Article
Food Science & Technology
Alicia Lopez-Maldonado, Silvia Pastoriza, Jose Angel Rufian-Henares
Summary: The study evaluated the antioxidant and metabolic effects of a dietary supplement based on ALA and ALC, finding significant preventive effects against oxidative stress and recommending 2 capsules as a reasonable dosage.
CURRENT RESEARCH IN FOOD SCIENCE
(2021)
Article
Andrology
Rahil Jannatifar, Elham Asa, Seyedeh Saeideh Sahraei, Atefeh Verdi, Hamid Piroozmanesh
Summary: The aim of this study was to evaluate the beneficial effects of NAC, ALA, and NAC+ALA combination supplement on sperm structural and functional characteristics in asthenoteratozoospermia patients in freezing medium. The results showed that NAC and ALA significantly improved sperm motility and DNA fragmentation, and NAC and ALA groups exhibited higher expression of antioxidant enzymes and NRF2 gene.
Article
Medicine, General & Internal
Paola Scaruffi, Emanuele Licata, Elena Maccarini, Claudia Massarotti, Francesca Bovis, Fausta Sozzi, Sara Stigliani, Alessandro Dal Lago, Ida Casciano, Rocco Rago, Paola Anserini
Summary: Oral antioxidant supplementation can improve reproductive competence in men with low fertilization rates in previous ICSI cycles by increasing sperm concentration and total motile sperm count, and improving embryological outcomes. This treatment may contribute to better clinical outcomes for ICSI cycles.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Adel R. Moawad, Ali Salama, Magdy R. Badr, Mohamed Fathi
Summary: Supplementation of L-Carnitine (LC) during in vitro maturation (IVM) of canine oocytes improves maturation, fertilization, and preimplantation embryo development rates following IVF and in vitro culture (IVC).
Article
Plant Sciences
Amr Elkelish, Mohamed M. El-Mogy, Gniewko Niedbala, Magdalena Piekutowska, Mohamed A. M. Atia, Maha M. A. Hamada, Mostafa Shahin, Soumya Mukherjee, Ahmed Abou El-Yazied, Mohamed Shebl, Mohammad Shah Jahan, Ali Osman, Hany G. Abd El-Gawad, Hatem Ashour, Reham Farag, Samy Selim, Mohamed F. M. Ibrahim
Summary: The study found that cysteine and alpha-lipoic acid can improve physiological metabolic responses in wheat plants under drought stress, enhancing antioxidant enzyme activity and yield quality.
Article
Endocrinology & Metabolism
M. Gelardi, P. G. Marano, R. Giancaspro, M. Cassano
Summary: Craniofacial neuralgias are considered a highly unmet medical need, with oxidative stress playing a crucial role in pathogenesis and antioxidant compounds showing potential in reducing neuropathic pain.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Review
Biochemistry & Molecular Biology
Tabatha Petrillo, Elisa Semprini, Veronica Tomatis, Melania Arnesano, Fedora Ambrosetti, Christian Battipaglia, Alessandra Sponzilli, Francesco Ricciardiello, Andrea R. Genazzani, Alessandro D. Genazzani
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine-metabolic disorder among women at reproductive age. This review analyzes the pathogenesis and various treatment methods of PCOS, highlighting the importance of personalized therapeutic strategies.
Article
Multidisciplinary Sciences
Sethu C. Nair, Justin T. Munro, Alexis Mann, Manuel Llinas, Sean T. Prigge
Summary: Coenzyme A (CoA) biosynthesis is a critical target for combating malaria. The study reveals the essential role of the mitochondrion in cellular acetyl-CoA biosynthesis and identifies a synthetic lethal relationship between two key ketoacid dehydrogenase enzymes. The lipoate attachment enzyme LipL2 is found to be crucial for the activity of these enzymes, which is indispensable for parasite survival due to its involvement in acetyl-CoA metabolism. Additionally, the study highlights the importance of mitochondrial-derived acetyl-CoA for protein acetylation outside the mitochondrion. Overall, these findings underscore the significance of the mitochondrion in cellular acetyl-CoA metabolism and protein acetylation crucial for parasite survival.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Pharmacology & Pharmacy
Reza Hakimizad, Rasool Soltani, Farzin Khorvash, Majid Marjani, Farzaneh Dastan
Summary: The combination of ALCAR, ALA, and CoQ10 may effectively prevent drug-induced liver injury caused by anti-tuberculosis drugs, as indicated by significantly lower serum enzyme levels and reduced incidence of DILI in the experimental group compared to the placebo group.
