Article
Oncology
Junjie Huang, Sze Chai Chan, Chun Ho Ngai, Veeleah Lok, Lin Zhang, Don Eliseo Lucero-Prisno, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C. S. Wong
Summary: The incidence and mortality rates of childhood cancer vary between different countries. This study used data from the Cancer Incidence in Five Continents Time Trends, Nordic Cancer Registries, Surveillance, Epidemiology and End Results, and WHO Mortality databases to extract the Age-Standardised Rates (ASR) of cancer incidence and mortality among children aged 0-14 years old. The country-specific Average Annual Percentage Change (AAPC) and its corresponding 95% confidence interval (CI) were calculated to determine the epidemiological cancer trend. The results showed that low-income countries had the highest mortality and mortality to incidence ratio of childhood cancer. The incidence of childhood cancer showed an overall increasing trend, while the mortality rate decreased over the past decade.
Article
Oncology
Gabriela A. Rojas, Aubrey K. Hubbard, Brandon J. Diessner, Karina B. Ribeiro, Logan G. Spector
Summary: The study analyzed the incidence of osteosarcoma in different geographic regions and age groups using CI5 data, finding that there was little variation in incidence between regions during 2008-2012. The incidence exhibited a bimodal distribution, with peaks in the 10-19 and 60-79 age groups.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Hematology
Joel Joelsson, Tove Wasterlid, Richard Rosenquist, Lasse Hjort Jakobsen, Tarec C. El-Galaly, Karin E. Smedby, Sandra Eloranta
Summary: Considering the changes in treatment and prognosis for non-Hodgkin lymphoma (NHL), understanding long-term health outcomes and treatment-related complications has become increasingly important. This study investigates the time trends of second primary malignancies (SPMs) in Swedish NHL patients, both before and after the introduction of anti-CD20 antibody therapy. The findings indicate that NHL survivors have a higher risk of solid tumors and hematologic malignancies, particularly myelodysplastic syndrome/acute myeloid leukemia. The study also suggests that modern treatment standards are not associated with modified SPM risk, but nonchemotherapy-based treatments may help reduce the risk of myelodysplastic syndrome/acute myeloid leukemia in follicular lymphoma patients.
Article
Multidisciplinary Sciences
Bolun Zhou, Fenglong Bie, Ruochuan Zang, Moyan Zhang, Peng Song, Lei Liu, Yue Peng, Guangyu Bai, Qilin Huai, Yuan Li, Liang Zhao, Shugeng Gao
Summary: This study provides a comprehensive analysis of the global geographic patterns and temporal trends in the mortality and incidence of oesophageal cancer. The results show that the mortality and incidence trends have significantly decreased in most countries of South America and Asia, but varied in European countries. The study highlights the importance of implementing preventative efforts for populations with rising mortality and incidence trends.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Medicine, General & Internal
Jaeyoung Choi, Esther Park, Ah Young Choi, Meong Hi Son, Joongbum Cho
Summary: Monitoring mortality trends in critically ill children can help improve survival rates. The study found that the in-hospital mortality rate of critically ill children in Korea decreased from 2012 to 2018, and this improvement was associated with the presence of dedicated intensivists and admission to pediatric ICU.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Chung-Fen Tsai, Ya-Hui Wang, Nai-Chi Teng, Ping-Keung Yip, Li-Kwang Chen
Summary: The incidence rate of first-ever stroke in Taiwan has decreased in both Chinese men and women in the early 21st century. Men have a higher incidence rate than women. Furthermore, the incidence of intracerebral hemorrhage has significantly decreased, while that of ischemic stroke has slightly decreased, with a significant decrease observed only in women.
