affect protein translation levels, highlighting its potential as a therapeutic target. This study demonstrates the essential role of SAMMSON expression in uveal melanoma cell survival, suggesting ASO-mediated silencing of SAMMSON as a promising treatment strategy for both primary and metastatic uveal melanoma patients.
Article
Oncology
Zhang Yang, Shun-Qing Liang, Liang Zhao, Haitang Yang, Thomas M. Marti, Balazs Hegedus, Yanyun Gao, Bin Zheng, Chun Chen, Wenxiang Wang, Patrick Dorn, Gregor J. Kocher, Ralph A. Schmid, Ren-Wang Peng
Summary: This study reveals the metabolic dependency induced by mutant KRAS and identifies nucleolar protein 5A (NOP56) and mTOR as potential targets for the treatment of KRAS-mutant cancers. The depletion of NOP56 leads to synthetic lethal susceptibility to mTOR inhibition due to the regulation of ROS homeostasis. Co-targeting NOP56 and mTOR significantly enhances cell death in KRAS-mutant tumor cells.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
E. C. de Heer, C. E. Zois, E. Bridges, B. van der Vegt, H. Sheldon, W. A. Veldman, M. C. Zwager, T. van der Sluis, S. Haider, T. Morita, O. Baba, C. P. Schroder, S. de Jong, A. L. Harris, M. Jalving
Summary: The study found that the gene GYS1 is related to tumor growth and therapy resistance in breast cancer, especially in triple-negative breast cancer. Inhibiting GYS1 weakens the proliferation ability of breast cancer cells and makes them more sensitive to inhibition of mitochondrial proteostasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biology
Tingting Shao, Yunjin Xie, Jingyi Shi, Changbo Yang, Haozhe Zou, Yongsheng Li, Juan Xu, Xia Li
Summary: This study proposes a multiple-step model to identify lncRNA-lncRNA immune cooperation and constructs lncRNA immune cooperative networks. These networks may modulate tumor-immune microenvironment by regulating immune-related functions. The study also reveals important immune cooperative lncRNAs that play central roles in multiple cancers and are correlated with known anticancer drug targets.
COMMUNICATIONS BIOLOGY
(2022)
Article
Oncology
Maisoon Matareed, Eleftheria Maranou, Saara A. Koskela, Arfa Mehmood, Helen Kalirai, Sarah E. Coupland, Carlos R. Figueiredo
Summary: Loss of BAP1 gene expression in metastatic uveal melanoma triggers immunosuppressive mechanisms in the tumor microenvironment. PLIN2 expression serves as a prognostic biomarker in uveal melanoma. Loss of adipophilin expression is significantly associated with monosomy 3 status and nuclear BAP1 losses in uveal melanoma tumors.
JOURNAL OF PATHOLOGY
(2023)
Article
Oncology
Yijie Xie, Guangxiong Chen
Summary: This study found that SNHG12 is highly expressed in melanoma and promotes the expression of ETS1, PXN, JAG1, and DDR1 through targeted regulation of miR-199b, thereby promoting the proliferation, migration, and invasion of melanoma cells.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Fatemeh Zahedipour, Parvin Zamani, Khadijeh Jamialahmadi, Mahmoud Reza Jaafari, Amirhossein Sahebkar
Summary: Angiogenesis plays a significant role in the metastasis and progression of melanoma. Vaccines targeting angiogenesis in melanoma, including specific immunotherapy, show promise in inducing strong anti-tumor immune responses by targeting genetically stable endothelial cells. Various types of vaccines, such as DNA, peptide, protein, dendritic cell-based, and endothelial cell vaccines, have been studied to target angiogenesis in melanoma for potential progress in developing effective treatments.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Clinical Neurology
Wen Pan, Yuan Gao, Weifeng Wan, Wenfeng Xiao, Chao You
Summary: The study revealed that SAMMSON is overexpressed in intracranial aneurysm (IA) and suppresses vascular smooth muscle cell (VSMC) proliferation by inhibiting the maturation of miR-130a.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Review
Oncology
Dimitri Kasakovski, Marina Skrygan, Thilo Gambichler, Laura Susok
Summary: Cutaneous Melanoma (CM) is an aggressive cancer originating from pigment-producing melanocytes in the skin, with high metastatic potential. Although it represents a small fraction of skin cancers, it accounts for most skin-cancer-related deaths globally. Immune checkpoint inhibition has been a significant therapeutic approach, but challenges such as the immunosuppressive tumor microenvironment and treatment resistance persist. Combining local and systemic treatments can enhance therapeutic response and overcome resistance, yet complex drug combinations may increase the risk of immune-related adverse events.
Review
Oncology
Julia S. L. Lim, Phyllis S. Y. Chong, Wee-Joo Chng
Summary: The advent of novel therapeutics has revolutionized the therapeutic scene of multiple myeloma. The emerging field of cancer metabolism has revealed metabolic vulnerabilities in myeloma that can be exploited for new therapeutic interventions. This review summarizes recent findings on metabolic abnormalities in myeloma and their clinical implications, highlighting the potential targets that might revolutionize the field.
