Review
Gastroenterology & Hepatology
Nour Hamade, Amrit K. Kamboj, Rajesh Krishnamoorthi, Siddharth Singh, Leslie C. Hassett, David A. Katzka, Charles J. Kahi, Hala Fatima, Prasad G. Iyer
Summary: Through analysis of multiple studies, a statistically significant inverse correlation was found between neoplasia detection rate and post-endoscopy Barrett's neoplasia, indicating that with an increase in neoplasia detection rate, post-endoscopy Barrett's neoplasia decreases. Further studies are needed to validate this correlation.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Oncology
Jouke J. H. van der Laan, Joost A. van der Putten, Xiaojuan Zhao, Arend Karrenbeld, Frans T. M. Peters, Jessie Westerhof, Peter H. N. de With, Fons van der Sommen, Wouter B. Nagengast
Summary: This study investigated whether artificial intelligence (AI) as a second assessor can assist doctors in assessing complex, microscopic endoscopy images for the presence of oesophageal cancer. The findings showed that the best diagnostic scores for cancer recognition emerged through the collaboration between doctors and AI as the second assessor.
Article
Multidisciplinary Sciences
Mamoru Tokunaga, Kenichiro Okimoto, Naoki Akizue, Kentaro Ishikawa, Yosuke Hirotsu, Kenji Amemiya, Masayuki Ota, Keisuke Matsusaka, Motoi Nishimura, Kazuyuki Matsushita, Tsubasa Ishikawa, Ariki Nagashima, Wataru Shiratori, Tatsuya Kaneko, Hirotaka Oura, Kengo Kanayama, Yuki Ohta, Takashi Taida, Keiko Saito, Tomoaki Matsumura, Tetsuhiro Chiba, Hitoshi Mochizuki, Makoto Arai, Jun Kato, Jun-ichiro Ikeda, Masao Omata, Naoya Kato
Summary: This study investigated the genetic characteristics of nondysplastic Barrett's esophagus (NDBE) to early esophageal adenocarcinoma (EAC) in the Japanese population. The results showed that the genetic variants of TP53 in Japanese early EAC were similar to those in western countries, and TP53 putative drivers were even detected in Japanese patients with nondysplastic short-segment Barrett's esophagus, indicating a potential higher risk of progression. Proper follow-ups may be necessary for patients with short-segment Barrett's esophagus to monitor the risk of progression to high-grade dysplasia or EAC.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Sarah Killcoyne, Rebecca C. Fitzgerald
Summary: Cancer cells evolve through DNA mutation, cell selection, and population expansion, driven by mutated driver genes and structural alterations to the genome. Early genomic instability in Barrett's esophagus (BE) may lead to esophageal adenocarcinoma (EAC). Understanding these patterns and genomic changes can improve early detection of EAC and provide insights into cancer evolution.
NATURE REVIEWS CANCER
(2021)
Article
Cell Biology
Robert Odze, Nicola Frei, Amir M. Khoshiwal, Lucas C. Duits, Jacques Bergman, Matthew D. Stachler
Summary: This study aimed to evaluate whether the degree of crypt atypia in non-dysplastic Barrett's oesophagus patients correlates with progression to high-grade dysplasia/adenocarcinoma. The study showed that non-dysplastic crypts in Barrett's oesophagus are biologically abnormal, suggesting that neoplastic progression begins prior to the onset of dysplasia. The degree of crypt atypia in non-dysplastic Barrett's oesophagus patients correlates with disease progression.
Article
Gastroenterology & Hepatology
Edward H. Tsoi, Puneet Mahindra, Georgina Cameron, Richard Williams, Richard Norris, Paul Desmond, Spiro Raftopoulos, Darren Pavey, Arti Rattan, Luke F. Hourigan, Richard Lee, Michael J. Bourke, Naaz Sidhu, Rajvinder Singh, Andrew Chan, Sudarshan Krishnamurthi, Andrew C. F. Taylor
Summary: This study aimed to determine the proportion of prevalent HGD or EAC detected in Barrett's esophagus (BE) patients referred from the community with a recent diagnosis of low-grade dysplasia (LGD). The results showed that BERU assessment endoscopy identified more visible lesions than community referral endoscopy and identified HGD or EAC in 27% of patients referred from the community with a recent diagnosis of LGD. Reported progression rates from LGD to HGD or EAC may be overestimated.