Article
Orthopedics
Charles A. Johnson, William N. Newton, Luke LaRochelle, Charles A. Daly
Summary: Bicycle utilization has been increasing annually, with a recent surge due to the COVID-19 pandemic. However, there is limited epidemiologic data on bicycle-related injuries. This study aimed to analyze trends in bicycle-related injuries from 2012 to 2021. The results showed a significant decrease in injury rates over time, but an increase in injuries among elderly patients. Head injuries were the most common among all age groups, emphasizing the importance of bicycle safety initiatives and helmet-wearing regardless of age.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Mehul Lamba, Jing Hieng Ngu, Catherine A. M. Stedman
Summary: In a population-based prospective study conducted in Canterbury, New Zealand, it was found that the incidence of autoimmune hepatitis (AIH) was significantly higher in the period of 2014-2016 compared to 2008-2010, while the incidences of primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) remained unchanged over the same period. Further research is needed to understand the reasons for these changes in incidence rates of autoimmune liver diseases.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Junjie Huang, Sze Chai Chan, Yat Ching Fung, Fung Yu Mak, Veeleah Lok, Lin Zhang, Xu Lin, Don Eliseo Lucero-prisno, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C. S. Wong
Summary: This study comprehensively analyzed the incidence, risk factors, and trends of small intestinal cancer by sex, age, and country. It found a significant geographic disparity in the burden of small intestinal cancer, with higher incidence in countries with higher human development index, gross domestic product, and prevalence of unhealthy lifestyle habits, metabolic disorders, and inflammatory bowel disease. The study also revealed an overall increasing trend in small intestinal cancer incidence.
Article
Immunology
Cosmos L. T. Guo, Thomas N. Y. Kwong, Joyce W. Y. Mak, Lin Zhang, Grace C. Y. Lui, Grace L. H. Wong, Margaret Ip, Jun Yu, Joseph J. Y. Sung, William K. K. Wu, Sunny H. Wong
Summary: A territorywide survey in Hong Kong found a significant number of CDI cases among hospitalized patients, with the majority being healthcare-associated. While the incidence of CDI increased over the years, it plateaued in 2018 and 2019, with a decrease in 30-day mortality rates and constant 60-day recurrence rates. The study also showed a strong correlation between CDI incidence trend and overall antimicrobial drug use, which has decreased due to an antibiotic stewardship program initiated in 2017.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Pediatrics
Jitendra Meena, Georgie Mathew, Jogender Kumar, Rahul Chanchlani
Summary: Limited literature shows a high incidence of acute kidney injury (AKI) and increased mortality risk in hospitalized children. The incidence of AKI and associated mortality vary in different countries with different income levels.
Article
Medicine, General & Internal
Santina Conte, Francois Lagace, Feras M. M. Ghazawi, Leila Cattelan, Siddharth Nath, Jobanpreet Dhillon, Hacene Nedjar, Elham Rahme, Denis Sasseville, Miguel N. N. Burnier Jr, Ivan V. V. Litvinov
Summary: This study shows a consistent increase in the incidence of uveal melanoma in Canada from 2011 to 2017.
FRONTIERS IN MEDICINE
(2023)
Article
Oncology
Mingaile Drevinskaite, Ausvydas Patasius, Marius Kincius, Justinas Jonusas, Adomas Ladukas, Mindaugas Jievaltas, Laura Kairevice, Giedre Smailyte
Summary: This study analyzed trends in penile cancer incidence, mortality, and relative survival in Lithuania from 1998 to 2017. The results showed an increasing incidence rate of penile cancer in Lithuania, but a decreasing mortality rate. One-year and five-year relative survival rates of patients with penile cancer improved over time, but were still lower than those in Northern European countries.
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Anne Eudes Jean Baptiste, Balcha Masresha, John Wagai, Richard Luce, Joseph Oteri, Boubacar Dieng, Samuel Bawa, Obianuju Caroline Ikeonu, Martin Chukwuji, Fiona Braka, E. A. M. Sanders, Susan Hahne, Eelko Hak
Summary: Nigeria is focusing on improving measles vaccination coverage and case-based surveillance to achieve measles elimination. However, survey results show suboptimal vaccination coverage and critically high measles incidence rates, especially in the Northern region.