Article
Pharmacology & Pharmacy
Xiang Gu, Yu Hua, Jie Yu, Ludi Yang, Shengfang Ge, Renbing Jia, Peiwei Chai, Ai Zhuang, Xianqun Fan
Summary: Uveal melanoma (UM) is a common and dangerous ocular malignancy in adults, and aberrant histone methylation plays a role in its development. This study identified that DOT1L, a methyltransferase of histone H3 lysine 79 (H3K79), was activated in UM, especially in high-risk cases. DOT1L inhibitors showed tumor-selective inhibitory effects on UM cells. The study also revealed that DOT1L facilitated H3K79 methylation of NAPRT, which enhanced NAD+ synthesis and contributed to oncogenesis. DOT1L inhibition silenced NAPRT expression and inhibited the malignant behaviors of UM. These findings provide insights into the histone methylation landscape in UM and uncover a novel oncogenic mechanism involving DOT1L and NAPRT.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Article
Biotechnology & Applied Microbiology
Jiongliang Wang, Yinguang Hou, Yu Wang, Hansheng Zhao
Summary: This study provides a comprehensive landscape of lncRNAs in moso bamboo, identifying SCW-related lncRNAs and shedding light on lignin and flavonoids biosynthesis. Through extensive data collection and machine learning methods, the researchers established a network of lncRNA-coding genes and proposed a mechanism for directing phenylpropanoid intermediates in bamboo.
Article
Cell Biology
Shen Wang, Jun Zhang, Yu'an Ding, Haotian Zhang, Xiang Wu, Lingci Huang, Junjie He, Jun Zhou, Xiao-Min Liu
Summary: Long noncoding RNAs (lncRNAs) play vital roles in the regulation of gene expression during embryonic stem cell (ESC) self-renewal and differentiation. This study systematically analyzed the differentially regulated lncRNAs during ESC-derived cardiomyocyte (CM) differentiation and revealed their interaction with transcription factors and epigenetic and epitranscriptomic factors. The study also identified the interplay between epitranscriptomic modification and key lncRNAs in the regulation of cell fate decision.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
B. Tellman, J. A. Sullivan, C. Kuhn, A. J. Kettner, C. S. Doyle, G. R. Brakenridge, T. A. Erickson, D. A. Slayback
Summary: Satellite imagery from 2000 to 2018 indicates that the proportion of global population exposed to floods is increasing, highlighting the importance of investing in flood adaptation strategies to reduce loss of life and livelihood. Changes in where and how floods occur, as well as the population exposed, are being influenced by urbanization, flood mitigation infrastructure, and settlements in floodplains. The high spatial and temporal resolution of satellite observations will enhance understanding of flood changes and adaptation methods.
Article
Oncology
Anna M. Grawenda, Elen K. Moller, Suzanne Lam, Emmanouela Repapi, Amina F. A. S. Teunisse, Grethe I. G. Alnaes, Anne-Lise Borresen-Dale, Vessela N. Kristensen, Colin R. Goding, Aart G. Jochemsen, Hege Edvardsen, Gareth L. Bond
Article
Biochemistry & Molecular Biology
Nikola Vlahov, Simon Scrace, Manuel Sarmiento Soto, Anna M. Grawenda, Leanne Bradley, Daniela Pankova, Angelos Papaspyropoulos, Karen S. Yee, Francesca Buffa, Colin R. Goding, Paul Timpson, Nicola Sibson, Eric O'Neill
Article
Cell Biology
Tianyi Zhang, Qingxiang Zhou, Margret Helga Ogmundsdottir, Katrin Moeller, Robert Siddaway, Lionel Larue, Michael Hsing, Sek Won Kong, Colin Ronald Goding, Arnar Palsson, Eirikur Steingrimsson, Francesca Pignoni
JOURNAL OF CELL SCIENCE
(2015)
Correction
Oncology
