Article
Oncology
Marco Maltoni, Emanuela Scarpi, Monia Dall'Agata, Simona Micheletti, Maria Caterina Pallotti, Martina Pieri, Marianna Ricci, Antonino Romeo, Maria Valentina Tenti, Luca Tontini, Romina Rossi
Summary: This study evaluated the accuracy of various clinical prediction models in predicting survival in cancer patients, and found that the PaP score had higher accuracy in predicting survival. This is important for selecting candidates for palliative radiotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yusuke Hiratsuka, Seok-Joon Yoon, Sang-Yeon Suh, Sung-Eun Choi, David Hui, Sun-Hyun Kim, Eon Sook Lee, Sun Wook Hwang, Shao-Yi Cheng, Ping-Jen Chen, Masanori Mori, Takashi Yamaguchi, Tatsuya Morita, Satoru Tsuneto, Akira Inoue
Summary: This study compared the performance of the Palliative Prognostic Scores (PaP) with or without clinicians' prediction of survival (CPS) across Japan, Korea, and Taiwan. The PaP total scores and the PaP-CPS showed similar discriminative accuracy in predicting 30-day survival among patients with advanced cancer in these countries. It may be sufficient for experienced clinicians to use the CPS alone for estimating short-term survival in this patient population, while the PaP may help improve prognostic confidence and reduce subjective variations.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Biochemistry & Molecular Biology
Zengyu Feng, Hao Qian, Kexian Li, Jianyao Lou, Yulian Wu, Chenghong Peng
Summary: This study established a seven-gene signature that can effectively predict the overall survival and disease-free survival of patients with pancreatic ductal adenocarcinoma, providing potential for personalized treatment and management strategies.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Medicine, General & Internal
Wenlin Chen, Chuxiang Lei, Yuekun Wang, Dan Guo, Sumei Zhang, Xiaoxi Wang, Zixin Zhang, Yu Wang, Wenbin Ma
Summary: In this study, ferroptosis-related genes associated with glioblastoma (GBM) were identified and a risk score model was constructed based on these genes. The model showed a significant difference in overall survival between high- and low-risk groups, suggesting its potential as a prognostic tool for GBM patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Ning Xue, Guoping Ou, Weiguo Ma, Lina Jia, Jiahe Sheng, Qingxia Xu, Yubo Liu, Miaomiao Jia
Summary: The study developed and validated a predictive model for the overall survival of patients with nasopharyngeal carcinoma, and identified important features associated with patient survival. The established risk score model and nomogram provided more accurate prognostic prediction for individual patients.
CANCER CELL INTERNATIONAL
(2021)
Review
Oncology
Patrick Stone, Nicola White, Linda J. M. Oostendorp, Henry Llewellyn, Victoria Vickerstaff
Summary: A systematic review compared the prognostic tools PaP and CPS in patients with advanced cancer, finding that both were equally accurate in predicting survival probabilities. Total PaP scores showed good discrimination in predicting patients' length of survival, indicating potential utility in clinical practice but requiring further definition of its role.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Christoph Fisser, Luis Alberto Rincon-Gutierrez, Tone Bull Enger, Fabio Silvio Taccone, Lars Mikael Broman, Mirko Belliato, Leda Nobile, Federico Pappalardo, Maximilian V. Malfertheiner
Summary: The study compared and validated multiple prediction scores in different ECMO patient populations, with SAPS II showing the best discrimination among survivors and non-survivors in V-A ECMO patients, while PRESET score performed the best in V-V ECMO patients. The prognostic performance of most scores was moderate in ECMO patients, discouraging their use in deciding ECMO implementation in potential candidates.
Article
Oncology
Shuchita Dhwiren Patel, Andrew Davies, Emma Laing, Huihai Wu, Jeewaka Mendis, Derk-Jan Dijk
Summary: Combining sleep-wake parameters with routine clinical data can improve survival prediction in advanced cancer patients. Machine learning models identified both established and new predictors of survival. This study is significant for the development of prognostic tools.