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Houjin Dongye, Yizheng Tian, Dan Qi, Yanbo Du, Lei Yan
Summary: The influence of endometrioma on oocyte and embryo competence is inconclusive, and the benefits of surgical treatment remain uncertain. This study aimed to investigate the effect of endometrioma on oocyte and embryo quality from a morphological perspective and explore whether surgery could improve oocyte and embryo competence.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
M. Gelardi, R. Giancaspro, M. R. Ferro, M. Balestra, M. Cassano
Summary: During physiological processes and stressful conditions, the release of free radicals can lead to oxidative stress, damaging the structure and functionality of proteins, lipids, and nucleic acids. Mitochondria are highly impacted by oxidative stress, causing mitochondrial dysfunction and tissue damage. Oxidative stress is involved in the development of various pathological processes, and antioxidant molecules can inhibit the production of free radicals and the perpetuation of inflammation.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Review
Biochemistry & Molecular Biology
Martina Placidi, Giovanna Di Emidio, Ashraf Virmani, Angela D'Alfonso, Paolo Giovanni Artini, Anna Maria D'Alessandro, Carla Tatone
Summary: The importance of bioenergetics in the reproductive process has highlighted the role of carnitines as mitochondrial modulators. Carnitine supplementation may help counteract energetic and redox imbalances during in vitro culture and cryopreservation. Carnitines activate pathways involved in antiapoptotic, antiglycative, antioxidant, and antiinflammatory signaling, potentially improving oocyte and embryo competence.
Article
Environmental Sciences
Xueqian Ma, Long Cui, Lin Chen, Jun Zhang, Xiaohui Zhang, Quanmin Kang, Fan Jin, Yinghui Ye
Summary: This study found that maternal plasma concentrations of perfluorooctanoic acid (PFOA) were negatively associated with the numbers of retrieved oocytes, mature oocytes, 2 PN zygotes, and good-quality embryos, while higher paternal plasma PFOA concentrations were significantly associated with reduced numbers of 2 PN zygotes. However, none of the maternal or paternal PFAS were significantly associated with the probability of implantation, clinical pregnancy, or live birth.
ENVIRONMENTAL POLLUTION
(2021)
Review
Nutrition & Dietetics
Ruey-Yu Hsieh, I-Chen Huang, Chiehfeng Chen, Jia-Ying Sung
Summary: Alpha-lipoic acid (ALA) improves symptoms in patients with diabetic sensorimotor peripheral neuropathy (DSPN) by reducing oxidative stress and improving microcirculation. A meta-analysis of randomized controlled trials (RCTs) evaluated the effects of orally-administered ALA versus placebo in patients with DSPN, finding that ALA treatment had favorable effects on sensory symptoms, total symptoms' score (TSS), neurological disability score (NDS), and global satisfaction. However, it did not produce favorable results for vibration perception, nerve conduction, and neuropathy impairment.
Article
Biochemistry & Molecular Biology
Kaio Murilo Monteiro Espindola, Everton Luiz Pompeu Varela, Rosyana de Fatima Vieira de Albuquerque, Rosiane Araujo Figueiredo, Savio Monteiro dos Santos, Nivea Silva Malcher, Pamela Suelen da S. Seabra, Andreia do Nascimento Fonseca, Karla Marcely de Azevedo Sousa, Susan Beatriz Batista de Oliveira, Agnaldo da Silva Carneiro, Michael D. Coleman, Marta Chagas Monteiro
Summary: This study evaluated the protective effect of racemic alpha lipoic acid (ALA) and its enantiomers on methemoglobin induction caused by Dapsone (DDS) therapy. The results showed that ALA could effectively inhibit the formation of methemoglobin induced by DDS-NOH and reduce DNA damage. This study suggests that ALA could be used as a treatment in patients who chronically use DDS, including leprosy patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Kathryn H. Gurner, Jemma Evans, Jennifer C. Hutchison, Alexandra J. Harvey, David K. Gardner
Summary: This study suggests that lactate may play an important role in maternal-fetal dialogue, promoting endometrial receptivity and implantation. Further investigation of the role of lactate in infertile or compromised endometrium could potentially improve pregnancy success.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Genetics & Heredity
Meagan Allen, Lyndon Hale, Daniel Lantsberg, Violet Kieu, John Stevens, Catharyn Stern, David K. Gardner, Yossi Mizrachi
