Structural basis for strand-transfer inhibitor binding to HIV intasomes

Non-Uniformity of Projection Distributions Attenuates Resolution in Cryo-EM

(2019) Philip R. Baldwin et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Real-time cryo-electron microscopy data preprocessing with Warp

(2019) Dimitry Tegunov et al.   NATURE METHODS

HIV-1 integrase inhibitors that are broadly effective against drug-resistant mutants

(2018) Steven J. Smith et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efficacies of Cabotegravir and Bictegravir against drug-resistant HIV-1 integrase mutants

(2018) Steven J. Smith et al.   Retrovirology

cisTEM, user-friendly software for single-particle image processing

(2018) Timothy Grant et al.   eLife

2018 IAS-USA Recommendations for the Use of Antiretroviral Therapy for HIV

(2018) James Riddell   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors

(2017) Xue Zhi Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Addressing preferred specimen orientation in single-particle cryo-EM through tilting

(2017) Yong Zi Tan et al.   NATURE METHODS

HIV drug resistance against strand transfer integrase inhibitors

(2017) Kaitlin Anstett et al.   Retrovirology

Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome

(2017) Dario Oliveira Passos et al.   SCIENCE

A supramolecular assembly mediates lentiviral DNA integration

(2017) Allison Ballandras-Colas et al.   SCIENCE

HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases

(2016) Xue Zhi Zhao et al.   ACS Chemical Biology

Progress Toward HIV Eradication: Case Reports, Current Efforts, and the Challenges Associated with Cure

(2016) Alyssa R. Martin et al.   Annual Review of Medicine

Retroviral DNA Integration

(2016) Paul Lesbats et al.   CHEMICAL REVIEWS

Crystal structure of the Rous sarcoma virus intasome

(2016) Zhiqi Yin et al.   NATURE

Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function

(2016) Allison Ballandras-Colas et al.   NATURE

Rilpivirine analogs potently inhibit drug-resistant HIV-1 mutants

(2016) Steven J. Smith et al.   Retrovirology

Improving Viral Protease Inhibitors to Counter Drug Resistance

(2016) Nese Kurt Yilmaz et al.   TRENDS IN MICROBIOLOGY

Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6

(2015) Timothy Grant et al.   eLife

4-Amino-1-hydroxy-2-oxo-1,8-naphthyridine-Containing Compounds Having High Potency against Raltegravir-Resistant Integrase Mutants of HIV-1

(2014) Xue Zhi Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Engineered Hyperactive Integrase for Concerted HIV-1 DNA Integration

(2014) Min Li et al.   PLoS One

Resistance to HIV integrase strand transfer inhibitors: in vitro findings and clinical consequences

(2014) Jay A. Grobler et al.   Current Opinion in Virology

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

(2014) Steven J. Smith et al.   Jove-Journal of Visualized Experiments

Substrate Envelope-Designed Potent HIV-1 Protease Inhibitors to Avoid Drug Resistance

(2013) Madhavi N.L. Nalam et al.   CHEMISTRY & BIOLOGY

HIV-1 Antiretroviral Drug Therapy

(2013) E. J. Arts et al.   Cold Spring Harbor Perspectives in Medicine

HIV DNA Integration

(2013) R. Craigie et al.   Cold Spring Harbor Perspectives in Medicine

HIV integrase as a target for antiretroviral therapy

(2012) Daria J. Hazuda   Current Opinion in HIV and AIDS

Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)

(2011) S. Hare et al.   MOLECULAR PHARMACOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Retroviral intasome assembly and inhibition of DNA strand transfer

(2010) Stephen Hare et al.   NATURE

The mechanism of retroviral integration from X-ray structures of its key intermediates

(2010) Goedele N. Maertens et al.   NATURE

Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance

(2010) S. Hare et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

electronic Ligand Builder and Optimization Workbench(eLBOW): a tool for ligand coordinate and restraint generation

(2009) Nigel W. Moriarty et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Appion: An integrated, database-driven pipeline to facilitate EM image processing

(2009) Gabriel C. Lander et al.   JOURNAL OF STRUCTURAL BIOLOGY

The Terminal (Catalytic) Adenosine of the HIV LTR Controls the Kinetics of Binding and Dissociation of HIV Integrase Strand Transfer Inhibitors

(2008) David R. Langley et al.   BIOCHEMISTRY