Letter
Endocrinology & Metabolism
Mayer B. Davidson, Seth Joshua Davidson
Summary: A clinical pharmacist effectively improved blood sugar control in poorly controlled insulin-requiring diabetic patients by using FDA-cleared computerized insulin dose adjustment algorithms, resulting in a decrease in HbA1c levels.
JOURNAL OF DIABETES
(2021)
Article
Biology
Benjamin J. Lobo, Boris P. Kovatchev
Summary: As the amount of CGM data increases, the need for simplified storage and analysis methods becomes crucial. Lobo et al. developed a classifier that can successfully classify CGM data and validated its performance on an external validation set. The classifier has proven to be robust and generalizable across different datasets.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Endocrinology & Metabolism
Davida F. Kruger, John E. Anderson
Summary: Recent studies have shown the clinical utility of CGM in T2D patients, with significant reductions in A1c levels and health resource utilization. However, current eligibility criteria are denying many individuals access to this valuable technology. Therefore, modifying these criteria is necessary for more people to benefit from CGM.
DIABETES TECHNOLOGY & THERAPEUTICS
(2021)
Review
Endocrinology & Metabolism
Yu Song, Xiaodan Zhai, Yu Bai, Cong Liu, Le Zhang
Summary: Gestational diabetes mellitus is a common endocrine disease during pregnancy that can lead to adverse pregnancy outcomes. Continuous glucose monitoring (CGM) can effectively monitor blood glucose changes and improve gestational outcomes by reducing fluctuations and serious hypoglycemia or hyperglycemia events. Time in range (TIR) is an important indicator of blood glucose level, and patients with higher TIR during pregnancy have better outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Concetta Irace, Sara Coluzzi, Graziano Di Cianni, Elisa Forte, Francesco Landi, Maria Rosaria Rizzo, Giorgio Sesti, Elena Succurro, Agostino Consoli
Summary: The outpatient use of continuous glucose monitoring (CGM) has been supported by consistent data to improve glycemic control and reduce hypoglycemia burden. However, limited data exist regarding its use in the hospital setting, especially in non-intensive care units (non-ICU). This Expert Opinion paper evaluates the state of the art and provides a practical model for implementing CGM in hospitals. The practical approach outlined here can guide hospitals in their diabetes management initiatives using CGM to identify the most suitable patients and maximize clinical benefits.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Review
Pediatrics
Maria-Sofia Kalogeropoulou, Isabel Iglesias-Platas, Kathryn Beardsall
Summary: The National Institute for Clinical Excellence (NICE) recommends continuous glucose monitoring (CGM) for adults and children with diabetes at risk of hypoglycemia. CGM can detect silent hypoglycemia in neonates, which is associated with poor neurodevelopmental outcome. Despite advancements in technology, adoption in clinical practice is limited due to device limitations for newborns. However, CGM offers the opportunity to improve understanding of hypoglycemia risks and the impact of interventions.
FRONTIERS IN PEDIATRICS
(2023)
Article
Endocrinology & Metabolism
M. Rodacki, L. E. Calliari, A. C. Ramalho, A. G. D. Vianna, D. R. Franco, K. F. S. Melo, L. R. Araujo, M. Krakauer, M. Scharf, W. Minicucci, R. Ziegler, M. Gabbay
Summary: This manuscript discusses the Brazilian Diabetes Society's position on insulin adjustments based on trend arrows observed in continuous glucose monitoring systems, providing tables for insulin adjustment and strategies to optimize the use of trend arrows in clinical practice. It suggests that only upward trend arrows should be used for adjustments for patients on insulin pumps with predictive low-glucose suspend feature.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Review
Engineering, Chemical
Yan Zheng, Dunyun Shi, Zheng Wang
Summary: Continuous glucose monitoring (CGM) systems are increasingly important in glycemic control for diabetes patients, but immune responses to poorly biocompatible sensors affect their accuracy and lifespan. This review summarizes recent research efforts to mitigate immune responses by enhancing the anti-biofouling ability of sensors. The review categorizes these efforts into active immune engaging strategies and passive immune escape strategies, describing various biocompatible layers on the sensor surface in detail. This review provides vital information for researchers developing implantable biosensors for CGM systems with improved anti-biofouling properties.
FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING
(2023)
Article
Computer Science, Information Systems
Simon Lebech Cichosz, Morten Hasselstrom Jensen, Ole Hejlesen
Summary: This study aimed to develop and validate a model for predicting future CGM measurements to overcome time-delay. Using an artificial neural network regression approach, the model yielded good results in both internal and external validation, performing better than alternative methods.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2021)
Article
Endocrinology & Metabolism
Shridhara Alva, Ronald Brazg, Kristin Castorino, Mark Kipnes, David R. Liljenquist, Hanqing Liu
Summary: This study evaluated the performance of the FreeStyle Libre (R) 3 continuous glucose monitoring system (FSL3) and compared it to different reference glucose values. The results showed that the FSL3 demonstrated accurate performance during the 14-day sensor wear period.
Article
Endocrinology & Metabolism
So Hyun Cho, Seohyun Kim, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Gyuri Kim, Jae Hyeon Kim
Summary: This study examined the impact of continuous glucose monitoring on glycated A1c levels in adults with type 1 diabetes mellitus over a period of 1 year. The results showed that individuals who used continuous glucose monitoring had significant reductions in glycated A1c levels at 3, 6, 9, and 12 months compared to baseline. Furthermore, the reduction in glycated A1c levels was more pronounced in the continuous glucose monitoring user group compared to the non-user group.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Tadej Battelino, Charles M. Alexander, Stephanie A. Amiel, Guillermo Arreaza-Rubin, Roy W. Beck, Richard M. Bergenstal, Bruce A. Buckingham, James Carroll, Antonio Ceriello, Elaine Chow, Pratik Choudhary, Kelly Close, Thomas Danne, Sanjoy Dutta, Robert Gabbay, Satish Garg, Julie Heverly, Irl B. Hirsch, Tina Kader, Julia Kenney, Boris Kovatchev, Lori Laffel, David Maahs, Chantal Mathieu, Didac Mauricio, Revital Nimri, Rimei Nishimura, Mauro Scharf, Stefano Del Prato, Eric Renard, Julio Rosenstock, Banshi Saboo, Kohjiro Ueki, Guillermo E. Umpierrez, Stuart A. Weinzimer, Moshe Phillip
Summary: Randomised controlled trials and other prospective clinical studies have traditionally used HbA1c as a measure of average blood glucose levels, but with the increasing use of continuous glucose monitoring (CGM), CGM-derived metrics are being considered for use in these studies. This consensus statement recommends the use of CGM data in clinical studies to provide additional clinical information beyond HbA1c. Standardizing the collection and reporting of CGM data in clinical trials can enhance the interpretability of the data and inform therapeutic decisions related to hypoglycaemia, postprandial hyperglycaemia, and glucose variability.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Li Li, Jie Sun, Liemin Ruan, Qifa Song
Summary: The study utilized time-series analysis of CGM measurements to predict treatment effects in patients with type 2 diabetes mellitus. Patients were classified into different groups based on the trend components of CGM values and showed varying changes in FPG and HbA1c levels after 6 months of treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Chemistry, Analytical
Ananthakrishnan Soundaram Jeevarathinam, Waqas Saleem, Nya Martin, Connie Hu, Michael J. McShane
Summary: A sensitive and scalable phosphorescent oxygen sensor formulation using ethyl cellulose (EC) and polystyrene (PS) nanoparticles stabilized with various surfactants was evaluated. The EC nanoparticles showed higher sensitivity and narrow size distribution compared to PS nanoparticles. The preferred formulation of EC nanoparticles protected with PF68 exhibited high oxygen sensitivity, wide phosphorescence lifetime response, and low cytotoxicity. These EC-PF68 nanoparticles were then encapsulated in alginate microspheres to create phosphorescent nanoparticles-in-microparticle (NIMs) for glucose and lactate sensing.