Article
Oncology
Yoshihide Nagasako, Masahiro Suzuki, Tetsuji Iriyama, Yoko Nagasawa, Yoshiki Katayama, Kaori Masuda
Summary: The Glasgow Prognostic Score (GPS) was optimized with thrombocytopenia to enhance prognostic value, and it exhibited high specificity and positive likelihood ratio for predicting 3-day mortality in advanced cancer patients admitted to an acute palliative care unit (APCU). This combination could assist in making personal and clinical decisions for patients with limited time of survival.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Leqi Zhou, Yue Yu, Rongbo Wen, Kuo Zheng, Siyuan Jiang, Xiaoming Zhu, Jinke Sui, Haifeng Gong, Zheng Lou, Liqiang Hao, Guanyu Yu, Wei Zhang
Summary: A robust gene signature containing 8 genes associated with both OS and RFS of CRC patients was constructed in this study. The signature showed good predictive performance for both OS and RFS, with a potential to improve personalized treatment and patient survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Fumihiko Kinoshita, Tomoyoshi Takenaka, Takanori Yamashita, Koutarou Matsumoto, Yuka Oku, Yuki Ono, Sho Wakasu, Naoki Haratake, Tetsuzo Tagawa, Naoki Nakashima, Masaki Mori
Summary: This study aimed to develop an AI prognostic model for surgically resected non-small cell lung cancer (NSCLC) using the eXtreme Gradient Boosting (XGBoost) machine learning algorithm. The AI model showed good prediction accuracy and provided accurate predictive probability of postoperative prognosis of NSCLC.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
P. Stone, V. Vickerstaff, A. Kalpakidou, C. Todd, J. Griffiths, V. Keeley, K. Spencer, P. Buckle, D. Finlay, R. Z. Omar
Summary: The study found that four commonly used prognostic algorithms for palliative care generally showed good discrimination and calibration, but none of them demonstrated superiority to clinical predictions of survival. Prognostic tools less accurate than clinical predictions are clinically useless, while those performing similarly may have other advantages for clinical practice.
Article
Oncology
Toshifumi Tada, Takashi Kumada, Atsushi Hiraoka, Kazuya Kariyama, Joji Tani, Masashi Hirooka, Koichi Takaguchi, Masanori Atsukawa, Shinya Fukunishi, Ei Itobayashi, Kunihiko Tsuji, Kazuto Tajiri, Hironori Ochi, Toru Ishikawa, Satoshi Yasuda, Chikara Ogawa, Hidenori Toyoda, Takeshi Hatanaka, Takashi Nishimura, Satoru Kakizaki, Kazuhito Kawata, Noritomo Shimada, Fujimasa Tada, Kazuhiro Nouso, Akemi Tsutsui, Hideko Ohama, Asahiro Morishita, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Hisashi Kosaka, Michitaka Imai, Atsushi Naganuma, Shinichiro Nakamura, Yohei Koizumi, Masaki Kaibori, Hiroko Iijima, Yoichi Hiasa
Summary: The aim of this study was to investigate whether the neo-GPS could predict prognosis in HCC patients treated with Atez/Bev. The results showed that the neo-GPS was independently associated with overall survival and performed better than the traditional GPS in predicting prognosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Gerard M. Healy, Emmanuel Salinas-Miranda, Rahi Jain, Xin Dong, Dominik Deniffel, Ayelet Borgida, Ali Hosni, David T. Ryan, Nwabundo Njeze, Anne McGuire, Kevin C. Conlon, Jonathan D. Dodd, Edmund Ronan Ryan, Robert C. Grant, Steven Gallinger, Masoom A. Haider
Summary: A multi-institutional pre-operative clinical-radiomic model for resectable PDAC prognostication showed superior net benefit compared to a clinical model but limited clinical utility during external validation. Despite the promising results in predicting overall and disease-free survival, the radiomic model may have inherent limitations when applied in real-world settings.
EUROPEAN RADIOLOGY
(2022)
Article
Multidisciplinary Sciences
Shasha Yuan, Chen Wei, Mengyu Wang, Wenying Deng, Chi Zhang, Ning Li, Suxia Luo
Summary: This study aimed to determine the optimal threshold for the examined lymph node count in esophageal cancer patients and develop a model to predict their survival. The findings suggest that a lymph node count beyond 18 is associated with better overall survival, and a random survival forest model was successfully developed with high prediction accuracy.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Masanori Mori, Takashi Yamaguchi, Kozue Suzuki, Yoshinobu Matsuda, Ryo Matsunuma, Hiroaki Watanabe, Tomoo Ikari, Yoshihisa Matsumoto, Kengo Imai, Naosuke Yokomichi, Satoru Miwa, Toshihiro Yamauchi, Soichiro Okamoto, Satoshi Inoue, Akira Inoue, Tatsuya Morita, Eriko Satomi
Summary: This study examined adherence to a comprehensive pharmacological treatment algorithm for patients with terminal dyspnea and its outcomes. The results showed that the algorithm was feasible and effective in helping patients achieve treatment goals and reducing dyspnea levels significantly. Most adverse events were mild to moderate.