GASTROINTESTINAL ENDOSCOPY
(2021)
Review
Gastroenterology & Hepatology
Robert D. Odze, John Goldblum, Vivek Kaul
Summary: Barrett's esophagus (BE) is a premalignant condition that can be effectively monitored and managed using the Wide-area transepithelial sampling with computer-assisted three-dimensional analysis (WATS(3D)) technique, which has shown to significantly increase detection rates of dysplasia and intestinal metaplasia in BE patients.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Review
Oncology
Leonardo Henry Eusebi, Andrea Telese, Chiara Castellana, Rengin Melis Engin, Benjamin Norton, Apostolis Papaefthymiou, Rocco Maurizio Zagari, Rehan Haidry
Summary: Barrett's oesophagus is a pathological condition characterized by the replacement of normal oesophageal squamous mucosa with specialised, intestinal-type metaplasia, which is strongly associated with chronic gastro-oesophageal reflux. Accurate diagnosis is crucial for managing Barrett's oesophagus to identify patients at high risk of developing neoplasia and guide appropriate endoscopic therapy.
Article
Gastroenterology & Hepatology
Blake Jones, J. Lucas Williams, Srinadh Komanduri, V. Raman Muthusamy, Nicholas J. Shaheen, Sachin Wani
Summary: Black patients with Barrett's esophagus have lower diagnosis rates, are less likely to be recommended appropriate surveillance intervals, and are less likely to follow the Seattle biopsy protocol compared to white patients.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Emily L. Black, Emma Ococks, Ginny Devonshire, Alvin Wei Tian Ng, Maria O'Donovan, Shalini Malhotra, Monika Tripathi, Ahmad Miremadi, Adam Freeman, Hannah Coles, Rebecca C. Fitzgerald
Summary: The controversy of whether gastric metaplasia should be considered as Barrett's esophagus is explored in this study. Through clinical and genomic analysis, the researchers found that the malignant potential of gastric metaplasia is lower than intestinal metaplasia. Therefore, the inclusion of gastric metaplasia in the surveillance of Barrett's esophagus is questionable.
Review
Oncology
Darragh O'Dowd, Jacintha O'Sullivan, Simone Marcone
Summary: Oesophageal adenocarcinoma (OAC) is a type of cancer with poor patient outcomes. Surveillance programs for its precursor lesion, Barrett's oesophagus (BO), are expensive and unpleasant. Prognostic and diagnostic biomarkers can improve surveillance and early detection, while predictive biomarkers can enhance individualized therapy.
Article
Gastroenterology & Hepatology
Claire A. Beveridge, Chetan Mittal, V. Raman Muthusamy, Amit Rastogi, Vladimir Kushnir, Mariah Wood, Sachin Wani, Srinadh Komanduri
Summary: This study aimed to assess the rate of visible lesion (VL) detection by academic and community endoscopists using high-definition white-light endoscopy (HD-WLE) and narrow-band imaging (NBI). Participants identified VLs using HD-WLE and NBI, and the results showed that 28% and 31% of VLs were not identified using HD-WLE and NBI respectively. The study also found that the rate of VL detection was associated with the endoscopist's experience and the number of surveillance endoscopies performed each month.
GASTROINTESTINAL ENDOSCOPY
(2023)
Review
Cell Biology
M. Priyanthi Kumarasinghe, Michael Armstrong, Jonathan Foo, Spiro C. Raftopoulos
Summary: Modern management of Barrett's esophagus and related neoplasia focuses on surveillance for early detection of low-risk lesions and offering minimally invasive treatments, reserving surgery for high-risk cases. Pathological assessment guides treatment choice, with endoscopic resections being curative for certain early-stage carcinomas. Management involves a multidisciplinary approach for risk stratification and personalized treatment.
Review
Biology
Marco Spadaccini, Ludovico Alfarone, Viveksandeep Thoguluva Chandrasekar, Roberta Maselli, Antonio Capogreco, Gianluca Franchellucci, Davide Massimi, Alessandro Fugazza, Matteo Colombo, Silvia Carrara, Antonio Facciorusso, Pradeep Bhandari, Prateek Sharma, Cesare Hassan, Alessandro Repici
Summary: Over the last two decades, endoscopic eradication therapy has become the preferred treatment strategy for patients with Barrett's oesophagus-related dysplasia and early oesophageal adenocarcinoma. Radiofrequency ablation is the first-line option due to its proven effectiveness and safety, although it is expensive and not universally applicable. Cryotherapy techniques and hybrid argon plasma coagulation have shown promising results as potential alternatives to radiofrequency ablation. This review aims to provide a practical guide for the different ablative options for Barrett's oesophagus.