Summary: This study found that post-warming re-expansion and high cell survival rate are associated with higher live birth rate. Embryos with fully expanded blastocysts and high cell survival rate have a higher chance of live birth, but embryos with poor post-warming morphology still have a considerable probability of live birth.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Obstetrics & Gynecology
Thi Truong, Alexandra J. Harvey, David K. Gardner
Summary: This study investigated the effect of combined antioxidants on mouse fetal gene expression. The results showed that both in-vitro culture in the presence of 20% oxygen and vitrification of blastocysts significantly perturbed fetal liver and placental gene expression. However, supplementation with A3 reduced the number of differentially expressed genes and altered biological processes, establishing a more in-vivo-like gene expression profile, particularly in the placenta. Additionally, A3 supplementation significantly reduced the expression of genes associated with pre-eclampsia and intrauterine growth restriction.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
David K. Gardner
Summary: By introducing more technologies in the ART laboratory, outcomes such as live birth rate, time to pregnancy, and automation can be improved. New technologies have the potential to assist more patients in becoming parents of healthy children in a shorter period of time.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Biochemical Research Methods
Ricardo Correia, Brett Gadsby, Sergiy Korposh, Andrew M. Norris, Barrie r. Hayes-gill, Rishie Sinha, Jonathan G. Hardman, David S. Gardner, Simon Talbot, Daniel Harvey, Julian Mcglashan, Stephen P. Morgan
Summary: This study describes the development of a smart endotracheal tube (ETT) that can measure contact pressure and blood perfusion at the cuff-trachea interface. Testing on a porcine model during mechanical ventilation shows that the device can accurately obtain relevant data, and blood occlusion caused by over-inflation of the cuff can be observed.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Nutrition & Dietetics
David S. Gardner, Clint Gray
Summary: Development from early conceptus to a complex, multi-cellular organism is a highly ordered process that is dependent on an adequate supply of nutrients. Variation in environmental stimuli, such as drug or hormone exposure and nutrient delivery pattern, can significantly impact fetal and neonatal growth patterns and later health outcomes.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Multidisciplinary Sciences
R. Alborough, P. A. Graham, D. S. Gardner
Summary: This study assessed the habitual iodine intake in domestic cats by conducting a dietary survey and analyzing commercial cat feeds. The findings suggest that domestic cats are likely to experience chronically low or fluctuating dietary iodine intake, which is supported by wide variation in urine iodine content.
SCIENTIFIC REPORTS
(2022)
Article
Urology & Nephrology
David S. Gardner, Jennifer C. Allen, Deborah Goodson, Daniel Harvey, Andrew Sharman, Henry Skinner, Adam Szafranek, John S. Young, Elizabeth H. Bailey, Mark A. J. Devonald
Summary: Urinary cadmium, copper, and zinc are novel biomarkers for early detection of acute kidney injury. Urinary trace metals have advantages over proteins as they are stable and can be tested economically using electrochemistry.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Veterinary Sciences
C. Schrurs, G. Dubois, F. Patarin, M. Cobb, D. S. Gardner, E. Van Erck-Westergren
Summary: This study used a new device to record the changes in speed, heart rate, and biomechanical parameters of racehorses during training. The results showed that the increase in speed was mainly achieved by changing stride length and frequency, which were influenced by track surface, horse age, and sex. The study also found that as training intensity increased, the heart rate of racehorses also increased, although not in a linear manner.
COMPARATIVE EXERCISE PHYSIOLOGY
(2022)
Article
Anatomy & Morphology
Jennie N. Jeyapalan, Victoria. James, David S. Gardner, Jennifer H. Lothion-Roy, Nigel P. Mongan, Catrin Sian Rutland
Summary: Research is an essential part of veterinary medicine degrees, and remote learning during the COVID-19 pandemic has affected the performance and experience of students. This study analyzed the outcomes and feedback of students who completed independent research projects, showing that the pandemic cohorts achieved higher grades with increased access to resources while facing challenges in workload management and conceptual exploration.