Letter
Geriatrics & Gerontology
Tomomi Hayase, Hiroshi Saiga, Takashi Yamaguchi
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Health Care Sciences & Services
Steffen T. Simon, Masanori Mori, Magnus Ekstrom, Anne Pralong, Takashi Yamaguchi, David Hui
Summary: In summary, dyspnea is a common and distressing symptom in patients with advanced illnesses. Despite optimal management and non-pharmacologic interventions, many patients still experience chronic dyspnea, leading to the consideration of pharmacologic therapies. However, existing data suggests that benzodiazepines alone do not provide benefits for dyspnea in advanced illnesses. Concerns about potential adverse effects and recommendations against first-line use are also expressed. Selective use in patients with severe anxiety and adjunctive use in patients with severe dyspnea despite opioids may be considered. Further research is needed to confirm the efficacy of benzodiazepines in these populations.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Article
Health Care Sciences & Services
Takashi Yamaguchi, Ryo Matsunuma, Yoshinobu Matsuda, Junichi Tasaki, Tomoo Ikari, Satoru Miwa, Sayo Aiki, Yusuke Takagi, Daisuke Kiuchi, Kozue Suzuki, Shunsuke Oyamada, Keisuke Ariyoshi, Kota Kihara, Masanori Mori
Summary: This study aims to evaluate the effectiveness and safety of systemic regular opioids for dyspnea in cancer patients in real-world palliative care practice. The results showed that regular systemic opioids were effective for relieving dyspnea in cancer patients and were well-tolerated.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Review
Oncology
Masanori Mori, Satoru Miwa, Tomoo Ikari, Jun Kako, Takaaki Hasegawa, Ryo Matsunuma, Kozue Suzuki, Yoshinobu Matsuda, Hiroaki Watanabe, Tatsuya Morita, Takashi Yamaguchi
Summary: Dyspnea is a common and distressing symptom in advanced cancer patients. Comprehensive assessment and timely treatment are important to improve quality of life. There is a lack of clinical trials on dyspnea in cancer patients, resulting in weak overall evidence. Recent studies on palliative care specialists' practice patterns provide valuable insights. This paper summarizes current management options, discusses controversies, and proposes future research directions for quality care.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2023)
Review
Oncology
Yusuke Takagi, Junya Sato, Yoshihiro Yamamoto, Ryo Matsunuma, Hiroaki Watanabe, Masanori Mori, Takaaki Hasegawa, Yoshinobu Matsuda, Jun Kako, Yoko Kasahara, Sho Goya, Hiroyuki Kohara, Takeo Nakayama, Takashi Yamaguchi
Summary: Dyspnea is a common symptom in cancer patients that significantly affects their quality of life. This study aimed to evaluate the efficacy and safety of opioids in treating dyspnea in cancer patients. The results showed that opioids were more effective than placebo in relieving dyspnea, but robust evidence is lacking.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Masanori Mori, Takashi Yamaguchi, Kozue Suzuki, Yoshinobu Matsuda, Ryo Matsunuma, Hiroaki Watanabe, Tomoo Ikari, Yoshihisa Matsumoto, Kengo Imai, Naosuke Yokomichi, Satoru Miwa, Toshihiro Yamauchi, Soichiro Okamoto, Satoshi Inoue, Akira Inoue, David Hui, Tatsuya Morita, Eriko Satomi, Japanese Dyspnea Relief Investigators
Summary: This study analyzed the effectiveness and safety of different medications for the treatment of dyspnea in cancer patients. The results showed that morphine, oxycodone, and hydromorphone were similarly effective in reducing dyspnea, with few adverse events.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Article
Health Care Sciences & Services
Harriette Johanna van Esch, Margret L. Campbell, Masanori Mori, Takayashi Yamaguchi
Summary: Death rattle is a common symptom in the dying phase and has different opinions regarding its management among experts. While explanation and reassurance may be sufficient, medication could be considered for relieving the symptom, especially considering the burden on relatives. The assessment and treatment of death rattle in the dying phase remains a matter of debate and further research is needed.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Article
Health Care Sciences & Services
Seok-Joon Yoon, Sang-Yeon Suh, Yusuke Hiratsuka, Sung-Eun Choi, Sun-Hyun Kim, Su-Jin Koh, Shin Ae Park, Ji-Yeon Seo, Jung Hye Kwon, Jeanno Park, Youngmin Park, Sun Wook Hwang, Eon Sook Lee, Hong-Yup Ahn, Shao-Yi Cheng, Ping-Jen Chen, Takashi Yamaguchi, Satoru Tsuneto, Masanori Mori, Tatsuya Morita
Summary: This study aimed to validate modified models of objective prognostic score (OPS) with few or no laboratory tests for patients with advanced cancer. An observational study was performed on a cohort of patients in East Asia, and it was found that the modified OPS models had relatively good accuracy and calibration in predicting two-week survival.