Article
Gastroenterology & Hepatology
Swathi Eluri, Anna Paterson, Brianna N. Lauren, Maria O'Donovan, Pradeep Bhandari, Massimiliano di Pietro, Minyi Lee, Rehan Haidry, Laurence Lovat, Krish Ragunath, Chin Hur, Rebecca C. Fitzgerald, Nicholas J. Shaheen
Summary: This study assessed the application value of Cytosponge in BE patients after RFA. The results showed that Cytosponge testing is a cost-effective surveillance method and is strongly associated with residual BE after ablation.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Colin J. Crooks, Joe West, Andrew Fogarty, Joanne R. Morling, Matthew J. Grainge, Sherif Gonem, Mark Simmonds, Andrea Race, Irene Juurlink, Steve Briggs, Simon Cruickshank, Susan Hammond-Pears, Timothy R. Card
Summary: This study compared the performance of prognostic tools for SARS-CoV-2 using parameters fitted at the time of hospital admission or throughout the hospital stay. The researchers developed a dynamic risk prediction model for SARS-CoV-2 prognosis using clinical data from a single hospital center in the UK. The study found that a customized daily SARS-CoV-2 escalation risk prediction score performed better than generic early warning scores or single risk estimations calculated at admission in predicting the need for clinical escalation.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Sanne N. van Munster, Philippe Leclercq, Rehan Haidry, Helmut Messmann, Andreas Probst, Krish Ragunath, Pradeep Bhandari, Alessandro Repici, Miguel Munoz-Navas, Stefan Seewald, Arnaud Lemmers, Gloria Fernandez-Esparrach, Oliver Pech, Erik J. Schoon, Revital Kariv, Horst Neuhaus, Bas L. A. M. Weusten, Peter D. Siersema, Loredana Correale, Sybren L. Meijer, Gert de Hertogh, Jacques J. G. H. M. Bergman, Cesare Hassan, Raf Bisschops
Summary: In this study, the researchers aimed to evaluate wide-area transepithelial sampling (WATS) as a substitute for four-quadrant random forceps biopsies (FB). Although using WATS as an adjunct to FB significantly increased the detection rate of high grade dysplasia (HGD) and esophageal adenocarcinoma (EAC), there was no statistically significant difference between WATS and FB for the detection of HGD/EAC as a single modality.
Article
Medicine, General & Internal
C. J. Crooks, J. West, J. R. Morling, M. Simmonds, I Juurlink, S. Briggs, S. Cruickshank, S. Hammond-Pears, D. Shaw, T. R. Card, A. W. Fogarty
Summary: This study suggests that patients with pigmented skin may have more severe illness at the time of transfer to intensive care units (ICUs) and lower oxygen saturations in Indian/Pakistani and Black/Mixed ethnic groups. These findings have implications for healthcare and health outcomes across ethnic groups globally.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Timothy R. Card, Georgina Nakafero, Matthew J. Grainge, Christian D. Mallen, Jonathan S. Nguyen Van-Tam, Hywel C. Williams, Abhishek Abhishek
Summary: This study investigated the association between COVID-19 vaccination and IBD flare. The results showed no significant association between COVID-19 vaccination and IBD flares, regardless of prior COVID-19 infection and whether mRNA or DNA vaccines were used.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Letter
Dermatology
Laura Adams, Georgina Nakafero, Matthew J. Grainge, Tim Card, Christian D. Mallen, Jonathan S. Nguyen Van-Tam, Hywel C. Williams, Abhishek Abhishek
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Gastroenterology & Hepatology
William Knight, Kaveetha Kandiah, Zoi Vrakopoulou, Annabel White, Lavinia Barbieri, Nilanjana Tewari, Jennifer Couch, Francesco DiMaggio, Mark Barley, Krish Ragunath, James Catton, Abraham Botha
Summary: FLIP-guided POEM, which measures lower esophageal distensibility intraoperatively, helps tailor myotomies to ensure adequate distensibility and minimize postoperative reflux risk. This study shows that shorter myotomies guided by EndoFLIP remained clinically effective at 6 weeks, with improved symptom response rates in the latter half of each series.
DISEASES OF THE ESOPHAGUS
(2023)
Article
Emergency Medicine
Colin J. Crooks, Joe West, Jo Morling, Mark Simmonds, Irene Juurlink, Steve Briggs, Simon Cruickshank, Susan Hammond-Pears, Dominick Shaw, Tim Card, Andrew W. Fogarty
Summary: This study aimed to explore the association between the measurement error of pulse oximeters and systolic BP, diastolic BP, and heart rate. The results showed that in patients with lower systolic and diastolic BPs, and heart rates, pulse oximetry measurements overestimated oxygen saturation.