Article
Endocrinology & Metabolism
Georgia M. Davis, Eileen Faulds, Tara Walker, Debbie Vigliotti, Marina Rabinovich, Joi Hester, Limin Peng, Barbara McLean, Patricia Hannon, Norma Poindexter, Petrena Saunders, Citlalli Perez-Guzman, Seema S. Tekwani, Greg S. Martin, Guillermo Umpierrez, Shivani Agarwal, Kathleen Dungan, Francisco J. Pasquel
Summary: The study shows that a hybrid protocol integrating CGM and POC is helpful for managing critically ill patients with COVID-19 requiring insulin infusion. Sensor accuracy is impacted by mechanical interferences, but the majority of sensor values are within 20% of reference POC glucose levels.
Article
Chemistry, Multidisciplinary
Max Heyl, Sarah Gruetzmacher, Steffen Ruehl, Giovanni Ligorio, Norbert Koch, Emil J. W. List-Kratochvil
Summary: This study presents a silver-mediated exfoliation process that rivals gold in performance, showing that a combination of freshly cleaved silver surfaces and low-temperature annealing is crucial. The exfoliation yield is found to depend on annealing temperature, with a loss in performance at higher temperatures. Raman studies indicate inhomogeneous strain at the MoS2/Ag interface at these temperatures.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Khan Le, Florian von Toperczer, Feray Uenlue, Gopinath Paramasivam, Florian Mathies, Edgar Nandayapa, Emil J. W. List-Kratochvil, Thomas Fischer, Klas Lindfors, Sanjay Mathur
Summary: This research report firstly presents the single-step fabrication of CsPbBr3@PVP nanofibers in a customized electrospinning process performed under ambient conditions from a water-based precursor solution. The water-based approach enables the incorporation of a conductive polymer into the compound fiber by blending the perovskite precursor ink with commercially available PEDOT:PSS dispersion. The electrospun fiber mats show structural stability at ambient conditions for at least 5 months and can be utilized in electroluminescence devices, demonstrating the promising applications of perovskite nanofibers in flexible and stretchable optoelectronics.
ADVANCED ENGINEERING MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Dongguen Shin, Fengshuo Zu, Edgar R. Nandayapa, Lennart Frohloff, Emily Albert, Emil J. W. List-Kratochvil, Norbert Koch
Summary: In this study, it is revealed that a straddling type-I energy level alignment is present at the 2D PEA(2)PbI(4)/3D MAPbI(3) interfaces, explaining the enhanced photoluminescence of the 3D perovskite induced by energy transfer from the 2D perovskite. These results provide a fundamental understanding of the electronic properties at the investigated 2D/3D MHP interfaces and suggest reconsideration of the electronic properties of other 2D/3D MHP heterostructures.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Max Heyl, Emil J. W. List-Kratochvil
Summary: Following the success of the scotch tape method in graphene research, gold-mediated exfoliations have emerged as a matured technique for obtaining high-quality 2D materials, including transition metal dichalcogenides (TMDCs). This review focuses on recent developments and methods for gold-mediated exfoliations, which enable the assembly of macroscopic van der Waals heterostructures or twistronics.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2023)
Article
Chemistry, Multidisciplinary
Josefine Sprachmann, Tommy Wachsmuth, Manik Bhosale, David Burmeister, Glen J. Smales, Maximilian Schmidt, Zdravko Kochovski, Niklas Grabicki, Robin Wessling, Emil J. W. List-Kratochvil, Birgit Esser, Oliver Dumele
Summary: Despite being unstable, 4n pi systems have gained attention for their unique optical and electronic properties. The first antiaromatic framework materials were synthesized and a series of highly crystalline and porous COFs based on DBP were obtained. These antiaromatic COFs show potential applications in positive electrode materials for Li-organic batteries and exhibit photoconductivity upon visible light irradiation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Materials Science, Multidisciplinary
Alberto Taffelli, Giovanni Ligorio, Lucio Pancheri, Alberto Quaranta, Riccardo Ceccato, Andrea Chiappini, Marco Vittorio Nardi, Emil J. W. List-Kratochvil, Sandra Dire
Summary: This study optimizes a sol-gel synthesis method for the fabrication of MoS2 films, enabling the deposition of large area MoS2 films on different substrates. The films exhibit desired chemical and physical properties expected for 2D-MoS2 and show uniformity across the entire film area. Photodetector devices made using this fabrication method demonstrate responsivity values of few mA/W in the NUV-VIS-NIR spectrum, expanding the spectral response range of MoS2-based photodetectors previously reported. Despite the influence of residual electronic defects on the device response time and light-to-dark current ratio, this work presents a scalable and versatile process for fabricating 2D-MoS2 and photodetectors based on it.