Min Lu, Hilde Breyssens, Victoria Salter, Shan Zhong, Ying Hu, Caroline Baer, Indrika Ratnayaka, Alex Sullivan, Nicholas R. Brown, Jane Endicott, Stefan Knapp, Benedikt M. Kessler, Mark R. Middleton, Christian Siebold, E. Yvonne Jones, Elena V. Sviderskaya, Jonathan Cebon, Thomas John, Otavia L. Caballero, Colin R. Goding, Xin Lu
Article
Biochemistry & Molecular Biology
F. Faiao-Flores, D. K. Alves-Fernandes, P. C. Pennacchi, S. Sandri, A. L. S. A. Vicente, C. Scapulatempo-Neto, V. L. Vazquez, R. M. Reis, J. Chauhan, C. R. Goding, K. S. Smalley, S. S. Maria-Engler
Article
Multidisciplinary Sciences
Eva Perez-Guijarro, Panagiotis Karras, Metehan Cifdaloz, Raul Martinez-Herranz, Estela Canon, Osvaldo Grana, Celia Horcajada-Reales, Direna Alonso-Curbelo, Tonantzin G. Calvo, Gonzalo Gomez-Lopez, Nicolas Bellora, Erica Riveiro-Falkenbach, Pablo L. Ortiz-Romero, Jose L. Rodriguez-Peralto, Lorena Maestre, Giovanna Roncador, Juan C. de Agustin Asensio, Colin R. Goding, Eduardo Eyras, Diego Megias, Raul Mendez, Maria S. Soengas
NATURE COMMUNICATIONS
(2016)
Article
Cell Biology
Pavel Savitsky, Tobias Krojer, Takao Fujisawa, Jean-Philippe Lambert, Sarah Picaud, Chen-Yi Wang, Erin K. Shanle, Krzysztof Krajewski, Hans Friedrichsen, Alexander Kanapin, Colin Goding, Matthieu Schapira, Anastasia Samsonova, Brian D. Strahl, Anne-Claude Gingras, Panagis Filippakopoulos
Article
Cell Biology
Paola Falletta, Luis Sanchez-del-Campo, Jagat Chauhan, Maike Effern, Amy Kenyon, Christopher J. Kershaw, Robert Siddaway, Richard Lisle, Rasmus Freter, Matthew J. Daniels, Xin Lu, Thomas Tueting, Mark Middleton, Francesca M. Buffa, Anne E. Willis, Graham Pavitt, Ze'ev A. Ronai, Tatjana Sauka-Spengler, Michael Hoelzel, Colin R. Goding
GENES & DEVELOPMENT
(2017)
Article
Oncology
Bengt Phung, Julhash U. Kazi, Alicia Lundby, Kristin Bergsteinsdottir, Jianmin Sun, Colin R. Goding, Goran Jonsson, Jesper V. Olsen, Eirikur Steingrimsson, Lars Ronnstrand
MOLECULAR CANCER RESEARCH
(2017)
Article
Multidisciplinary Sciences
Shuyang Chen, Bo Zhu, Chengqian Yin, Wei Liu, Changpeng Han, Baoen Chen, Tongzheng Liu, Xin Li, Xiang Chen, Chunying Li, Limin Hu, Jun Zhou, Zhi-Xiang Xu, Xiumei Gao, Xu Wu, Colin R. Goding, Rutao Cui
Article
Multidisciplinary Sciences
Jose Mario Gonzalez-Meljem, Scott Haston, Gabriela Carreno, John R. Apps, Sara Pozzi, Christina Stache, Grace Kaushal, Alex Virasami, Leonidas Panousopoulos, Seyedeh Neda Mousavy-Gharavy, Ana Guerrero, Mamunur Rashid, Nital Jani, Colin R. Goding, Thomas S. Jacques, David J. Adams, Jesus Gil, Cynthia L. Andoniadou, Juan Pedro Martinez-Barbera
NATURE COMMUNICATIONS
(2017)
Article
Medicine, General & Internal
Mitchell E. Fane, Yash Chhabra, David E. J. Hollingsworth, Jacinta L. Simmons, Loredana Spoerri, Tae Gyu Oh, Jagat Chauhan, Toby Chin, Lachlan Harris, Tracey J. Harvey, George E. O. Muscat, Colin R. Goding, Richard A. Sturm, Nikolas K. Haass, Glen M. Boyle, Michael Piper, Aaron G. Smith
Article
Multidisciplinary Sciences
Bo Zhu, Shuyang Chen, Hongshen Wang, Chengqian Yin, Changpeng Han, Cong Peng, Zhaoqian Liu, Lixin Wan, Xiaoyang Zhang, Jie Zhang, Christine G. Lian, Peilin Ma, Zhi-xiang Xu, Sharon Prince, Tao Wang, Xiumei Gao, Yujiang Shi, Dali Liu, Min Liu, Wenyi Wei, Zhi Wei, Jingxuan Pan, Yongjun Wang, Zhenyu Xuan, Jay Hess, Nicholas K. Hayward, Colin R. Goding, Xiang Chen, Jun Zhou, Rutao Cui
NATURE COMMUNICATIONS
(2018)
Article
Oncology
Giovanni Stracquadanio, Xuting Wang, Marsha D. Wallace, Anna M. Grawenda, Ping Zhang, Juliet Hewitt, Jorge Zeron-Medina, Francesc Castro-Giner, Ianp. Tomlinson, Colin R. Goding, Kamil J. Cygan, William G. Fairbrother, Laurent F. Thomas, Pal Soetrom, Federica Gemignani, Stefano Landi, Benjamin Schuster-Boeckler, Douglas A. Bell, Gareth L. Bond
NATURE REVIEWS CANCER
(2016)