Article
Oncology
Kayo Nakata, Sumiyo Okawa, Shigeo Fuji, Akira Sato, Toshitaka Morishima, Yuma Tada, Masami Inoue, Junichi Hara, Keisei Kawa, Isao Miyashiro
Summary: The study focused on examining the trends in leukemia survival among children and AYAs over a 37-year period in Osaka, Japan. Significant improvements were observed in 5-year overall survival probability for all leukemia types, especially after the introduction of treatment regimens or molecularly targeted therapies. Patient centralization at designated cancer care hospitals may be an effective strategy to improve survival outcomes.
Article
Public, Environmental & Occupational Health
Catherine Enders, Rebecca J. Hyde, Steve Selvin, Catherine Metayer, Stephen Starko Francis
Article
Oncology
Yukiko Yano, Courtney Schiffman, Hasmik Grigoryan, Josie Hayes, William Edmands, Lauren Petrick, Todd Whitehead, Catherine Metayer, Sandrine Dudoit, Stephen Rappaport
Article
Oncology
Chenan Zhang, Quinn T. Ostrom, Helen M. Hansen, Julio Gonzalez-Maya, Donglei Hu, Elad Ziv, Libby Morimoto, Adam J. de Smith, Ivo S. Muskens, Cassie N. Kline, Zalman Vaksman, Hakon Hakonarson, Sharon J. Diskin, Carol Kruchko, Jill S. Barnholtz-Sloan, Vijay Ramaswamy, Francis Ali-Osman, Melissa L. Bondy, Michael D. Taylor, Catherine Metayer, Joseph L. Wiemels, Kyle M. Walsh
Review
Environmental Sciences
Stephanie M. Holm, Mark D. Miller, John R. Balmes
Summary: Wildfire smoke poses a growing threat to children's health, prompting the need for improved public health messaging and responses. Tools such as low-cost sensors, respirators, and measures to reduce exposure in school environments can help mitigate the impact of wildfire smoke on children.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2021)
Article
Endocrinology & Metabolism
Nicole C. Deziel, Yawei Zhang, Rong Wang, Joseph L. Wiemels, Libby Morimoto, Cassandra J. Clark, Catherine Metayer, Xiaomei Ma
Summary: The study revealed that Hispanic ethnicity, higher birth weight, higher maternal education, and lower birth order are associated with an increased risk of pediatric thyroid cancer, while male sex and higher birth order are associated with a decreased risk. Additional areas of investigation into biological mechanisms of this malignancy have been suggested based on the findings.
Article
Environmental Sciences
David C. Wheeler, Salem Rustom, Matthew Carli, Todd P. Whitehead, Mary H. Ward, Catherine Metayer
Summary: This study highlights the importance of evaluating multiple chemical exposures in identifying cancer risk factors. The GWQS regression method proves to be effective in estimating exposure effects for multiple chemical groups and correctly identifying important chemicals, showing favorable performance compared to other methods used in mixture analysis. The method was applied in the California Childhood Leukemia Study, revealing a positive association between exposure to the herbicide dacthal and an increased risk of childhood leukemia.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Letter
Food Science & Technology
Mark D. Miller, Mari S. Golub, Melanie A. Marty
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Chemistry, Medicinal
Nathalie Pham, Mark D. Miller, Melanie Marty
Summary: Evidence from human and animal studies suggests a link between synthetic food dyes and adverse neurobehavioral outcomes in children. This study developed a method to evaluate FDA-certified food dyes using HTS data to assess potential molecular mechanisms related to neurological pathway disturbances. Results showed some dyes impacting neurological gene targets, providing insight into the possible mechanisms behind neurobehavioral effects observed in in vivo studies.
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Review
Environmental Sciences
Mark D. Miller, Craig Steinmaus, Mari S. Golub, Rosemary Castorina, Ruwan Thilakartne, Asa Bradman, Melanie A. Marty
Summary: The California Office of Environmental Health Hazard Assessment (OEHHA) conducted a review on the impact of synthetic food dyes on children's behavior and found evidence from clinical trials and animal toxicology literature supporting an association between synthetic food dyes and behavioral impacts in children. The current acceptable daily intake standards by the Food and Drug Administration (FDA) may not adequately protect neurobehavior in susceptible children, and there is a need for re-evaluation and additional research.