Article
Chemistry, Physical
Meysam Raoufi, Sreelakshmi Chandrabose, Rongbin Wang, Bowen Sun, Nicolas Zorn Morales, Safa Shoaee, Sylke Blumstengel, Norbert Koch, Emil List-Kratochvil, Dieter Neher
Summary: Monolayer transition-metal dichalcogenides (TMDCs) combined with organic semiconductors form heterostructures with tunable optoelectronic properties. The efficiency and lifetime of photoinduced charge transfer can be controlled by tuning the energy level offset. Direct electron-hole recombination across the hybrid interface is not the main decay pathway for photogenerated carriers, instead, holes are suggested to transfer back to the TMDC layer. Adding a 1 nm LiF interlayer can slow down interfacial carrier recombination without suppressing free carrier formation.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Nanoscience & Nanotechnology
Paul Haensch, Selen Solak, Hyung Seok Choi, Yohan Kim, Giovanni Ligorio, Manuel Gensler, Jiyong Kim, Christine Boeffel, Emil J. W. List-Kratochvil, Felix Hermerschmidt
Summary: Quantum dot (QD) materials are being increasingly used in display applications due to their high color purity and fluorescence quantum yield, resulting in devices with higher brightness and efficiency. In this study, a zinc selenide-based blue QD material was synthesized and air-fabricated into light-emitting diodes (LEDs) and single-carrier devices. The QD-LED devices showed pure deep blue/purple fluorescence emission with a high photoluminescence quantum yield of 78%. By utilizing different electron transport layers, the devices achieved maximum luminance values of 6200 cd m(-2) and 3000 cd m(-2) with turn-on voltages of 3.5 V and 3 V, respectively. This study demonstrates, for the first time, the air-fabrication of ZnSe-based QD-LEDs, opening up possibilities for large-scale display applications and high-performance printed electronics.
Article
Materials Science, Multidisciplinary
Seon-Young Rhim, Max Heyl, Kurt Busch, Emil J. W. List-Kratochvil
Summary: Photonic circuits are promising candidates to overcome the drawbacks of electronic counterparts, providing a comprehensive platform for the future. This study presents a simple method for addressing parallel optical channels exclusively with 2-bit signals, combining optical communication with electronic signals into a hybrid circuit. By using electrochromic material for intensity modulation, light transmission or absorption is controlled, enabling parallel computations optically.
PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Johannes Mueller, Max Heyl, Thorsten Schultz, Kristiane Elsner, Marcel Schloz, Steffen Ruehl, Helene Seiler, Norbert Koch, Emil J. W. List-Kratochvil, Christoph T. Koch
Summary: 4D scanning transmission electron microscopy (4D-STEM) is a powerful technique that can characterize electron-transparent samples with high spatial resolution. By rastering an electron beam over a sample area and acquiring transmission diffraction patterns, 4D-STEM can provide detailed information about the atomic structure, crystallinity, orientation, and other properties of the sample. It can be used in scanning electron microscopes (SEMs) to study 2D materials and vdWH, with their inherently thin thickness. A unique 4D-STEM-in-SEM system is applied to reveal the single crystallinity of MoS2 exfoliated with gold-mediation and determine the crystal orientation and coverage of both components in a C60/MoS2 vdWH.
PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Sarah Gruetzmacher, Max Heyl, Marco Vittorio Nardi, Norbert Koch, Emil J. W. List-Kratochvil, Giovanni Ligorio
Summary: 2D transition metal dichalcogenides (TMDCs) are semiconductors with potential for optoelectronic applications, and their properties can be altered by chemically engineering the substrate surface. This study demonstrates local doping and adjustment of the electronic and optical properties of TMDCs (WSe2 and MoS2) by decorating the substrate with self-assembled monolayers (SAMs) with different molecular dipoles and dielectric constants. The interaction between SAMs and TMDCs leads to changes in the electronic band gap width, which can be predicted using the Schottky-Mott rule and knowledge of the dielectric screening effects. Understanding these effects allows for accurate prediction of TMDCs behavior for device design.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Alberto Taffelli, Max Heyl, Matteo Favaro, Sandra Dire, Lucio Pancheri, Emil J. W. List-Kratochvil, Alberto Quaranta, Giovanni Ligorio
Summary: Two-dimensional transition metal dichalcogenides (TMDCs) show great potential as semiconductors for optoelectronic applications in the ultraviolet-visible spectral range, but their characteristics under x-rays have not been characterized yet. This paper demonstrates the use of TMDCs as direct x-ray detectors, and improves the x-ray photoresponse by coupling with a polymer film integrated with a scintillator. This may pave the way for the production of ultrathin real-time dosimeters for in vivo applications.
Article
Chemistry, Multidisciplinary
Vincent R. F. Schroeder, Nicolas Fratzscher, Florian Mathies, Edgar R. Nandayapa, Felix Hermerschmidt, Eva L. Unger, Emil J. W. List-Kratochvil
Summary: We demonstrate the upscaling of inkjet-printed metal halide perovskite light-emitting diodes by optimizing the drying process with an airblade-like slit nozzle. This results in large, continuous perovskite layers in light-emitting diodes with an active area up to 1600 mm(2).
Article
Chemistry, Multidisciplinary
David Burmeister, Alberto Eljarrat, Michele Guerrini, Eva Rock, Julian Plaickner, Christoph T. Koch, Natalie T. Banerji, Caterina Cocchi, Emil J. W. List-Kratochvil, Michael J. Bojdys
Summary: Graphitic carbon nitrides are promising materials for overcoming the limitations of 0D molecular and 1D polymer semiconductors due to their covalently-bonded, layered, and crystalline structure. This study investigates the structural, vibrational, electronic, and transport properties of poly(triazine-imide) (PTI) derivatives with and without intercalated ions. It is found that PTI nano-crystals exhibit high charge carrier density and THz conductivity, but the electroluminescence from the pi-pi* transition is quenched, limiting their use in electroluminescent devices. Macroscopic charge transport in PTI films is also hindered by disorder at crystal-crystal interfaces.
Article
Chemistry, Multidisciplinary
Josefine Sprachmann, Tommy Wachsmuth, Manik Bhosale, David Burmeister, Glen J. Smales, Maximilian Schmidt, Zdravko Kochovski, Niklas Grabicki, Robin Wessling, Emil J. W. List-Kratochvil, Birgit Esser, Oliver Dumele
Summary: In recent years, 4n pi systems have attracted significant attention due to their unique optical and electronic properties. We synthesized the first antiaromatic framework materials based on dibenzopentalene and obtained highly crystalline and porous covalent organic frameworks (COFs). These COFs exhibit excellent conductivity and photoconductivity, and show enhanced performance as positive electrode materials in Li-organic batteries.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