JOURNAL OF PALLIATIVE MEDICINE
(2023)
Article
Health Care Sciences & Services
Eon Sook Lee, Yusuke Hiratsuka, Sang-Yeon Suh, Seon-Hye Won, Sun-Hyun Kim, Seok-Joon Yoon, Sung-Eun Choi, Hana Choi, Hong-Yup Ahn, Yoonjoo Kim, David Hui, Shao-Yi Cheng, Ping-Jen Chen, Chien-Yi Wu, Masanori Mori, Tatsuya Morita, Takashi Yamaguchi, Satoru Tsuneto
Summary: This study aimed to examine the accuracy and confidence of clinicians' prediction of survival in East-Asian countries. The results showed that clinicians had the highest accuracy in predicting 7-day survival, while the Performance Status-based Palliative Prognostic Index had lower accuracy.
JOURNAL OF PALLIATIVE MEDICINE
(2023)
Article
Health Care Sciences & Services
Sayaka Maeda, Tatsuya Morita, Naosuke Yokomichi, Kengo Imai, Satoru Tsuneto, Isseki Maeda, Tomofumi Miura, Hiroto Ishiki, Hiroyuki Otani, Yutaka Hatano, Masanori Mori
Summary: This study investigated the use of continuous deep sedation (CDS) for psycho-existential suffering in patients. It found that patients without specific religious beliefs and those with a desire for hastened death may require CDS to alleviate their suffering. For these patients, CDS lasted longer and caused more discomfort for physicians, but it may lead to better therapeutic outcomes.
JOURNAL OF PALLIATIVE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Jun Hamano, Ayano Takeuchi, Masanori Mori, Yasuhiro Saitou, Takahide Yamaguchi, Nobuyuki Miyata, Masakatsu Shimizu, Ryo Yamamoto, Yousuke Kimura, Yoshiyuki Kamiyama, Yasuyuki Arai, Hiroshi Matsuo, Hideki Shishido, Kazushi Nakano, Tomohiro Nishi, Hiroka Nagaoka, Naosuke Yokomichi, Isseki Maeda, Takashi Yamaguchi, Tatsuya Morita, Takuya Shinjo
Summary: This study aimed to compare the survival times of advanced cancer patients receiving home-based and hospital-based palliative care. After adjusting for symptoms and treatments, the study found that patients receiving home-based palliative care had significantly longer survival times than those receiving hospital-based care.
Editorial Material
Health Care Sciences & Services
Haruka Harano, Ryo Matsunuma, Yukako Tanaka-Yagi, Madoka Ito, Junichi Tasaki, Aki Egawa, Takashi Yamaguchi
Summary: Metronidazole gel or ointment is recommended for treating malodour in malignant fungating wounds, but may not work well in oral lesions due to discomfort and being washed out by saliva. Here we report a case where malodour caused by an oral lesion was effectively controlled with sprayed metronidazole.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
Article
Health Care Sciences & Services
Ryuto Shiraishi, Yoshiyuki Kizawa, Masanori Mori, Isseki Maeda, Yutaka Hatano, Hiroto Ishiki, Tomofumi Miura, Naosuke Yokomichi, Maiko Kodama, Keiko Inoue, Sen Otomo, Takashi Yamaguchi, Jun Hamano
Summary: This study compared the prevalence of symptom worsening between advanced cancer patients receiving palliative care at home and in palliative care units (PCUs). The results showed that patients receiving palliative care at home were more likely to experience worsening of pain and drowsiness. However, after adjusting for patient background, there was no significant difference in the prevalence of symptom worsening between patients receiving palliative care at home and in PCUs.
PALLIATIVE MEDICINE REPORTS
(2023)
Article
Oncology
Hsien-Liang Huang, Ping-Jen Chen, Masanori Mori, Sang-Yeon Suh, Chien-Yi Wu, Jen-Kuei Peng, Chih-Yuan Shih, Chien-An Yao, Jaw-Shiun Tsai, Tai-Yuan Chiu, Yusuke Hiratsuka, Sun-Hyun Kim, Tatsuya Morita, Takashi Yamaguchi, Satoru Tsuneto, David Hui, Shao-Yi Cheng
Summary: This study investigated how symptom changes affect the quality of dying and death for cancer patients. The results found that better symptom control, particularly for dyspnea and delirium, was associated with improved quality of dying and death.