Article
Immunology
Donghyun Kim, Ye Jin Jeong, Yerin Lee, Jihoon Choi, Young Min Park, Oh Chan Kwon, Yong Woo Ji, Sung Jun Ahn, Hyung Keun Lee, Min-Chan Park, Jae-Yol Lim
Summary: Recent studies have shown that the oral microbiome in patients with Sjogren's syndrome (SS) differs significantly from that in healthy individuals. The composition and diversity of the oral microbiome are correlated with clinical features of SS, especially ductal structures and salivary flow, suggesting that the oral microbiome may serve as a potential diagnostic biomarker for SS.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Rheumatology
Valerie Devauchelle-Pensec, Alen Zabotti, Guillermo Carvajal-Alegria, Nenad Filipovic, Sandrine Jousse-Joulin, Salvatore De Vita
Summary: Salivary gland ultrasonography plays an important role in detecting structural abnormalities in primary Sjogren's Syndrome, and could potentially be used for classification. The ongoing HarmonicSS project, supported by the EU, aims to apply artificial intelligence to SGUS in pSS for future study. Many questions remain unresolved, but data collected so far suggest that SGUS will be a significant tool in the study of pSS in the near future.
Article
Pathology
Harim Tavares dos Santos, Kihoon Nam, Frank Maslow, Bryan Trump, Olga J. Baker
Summary: The study investigated the expression of different SPM receptors in non-SS and SS patients' minor salivary glands, finding the presence of ALX/FPR2, BLT1, and CMKLR1 receptors in both groups in mucous acini and striated ducts, while GPR32 was absent. These various SPM receptors may serve as potential targets for promoting pro-epithelial and anti-inflammatory/pro-resolution signaling in SS patients.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2022)
Article
Immunology
Akinsola Oyelakin, Erich Horeth, Eun-Ah Christine Song, Sangwon Min, Monika Che, Brandon Marzullo, Christopher J. Lessard, Astrid Rasmussen, Lida Radfar, R. Hal Scofield, David M. Lewis, Donald U. Stone, Kiely Grundahl, Scott S. De Rossi, Zoya Kurago, A. Darise Farris, Kathy L. Sivils, Satrajit Sinha, Jill M. Kramer, Rose-Anne Romano
Summary: Primary Sjogren's syndrome is a systemic autoimmune disease primarily affecting women, leading to loss of saliva and tears. Currently, there is no effective cure due to limited understanding of disease etiology and pathology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Arso M. Vukicevic, Milos Radovic, Alen Zabotti, Vera Milic, Alojzija Hocevar, Sara Zandonella Callegher, Orazio De Lucia, Salvatore De Vita, Nenad Filipovic
Summary: This study proposed a deep learning-based solution for automated segmentation of salivary gland ultrasound images to address the low inter/intra observer reliability in diagnosing primary Sjögren's syndrome. After training with different architectures, the FCN-DenseNet network showed superior performance in accuracy and speed, indicating its potential for wider clinical applications. Further work will focus on integrating methods for pSS scoring to establish SGUS as an effective noninvasive diagnostic tool.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Immunology
Hongming Du, Zhen Fu, Yi Zhong, Yi Yuan, Jing Zhao, Xu Ding, Sheng Li, Shiyu Gao, Yuchi Zhu, Haiyang Song, Heming Wu
Summary: This study aimed to investigate the effects of triamcinolone acetonide (TA) and saline irrigation on relieving xerostomia in Sjogren's syndrome (SS) patients. The results showed that irrigating the major salivary glands with TA or saline led to improved saliva flow and reduced dryness symptoms. Patients with milder xerostomia responded better to the treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ning Li, Yusi Li, Jiawei Hu, Yicheng Wu, Jie Yang, Hongmei Fan, Lei Li, Danyang Luo, Yulin Ye, Yiming Gao, Haimin Xu, Wangxi Hai, Liting Jiang
Summary: This study revealed the interaction between mitochondrial dysfunction and the immune microenvironment in salivary glands of pSS patients and provided important insights into the clinical management of SS based on modulation of mitochondrial function.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
S. Rastelli, M. D'Amario, E. Iacomino, M. Lacarbonara, D. Guerra, M. Capogreco
Summary: Sjogren's Syndrome is a systemic autoimmune disease that mainly affects women in the age group of 50-80 years, causing glandular secretory disorders and significantly impacting the patient's quality of life. Early diagnosis plays a crucial role.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Medicine, General & Internal
Patricia Carvajal, Veronica Bahamondes, Daniela Jara, Isabel Castro, Soledad Matus, Sergio Aguilera, Claudio Molina, Sergio Gonzalez, Marcela Hermoso, Maria-Jose Barrera, Maria-Julieta Gonzalez
