Local therapy reduces the risk of liver failure and improves survival in patients with intrahepatic cholangiocarcinoma: A comprehensive analysis of 362 consecutive patients

BACKGROUNDTreatment methods for intrahepatic cholangiocarcinoma (ICC) have improved, but their impact on outcome remains unclear. We evaluated the outcomes of patients definitively treated with resection, radiation, and chemotherapy for ICC, stratified by era. METHODSClinico-pathologic characteristics, cause of death, disease-specific survival (DSS), and intrahepatic progression-free survival (IPFS) were compared among patients who underwent resection, radiation, or chemotherapy as definitive treatment strategies for ICC (without distant organ metastasis) between 1997 and 2015. Variables were also analyzed by era (1997-2006 [early] or 2007-2015 [late]) within each group. RESULTSAmong 362 patients in our cohort, 122 underwent resection (early, 38; late, 84), 85 underwent radiation (early, 17; late, 68), and 148 underwent systemic chemotherapy alone (early, 51; late, 97) as definitive treatment strategies, and 7 patients received best supportive care. In the resection group, the 3-year DSS rate was 58% for the early era and 67% for the late era (P=.036), and the 1-year IPFS was 50% for the early era and 75% for the late era (P=.048). In the radiation group, the 3-year DSS was 12% for the early era and 37% for the late era (P=.048), and the 1-year IPFS was 48% for the early era and 64% for the late era (P=.030). In the chemotherapy group, DSS and IPFS did not differ by era. Patients treated with chemotherapy developed liver failure at the time of death significantly more frequently than patients treated with resection (P<.001) or radiation (P<.001). Multivariable analysis identified local therapy (resection or radiation) as a sole predictor of death without liver failure. CONCLUSIONSurvival outcomes have improved for local therapy-based definitive treatment strategies for ICC, which may be attributable to maintaining control of intrahepatic disease, thereby reducing the occurrence of death due to liver failure. Cancer 2017;123:1354-1362. (c) 2016 American Cancer Society. This study evaluates the prognosis and causes of death in patients definitively treated with resection, radiation, and chemotherapy for intrahepatic cholangiocarcinoma, stratified by era. Both disease-specific survival and intrahepatic progression-free survival have improved for local therapy (resection or radiation)-based definitive treatment strategies, which may be attributable to maintaining control of intrahepatic disease, thereby reducing the occurrence of death due to liver failure.