ANATOMIA HISTOLOGIA EMBRYOLOGIA
(2023)
Article
Obstetrics & Gynecology
Emma G. Whatley, Thi T. Truong, Dagmar Wilhelm, Alexandra J. Harvey, David K. Gardner
Summary: Exposure to the ketone beta-hydroxybutyrate (beta OHB) impairs preimplantation mouse embryo development, metabolism, epigenetics, and post-transfer viability, with significant effects seen at ketogenic diet (KD)-relevant serum concentrations. These findings suggest a potential detrimental impact on embryo development and viability due to maternal diets that elevate beta OHB levels.
HUMAN REPRODUCTION
(2022)
Article
Biology
James D. Gillis, William V. V. Holt, Linda M. Penfold, Kathryn J. Woad, James K. Graham, Julie A. Watts, David S. Gardner, Lisa Yon
Summary: The effect of ice morphology on the post-thaw survival of domestic boar spermatozoa cryopreserved in 0.5 ml straws was investigated. The study found that ice morphology had little impact on post-thaw sperm survival, and there was no difference in survival between conventionally and directionally cryopreserved samples at optimal interface velocities.
Article
Multidisciplinary Sciences
Charlotte Schrurs, Guillaume Dubois, Emmanuelle Van Erck-Westergren, David S. Gardner
Summary: This study, using objectively obtained data, demonstrates for the first time no overt effect of the rider's sex on racehorse physiology in training and performance in racing. Such data could encourage greater female participation in racing and improve access of female jockeys to better quality mounts in racing events.
Article
Agriculture, Dairy & Animal Science
Charlotte Schrurs, Sarah Blott, Guillaume Dubois, Emmanuelle Van Erck-Westergren, David S. S. Gardner
Summary: Using a stride tracking device, this study objectively measures and compares the stride lengths of racehorses categorized as sprinters or stayers. The results show that there are significant differences in stride length between these two categories, even before they compete in races. The study also finds that stride length during training cannot predict racing success, but stayers tend to have better race results than sprinters. This objective data on stride characteristics can be helpful for trainers in selecting appropriate races for each racehorse.
Article
Biochemistry & Molecular Biology
Lesia O. O. Kurlak, Paula J. J. Scaife, Louise V. V. Briggs, Fiona Broughton Pipkin, David S. S. Gardner, Hiten D. D. Mistry
Summary: This study aimed to investigate the relationship between the concentrations of trace elements and angiogenic markers in women with pre-eclampsia and their fetuses. The results showed that pregnant women with pre-eclampsia had lower levels of selenium, zinc, and manganese, and higher levels of copper. Additionally, maternal plasma zinc concentration was positively correlated with plasma sFlt-1 concentration, suggesting an imbalance in antioxidant status.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Alice Newman-Sanders, Jackson C. Kirkman-Brown, Meurig T. Gallagher
Summary: This study revealed a significant lack of awareness among young adults in the UK regarding the potential impacts of gym lifestyles and supplementation on male infertility. Men were found to have a concerning lack of concern for their own fertility, with differences in awareness levels between men and women. It was also observed that men were more likely to consider making changes to their behavior if it had a long-term impact on their fertility compared to short-term effects.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Shachar Reuvenny, Michal Youngster, Almog Luz, Rohi Hourvitz, Ettie Maman, Micha Baum, Ariel Hourvitz
Summary: Using a machine-learning model to determine the optimal trigger days can improve the outcomes of antagonist protocol cycles in freeze-all or fresh transfer cycles, for all age groups. Implementing these models can more accurately predict the number of retrieved oocytes, optimizing physicians' decisions, balancing workloads, and creating more standardized yet patient-specific protocols.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Hang
Summary: This study investigates the proteomic and phosphoproteomic differences in the endometrium of women with recurrent pregnancy loss (RPL) compared to healthy control women during different phases of the menstrual cycle. The results identify differentially expressed proteins and phosphorylated proteins, and highlight the insulin/cyclic nucleotide signalling pathway and AMPK/mTOR signalling pathway as major contributors to the abnormality of RPL endometrium. The findings provide insights into potential proteins associated with the pathogenesis of RPL and contribute to the identification of potential targets for RPL treatment.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Jaime Guerrero, Juan Carlos Castillo, Jorge Ten, Jose Antonio Ortiz, Belen Lledo, Domingo Orozco, Francisco Quereda, Andrea Bernabeu, Rafael Bernabeu
Summary: The study found no significant differences in clinical outcomes between using oocytes obtained from random-start protocols and those from conventional ovarian stimulation in oocyte donation treatments. Luteal-phase stimulation required longer stimulation and higher FSH consumption.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