Summary: In this study, it was found that the acinar cells of salivary glands in patients with primary Sjogren's syndrome (SS) lose cellular homeostasis and experience endoplasmic reticulum and oxidative stress. The integrated cellular stress response (ISR) is activated in the salivary glands of SS patients, with increased expression of ATF4 protein and ATF4-target genes involved in redox homeostasis, suggesting a rescue response to promote cell survival.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Iris Y. K. Tang, Carmen T. K. Ho, Teresa W. L. Li, Philip H. Li
Summary: This article presents a standardized approach to diagnostic salivary gland ultrasonography (SGUS) for Sjogren's syndrome (SS) in daily clinical settings. SGUS is a non-invasive imaging modality that can aid in the diagnosis and monitoring of SS. The article explains the stepwise approach for scanning the major salivary glands and examines various features of the glands and lymph nodes. The most distinctive sonographic feature in SS is glandular heterogeneity with the presence of hypoechoic/hyperechoic areas within the glands.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Immunology
Geoffrey Urbanski, Floris Chabrun, Estelle Delattre, Carole Lacout, Brittany Davidson, Odile Blanchet, Juan Manuel Chao de la Barca, Gilles Simard, Christian Lavigne, Pascal Reynier
Summary: This study aimed to find early biomarkers of primary Sjogren's syndrome in labial salivary gland using metabolomics and machine-learning approaches. A discriminant signature composed of six metabolites, including the immune-metabolite kynurenine and five phospholipids, accurately predicted primary Sjogren's syndrome status. These findings demonstrate the potential of an immuno-lipidomic signature in labial salivary gland as an accurate diagnostic tool for early primary Sjogren's syndrome.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Ana Isabel Lopes, Raquel Machado-Neves, Mrinalini Honavar, P. Ricardo Pereira
Summary: The minor salivary glands' biopsy is an effective and simple diagnostic procedure for Sjogren's syndrome and amyloidosis. Its use can increase the number of patients meeting the classification criteria for Sjogren's syndrome and appears to be useful in diagnosing amyloidosis.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Rheumatology
Konstantina Delli, Martha S. van Ginkel, Arjan Vissink, Alja J. Stel, Bert van der Vegt, Frederik K. L. Spijkervet, Frans G. M. Kroese, Suzanne Arends, Hendrika Bootsma
Summary: Ultrasound is a promising method for evaluating major salivary gland involvement in pSS patients, but its ability to replace salivary gland biopsy is still debated. While SGUS has good reliability, replacing biopsy reduces the accuracy of classification criteria.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Rheumatology
Pilar Jimenez-Royo, Michele Bombardieri, Coziana Ciurtin, Michalis Kostapanos, Anwar R. Tappuni, Natasha Jordan, Azeem Saleem, Teresa Fuller, Kathleen Port, Elena Pontarini, Davide Lucchesi, Robert Janiczek, Paul Galette, Graham Searle, Neel Patel, Lucy Kershaw, Calum Gray, Nirav Ratia, Andre van Maurik, Marius de Groot, Nicolas Wisniacki, Mats Bergstrom, Ruth Tarzi
Summary: In this study, non-invasive imaging techniques including PET-CT and MRI were used to assess gland structure, inflammation, and function in patients with pSS. Results indicated that pSS patients had impaired glandular synthetic function, increased inflammation, and more severe fat accumulation compared to healthy volunteers, with disease duration positively correlating with MRI parameters and negatively correlating with C-11-MET and F-18-FDG uptake.
Article
Immunology
Erich Horeth, Akinsola Oyelakin, Eun-Ah Christine Song, Monika Che, Jonathan Bard, Sangwon Min, Jeremy Kiripolsky, Jill M. Kramer, Satrajit Sinha, Rose-Anne Romano
Summary: Sjogren's Syndrome is a chronic autoimmune disease affecting salivary and lacrimal glands. RNA sequencing and single-cell RNA sequencing have revealed important pathways and regulatory networks in the pathobiology of SS, as well as the diversity in activated state of salivary gland epithelial cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Geriatrics & Gerontology
Soledad Retamozo, Chiara Baldini, Hendrika Bootsma, Salvatore De Vita, Thomas Doerner, Benjamin A. Fisher, Jacques-Eric Gottenberg, Gabriela Hernandez-Molina, Agnes Kocher, Belchin Kostov, Aike A. Kruize, Thomas Mandl, Wan-Fai Ng, Raphaele Seror, Yehuda Shoenfeld, Antoni Siso-Almirall, Athanasios G. Tzioufas, Arjan Vissink, Claudio Vitali, Simon J. Bowman, Xavier Mariette, Manuel Ramos-Casals, Pilar Brito-Zeron
Summary: Primary Sjogren's syndrome is a systemic autoimmune disease commonly diagnosed in middle-aged women, with two-thirds of patients diagnosed between 30 and 60 years old. Older patients are more likely to have organ-related comorbidities and require caution when using various medications. A thorough evaluation of medical history is essential for older patients when prescribing drugs included in the EULAR guidelines, with specific attention to factors commonly associated with aging.