ENVIRONMENTAL HEALTH
(2022)
Article
Environmental Sciences
Ruwan Thilakaratne, Rosemary Castorina, Mayela Gillan, Dorothy Han, Teja Pattabhiraman, Anuroop Nirula, Mark D. Miller, Melanie Marty, Arlie Lehmkuhler, Alyson Mitchell, Asa Bradman
Summary: Through studying over-the-counter medications and vitamins, it was found that children and pregnant women may be exposed to synthetic color additives (SCAs) at levels comparable to those from food consumption. The findings of this research are important for assessing the impact of SCA exposure on health and providing valuable information for parents concerned about the health effects of SCAs.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Article
Environmental Sciences
Asa Bradman, Rosemary Castorina, Ruwan Thilakaratne, Mayela Gillan, Teja Pattabhiraman, Anuroop Nirula, Melanie Marty, Mark D. Miller
Summary: This study investigated the exposure to artificial food colors (AFCs) in women of childbearing age, pregnant women, and children in the United States and compared them to acceptable daily intakes (ADIs) set by the FDA and WHO. The findings showed higher exposure in children, especially to Red No. 40. Juice drinks, soft drinks, icings, and ice cream cones were major contributors to AFC exposure in children. Participants with lower incomes, education, and of African American ethnicity had higher AFC intakes.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Oncology
Daphne Y. Lichtensztajn, Brenda M. Hofer, John T. Leppert, James D. Brooks, Benjamin I. Chung, Sumit A. Shah, Mindy C. DeRouen, Iona Cheng
Summary: This study found associations between renal cell carcinoma (RCC) subtype and patient demographics, comorbidity, and neighborhood socioeconomic status (nSES). The distribution of RCC subtypes varied significantly by race and ethnicity. Hypertension, diabetes, and kidney disease were associated with specific RCC subtypes. These findings suggest that targeted treatments or prevention efforts for RCC may have varying effects across different population subgroups.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Respiratory System
Mary B. Rice, Sarah B. Henderson, Allison A. Lambert, Kevin R. Cromar, John A. Hall, Wayne E. Cascio, Paul G. Smith, Brenda J. Marsh, Sarah Coefield, John R. Balmes, Ali Kamal, M. Ian Gilmour, Chris Carlsten, Kathleen M. Navarro, Gwen W. Collman, Ana Rappold, Mark D. Miller, Susan L. Stone, Daniel L. Costa
Summary: Wildland fires are reducing air quality and posing respiratory health risks. Research is needed to understand the short-term and long-term health effects of wildland fire smoke exposure, especially for vulnerable populations like children, adults, and occupational groups. It is important to invest in research, communication strategies, and public policy to address the growing problem of wildland fires and their health impacts.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Oncology
Stephen S. Francis, Rong Wang, Catherine Enders, Isabel Prado, Joseph L. Wiemels, Xiaomei Ma, Catherine Metayer
Summary: The study found that lower socioeconomic status is associated with a reduced risk of childhood CNS tumors. This relationship was most consistent in astrocytomas and ependymomas, with varying findings for embryonal tumors. Further research is needed to determine specific exposures that may explain the increased risk of childhood CNS tumors associated with higher parental SES.
CANCER CAUSES & CONTROL
(2021)
Article
Neurosciences
Chenan Zhang, Quinn T. Ostrom, Eleanor C. Semmes, Vijay Ramaswamy, Helen M. Hansen, Libby Morimoto, Adam J. de Smith, Melike Pekmezci, Zalman Vaksman, Hakon Hakonarson, Sharon J. Diskin, Catherine Metayer, Michael D. Taylor, Joseph L. Wiemels, Melissa L. Bondy, Kyle M. Walsh
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2020)