EMERGENCY MEDICINE JOURNAL
(2023)
Article
Emergency Medicine
Andrew W. Fogarty, Tim Card, Dominick Shaw, Joe West, Mark Simmons, Colin J. Crooks
EMERGENCY MEDICINE JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Mathew Vithayathil, Ines Modolell, Jacobo Ortiz-Fernandez-Sordo, Apostolos Pappas, Wladyslaw Januszewicz, Maria O'Donovan, Michele Bianchi, Jonathan. R. R. White, Philip Kaye, Krish Ragunath, Massimiliano di Pietro
Summary: For patients with Barrett's esophagus without clearly visible dysplastic lesions, longer procedural time is associated with a higher dysplasia detection rate. Adequate time is needed to perform high-quality surveillance and maximize dysplasia detection.
Article
Medicine, General & Internal
Mohammad Farhad Peerally, Clare Jackson, Pradeep Bhandari, Krish Ragunath, Hugh Barr, Clive Stokes, Rehan Haidry, Laurence B. Lovat, Howard Smart, John De Caestecker
Summary: This study investigated the feasibility of a multicenter randomized controlled trial for the management of early Barrett's neoplasia, and identified factors influencing patient participation and their views on a potential future trial comparing surgery with endotherapy. Four main influences were identified, highlighting the importance of qualitative research in informing the design of larger randomized controlled trials.
Letter
Gastroenterology & Hepatology
Joe West, Peter Jepsen, Timothy R. Card, Colin J. Crooks, Mark Bishton
Article
Medicine, General & Internal
Madoka Inoue, Niwansa Adris, Richmond Cai, Chiang Siah, Jee Kong, Krish Ragunath
Summary: This retrospective observational study investigated the prevalence and trends in incidence rates of achalasia in Australia, as well as the types of treatment used for different subtypes. The results showed a significant increase in the incidence rate of type 2 achalasia, with pneumatic balloon dilatation being the most commonly performed treatment, though peroral endoscopic myotomy has become more popular in recent years.
INTERNAL MEDICINE JOURNAL
(2023)
Review
Gastroenterology & Hepatology
Madoka Inoue, Krish Ragunath
Summary: There is a growing interest in establishing quality indicators (QIs) for endoscopic screening and surveillance in Barrett's esophagus (BE), as it is important for early and accurate detection of dysplasia and neoplasia. However, issues remain in determining the most appropriate QIs, including inconsistent use of terminology and a scarcity of studies linking QIs with patient outcomes. It is urgent to determine appropriate QIs for Barrett's endoscopy, define QI items, and identify ways to measure key performance indicators (KPIs) to ensure clinically effective and patient-focused care.
DIGESTIVE ENDOSCOPY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Nasar Aslam, Mohamed Hussein, Durayd Alzoubaidi, Michael O'Donnell, Alvaro De La Serna, Ioannis Varbobitis, Tricia A. Hengehold, Miguel Fraile Lopez, Jacobo Ortiz Fernandez-Sordo, Johannes W. Rey, Bu Hayee, Edward J. Despott, Alberto Murino, Sulleman Moreea, Phil Boger, Jason M. Dunn, Inder Mainie, David Graham, Dan Mullady, Dayna Early, Melissa Latorre, Krish Ragunath, John T. Anderson, Martin Goetz, Ralf Kiesslich, Emmanuel Coron, Enrique Rodriguez De Santiago, Tamas A. Gonda, Seth Gross, Laurence B. Lovat, Rehan Haidry, Pradeep Bhandari
GASTROINTESTINAL ENDOSCOPY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Nasar Aslam, Mohamed Hussein, Durayd Alzoubaidi, Michael O'Donnell, Alvaro De La Serna, Ioannis Varbobitis, Tricia A. Hengehold, Miguel Fraile Lopez, Jacobo Ortiz Fernandez-Sordo, Johannes W. Rey, Bu Hayee, Edward J. Despott, Alberto Murino, Sulleman Moreea, Phil Boger, Jason M. Dunn, Inder Mainie, David G. Graham, Dan Mullady, Dayna Early, Melissa Latorre, Krish Ragunath, John T. Anderson, Pradeep Bhandari, Martin Goetz, Ralf Kiesslich, Emmanuel Coron, Enrique R. De Santiago, Tamas A. Gonda, Seth Gross, Laurence B. Lovat, Rehan Haidry
GASTROINTESTINAL ENDOSCOPY
(2022)