Article
Critical Care Medicine
Benjamin A. Fisher, Tonny Veenith, Daniel Slade, Charlotte Gaskell, Matthew Rowland, Tony Whitehouse, James Scriven, Dhruv Parekh, Madhu S. Balasubramaniam, Graham Cooke, Nick Morley, Zoe Gabriel, Matthew P. Wise, Joanna Porter, Helen McShane, Ling-Pei Ho, Philip N. Newsome, Anna Rowe, Rowena Sharpe, David R. Thickett, Julian Bion, Simon Gates, Duncan Richards, Pamela Kearns
Summary: This study aimed to evaluate the efficacy of two drugs in hospitalized patients with COVID-19. The results showed that namilumab was able to reduce the inflammatory response, while infliximab did not show significant efficacy compared to usual care. Although there were some differences in adverse events and mortality rates, these differences were not significant.
LANCET RESPIRATORY MEDICINE
(2022)
Letter
Rheumatology
Florian Kollert, Valentina Pucino, Saba Nayar, Jason Turner, Saaeha Rauz, Andrea Richards, Jon Higham, Ana Poveda-Gallego, Rachel M. Brown, Timothy Bates, Simon J. Bowman, Francesca Barone, Benjamin A. Fisher
Article
Rheumatology
Valentina Pucino, Jason D. Turner, Saba Nayar, Florian Kollert, Saaeha Rauz, Andrea Richards, Jon Higham, Ana Poveda-Gallego, Simon J. Bowman, Francesca Barone, Benjamin A. Fisher
Summary: This study aimed to compare clinical and proteomic predictors of primary Sjogren's syndrome (SjS) and non-SjS sicca syndrome (sicca), and identify the key predictors of symptoms. The results showed that obesity-related metabolic factors may regulate symptoms in sicca, while further research is needed to explore the non-inflammatory drivers of high symptom burden in SjS.
Meeting Abstract
Rheumatology
A. C. Sarbu, S. Guler, O. Stadler, Y. Allanore, V. Bernardino, J. H. W. Distler, A. Gabrielli, A. M. Hoffmann-Vold, M. Matucci-Cerinic, U. Mueller-Ladner, V. Ortiz-Santamaria, S. Rednic, V. Riccieri, V. Smith, S. Ullman, U. Walker, T. Geiser, O. Distler, B. Maurer, F. Kollert
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Meeting Abstract
Rheumatology
L. Christ, A. Gloor, F. Kollert, S. Reichenbach, P. Villiger
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Mirjam Kolev, Adela-Cristina Sarbu, Burkhard Moller, Britta Maurer, Florian Kollert, Nasser Semmo
Summary: This study retrospectively investigated the treatment response of six patients with AIH or PBC, three of whom had concomitant Sjo center dot gren's disease, using the anti-BAFF therapy belimumab. The results showed that belimumab improved disease control in AIH patients and helped reduce side effects from corticosteroids and calcineurin inhibitors. In PBC patients, there was no clear improvement in liver function tests, but a reduction in IgM levels was observed. Patients with concomitant Sjo center dot gren's disease experienced improvements in sicca symptoms and fatigue.
JOURNAL OF TRANSLATIONAL AUTOIMMUNITY
(2023)
Meeting Abstract
Respiratory System
S. A. Guler, A. Sarbu, O. Stadler, Y. Allanore, V Bernardino, J. H. Distler, A. Gabrielli, A. Hoffmann-Vold, M. Matucci-Cerinic, U. Mueller-Ladner, V Ortiz-Santamaria, S. Rednic, V Riccieri, V Smith, S. Ullman, U. Walker, T. Geiser, O. Distler, B. Maurer, F. Kollert
EUROPEAN RESPIRATORY JOURNAL
(2022)
Meeting Abstract
Medicine, General & Internal
A-C Sarbu, S. Guler, O. Stadler, Y. Allanore, V Bernardino, J. Distler, A. Gabrielli, A-M Hoffmann-Vold, M. Matucci-Cerinic, U. Mueller-Ladner, V Ortiz, S. Rednic, V Riccieri, V Smith, S. Ullman, U. Walker, T. Geiser, O. Distler, B. Maurer, F. Kollert
SWISS MEDICAL WEEKLY
(2022)
Meeting Abstract
Medicine, General & Internal
L. Christ, L. Seitz, G. Scholz, L. Butikofer, F. Kollert, S. Reichenbach, P. Villiger
SWISS MEDICAL WEEKLY
(2022)
Meeting Abstract
Rheumatology
Lisa Christ, Luca Seitz, Godehard Scholz, Lukas Buetikofer, Florian Kollert, Stephan Reichenbach, Peter Villiger
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Lisa Christ, Andrea Gloor, Florian Kollert, Timo Gaber, Frank Buttgereit, Stephan Reichenbach, Peter Villiger
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Medicine, General & Internal
Mirjam Kolev, Adela-Cristina Sarbu, Anna Walder, Burkhard Moeller, Britta Maurer, Florian Kollert, Nasser Semmo
SWISS MEDICAL WEEKLY
(2021)
